9th Annual Biomarkers Congress
Compound Profiling & Chemogenomic Approaches to Drive Decision Making and Predict Clinical Adverse Effects (Oct 11-12)
Loews Philadelphia Hotel
1200 Market Street
Philadelphia, PA
http://www.healthtech.com/2007/cpf/day1.asp
Cambridge Healthtech Institute
Compound Profiling & Chemogenomic Approaches to Drive Decision Making and Predict Clinical Adverse Effects

Schedule of Presentations:

Thursday, October 11, 2007
12:30:00 Registration (12:30-13:30)
12:30:00 SCREENING AGAINST MULTIPLE TARGETS (Shared Session with Drug Repositioning Summit) (12:30-17:15) Jonathan Mason, Tudor I. Oprea, Rebecca A. Taub, David Grass, Jill Heemskerk, Mark Murcko, David M. Manyak, Jeremy S. Caldwell, Laszlo Urban
13:30:00 SCREENING AGAINST MULTIPLE TARGETS: Chairperson’s Remarks (13:30-13:40) David M. Manyak
13:40:00 SCREENING AGAINST MULTIPLE TARGETS: Featured Presentation - Is Repositioning a Viable Option for Creating Differentiated Medicines? (13:40-14:15) Rebecca A. Taub
14:15:00 SCREENING AGAINST MULTIPLE TARGETS: Automated Robotic Molecular Profiling in Cells for New Therapeutic Directions (14:15-14:45) Jeremy S. Caldwell
14:45:00 SCREENING AGAINST MULTIPLE TARGETS:Poster Session, Exhibit Viewing and Refreshment Break(14:45-15:15)
15:15:00 SCREENING AGAINST MULTIPLE TARGETS: An Efficient Platform for Genetic Target and Compound Positioning (15:15-15:45) David Grass
15:45:00 SCREENING AGAINST MULTIPLE TARGETS: Integrative In Vitro Safety Pharmacology Profiling to Predict Clinical Adverse Effects (15:45-16:15) Laszlo Urban
16:15:00 SCREENING AGAINST MULTIPLE TARGETS: Ceftriaxone and Results of Large Scale Screening Efforts (16:15-16:45) Jill Heemskerk
16:45:00 Panel Discussion: How to Choose a Compound with the Best Profile (16:45-17:15)
17:15:00 Close of Day
Friday, October 12, 2007
08:00:00 Morning Coffee Breakfast Workshop (Sponsorship Available) or Breakfast on your own (08:00-08:30)
08:30:00 PROFILING TO OPTIMIZE EFFICACY (08:30-14:00) Jonathan Mason, Jeffrey J. Sutherland, Jacques Migeon, Mark Murcko, Tudor I. Oprea, Wolfgang Guba, Berta Strulovici
08:30:00 PROFILING TO OPTIMIZE EFFICACY: Chairperson’s Remarks (08:30-08:35) Mark Murcko
08:35:00 PROFILING TO OPTIMIZE EFFICACY: The Wisdom of Crowds versus the Inevitability of Black Swans: What we Can and Cannot Learn from History (08:35-09:15) Mark Murcko
09:15:00 PROFILING TO OPTIMIZE EFFICACY: Rethinking Similarity & the Chemotype Concept: Using Biological Fingerprints as a More Relevant Descriptor (09:15-09:45) Jonathan Mason
09:45:00 PROFILING TO OPTIMIZE EFFICACY: Black Swans and White Tablets (09:45-10:15) Tudor I. Oprea
10:15:00 PROFILING TO OPTIMIZE EFFICACY: Poster Session, Exhibit Viewing, and Coffee Break (10:15-10:45)
10:45:00 PROFILING TO OPTIMIZE EFFICACY: Prioritizing Hits from Phenotypic Assays Using Biochemical Profiling Data (10:45-11:15) Jeffrey J. Sutherland
11:15:00 PROFILING TO OPTIMIZE EFFICACY: Case Study - Chemogenomic Strategies for GPCR Hit Finding (11:15-11:45) Case Study Wolfgang Guba
11:45:00 PROFILING TO OPTIMIZE EFFICACY: Interpreting Compound Profiles in the Context of the Human Drug Experience (11:45-12:15) Jacques Migeon
12:15:00 PROFILING TO OPTIMIZE EFFICACY: Panel Discussion - The Value of Doing Systems Biology after HTS (12:15-12:45) Berta Strulovici, Mark Murcko
12:45:00 PROFILING TO OPTIMIZE EFFICACY: Luncheon Workshop (Sponsorship Available) or Lunch on Your Own (12:45-14:00)
14:00:00 SELECTING LEADS AND DETECTING ADVERSE ACTIVITY (14:00-17:30) Tudor I. Oprea, William T. Loging, Andreas Bender, Dana E. Vanderwall, Petra Ross-Macdonald, Stephen Horrigan
14:00:00 SELECTING LEADS AND DETECTING ADVERSE ACTIVITY: Chairperson’s Remarks (14:00-14:05) Tudor I. Oprea
14:05:00 SELECTING LEADS AND DETECTING ADVERSE ACTIVITY: Analysis of Biological Mechanism of Action, and Characterization of Profiles across the Progression Path (14:05-14:35) Dana E. Vanderwall
14:35:00 SELECTING LEADS AND DETECTING ADVERSE ACTIVITY: Analysis of Drug Induced Effect Patterns for Investigating Systems Structure Effect Relationships (14:35-15:05) William T. Loging
15:05:00 SELECTING LEADS AND DETECTING ADVERSE ACTIVITY: Characterizing the Multiple Activities of Kinase Inhibitors (15:05-15:35) Petra Ross-Macdonald
15:35:00 SELECTING LEADS AND DETECTING ADVERSE ACTIVITY: Poster Session, Exhibit Viewing, and Refreshment Break (15:35-16:00)
16:00:00 SELECTING LEADS AND DETECTING ADVERSE ACTIVITY: Compound Profiling by Predicting On-Target Activities, Compound Promiscuity and Adverse Drug Reactions (16:00-16:30) Andreas Bender
16:30:00 SELECTING LEADS AND DETECTING ADVERSE ACTIVITY: Molecular Profiling Driven Drug Discovery - Use of Compound Profiling from Discovery to the Clinic and Back Again (16:30-17:00) Stephen Horrigan
17:00:00 SELECTING LEADS AND DETECTING ADVERSE ACTIVITY: Panel Discussion - Comparing Available Databases, Public vs. Private (17:00-17:30)
17:30:00 Close of Conference
4th Annual Pharma R&D Asia Congress
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