3D Tissue Models
Fourth Annual FRAGMENT-BASED DRUG DISCOVERY
HILTON SAN DIEGO RESORT
1775 East Mission Bay Drive
San Diego, CA 92109
http://www.healthtech.com
Fourth Annual FRAGMENT-BASED DRUG DISCOVERY
Cambridge Healthtech Institute
HILTON SAN DIEGO RESORT

Schedule of Presentations:

Monday, April 6, 2009
07:00:00 Registration and Morning Coffee
08:00:00 Chairperson’s Opening Remarks
08:10:00 Keynote Presentation In Silico Fragment-Based Drug Design Eric Springman
08:50:00 Fragment-Based Screening using Libraries in-silico and X-Ray Crystallography Kal Ramnarayan
09:20:00 Virtual Fragment Linking: An Approach to Identify Potent Binders from Low Affi nity Fragment Hits Meir Glick
09:50:00 Networking Coffee Break
10:15:00 Fragment-Based Drug Discovery - from Crystal to Clinic Gordon Saxty
10:45:00 Recent Lessons in Fragment-Based Discovery Roderick Hubbard
11:15:00 Bridging the Gap between Ligand- and Structure-Based Drug Design through the Application of Pharamophcores Derived from Fragment Docking Noeris Salam
11:30:00 Fragment-Based Drug Discovery by NMR: Reaping the Benefi ts of Orthogonal Screening Approaches to Validate Hit Compounds Sponsored Presentation by Evotec Jan D. Kahmann
12:00:00 Luncheon Presentation
13:00:00 Session Break
13:25:00 Chairperson’s Remarks
13:30:00 Fragment-Based Screening of Antibacterial Targets Igor Mochalkin
14:00:00 Fragment Based Lead Design with Multiple Copy Simultaneous Search Shikha Varma-O’Brien
14:30:00 Assessment of Additive/Non-Additive Effects in SAR: Implications in the Drug Discovery Iterative Process Julen Oyarzabal
15:00:00 Sponsored Presentation (Opportunity Available)
15:15:00 Networking Refreshment Break in Exhibit Hall
16:00:00 Impact of Fragment Screening on the Rapid Discovery of Novel and Selective Protein Kinase Inhibitors Andreas Kuglstatter
16:30:00 Panel Discussion: The Challenge of Turning Leads Into Results
17:30:00 Reception in the Exhibit Hall
18:30:00 End of day
Tuesday, April 7, 2009
08:00:00 Continental Breakfast Breakout Discussions
08:05:00 Topic 1: Fragment Library Screening Alex Burgin
08:10:00 Topic 2: Fragment Based Drug Discovery Case Studies - What is the output in the last 10 years? Gordon Saxty
08:15:00 Topic 3: Computational Practices in Fragment-based Lead Design Shikha Varma-O’Brien
08:20:00 Topic 4: Fragment-Based Drug Discovery - Are the Expectations being met? Roderick Hubbard
09:00:00 Chairperson’s Remarks
09:05:00 Fragment-Based Discovery of a Prolinol Derivative (DG-051) as a Novel Leukotriene A 4 Hydrolase Inhibitor for the Prevention of Myocardial Infarction Alex Kiselyov
09:35:00 Effi cient Lead Discovery by Combining Structurally Related Fragment and Screening Libraries Daniel Obrecht
10:05:00 Sponsored Presentation (Opportunity Available)
10:20:00 Networking Coffee Break in Exhibit Hall
11:00:00 Breakout Discussion Feedback by Moderators
11:30:00 An RNA-Directed Fragment Library Fareed Aboul-ela
12:00:00 End of Conference
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