Biotech China 2014
Track 4: Fourth Annual GPCR-based drug discovery
Intercontinental Hotel Boston Massachusetts
510 ATLANTIC AVENUE
BOSTON, 02210 • UNITED STATES, MA
http://www.discoveryontarget.com/gpc
Track 4: Fourth Annual GPCR-based drug discovery
Cambridge Healthtech Institute

Schedule of Presentations:

Monday, November 2, 2009
07:00:00 Registration and Morning Coffee
07:05:00 APPLYING STRUCTURE-BASED KNOWLEDGE TO GPCR DRUG DISCOVERY
08:30:00 Chairperson’s Opening Remarks
08:40:00 Key Challenges in Understanding GPCR Structure and Function for Drug Discovery KEYNOTE PRESENTATION Graeme Milligan
09:10:00 The Impact of Recent X-Ray Structure Determinations on Structure-based Drug Design for GPCRs and other CNS Targets Sidney W. Topiol
09:40:00 The Structure of G Protein Coupled Receptors: Implications for Signaling and Pharmacology
10:10:00 Grand Opening Coffee Break in the Exhibit Hall
10:40:00 Mapping Ligand Specific States for Drug Design in GPCRs Nagarajan Vaidehi
11:10:00 Monitoring the Multiple Signaling Pathways of GPCRs: Insights into the Molecular Determinants of Ligand-Biased Signaling Michel Bouvier
11:40:00 Using Stabilised GPCRs to Enable Structure Based Drug Discovery Fiona Marshall
12:10:00 Sponsored Presentations (Sponsorship Opportunity Available)
12:40:00 Luncheon Presentation (Sponsorship Opportunity Available) or Lunch on Your Own
12:45:00 NEW METHODS FOR PROBING OR SCREENING GPCRS
14:20:00 Chairperson’s Remarks
14:25:00 Targeting GPCR Activity: Conventional and Novel Label-free cAMP Assays Sandra Siehler, Ph.D., Research Investigator II, Novartis Institute for BioMedical Research Sandra Siehler
14:55:00 Hit Identification Practices for GPCR Targets at Bristol-Myers Squibb Company Neil Burford
15:25:00 Allosteric Regulation of Agonist and Inverse Agonist Binding to Monomeric GPCRs by G Proteins Roger Sunahara
15:55:00 Networking Refreshment Break in the Exhibit Hall
16:30:00 Pepducins – Novel Mediators of GPCR Signaling Stephen Hunt
17:00:00 Testing the Hypothesis of Allosteric Compound Selectivity through Large Scale Selectivity-Profiling Blaine N. Armbruster
17:15:00 Membrane-tethered Ligands Provide a Novel Strategy for Modulating GPCR Function Alan S. Kopin
17:45:00 Happy Hour in the Exhibit Hall
19:00:00 Close of Day
Tuesday, November 3, 2009
07:30:00 Continental Breakfast Breakout Discussion Sessions
07:35:00 OPTIMIZING GPCR-CANDIDATES FOR CNS TARGETS AND CALCIUM REGULATORS
08:30:00 Chairperson’s Remarks
08:40:00 CGRP Receptor Antagonists for the Acute Treatment of Migraine Donnette Staas
09:10:00 Optimization and Mechanism of Action Studies of Allosteric Modulators of Calcium-Regulation Jeff Reagan
09:40:00 Networking Coffee Break in the Exhibit Hall
10:40:00 Case Study of Preladenant, an A2A Antagonist for the Treatment of Parkinson’s Disease Andy Stamford
11:10:00 Pimavanserin: From Target to Clinic Using Sensitive, HTP and Quantitative Drug Discovery Technologies Doug Bonhaus
11:40:00 Negative Allosteric Modulators of mGluR5 in Parkinson’s Disease Simon Jones
12:10:00 Discovery of GPCR Ligands for GPR3, a GPCR Modulating Amyloid Secretion in Alzheimer’s Disease David Fischer
12:40:00 Close of Conference
4th Annual Pharma R&D Asia Congress
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