3D Tissue Models
Antibody Optimization
Sheraton Boston Hotel

Boston, Massachusetts
http://www.pegsummit.com/mab
   Speakers
   --------

   N/A

   The second stage of antibody drug or diagnostic development can
   sometimes be the most difficult-the optimization. This conference will
   present methods researchers can apply to make their antibody the best,
   most functional and least immunogenic it can be.

Schedule of Presentations:

Thursday, May 20, 2010
12:00:00 Registration
13:25:00 TARGETING, SPECIFICITY AND AFFINITY
13:30:00 Chairperson’s Opening Remarks
13:40:00 Conferring Meaningful Anti-Tumor Activity to Monoclonal Antibodies by Linking Cell Killing Agents Ravi V. Chari
14:10:00 Recombinant Human Multi-Domain Fusion Proteins Stefan Barth
14:40:00 Design and Produce Better Antibodies with Antigen Profiler Matt Baker
15:10:00 Networking Refreshment Break, Poster and Exhibit Viewing
16:00:00 Optimizing Antibody Homogeneity and Development: Lessons Learned from Structural and Functional Studies Alain Beck
16:30:00 Antibody-Drug Conjugates to Improve Therapeutic Index Wei Liao
17:00:00 End of Day
Friday, May 21, 2010
07:45:00 Continental Breakfast in the Exhibit Hall
08:25:00 HALF-LIFE, SENSITIVITY AND EFFICACY
08:30:00 Chairperson’s Opening Remarks Gerald Casperson
08:35:00 Trastuzumab Conjugate for the Treatment of Trastuzumab-Resistant Human Breast Cancer: Increasing Magnitude and Duration of Response Wen Jin Wu
09:05:00 Fc-Optimized Monoclonal Antibody for HER2- Expressing Tumors Jeffrey L. Nordstrom
09:35:00 Optimization of a Monoclonal Antibody for Improved Anti-Tumor Efficacy Gerald Casperson
10:05:00 Coffee Break, Poster and Exhibit Viewing
11:00:00 WHEN LESS IS MORE: ANTIBODY FRAGMENTS
11:05:00 Recombinant Immunotoxins for the Treatment of Hematologic Malignancies Robert J. Kreitman
11:35:00 Engineered Avibodies Optimized for Clinical Diagnosis and Therapy Peter Hudson
12:05:00 Luncheon Presentations (Sponsorship Opportunities Available) or Lunch on Your Own
13:05:00 Break
13:20:00 STABILITY, GLYCOSYLATION, IMMUNOGENICITY AND HUMANIZATION
13:25:00 Chairperson’s Remarks Ira Pastan
13:30:00 Antibody Therapeutics: Isotype and Glycoform Selection Roy Jefferis
14:00:00 Early Stage Engineering to Improve Pharmaceutical Properties of Antibodies Alexey Lugovskoy
14:30:00 Networking Refreshment Break
15:00:00 Deimmunizing Non-Human Proteins Ira Pastan
15:30:00 Antibody Optimization from Pharmacokinetic-Pharmacodynamic Perspectives Liang Zhao
16:00:00 Probodies: Site-Directed Antibodies to Improve Therapeutic Indices Nancy Stagliano
16:30:00 End of Conference
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