Biotech China 2014
Renal Hemodynamics: Biomolecular Control Mechanisms
Vermont Academy, Saxtons River, VT
20 Pleasant St, Saxtons River, 05154, USA
mm, VT
http://src.faseb.org
1. Genetic Regulation of the Renin-Angiotensin System and Signaling
Pathways in the Juxtaglomerular Apparatus
2. Renin / Angiotensin II Receptors and G-protein-Coupled Receptor
Interactions
3. Communication between Vascular and Tubular Cells
4.Featured “Hot-Topic� Presentations of Poster Group A
5. Macula Densa Signaling and Tubular – Vascular Interactions
6. Dynamic Autoregulation: Modulation of Myogenic and Tubuloglomerular
7. Oxidative Stress and Reactive Oxygen Species
8. Featured “Hot-Topic� Presentations of Poster Group B
9. Control Mechanisms of Tubular and Vascular Function
10. Regulation by the Sympathetic Nervous System
11. Eicosanoid Regulation of the Renal Circulation and Tubular Transport
12. Featured “Hot-Topic� Presentations of Poster Group C.

Schedule of Presentations:

Saturday, July 7, 2007
14:00:00 Conference Registration
18:00:00 Dinner
18:00:00 Opening Reception
20:30:00 Welcome William J Arendshorst
20:40:00 Opening Address Friedrich C Luft
Sunday, July 8, 2007
07:00:00 Breakfast
08:30:00 Enhancer-dependent and -independent mechanisms for renin expression Curt D Sigmund
08:55:00 Electrophysiology of the renin-producing juxtaglomerular cells Ulla G Friis
09:20:00 Novel mechanisms for calcium regulation of renin secretion William H Beierwaltes
09:45:00 Role of connexin 40 in local baroreceptor control of renin secretion Charlotte Wagner
10:00:00 Coffee Break - Group picture
10:35:00 Lipid raft / caveolae in cardiovascular cells: Role in G-protein-coupled receptor signaling Paul A Insel
11:00:00 Cell-specific gene targeting of AT1 receptors Thomas M Coffman
11:25:00 D5 dopamine receptors regulate blood pressure via proteosomal degradation of AT1 angiotensin receptors Pedro A Jose
11:50:00 Enhanced interaction between Gi-coupled receptors and angiotensin II in the SHR renal vasculature Edwin K Jackson
12:15:00 Lunch
13:15:00 Free Afternoon
16:30:00 Poster Session - A (A-1 – A-41)
18:00:00 Dinner
19:00:00 Metabolic control of macula densa-JGA signaling Janos Peti Peterdi
19:25:00 ACE-2 and angiotensin-(1-7) formation in the proximal tubule Mark C Chappell
19:50:00 ETB receptor activation of NOS1 mediates excretion of an acute salt load Jennifer S Pollock
20:15:00 Molecular regulation of thick ascending limb transport by NO Pablo A Ortiz
20:40:00 Coffee Break
21:00:00 Angiotensin II signaling is necessary for normal development of postglomerular capillaries including vasa recta bundles during postnatal kidney development Kirsten Madsen
21:10:00 Aquaporin-1 facilitates the diffusion of NO into vascular smooth muscle cells and thus enhances the vasorelaxant effects of NO Marcela Herrera
21:20:00 ADP ribosyl cyclase mediates renal vascular responses to endothelin-1 Tiffany L Thai
21:30:00 Potassium and acetylcholine induced renal vasodilation in SHR Linda Magnusson
21:40:00 Potassium channel contributions to afferent arteriolar tone in normal and diabetic rats Carmen Troncoso Brindeiro
21:50:00 Adenosine triphosphate increases the sensitivity of the isolated perfused afferent arteriole to low concentrations of norepinephrine through a receptordependent pathway Michael Hultström
22:00:00 (Poster A-39) Kin Lung Siu
Monday, July 9, 2007
07:00:00 Breakfast
08:30:00 Macula densa cell signaling Darwin P Bell
08:55:00 Purinergic signaling in the juxtaglomerular apparatus Hayo Castrop
09:20:00 Adenosine increases angiotensin II-induced contractions in renal afferent arterioles via non-receptor pathways Andreas Patzak
09:45:00 A new cross-talk pathway between the renal tubule and its own glomerulus Oscar A Carretero
10:10:00 Coffee Break
10:30:00 Tubuloglomerular feedback and adaptive mechanisms Scott C Thomson
10:55:00 TGF system multi-stability and dynamic complexity in spontaneouslyhypertensive rats Leon C Moore
11:20:00 Ca2+ mechanisms underlying the myogenic response and its rapid kinetics Rodger D Loutzenhiser
11:45:00 Modulation of mechanisms mediating renal blood flow autoregulation Armin Just
12:10:00 Lunch
13:10:00 Free Afternoon
16:30:00 Poster Session B (B-2 – B-42
18:00:00 Dinner
19:00:00 Does arterial-to-venous oxygen shunting contribute to dynamic regulation of intrarenal oxygenation? Roger E Evans
19:25:00 Renal oxygen usage, oxidative stress and hypertension William J Welch
19:50:00 Interaction of superoxide and nitric oxide in the kidney Dewan SA Majid
20:15:00 NOX2 and NOX4 are expressed by the macula densa and primary source of Ruisheng Liu
20:40:00 Coffee Break
21:00:00 Impaired luminal ATP release and pressure natriuresis in connexin 30 knockout mice Arnold Sipos
21:10:00 Prorenin activation contributes to the development of insulin resistance in fructose-fed rats Yukiko Nagai
21:20:00 Relaxin reduces blood pressure and attenuates kidney damage in angiotensin II- but not L-NAME-induced hypertension Jennifer Sasser
21:30:00 Mechanisms leading to hypertension in a female mouse model of systemic Lupus Erythematosus Michael J Ryan
21:40:00 Intrarenal oxidative stress contributes to hypertension in adult growthrestricted offspring Norma B Ojeda
21:50:00 Glomerular hypertension and hyperfiltration in young fvb.ROP Os/+ mice Mona Oppermann
Tuesday, July 10, 2007
07:00:00 Breakfast
08:30:00 Do vasa recta modulate medullary blood flow? Thomas L Pallone
08:55:00 Mechanosensitive beta and gamma ENaC mediate myogenic vasoconstriction in mouse renal interlobar arteries Heather A Drummond
09:20:00 Role of serum- and glucocorticoid-inducible kinase 1 in salt and potassium homeostasis Volker Vallon
09:45:00 Lessons from cell-specific gene targeting: Role of the collecting duct endothelin system in blood pressure regulation Donald E Kohan
10:10:00 Coffee Break
10:30:00 Adrenoceptor-induced calcium signaling in the afferent arteriole Max Salomonsson
10:55:00 Differential neural control of renal function: Role of neuropeptide Y Kate M Denton
11:20:00 Endothelin: A salt-sensitive neuromodulator Ulla C Kopp
11:45:00 Molecular sensors for salt and fluid homeostasis: Role of TRPV in the kidney Donna H Wang
12:10:00 Lunch
13:10:00 Free Afternoon
16:30:00 Poster Session C (C-1 – C-39)
18:00:00 Dinner
19:00:00 Interactions of the intrarenal dopaminergic system with COX-2 and renin expression. Raymond C Harris
19:25:00 Contribution of cytochrome P450 metabolites of arachidonic acid as mediators or modulators of pressure natriuresis Richard J Roman
19:50:00 Renal vascular actions of novel epoxide metabolites. John D Imig
20:15:00 Prevention of the salt-sensitive component of hypertension and proteinuria in stroke-prone SHR with the soluble epoxide hydrolase inhibitor AUDA Charles T Stier
20:40:00 Coffee Break
21:00:00 Implications of a high salt diet in a model of congenital nephron reduction Leah Anne M Ruta
21:10:00 Angiotensin (Ang) II AT-2-receptor-induced nitric oxide release sustains blood perfusion and oxygen availability in the post-clip kidney of two-kidney, one clip hypertensive rats Fredrik Palm
21:20:00 The role of CYP450 metabolites of arachidonic acid during the development of glomerular disease in the fawn-hooded hypertensive rat Jan M Williams
21:30:00 Failure to upregulate the adenosine 2A receptor-epoxyeicosatrienoic acid (EET) pathway may be a contributing factor in the development of salt-induced hypertension in Dahl salt-sensitive rats Elvira L Liclican
21:40:00 Role of protein kinase C in superoxide production by the renal medullary thick ascending limb from normal and diabetic rats Jing Yang
21:50:00 Renal concentrating mechanism - Tamm-Horsfall protein modulates AVPstimulated transport in TAL Sebastian Bachmann
22:00:00 Gender differences in endothelin-dependent sodium excretion in renal medulla Daisuke Nakano
Wednesday, July 11, 2007
07:00:00 Breakfast
08:30:00 Cellular mechanisms of renal vascular dysfunction in hypertension Raouf A Khalil
08:55:00 NO release attenuates ANG II-mediated contraction and Ca2+ signaling in afferent arterioles from the non-clipped kidney of 2K1C hypertensive rats Bjarne M Iversen
09:20:00 Salt-induced changes in the renal hemodynamic response to ET-1 David M Pollock
09:45:00 Oxidative stress enhances constrictor responses of renal afferent arterioles Christopher S Wilcox
10:10:00 Coffee Break
10:30:00 Genetics of diabetic nephropathy: Lessons from mice Matthew D Breyer
10:55:00 Is oxidative stress responsible for altered electromechanical coupling in afferent arteriole during type 1 diabetes? Pamela K Carmines
11:20:00 Tubular and hormonal mechanisms for controlling renal vascular resistance early in diabetes Michael W Brands
11:45:00 Renal microvascular damage and glomerular hemodynamic changes induced by experimental metabolic syndrome Martha Franco
12:10:00 Lunch
18:00:00 Dinner
19:00:00 Cascade of pressure natriuresis mechanisms L Gabriel Navar
19:25:00 Volume natriuresis, pressure natriuresis and the homeostatic control of sodium excretion Peter Bie
19:50:00 Extracellular renal cyclic GMP modulates nitric oxide and pressure-induced natriuresis. Robert M Carey
20:15:00 Redox control of renal medullary function and blood pressure Allen W Cowley
20:40:00 Coffee Break
21:00:00 Panel Discussion and Question / Answer Session
22:15:00 Meeting Remembrances
Thursday, July 12, 2007
07:00:00 Breakfast
08:30:00 Hypertension and renal damage: Protective role of autoregulation Karen Griffin
08:55:00 Afferent arteriolar abnormalities in rat hypertension. Does this have Michael J Mulvany
09:20:00 Role of aldosterone in the pathogenesis of renal injury Akira Nishiyama
09:45:00 Mechanisms of renal injury. Is injury reversible? Christos Chatziantoniou
10:05:00 Coffee Break
10:25:00 Business Meeting
10:35:00 Tubuloglomerular Feedback – Fetal programming of adult hypertension Russell D Brown
11:00:00 Reduction of nephron number during nephrogenic period leads to the development of hypertension and sex-dependent alterations in renal function F Javier Salazar
11:25:00 Sex chromosome effects in angiotensin II-induced hypertension that are independent of the gonadal hormone milieu Carolyn A Ecelbarger
11:50:00 Wrap-up: Summaries / Impressions of Previous Chairs
12:05:00 LUNCH / Box Lunches available
4th Annual Pharma R&D Asia Congress
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