Biotech China 2014
PROTEIN COFACTORS, RADICALS AND QUINONES

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Schedule of Presentations:

Sunday, January 20, 2008
16:00:00 Arrival and Check-in
18:00:00 Dinner
19:30:00 Welcome / Introductory Comments by GRC Site Staff and Chair of Conference
19:40:00 Oxygen Activation and Radical Initiation by a Manganese/Iron Cluster in Chlamydia trachomatis Ribonucleotide Reductase J Martin Bollinger
19:40:00 CHEMISTRY AND BIOLOGY OF RIBONUCLEOTIDE REDUCTASES Squire Booker
20:20:00 Discussion
20:30:00 Ribonucleotide reductases and horizontal gene transfer Britt-Marie Sjöberg
21:10:00 Discussion
Monday, January 21, 2008
07:30:00 Breakfast
08:30:00 Group Photo
09:00:00 Site specific incorporation of 3-Aminotyrosine into R1 and R2. Direct detection of intermediates on the PCET pathway in Ribonucleotide reductases JoAnne Stubbe
09:00:00 ELECTRON AND PROTON TRANSFER
09:35:00 Discussion
09:40:00 An atomistic picture of quantum tunneling in enzymatic hydrogen transfer reactions Michael Sutcliffe
10:20:00 Discussion
10:30:00 Coffee Break
11:00:00 Radical formation by energy driven electron transfer Wolfgang Bückel
11:35:00 Discussion
11:45:00 Molecular Wires to Probe the Structure and Mechanism of Peroxidases, P450, and Nitric Oxide Synthase David B Goodin
12:20:00 Discussion
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
18:00:00 Dinner
19:30:00 The CoA-dependent hydroxyethylidene-thiamin pyrophosphate free radical intermediate in pyruvate:ferredoxin oxidoreductase George Reed
19:30:00 RADICAL MECHANISMS - I
20:05:00 Discussion
20:15:00 Multifrequency EPR Studies of bilin radical intermediates in phytobilin synthesis R David Britt
20:50:00 Discussion
21:00:00 Tryptophan Oxygenation Mechanisms Aimin Liu
21:25:00 Discussion
Tuesday, January 22, 2008
07:30:00 Breakfast
09:00:00 Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme Catherine Drennan
09:00:00 B12 AND RADICAL SAM ENZYMES Joseph Jarrett
09:35:00 Discussion
09:45:00 The mechanism of benzylsuccinate synthase: a radical solution the metabolism of toluene in an anaerobic environment Neil Marsh
10:20:00 Discussion
10:30:00 Coffee Break
11:00:00 Thiazole Synthase from Escherichia coli Peter Roach
11:35:00 Discussion
11:45:00 Escort and Protector of a Radical B12 Enzyme Ruma Banerjee
12:20:00 Discussion
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
18:00:00 Dinner
19:30:00 The Structural Genomics Pathway to Cysteine Dioxygenase: Structure then Mechanism Brian Fox
19:30:00 CROSS-LINKED AMINO ACID COFACTORS Britt-Marie Sjöberg
20:05:00 Discussion
20:15:00 The Cross-linked Histidine-Tyrosine Cofactor at the Active Site of the Heme-Copper Proton Pumping Respiratory Oxidases Robert Gennis
20:50:00 Discussion
21:00:00 Autocatalytic formation of heme-protein covalent links in a heme peroxidase Emma Raven
21:25:00 Discussion
Wednesday, January 23, 2008
07:30:00 Breakfast
09:00:00 Insights into the nitrogenase mechanism Lance Seefeldt
09:00:00 COMPLEX REDOX COFACTORS: MECHANISM Sean Elliott
09:35:00 Discussion
09:45:00 Electrocatalytic properties of Ni Centers in Enzymes Fraser Armstrong
10:20:00 Discussion
10:30:00 Coffee Break
11:00:00 Water Oxidation Chemistry of Photosystem II
11:35:00 Discussion
11:45:00 Oxygen Activation by Mononuclear Non-heme Enzymes Carsten Krebs
12:20:00 Discussion
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
18:00:00 Dinner
19:00:00 Business Meeting
19:30:00 COMPLEX REDOX COFACTORS: ASSEMBLY John Peters
19:30:00 Complete synthesis of the iron-molybdenum cofactor of nitrogenase with purified NifB, NifEN, and NifH proteins Luis Rubio
20:05:00 Discussion
20:15:00 NiFe cofactor assembly in aerobic hydrogenases Barbel Friedrich
20:50:00 Discussion
21:00:00 Poster Talk (TBA)
21:15:00 Discussion
Thursday, January 24, 2008
07:30:00 Breakfast
09:00:00 QUINONE COFACTORS: BIOSYNTHESIS, MECHANISM, AND MEDICAL IMPLICATIONS Minae Mure
09:00:00 Novel Reaction Intermediates in MauG-dependent Tryptophan Tryptophylquinone Biosynthesis Victor Davidson
09:00:00 Novel Reaction Intermediates in MauG-dependent Tryptophan Tryptophylquinone Biosynthesis Victor Davidson
09:35:00 Discussion
09:45:00 Oxidative chemistry during TPQ biogenesis and catalysis Judith Klinman
10:20:00 Discussion
10:30:00 Coffee Break
11:00:00 Distal structural features controlling substrate and mechanism-based inhibitor selectivity in copper amine oxidases Lawrence Sayre
11:35:00 Discussion
11:45:00 Coenzyme Q10 biosynthesis deficiency in children Agnes Rotig
12:20:00 Discussion
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
18:00:00 Dinner
19:30:00 RADICAL MECHANISMS - II
19:30:00 Tyrosyl Radicals in Heme Proteins: From Mechanisms of Formation to Involvement in Catalysis Justine Roth
20:10:00 Discussion
20:20:00 Exploring amino-acid radicals and quinone redox chemistry in model proteins Cecilia Tommos
21:00:00 Discussion
Friday, January 25, 2008
07:30:00 Breakfast
09:00:00 Depart
4th Annual Pharma R&D Asia Congress
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