9th Annual Biomarkers Congress
TGF-beta in Immune Responses: From Bench to Bedside (A2)
Snowbird Resort
Little Cottonwood Canyon PO Box 929000
Sandy, Utah
http://keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=1104
   Deadlines
   ---------

     *  Abstract Deadline:
       14th September 2010

     *  Registration Deadline:
       8th November 2010


   Speakers
   --------

     *  Wanjun Chen, NIDCR , National Institutes of Health, USA

     *  Michael B. Sporn, Dartmouth Medical School, USA

     *  Joan Massagué, Memorial Sloan-Kettering Cancer Center, USA

     *  Rik Derynck, University of California, San Francisco, USA

     *  Daniel B. Rifkin, New York University, USA

     *  Xin-Hua Feng, Baylor College of Medicine, USA

     *  Speaker to be Announced,

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Short Talks to be Chosen from Abstracts, ,

     *  Richard A. Flavell, Yale University School of Medicine, USA

     *  Tim R. Mosmann, University of Rochester Medical Center, USA

     *  Alexander Y. Rudensky, Memorial Sloan Kettering Cancer Center,
       USA

     *  Short Talk to be Chosen from Abstracts,

     *  Wanjun Chen, NIDCR , National Institutes of Health, USA

     *  Harald von Boehmer, Harvard Medical School, USA

     *  Ethan M. Shevach, NIAID , National Institutes of Health, USA

     *  Jeffrey A. Bluestone, University of California, San Francisco,
       USA

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Short Talks to be Chosen from Abstracts, ,

     *  Speaker to be Announced,

     *  Yasmine Belkaid, NIAID , National Institutes of Health, USA

     *  Peter M. Henson, National Jewish Medical and Research Center, USA

     *  Short Talk to be Chosen from Abstracts,

     *  Dan R. Littman, New York University School of Medicine, USA

     *  Vijay K. Kuchroo, Brigham and Women’s Hospital, Harvard Medical
       School, USA

     *  Brigitta Stockinger, National Institute for Medical Research,
       United Kingdom

     *  Speaker to be Announced,

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Short Talks to be Chosen from Abstracts, ,

     *  Howard L. Weiner, Brigham and Women’s Hospital, USA

     *  Fiona M. Powrie, University of Oxford, United Kingdom

     *  Warren Strober, National Institutes of Health, USA

     *  Short Talk to be Chosen from Abstracts,

     *  Dean Sheppard, University of California, San Francisco, USA

     *  Herman Waldmann, University of Oxford, United Kingdom

     *  Lucienne Chatenoud, INSERM , Hopital Necker, France

     *  John J. O’Shea, NIAMS , National Institutes of Health, USA

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Maria Grazia Roncarolo, San Raffaele Telethon Institute for Gene
       Therapy, Italy

     *  Michael B. Sporn, Dartmouth Medical School, USA

     *  John M. McPherson, Genzyme Corporation, USA

     *  Short Talk to be Chosen from Abstracts,

   The recent discovery of TGF -beta as a key regulator in immune
   responses (particularly in regulatory T cell and Th17 cell
   differentiation) has put TGF -beta at the center stage of immunology,
   a position it deserves. Despite great progress in the field, key
   questions related to TGF -beta re-programming T cells are largely
   unknown. In this regard, it is imperative to understand the molecular
   mechanisms by which TGF -beta controls such a diverse T cell
   programming. Elucidation of these pathways would allow us to apply the
   knowledge and information acquired from basic studies to understand
   the pathogenesis of human immune-associated diseases and develop
   therapeutic practices in experimental and ultimately clinical
   settings. In addition, roles for TGF -beta in innate immunity, the
   mucosal immune system, autoimmunity and inflammation, anti-tumor
   immunity, and HIV -mediated immune deficiency have been gradually
   disclosed and appreciated. Thus, it is necessary to gather experts in
   the field together to discuss new findings and update the pivotal role
   of TGF -beta in the immune system, with the aim to lay out the
   critical and key questions and point out possible directions. The
   Keystone symposium is the ideal platform to reach this goal.

Schedule of Presentations:

Friday, January 7, 2011
15:00:00 Registration | Ballroom Lobby
19:15:00 Orientation for New Attendees and New Investigators | Ballroom 2-3
19:30:00 Opening Remarks | Ballroom 2-3 WanJun Chen
19:35:00 The Discovery of TGF-beta | Ballroom 2-3 Michael B Sporn
19:50:00 Keynote Address | Ballroom 2-3
19:50:00 TGF-beta Receptors, Mediators and Targets | Ballroom 2-3 Joan Massagué
Saturday, January 8, 2011
07:00:00 Breakfast | Golden Cliff/Eagles
08:00:00 Basic Mechanisms of TGF-beta Signal Transduction | Ballroom 2-3
08:10:00 TGF-beta-Induced Smad and non-Smad Signaling Pathways | Ballroom 2-3 Rik Derynck
09:00:00 TGF-beta Bioavailability: Latency and Activation | Ballroom 2-3 Daniel B. Rifkin
09:20:00 Coffee Break | Ballroom Lobby
10:00:00 Molecular Basis of Smad Signal Transduction and Termination | Ballroom 2-3 Xin-Hua Feng
10:20:00 Interactions between TGF-b and BMP Signals | Ballroom 2-3 Caroline S. Hill
10:25:00 Short Talk(s) to be Chosen from Abstracts | Ballroom 2-3
11:35:00 Poster Setup | Superior/Superior Lobby/Wasatch/Maybird
13:05:00 Poster Viewing | Superior/Superior Lobby/Wasatch/Maybird
14:25:00 Workshop 1: TGF-beta in B Cells: IgA and Other Antibodies | Ballroom 2-3
15:15:00 Short Talks to be Chosen from Abstracts | Ballroom 2-3
16:30:00 Coffee Break | Ballroom Lobby
17:05:00 TGF-beta Regulation of T and B Cell Function | Ballroom 2-3
17:25:00 TGF-beta in CD4 and CD8 T Cells | Ballroom 2-3 Richard A. Flavell
18:15:00 Long- and Short-term Regulation of T Cell Cytokine Patterns | Ballroom 2-3 Tim R. Mosmann
18:30:00 TGF-beta Regulation of T Cells: Treg-Dependent and -Independent Pathways | Ballroom 2-3 Alexander Y. Rudensky
18:55:00 Short Talk to be Chosen from Abstracts, | Ballroom 2-3
19:05:00 Social Hour w/ Lite Bites | Superior/Superior Lobby/Wasatch/Maybird
19:35:00 Poster Session 1 | Superior/Superior Lobby/Wasatch/Maybird
Sunday, January 9, 2011
07:00:00 Breakfast | Golden Cliff/Eagles
08:00:00 TGF-beta and Regulatory T Cells | Ballroom 2-3
08:25:00 The molecular mechanisms in TGF-beta induction of Foxp3 gene | Ballroom 2-3 WanJun Chen
09:00:00 Prevention of Type 1 Diabetes by Negative (Treg) Vaccination with an Insulin Mimetope | Ballroom 2-3 Harald von Boehmer
09:20:00 Coffee Break | Ballroom Lobby
09:25:00 Control of Immune Response by TGF-beta Induced Treg Cells | Ballroom 2-3 Ethan M. Shevach
10:10:00 Short Talk(s) to be Chosen from Abstracts, | Ballroom 2-3
10:55:00 Poster Setup | Superior/Superior Lobby/Wasatch/Maybird
12:55:00 Poster Viewing | Superior/Superior Lobby/Wasatch/Maybird
14:30:00 Workshop 2: Interactions between TGF-beta and Other Immune Cytokines: Impact on Immunity and Tolerance | Ballroom 2-3
16:15:00 Short Talks to be Chosen from Abstracts | Ballroom 2-3
16:30:00 Coffee Break | Ballroom Lobby
17:00:00 TGF-beta in Innate Immunity | Ballroom 2-3
17:05:00 Polarization of Tumor-Associated Neutrophil Phenotype by TGF-beta: Implications for Anti-Tumor Immunity. | Ballroom 2-3 Steven M. Albelda
17:55:00 Mucosal DCs and TGF-beta in Infection | Ballroom 2-3 Yasmine Belkaid
18:30:00 TGFb as a Mediator of Responses to Apoptotic Cells | Ballroom 2-3 Peter M. Henson
18:55:00 Short Talk to be Chosen from Abstracts | Ballroom 2-3
19:05:00 Social Hour w/ Lite Bites | Superior/Superior Lobby/Wasatch/Maybird
19:30:00 Poster Session 2 | Superior/Superior Lobby/Wasatch/Maybird
Monday, January 10, 2011
07:00:00 Breakfast | Golden Cliff/Eagles
07:55:00 TGF-beta and Th17 Cells | Ballroom 2-3
08:05:00 TGF-beta and RORgammaT in Murine and Human T Cells | Ballroom 2-3 Dan R. Littman
09:20:00 Coffee Break | Ballroom Lobby Vijay Kuchroo
09:45:00 TGF-beta Promotes IRF4-dependent Development of IL-9-producing Th9 Cells | Ballroom 2-3 Tobias Bopp
10:05:00 A Role for TGF-beta in Human IL-9 Producing TH17 Cells | Ballroom 2-3
10:40:00 Short Talk(s) to be Chosen from Abstracts | Ballroom 2-3
10:55:00 Poster Setup | Superior/Superior Lobby/Wasatch/Maybird
13:00:00 Poster Viewing | Superior/Superior Lobby/Wasatch/Maybird
14:25:00 Workshop 3: TGF-beta Effect on Anti-Tumor Immunity and Immunodeficiency | Ballroom 2-3
15:50:00 Short Talks to be Chosen from Abstracts | Ballroom 2-3
16:30:00 Coffee Break | Ballroom Lobby
16:55:00 TGF-beta in Mucosal Immunity and Tolerance | Ballroom 2-3
17:05:00 Induction of Tregs by Mucosal Administration of Aryl Hydrocarbon Receptor Ligands and anti-CD3 Monoclonal Antibody in Animals and Humans | Ballroom 2-3 Howard Weiner
18:00:00 Regulation of IBD by TGF-beta | Ballroom 2-3 Fiona Powrie
18:40:00 Molecular Regulation of TGF-beta/Retinoic Acid Induction of Foxp3 | Ballroom 2-3 Warren Strober
18:55:00 Short Talk to be Chosen from Abstracts | Ballroom 2-3
19:05:00 Social Hour w/ Lite Bites | Superior/Superior Lobby/Wasatch/Maybird
19:30:00 Poster Session 3 | Superior/Superior Lobby/Wasatch/Maybird
Tuesday, January 11, 2011
07:00:00 Breakfast | Golden Cliff/Eagles
07:10:00 TGF-beta in Autoimmunity, Inflammation and Transplantation | Ballroom 2-3
07:30:00 Regulation of T Cell Differentiation by the alpha-v beta-8 Integrin on Dendritic Cells | Ballroom 2-3 Dean , Sheppard
08:35:00 TGF-beta signaling to T-cells in long-term acceptance of allografts | Ballroom 2-3 Herman Waldmann
09:20:00 Coffee Break | Ballroom Lobby
09:45:00 CD3-Antibody, TGF-beta and Tregs in Type I Diabetes | Ballroom 2-3 Lucienne Chatenoud
10:30:00 TGF-beta and Furin in T Cells | Ballroom 2-3 John J O'Shea
10:40:00 Short Talk(s) to be Chosen from Abstracts | Ballroom 2-3
16:30:00 Coffee Available | Ballroom Lobby
16:55:00 TGF-beta in Human Immune Cells and Diseases | Ballroom 2-3
17:10:00 Role of TGF-beta in the Induction and Function of Human Type 1 Regulatory T (Tr1) Cells | Ballroom 2-3 Maria Grazia Roncarolo
18:00:00 Synthetic Triterpenoids and Inflammatory Diseases: Interactions with Immune Cells and TGF-beta | Ballroom 2-3 Michael B Sporn
18:30:00 Safety Considerations for the Clinical Use of Anti-TGF-beta Antibodies for Treatment of Fibrotic Diseases and Cancer | Ballroom 2-3 John M. McPherson
18:50:00 Short Talk to be Chosen from Abstracts | Ballroom 2-3
19:00:00 Social Hour w/ Lite Bites | Ballroom 2-3
20:00:00 Entertainment | Ballroom 2-3
Wednesday, January 12, 2011
06:00:00 Departure
4th Annual Pharma R&D Asia Congress
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