3D Tissue Models
AAA and Related ATP-Driven Protein Machines: Structure, Function and Mechanism (C6)
Granlibakken Resort
725 Granlibakken Road PO Box 6329, Tahoe City
Tahoe City, California

     *  Abstract Deadline:
       18th November 2010

     *  Registration Deadline:
       20th January 2011


     *  Tania A. Baker, Massachusetts Institute of Technology, USA

     *  Robert T. Sauer, Massachusetts Institute of Technology, USA

     *  Shigeo Murata, University of Tokyo, Japan

     *  Helen Ruth Saibil, Birkbeck College, United Kingdom

     *  Xiaodong Zhang, Imperial College London, United Kingdom

     *  Daniel J. Finley, Harvard University, USA

     *  Raymond J. Deshaies, California Institute of Technology, USA

     *  Andreas Matouschek, Northwestern University, USA

     *  Michael Botchan, University of California, Berkeley, USA

     *  Speaker to be Announced,

     *  James M. Berger, University of California, Berkeley, USA

     *  Stephen C. Kowalczykowski, University of California, Davis, USA

     *  Jorge E. Galan, Yale University School of Medicine, USA

     *  Speaker to be Announced,

     *  Briana M. Burton, Harvard University, USA

     *  Eva Nogales, HHMI – University of California, Berkeley, USA

     *  Antonina Roll-Mecak, National Institute of Neurological Disorders
       and Strokes, USA

     *  Ronald D. Vale, University of California, San Francisco, USA

     *  Nieng Yan, Tsinghua University School of Medicine, China

     *  Wesley I. Sundquist, University of Utah School of Medicine, USA

     *  Phyllis I. Hanson, Washington University School of Medicine, USA

     *  James H. Hurley, National Institutes of Health, USA

   AAA+ protein machines catalyze basic biological processes: they
   degrade proteins, remodel protein complexes and nucleic acids,
   transport macromolecules across membranes, and shape membranes. They
   are at the center of cellular processes such as cell cycle control,
   protein sorting, DNA replication, cytoskeleton dynamics, and membrane
   budding. Thus, AAA+ machines play roles in a wide range of disease
   including cancer, neurodegeneration and infection.

   Despite the diversity of function, there appears to be a common
   operating mode of AAA+ proteins and we are at the cusp of acquiring a
   deep understanding of their molecular mechanism. However, different
   aspects of the mechanism are understood in different systems.

   At this conference we would bring together speakers that have
   elucidated critical aspects of different AAA+ proteins. The group
   transcends molecular scales and methodology. We add a smaller number
   of speakers who have made breakthroughs in the understanding of
   proteins that do not belong to the AAA+ family but are either
   functionally or structurally related. We hope that this combination
   will lead to insights into the common mechanism of these proteins and
   inspire novel experimental approaches and discoveries.

Schedule of Presentations:

Sunday, March 20, 2011
15:00:00 Registration
18:15:00 Welcome and Buffet Dinner
19:15:00 Welcome and Keynote Address
19:30:00 Protein Quality Control by AAA Proteins Tania A Baker
Monday, March 21, 2011
07:00:00 Breakfast
08:00:00 AAA Proteases and Remodeling
08:30:00 The ClpXP Protein-Unfolding Machine Robert Sauer
09:00:00 Proteasome Diversity Shigeo Murata
09:20:00 Coffee Break
09:45:00 Hsp104 and Yeast Prions Helen Saibil
10:00:00 Structures and Mechanism of AAA+ Transcriptional Activators Xiaodong Zhang
10:30:00 Short Talk(s) to be Chosen from Abstracts
11:00:00 On Own for Lunch and Recreation
11:00:00 Poster Setup
13:00:00 Poster Viewing
16:30:00 Coffee Available
16:55:00 Proteasome and p97 | Targeting Proteins to AAA Machines
17:00:00 Assembly and Function of the Hetero-hexameric AAA ring of the Proteasome Daniel Finley
17:30:00 p97 as a Protein Targeting Platform Raymond J. Deshaies
18:00:00 A Second Component to the Degradation Signal | The Proteasome Initiation Site Andreas Matouschek
18:30:00 Short Talk to be Chosen from Abstracts
19:00:00 Dinner
20:00:00 Poster Session 1
20:10:00 Social Hour
Tuesday, March 22, 2011
07:00:00 Breakfast
08:00:00 DNA Gymnastics
08:30:00 Adaptors essential for the activity of the MCM Helicase Michael Botchan
09:00:00 Structural Basis for Hexameric Helicase Translocation and Polarity James Berger
09:20:00 Coffee Break
09:45:00 Visualization of DNA Helicases and DNA Strand Exchange Proteins at the Single-Molecule Level Stephen C Kowalczykowski
10:30:00 Short Talk(s) to be Chosen from Abstracts
11:00:00 On Own for Lunch and Recreation
13:00:00 Poster Viewing
16:30:00 Coffee Available
17:00:00 Moving Molecules Across Membranes
17:30:00 Type III Secretion Machines: Bacterial Devices for Protein Delivery into Eukaryotic Cells Jorge Galan
18:00:00 Importing DNA and exporting proteins
18:30:00 Short Talk to be Chosen from Abstracts
19:00:00 Dinner
20:00:00 Poster Viewing
20:10:00 Social Hour
Wednesday, March 23, 2011
07:00:00 Breakfast
08:00:00 Building and Rebuilding the Cytoskeleton
08:30:00 Visualizing the Regulated, Dynamic Interaction of Microtubules with Kinetochores Eva Nogales
09:00:00 Cytoskeleton Regulation by AAA+ Proteins: Molecular Dissection of Microtubule Severing Antonina Roll-Mecak
09:20:00 Coffee Break
09:45:00 The Structure of the Dynein Motor Ronald D Vale
10:00:00 Structure of the CED-4 Apoptosome: Insights into Its Assembly and Function Nieng Yan
10:30:00 Short Talk(s) to be Chosen from Abstracts
11:00:00 On Own for Lunch and Recreation
16:30:00 Coffee Available
17:00:00 Shaping Membranes
17:30:00 Structure and Function of the VPS4 ATPase Wesley Sundquist
18:00:00 VPS4, ESCRT-III, and Membrane Deformation Phyllis I. Hanson
18:30:00 Its all in the Neck | How the ESCRTs Make Multivesicular Bodies James H. Hurley
18:45:00 Short Talk to be Chosen from Abstracts
Thursday, March 24, 2011
09:00:00 Departure
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