9th Annual Biomarkers Congress
Omics Meets Cell Biology (E1)
Alpbach Congress Centrum
A-6236 Alpbach, Austria 246 Austria
Alpbach, Austria

     *  Abstract Deadline:
       6th January 2011

     *  Registration Deadline:
       8th March 2011


     *  Speaker to be Announced,

     *  Martin Beck, ETH Zurich, Switzerland

     *  Robert B. Russell, EMBL -Heidelberg, Germany

     *  Carol V. Robinson, University of Oxford, United Kingdom

     *  Sarah Teichmann, MRC Laboratory of Molecular Biology, United

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Short Talks to be Chosen from Abstracts, ,

     *  Jeff Hasty, University of California, San Diego, USA

     *  Norbert Perrimon, Harvard Medical School, USA

     *  Speaker to be Announced,

     *  Short Talk to be Chosen from Abstracts,

     *  Tony Pawson, Samuel Lunenfeld Research Institute, Canada

     *  Ruedi H. Aebersold, Institute of Molecular Systems Biology, ETH
       Zurich, Switzerland

     *  Matthias Mann, Max-Planck Institute for Biochemistry, Germany

     *  Anne-Claude Gavin, European Molecular Biology Laboratory, Germany

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Nick Luscombe, European Molecular Biology Laboratory, United

     *  Uwe Sauer, Institute of Molecular Systems Biology, ETH Zurich,

     *  Gerrit van Meer, Utrecht University, Netherlands

     *  Short Talk to be Chosen from Abstracts,

     *  Hirotada Mori?, Institute for Advanced Biosciences, Keio
       University, Japan

     *  Brenda Andrews, University of Toronto, Canada

     *  Fabio Piano, New York University, USA

     *  Speaker to be Announced,

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Yoshi Ohya, University of Tokyo, Japan

     *  Marian Walhout, University of Massachusetts Medical School, USA

     *  Anne-Claude Gingras, Samuel Lunenfeld Research Institute, Canada

     *  Short Talk to be Chosen from Abstracts,

     *  Gitte Neubauer, Cellzome AG, Germany

     *  Minoru Yoshida, RIKEN , Japan

     *  Joseph Lehar, Novartis Institutes for BioMed Research, USA

     *  Speaker to be Announced,

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Charlie M. Boone, University of Toronto, Canada

     *  Jan Ellenberg?, European Molecular Biology Laboratory, Germany

     *  Marie Evangelista, Genentech, Inc., USA

     *  Short Talk to be Chosen from Abstracts,

   Whole genome sequencing has become widespread and modern biologists
   currently access exponentially growing lists of genomes from organisms
   covering all three domains of life. This has fundamentally changed the
   way scientists address biological questions. A spectacular flourishing
   of technologies allows for global interrogation of gene activity and
   function and ever more comprehensive measurement of cellular
   macromolecules. These Omics approaches are still in full expansion but
   already increasingly contribute to the editing and annotation of
   systems-level networks charting physical and functional links between
   all cellular components. Nevertheless, an important challenge resides
   in the interpretation and integration of the data within the context
   of the whole physiology of a cell. We are for example, still learning
   and developing the bioinformatic tools to store and integrate
   different types of datasets. Emerging biochemical and chemical
   approaches contribute chemical tools and affinity reagents to
   systematically interrogate or perturb macromolecules within a cell.
   Live-cell imaging and quantitative microscopy have also moved
   large-scale allowing unprecedented phenotypic analysis. This
   conference will bring together the leading experts representing Omics
   technologies, cell biology, chemical-genetics, and bioinformatics to
   discuss and present these latest developments.

Schedule of Presentations:

Sunday, May 8, 2011
15:00:00 Registration
18:15:00 Refreshments
19:15:00 Welcome and Keynote Address
19:45:00 Origins of Regulated Cell-to-Cell Variability Lucas Pelkmans
Monday, May 9, 2011
07:00:00 Breakfast
08:00:00 Proteome Visualization: Toward a Molecular Anatomy of the Cell
08:05:00 Molecular Anatomy of the Human Pathogen Leptospira interrogans Martin Beck
08:30:00 Predicting protein-peptide and protein-chemical interactions within biological networks Robert B. Russell
09:00:00 Dehydrated but Unharmed? - The Mass Spectrometry of Protein Complexes Carol V. Robinson
09:20:00 Coffee Break
09:45:00 Evolution and Assembly of Protein Complexes Sarah Teichmann uuu
10:15:00 Short Talk | Stoichiometry and Architecture of Protein-DNA/RNA Complexes by Native Mass Spectrometry Combined with Ion Mobility
10:30:00 Short Talk | Global Proteomic Approaches Reveal Structural Diversity of Cysteines Endogenously Targeted for S-Nitrosylation
11:15:00 Poster Setup
11:15:00 On Own for Lunch and Recreation
13:00:00 Poster Viewing
14:30:00 Workshop 1 | Available Bioinformatic Resources for Cell Biologists
14:35:00 neXtProt, a Novel Human Protein Knowledge Platform in the Era of Omics Techologies
15:00:00 C-score, a Confidence Score for Reliable Protein Complex Determination from Orthogonal, High-Precision Quantitative Mass Spectrometry Experiments
15:30:00 Cyber-Infrastructures for Genetic Design Automation Jean Peccoud
15:45:00 Automatic Thresholding of Expression Data Captures Functional Responses in Genome-Scale Metabolic Models Paul Jensen
16:00:00 Delineating Points of Vulnerability in Mitogen Activated Signaling Networks
16:15:00 Statistical Methods and Tools for Protein Quantification in Mass Spectrometry-Based Proteomics
16:20:00 Detection of Multifunctional Proteins in Protein-Protein Interaction Networks
16:30:00 Coffee Available
17:00:00 Omics of Complex Systems
17:05:00 Genetic Clocks from Engineered Oscillators Jeff Hasty
17:30:00 Large-Scale Analyses of Signaling Networks Norbert Perrimon
18:00:00 Talk Title to be Determined Jochen Wittbrodt
18:30:00 Short Talk | High-Throughput in vivo Profiling of Kinase/HSP90 Interactions and Kinase Inhibitor Specificities
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 1
Tuesday, May 10, 2011
07:00:00 Breakfast
08:00:00 Omics and Signaling
08:05:00 The Evolution of Phosphotyrosine and Methylarginine Signaling Tony Pawson
08:15:00 Mass Spectrometric Collection of Proteomic and Phosphoproteomic Data for Systems Biology
08:30:00 Technologies for Comprehensive Proteome Quantification Matthias Mann
09:05:00 Molecular Networks from Proteins to Metabolites Anne-Claude Gavin
09:20:00 Coffee Break
10:00:00 Short Talk: Studying TGF-β Signaling using a High Resolution, Quantitative Mass Spectrometric Approach
10:15:00 Short Talk | The Drosophila Melanogaster Protein Interaction Map
11:15:00 Poster Setup
11:15:00 On Own for Lunch and Recreation
13:00:00 Poster Viewing
16:30:00 Coffee Available
17:00:00 Omics of Metabolic Networks
17:05:00 A Classification Model to Predict Enhancer Functions in the Early Drosophila Embryo Nicholas Luscombe
17:30:00 Unraveling Active Metabolic Regulation Networks by High-Throughput Omics Techniques Uwe Sauer
18:00:00 Protein Interaction Networks Regulating Cell Signaling in Human Health and Disease Igor Stagljar
18:30:00 Short Talk | Metabotyping of Breast Cancers by High throughput Metabolomics
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 2
Wednesday, May 11, 2011
07:00:00 Breakfast
08:00:00 From Omics to Phenomes I
08:05:00 Deciphering Molecular Networks using Genomics, Proteomics and Genetics Brenda Andrews
08:15:00 Toward a Comprehensive Molecular Description of Early Embryogenesis in C. elegans Fabio Piano
08:30:00 Automating Fluorescence Microscopy for Systems Biology | From Genome-Wide Profiling to the Analysis of Protein Complexes Jan Ellenberg
09:00:00 Short Talk | Constructing and Exploiting Constraint Interaction Networks for Understanding Cellular Processes
09:20:00 Coffee Break
09:45:00 Short Talk | Identification of Kinases and Phosphatases Regulating Muscle Protein Degradation and Dystrophies in C. elegans by a Genome-Wide RNAi Screen
10:15:00 Short Talk: A Large Scale RNAi Screen Identifies an Extensive Network of Mammalian Cell Polarity Regulators as Key Modifiers of the Oncogenic Properties of Sustained RAS-MAPK Signaling
10:30:00 Short Talk | Identification of Cell-Surface Proteins Enables Isolation of Viable Lineage-Specific Cells from Blastocysts by Flow Cytometry
11:15:00 Poster Setup
11:15:00 On Own for Lunch and Recreation
13:00:00 Poster Viewing
16:30:00 Coffee Available
17:00:00 From Omics to Phenomes II
17:05:00 Hi-Content and Quantitative Morphological Screening for the Drug Targets in Yeast Yoshikazu Ohya
17:30:00 Gene-Centered Regulatory Networks Marian Walhout
18:00:00 Protein Phosphatase Networks Anne-Claude Gingras
18:15:00 Short Talk | Evolutionary Fate of Alien Genes in Bdelloid Rotifers
18:30:00 Short Talk | Systems Cell Biology to Profile Cellular and Pathogen Responses to Bioactive Probes based on High Content Screening
19:15:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 3
Thursday, May 12, 2011
07:00:00 Breakfast
08:00:00 Omics Meets Chemistry and Drug Discovery
08:05:00 Interrogating Drugs, their Targets and their Complexes | Chemical Proteomics in Drug Discovery Gitte Neubauer
08:15:00 Reverse Proteomics Approaches for Discovery and Target Identification of Novel Bioactive Compounds Minoru Yoshida
08:30:00 Approaching Cancer Therapy via a Genomic, Phenotypic and Combination Campaign Joseph Lehar
09:00:00 Navigating Biologically Relevant Chemical Space: Targeting Protein Function and Networks with Small Molecules Herbert Waldmann
09:20:00 Coffee Break
09:45:00 Short Talk: Comprehensive Phosphoproteomic Mode of Action Analysis in Cultured Cell Lines and Xenograft Models
10:30:00 Short Talk | Interplay of Three Proteins (PGRP S, Hsp70, and S100A4) in Host vs. Cancer Combat
11:15:00 On Own for Lunch and Recreation
16:30:00 Coffee Available
17:00:00 Omics Meets Genetics and Gene Expression
17:05:00 The Genetic Landscape of a Cell Charlie Boone
17:30:00 Engineering of Synthetic Gene-Networks | From Biotechnology to Human Therapy Martin Fussenegger
18:00:00 Title to be Determined Marie Evangelista
18:15:00 Short Talk | Towards a Quantitative Model of Chromosome-Wide Recognition and Transcriptional Fine-Tuning of an Entire Chromosome
18:30:00 Short Talk: Genomic and Proteomic Characterization of Normal and Oncogenic CEBPA Variants in Myeloid Cells
19:15:00 Social Hour w/ Lite Bites
20:00:00 Entertainment
Friday, May 13, 2011
09:00:00 Departure
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