Biotech China 2014
Stem Cells, Cancer and Metastasis (C4)
Keystone Resort
21996 US Highway 6 PO Box 38
Keystone, Colorado
http://keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=1079
   Deadlines
   ---------

     *  Abstract Deadline:
       4th November 2010

     *  Registration Deadline:
       6th January 2011


   Speakers
   --------

     *  Robert A. Weinberg, Whitehead Institute for Biomedical Research,
       USA

     *  John E. Dick, Toronto General Research Institute, University
       Health Network, Canada

     *  Robert J. Wechsler-Reya, Duke University Medical Center, USA

     *  Michael A. Dyer, St. Jude Children’s Research Hospital, USA

     *  Richard J. Gilbertson, St. Jude Children’s Research Hospital, USA

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Richard O. Hynes, Massachusetts Institute of Technology, USA

     *  Dorothy A. Sipkins, University Of Chicago, USA

     *  David C. Lyden, Weill Cornell Medical College, USA

     *  Short Talk to be Chosen from Abstracts,

     *  Charles G. Mullighan, St Jude Children’s Research Hospital, USA

     *  Robert H. Blelloch, University of California, San Francisco, USA

     *  Joan Massagué, Memorial Sloan-Kettering Cancer Center, USA

     *  Sridhar Ramaswamy, Massachusetts General Hospital, Harvard
       Medical School, USA

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Speaker to be Announced,

     *  Daniel A. Haber, Massachusetts General Hospital, USA

     *  Speaker to be Announced,

     *  Short Talk to be Chosen from Abstracts,

     *  Max S. Wicha, University of Michigan, USA

     *  Margaret Read, Infinity Pharmaecuticals, Inc., USA

     *  Frederic J. de Sauvage, Genentech, Inc., USA

     *  Joan S. Brugge, Harvard Medical School, USA

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Jane E. Visvader, Walter and Eliza Hall Institute of Medical
       Research, Australia

     *  Kornelia Polyak, Dana-Farber Cancer Institute, USA

     *  Charlotte Kuperwasser, Tufts University School of Medicine, New
       England, USA

     *  Short Talk to be Chosen from Abstracts,

     *  Hans C. Clevers, Hubrecht Institute, Netherlands

     *  Elaine Fuchs, Howard Hughes Medical Institute, Rockefeller
       University, USA

     *  Courtney W. Houchen, University of Oklahoma Health Sciences
       Center, USA

     *  Carla Kim, Children’s Hospital, USA

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Sean J. Morrison, University of Michigan/Howard Hughes Medical
       Institute, USA

     *  Richard J. Gilbertson, St. Jude Children’s Research Hospital, USA

     *  Daniel A. Haber, Massachusetts General Hospital, USA

     *  Sean J. Morrison, University of Michigan/Howard Hughes Medical
       Institute, USA

     *  Robert A. Weinberg, Whitehead Institute for Biomedical Research,
       USA

     *  Hans C. Clevers, Hubrecht Institute, Netherlands

     *  Elaine Fuchs, Howard Hughes Medical Institute, Rockefeller
       University, USA

   Several concepts regarding the origins of cancer and metastasis have
   converged in recent years. In particular, special interest has focused
   on the possibility that tissue specific stem cells and cancer cells
   displaying the properties of these cells play fundamental roles in the
   malignant process. These concepts have been supported by studies of
   mouse models in which predictable patterns of tumor spread and access
   to both primary and metastatic lesions has allowed molecular analyses.
   With regard to primary tumors, emerging evidence suggests that
   important cancers, including those in the colon and brain, may arise
   directly from mutated progenitor cells that display deviant
   differentiation within “stem cell-niches�. Tumors appear also to
   contain stem-like cancer cells that are both necessary and required to
   propagate the disease. These findings overlap with observations of
   metastasis that suggest tumor dissemination may be driven by critical
   changes in tumor cell differentiation, including epithelial to
   mesenchymal transition ( EMT ), and the migration of malignant stem
   cells to “pre-metastatic niches�. We believe the time is ripe for a
   joint conference that will bring together scientists and clinicians
   with interests in stem cell biology, cancer and metastasis. The
   meeting will provide a forum for exchange of information and insights
   between these rapidly moving fields. In addition to increasing the
   sharing of key scientific approaches we believe this conference will
   galvanize collaborative efforts among disparate research communities
   to address several key outstanding questions: (i) What is the
   relationship between normal and malignant tissue stem cells? (ii) What
   is the relationship between cancer stem cells and the so-called
   “metastatic precursor�, that is capable of indefinite proliferation at
   the new metastatic site? (iii) What are the interactions between
   stromal and stem-like cancer cells in primary and metastatic disease
   sites? How do these interactions facilitate disease propagation and
   metastatic spread? (iv) How should we monitor in vivo the biology of
   stem-like cells in primary tumors and metastasis? (v) What are the
   optimal approaches to target therapeutically stem-like cancer cells in
   primary and metastatic disease? By focusing on these questions, we aim
   to elicit exciting fundamental biological discussions with significant
   translational application.

Schedule of Presentations:

Sunday, March 6, 2011
15:00:00 Registration | Longs Peak Foyer
18:30:00 Refreshments | Longs Peak Foyer
19:15:00 Orientation for New Attendees and New Investigators | Longs/Grays Peak
19:30:00 Keynote Address | Longs/Grays Peak Robert A Weinberg
Monday, March 7, 2011
07:00:00 Breakfast
08:00:00 Stem Cells in Cancer Pathogenesis I: The Controversy of Cancer Origins
08:15:00 Stem Cells in Leukemia: Do They Matter? John E. Dick
08:30:00 Stem Cells Behaving Badly: The Origins of Anaplastic Medulloblastoma Robert Wechsler-Reya
08:45:00 Mature Cells: A Hotbed of Cancer Susceptibility? Michael A Dyer
09:00:00 Do Normal Tissue Stem Cells Drive Cancer Heterogeneity? Richard J Gilbertson
09:15:00 Short Talk(s) to be Chosen from Abstracts
09:20:00 Coffee Break
11:00:00 Poster Setup
13:00:00 Poster Viewing
16:30:00 Coffee Available
17:00:00 Stem Cells in Cancer Pathogenesis II: Niches and the Metastatic Cascade
17:15:00 Extracellular Matrix Effects in Cancer Progression Richard Hynes
17:30:00 The Leukemic Stem Cell Niche Dorothy A. Sipkins
17:45:00 Priming the Soil: The Pre-Metastatic Niche David C Lyden
18:00:00 Short Talk to be Chosen from Abstracts
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 1
Tuesday, March 8, 2011
07:00:00 Breakfast
08:00:00 Genomic Analyses: Reading the Genome in Cancer Stem Cells and Metastatic Precursors
08:15:00 Unmasking the Origins of Leukemia with Genomics Charles G. Mullighan
08:30:00 MicroRNA Regulation of Stem Cells and Cancer Robert H. Blelloch
08:45:00 Mechanisms of the Metastatic Process Joan Massagué
09:00:00 Spontaneous Cancer Cell Quiescence Sridhar Ramaswamy
09:15:00 Short Talk(s) to be Chosen from Abstracts
09:20:00 Coffee Break
11:00:00 Poster Setup
13:00:00 Poster Viewing
16:30:00 Coffee Available
17:00:00 Breast Cancer
17:15:00 The Mammary Epithelial Hierarchy and its Implications for Identifying Cells of Origin of Breast Cancer Jane Visvader
17:30:00 Regulation of the Mammary Stem Cell Niche Rama Khokha
17:45:00 Genetic and Epigenetic Plasticity of Stem Cells in Breast Cancer Charlotte Kuperwasser
18:00:00 Short Talk to be Chosen from Abstracts
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 2
Wednesday, March 9, 2011
07:00:00 Breakfast
08:00:00 Cancer Stem Cells, Metastasis and Cancer Therapy
08:15:00 Therapeutic Implication of Stem Cells in Breast Cancer Max S Wicha
08:30:00 Drug Discovery in the Cancer Stem Cell Era Margaret Read
08:45:00 Developmental Regulatory Pathways and Cancer Drug Discovery Frederic J. de Sauvage
09:00:00 Genes that Regulate Migration and Invasion Joan S Brugge
09:15:00 Short Talk(s) to be Chosen from Abstracts
09:20:00 Coffee Break
11:00:00 Poster Setup
13:00:00 Poster Viewing
16:30:00 Coffee Available
17:00:00 Imaging and Tracking Cancer Stem Cells and Metastatic Precursors
17:15:00 High Definition Circulating Tumor Cells in Carcinoma Patients Peter Kuhn
17:30:00 Molecular characterization of circulating tumor cells Daniel A Haber
17:45:00 Systems Analysis in Single Cells Michael R.H. White
18:00:00 Short Talk to be Chosen from Abstracts
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 3
Thursday, March 10, 2011
07:00:00 Breakfast
08:00:00 Epithelial Cancers and Stem Cells
08:15:00 Wnt Signaling, Lgr5 Stem Cells and Cancer Hans Clevers
08:30:00 Stem Cells and Cancer in the Skin Elaine Fuchs
08:45:00 Pancreatic Cancer Stem Cell Marker DCAMKL-1 Regulates Epithelial-Mesenchymal Transition in Human Pancreatic Cells through a miR-200a-Dependent Mechanism Courtney W. Houchen
09:00:00 Stem Cells in Normal Lung and Lung Cancer Carla Bender Kim
09:15:00 Short Talk(s) to be Chosen from Abstracts
09:20:00 Coffee Break
16:30:00 Coffee Available
17:00:00 Closing Keynote Address
17:25:00 Stem Cells and Cancer: Where Are We Now? Sean J. Morrison
17:45:00 Roundtable: Cancer Stem Cells in Metastasis: Insights and Controversies Sean J. Morrison, Daniel A Haber, Richard J Gilbertson, Robert A Weinberg
18:00:00 Lgr5 Intestinal Stem Cells in Self-renewal and Cancer Elaine Fuchs, Hans Clevers
19:00:00 Social Hour w/ Lite Bites
20:00:00 Entertainment
Friday, March 11, 2011
09:00:00 Departure
4th Annual Pharma R&D Asia Congress
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