9th Annual Biomarkers Congress
Drugs from Bugs: The Anti-Inflammatory Drugs of Tomorrow (Z1)
Snowbird Resort

Sandy, Utah
http://keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=1095
   Deadlines
   ---------

     *  Abstract Deadline:
       2nd December 2010

     *  Registration Deadline:
       3rd February 2011


   Speakers
   --------

     *  Padraic G. Fallon, Trinity College, Ireland

     *  Jose-Carlos Gutierrez-Ramos, Pfizer, Inc, USA

     *  Albert B. Seymour, Pfizer Global Research and Development, USA

     *  Antonio Alcami, Centro de Biologia Molecular Severo Ochoa, Spain

     *  Grant McFadden, University of Florida, USA

     *  William Harnett, Strathclyde Institute for Biomedical Sciences,
       United Kingdom

     *  Short Talk(s) to be Chosen from Abstracts,

     *  James E. Audia?, Eli Lilly and Company, USA

     * 

     *  Robert Gould, Epizyme, Inc., USA

     *  Miles Congreve, Heptares Therapeutics Ltd, United Kingdom

     *  Linda Brady, National Institute of Mental Health, National
       Institutes of Health, USA

     *  Alexandra R. Lucas, University of Florida, USA

     *  Short Talks to be Chosen from Abstracts, ,

     *  Anne Cooke, University of Cambridge, United Kingdom

     *  Ana Marisa Chudzinski-Tavassi, Instituto Butantan, Brazil

     *  Cathryn Nagler, University of Chicago, USA

     *  Sarkis K. Mazmanian, California Institute of Technology, USA

     *  Bryan Roth, University of North Carolina, Chapel Hill, USA

     *  Daryl R. Sauer, Abbott Laboratories, USA

     * 

     *  Speaker to be Announced,

     *  Alexandra R. Lucas, University of Florida, USA

     *  Amanda E.I. Proudfoot Fichard, Merck Serono Geneva Research
       Centre, Switzerland

     *  Padraic G. Fallon, Trinity College, Ireland

     *  Wynne Weston-Davies, Polymed Development Ltd, United Kingdom

     *  Dennis C. Liotta, Emory University, USA

     *  P. Jeffrey Conn, Vanderbilt University School of Medicine, USA

     *  Julian Blagg, Institute of Cancer Research, United Kingdom

     *  James A. Wells, University of California, San Francisco, USA

     *  Jos van Strijp, University Medical Center Utrecht, Netherlands

     *  Daved Fremont, Washington University School of Medicine, USA

     *  Tracy M. Handel, University of California, San Diego, USA

     *  Short Talk to be Chosen from Abstracts,

     *  Cyrille Sur?, Merck & Co., Inc., USA

     * 

     *  Jacob M. Hooker, Athinoula A. Martinos Center for Biomedical
       Imaging, USA

     *  Javier Sanz, Mount Sinai School of Medicine, USA

     *  Victor Nizet, UCSD School of Medicine, USA

     *  Kate A. Fitzgerald, University of Massachusetts Medical School,
       USA

     *  Luke A.J. O’Neill, Trinity College Dublin, Ireland

     *  Speaker to be Announced,

     *  Short Talk(s) to be Chosen from Abstracts,

     *  H. Alex Brown, Vanderbilt University, USA

     *  Dinah Sah, Alnylam Pharmaceuticals Inc., USA

     *  Mark Layton?, Merck Research Laboratories, USA

     *  Craig W. Lindsley, Vanderbilt University, USA

     *  Padraic G. Fallon, Trinity College, Ireland

     *  Short Talks to be Chosen from Abstracts, ,

     *  Antonio Alcami, Centro de Biologia Molecular Severo Ochoa, Spain

     *  Michael K. Richardson, Leiden University, Netherlands

     *  Colin Macaulay, Viron Therapeutics Inc., Canada

     *  Reto Stöcklin, Atheris Laboratories, Switzerland

     *  Short Talk to be Chosen from Abstracts,

     *  Alan Palkowitz?, Eli Lilly and Company, USA

     * 

     *  Speaker to be Announced,

     *  Dimitri Grigoriadis, Neurocrine Biosciences, Inc., USA

   A recent global trend is that less novel therapeutics are progressing
   from the biopharmaceutical pipeline to the clinic. This has prompted
   the drug research and development sector to adopt less conventional
   approaches in broadening the search for new drugs. In this meeting we
   will examine the growing opportunities for discovery of novel drugs
   from pathogens, or the

Schedule of Presentations:

Sunday, April 3, 2011
15:00:00 Registration
18:15:00 Refreshments
19:10:00 Session | Early-Stage Drug Discovery (Z2)
19:15:00 Welcome and Keynote Address Padraic G. Fallon
19:15:00 Early-Stage Drug Discovery (Z2) | Welcome and Keynote Address
20:00:00 Anti-Inflammatory Drugs: The Path from Discovery to the Clinic Jose-Carlos Gutierrez-Ramos
20:05:00 Human Genetic Approaches to Biotherapeutics: Target ID to Patient Enrichment Albert B. Seymour
Monday, April 4, 2011
07:00:00 Breakfast
07:55:00 Session | Early-Stage Drug Discovery (Z2)
08:00:00 Early-Stage Drug Discovery (Z2) | Evolving Strategies for Screening and Early Lead Identification
08:00:00 Immune Modulating Molecules from Pathogens
08:30:00 Early-Stage Drug Discovery (Z2) | PD2: New Collaborative Models for Early Stage Drug Discovery Timothy A. Grese
08:30:00 Therapeutic Exploitation of Viral Chemokine-Modulators Antonio Alcami
09:00:00 Early-Stage Drug Discovery (Z2) | Histone Methyl Transferase Inhibitors: Targeted Therapeutics for Targeted Patients Robert Gould
09:00:00 When the Bug is the Drug: Exploiting Poxviruses for Oncolytic Virotherapy Grant McFadden
09:20:00 Coffee Break
09:45:00 The Path from a Pathogen Molecule to Synthetic Anti-Inflammatory Mimetics: The ES-62 Story William Harnett
09:45:00 Early-Stage Drug Discovery (Z2) | Fragment-Based Screening Approaches to GPCR Miles Congreve
10:00:00 Early-Stage Drug Discovery (Z2) | Probe Development within the Molecular Libraries Probe Production Centers Network (MLPCN): Leads for Drug Development from Previously Intractable Targets Linda Brady
10:30:00 Short Talk(s) to be Chosen from Abstracts
11:00:00 On Own for Lunch and Recreation
11:00:00 Poster Setup
13:00:00 Poster Viewing
14:30:00 Workshop 1: Recent Advances in Drug Discovery from Pathogens
15:00:00 Short Talks to be Chosen from Abstracts
16:30:00 Coffee Available
16:55:00 Session | Early-Stage Drug Discovery (Z2)
17:00:00 Pathogen Modulators of Immune-Mediated Diseases
17:00:00 Early-Stage Drug Discovery (Z2) | Novel Approaches and Technology for Early Stage Drug Discovery
17:30:00 Modulation of autoimmunity by pathogen derived molecules Anne Cooke
17:30:00 Early-Stage Drug Discovery (Z2) | Early-Stage Drug Discovery (Z2) | Bryan Roth
18:00:00 Novel Drugs from Ticks for Cancer Ana Marisa Chudzinski-Tavassi
18:30:00 Early-Stage Drug Discovery (Z2) | Chemical and Separation Technologies to Accelerate the Hit-to-Lead Phase: Case Studies Daryl R. Sauer
18:30:00 The Use of Enteric Infections for Treating Allergic Diseases Cathryn Nagler
18:45:00 Early-Stage Drug Discovery (Z2) | Speaker to be Announced
19:00:00 Exploiting Commensal Immune Modulation for New Drugs Sarkis K. Mazmanian
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 1
Tuesday, April 5, 2011
07:00:00 Breakfast
07:55:00 Session | Early-Stage Drug Discovery (Z2)
08:00:00 Early-Stage Drug Discovery (Z2) | Drug Discovery in Academia
08:00:00 Clinical Perspective/Development
08:30:00 Viral Bugs Make Great Drugs
08:30:00 Early-Stage Drug Discovery (Z2) | The Role of CXCR4 Modulators in Controlling HIV Entry, Inflammation and Certain Types of Cancer Dennis C. Liotta
09:00:00 Early-Stage Drug Discovery (Z2) | Partnering with Big Pharma to Develop mGluR Allosteric Modulators for CNS Disorders: From HTS to Clinical Candidates P. Jeffrey Conn
09:20:00 Coffee Break
09:45:00 Early-Stage Drug Discovery (Z2) | Novel Cancer Therapeutics Developed through Academic-Industrial Partnerships Julian Blagg
09:45:00 Pathogen-Derived and Anti-Inflammatory Drugs Amanda E.I. Proudfoot Fichard
10:00:00 Who needs a drug for allergies when a bug will do? Padraic G. Fallon
10:30:00 Clinical Trials of Arthropod-Derived Molecules Wynne Weston-Davies
10:30:00 Early-Stage Drug Discovery (Z2) | Turning Enzymes on with Small Molecules Jim Wells
11:00:00 Poster Setup
11:00:00 On Own for Lunch and Recreation
13:00:00 Poster Viewing
16:30:00 Coffee Available
16:55:00 Session | Early-Stage Drug Discovery (Z2)
16:55:00 Structure-Function Analysis of Therapeutic Pathogen Molecules
17:00:00 Anti-Inflammatory Drugs from Staphylococcus Aureus Jos van Strijp
17:00:00 Early-Stage Drug Discovery (Z2) | Imaging and Biomarkers in Early Stage Discovery
17:30:00 Structural Mechanisms of Viral Inflammation Modulators Daved Fremont
17:30:00 Early-Stage Drug Discovery (Z2) | Small Molecule Biomarkers in Drug Discovery: Optical and PET Imaging Approaches Cyrille Sur
18:00:00 Early-Stage Drug Discovery (Z2) | Advances in Carbon-11 Chemistry for Use in Positron Emission Tomography Jacob M. Hooker
18:00:00 Computational Structural Analysis for Design of Pathogen-Derived Therapeutics Tracy M. Handel
18:30:00 Short Talk to be Chosen from Abstracts
18:30:00 Early-Stage Drug Discovery (Z2) | New Approaches for Imaging of Atherosclerotic Cardiovascular Disease Javier Sanz
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 2
Wednesday, April 6, 2011
06:30:00 From Pathogen Immunomodulators to Novel Drugs Colin Macaulay
07:00:00 Breakfast
07:55:00 Session | Early-Stage Drug Discovery (Z2)
08:00:00 Pathogen Modulation of Inflammatory Signaling
08:00:00 Early-Stage Drug Discovery (Z2) | Emerging Targets and Approaches in Drug Discovery
08:30:00 Probing Bacterial-Phagocyte Interactions for Novel Infectious Disease (and Anti-Inflammatory?) Therapeutics Victor Nizet
08:30:00 Early-Stage Drug Discovery (Z2) | Phospholipase D: Discovery and Development of Isoform Selective PLD Inhibitors for the Treatment of Cancer H Alex Brown
09:00:00 Early-Stage Drug Discovery (Z2) | siRNA Therapeutics: Overview and Clinical Trial Update
09:00:00 Sensing from within: cytosolic sensors and anti-microbial defenses. Kate A. Fitzgerald
09:20:00 Coffee Break
09:45:00 Exploiting Pathogen Subversion of Immunity for New Drugs Luke A.J. O'Neill
09:45:00 Early-Stage Drug Discovery (Z2) | Allosteric Akt Kinase Inhibitors: Discovery Overview and Clinical Update Mark Layton
10:00:00 Possible Novel Drugs from Arthropod Venoms Maria Elena Lima
10:00:00 Early-Stage Drug Discovery (Z2) | Allosteric Modulation of Muscarinic Receptors for Treatment of Schizophrenia and Alzheimer's Disease Prof. Craig Lindsley
10:45:00 Short Talk(s) to be Chosen from Abstracts
11:00:00 On Own for Lunch and Recreation
14:30:00 Workshop 2: Recent Advances in Drug Discovery from Pathogens Padraic G. Fallon
15:00:00 Short Talks to be Chosen from Abstracts
16:30:00 Coffee Available
16:55:00 Session | Early-Stage Drug Discovery (Z2)
17:00:00 Early-Stage Drug Discovery (Z2) | Evolving Role of Big Pharma and Biotech
17:00:00 Screening Strategies/Technologies- Recent Advances Antonio Alcami
17:30:00 Early-Stage Drug Discovery (Z2) | Bruton’s Tyrosine Kinase from Bench to Bedside: Covalently Silencing B Cells with AVL-292 Juswinder Singh
18:00:00 Zebrafish in the Drug Development Pipeline Michael K. Richardson
18:00:00 Early-Stage Drug Discovery (Z2) | Speaker to be Announced
18:30:00 Early-Stage Drug Discovery (Z2) | Innovation and the Future of Novel Drug Discovery in Biotech Dimitri Grigoriadis
18:45:00 Venomics: Animal Venoms as Drug Discovery Platforms Reto Stöcklin
18:50:00 Short Talk to be Chosen from Abstracts
19:00:00 Social Hour w/ Lite Bites
20:00:00 Entertainment
Thursday, April 7, 2011
09:00:00 Departure
4th Annual Pharma R&D Asia Congress
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