Biotech China 2014
Mucosal Biology: A Fine Balance between Tolerance and Immunity (X5)
Fairmont Hotel Vancouver
900 West Georgia Street Vancouver, BC V6C 2W6
Vancouver, British Columbia
http://keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=1100
   Deadlines
   ---------

     *  Abstract Deadline:
       26th October 2010

     *  Registration Deadline:
       27th December 2010


   Speakers
   --------

     *  Patrick G. Holt, University of Western Australia, Australia

     *  Alice Prince, Columbia University, USA

     *  Marco Colonna, Washington University School of Medicine, USA

     *  Bana Jabri, University of Chicago, USA

     *  Dana Philpott, University of Toronto, Canada

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Hilde Cheroutre, La Jolla Institute for Allergy and Immunology,
       USA

     *  Joanne L. Viney, Amgen Inc., USA

     *  Maria T. Abreu, University of Miami, Miller School of Medicine,
       USA

     *  Adolfo Garcia-Sastre, Mount Sinai School of Medicine, USA

     *  Patricia W. Finn, University of California, San Diego, USA

     *  Shawn J. Skerrett, University of Washington, USA

     *  Thaddeus S. Stappenbeck, Washington University School of
       Medicine, USA

     *  Genoveffa Franchini, National Cancer Institute, National
       Institutes of Health, USA

     *  Jo-Ann Passmore, University of Cape Town, South Africa

     *  Paul J. Lehner, Cambridge Institute for Medical Research, United
       Kingdom

     *  Andrew D. Luster, Massachusetts General Hospital, USA

     *  Thomas J. Braciale, University of Virginia, USA

     *  David L. Woodland, Trudeau Institute, USA

     *  Tracy Hussell, Imperial College London, United Kingdom

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Shannon J. Turley, Dana Farber Cancer Institute, Harvard Medical
       School, USA

     *  Rachel R. Caspi, National Institutes of Health, USA

     *  Akiko Iwasaki, Yale University School of Medicine, USA

     *  Nicholas W. Lukacs, University of Michigan, USA

     *  Graham S. Le Gros, Malaghan Institute of Medical Research, New
       Zealand

     *  Clifford V. Harding, Case Western Reserve University, USA

     *  Yasmine Belkaid, NIAID , National Institutes of Health, USA

     *  Dominique Kaiserlian, INSERM -U851, France

     *  Wenjun Ouyang, Genentech, USA

     *  De’Broski R. Herbert, Cincinnati Children’s Research Foundation,
       USA

     *  Cherié L. Butts, Food & Drug Administration, USA

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Andrea Cerutti, Mount Sinai School of Medicine, USA

     *  Jo Spencer, King’s College London, United Kingdom

     *  Gerard Eberl, Institut Pasteur, France

     *  Liise-anne Pirofski, Albert Einstein College of Medicine, USA

     *  Joseph P. Mizgerd, Boston University School of Medicine, USA

     * 

     *  Speaker to be Announced,

     *  Rob Knight?, University of Colorado, USA

     *  Martin Fussenegger, ETH Zurich, Switzerland

     *  Paul Garside, University of Glasgow, United Kingdom

     *  Andrew Yates, Albert Einstein College of Medicine, USA

     *  Troy D. Randall, University of Rochester Medical Center, USA

     *  Allen G. Harmsen, Montana State University, USA

     *  Jory R. Baldridge, GlaxoSmithKline, USA

     *  Arturo Casadevall, Albert Einstein College of Medicine, USA

     *  Short Talk(s) to be Chosen from Abstracts,

     *  John D. Rioux, Université de Montréal, Canada

     *  Ludvig Magne Sollid, University of Oslo, Norway

     *  Hugh A. Sampson, Mount Sinai School of Medicine, USA

     *  Kanta Subbarao, NIAID , National Institutes of Health, USA

     *  Catharine M. Bosio, NIAID , National Institutes of Health, USA

     *  Jay K. Kolls, LSU Health Sciences Center, USA

   Experts from the basic science and clinical fields of mucosal biology
   will be brought together with leaders from other scientific
   disciplines for a stimulating discussion on the mechanisms regulating
   the maturation, development and maintenance of mucosal responses in
   health and disease. Attention will be given to gut, lung, skin, eye
   and genitourinary tract tissues. The latest information on novel cell
   types and receptors important for regulating immunity and enhancing
   mucosal protection will be presented. The influence of infection on
   driving altered host immunity will be interrogated. Modern approaches
   to vaccine development and imaging technology will be highlighted.
   And, the most up to date advances from the physical sciences and
   engineering will be discussed as we look to the medical needs and
   developments of the future.

Schedule of Presentations:

Saturday, February 26, 2011
15:00:00 Registration
18:15:00 Refreshments
19:15:00 Welcome and Keynote Address (Joint) David L. Woodland, Joanne L. Viney
20:00:00 Immunity and Inflammation in the Lung – Bridging Innate and Adaptive Immunity Patrick G. Holt
Sunday, February 27, 2011
07:00:00 Breakfast
08:00:00 Innate Immunity at Mucosal Surfaces: The Players (Joint)
08:15:00 Epithelial Cells: More than a Barrier Alice S. Prince
08:30:00 Short Talk: Exploring Pattern-Recognition Receptors and Ciliary Function Utilizing Primary Respiratory Epithelial Cell Cultures Cedar J. Fowler
08:45:00 Functional Plasticity of Human NK-22 Cells Marco Colonna
09:00:00 IL-15, a Checkpoint in Tissue Immunity Bana Jabri
09:20:00 Coffee Break
10:00:00 Short Talk: The Antibacterial C-Type Lectin RegIIIgamma Maintains Spatial Segregation between Microbiota and Host in the Intestine Shipra Vaishnava
10:30:00 NLR-Mediated Control of Bacterial Infection Dana Philpott
11:15:00 On Own for Lunch and Recreation
11:15:00 Poster Setup
13:00:00 Poster Viewing
14:30:00 Workshop 1: Cytokines, Chemokines and Mucosal Immunoregulation Paul Garside, Maria T. Abreu
14:45:00 The IL-13 Decoy Receptor Tightly Controls Pathogenic Th17 and Th2 Responses in the Mucosa Thomas A. Wynn
15:00:00 Role of IL-33 in Experimental Allergic Conjunctivitis Tomohiro Yoshimoto
15:15:00 LPS Promotes IL-35-Dependent Suppression of Allergen-Induced Airway Disease Donald N. Cook
15:30:00 Th17 Cells Contribute to Intestinal Homeostasis by Inducing Intestinal IgA and pIgR Expression Anthony Cao
15:45:00 CCL17 Drives Intestinal Inflammation and Counteracts Foxp3-Mediated Protection from Colitis Alexander Frank Heiseke
16:00:00 Proline-Glycine-Proline, a Chemotactic Collagen Breakdown Product, is Involved in Inflammatory Bowel Diseases: Future Target? Pim J. Koelink
16:10:00 A Novel Pathogenic Role for IL-22 in Chronic Intestinal Inflammation Rose Szabady
16:20:00 Dichotomous Consequences of IL-23 Signaling in Chemically Induced Colitis in Mice Jennifer H. Cox
16:30:00 Coffee Available
17:00:00 Immunity in Respiratory Tract (X6) | Lung Innate Immunity and Disease: First Line of Defense to Disease
17:00:00 Mechanisms for Protection from Intestinal Inflammation
17:15:00 Mechanisms for Protection from Intestinal Inflammation | Protecting the Border with a Fake ID: CD4 T Cells Stretch Beyond Plasticity Hilde Cheroutre
17:15:00 Immunity in Respiratory Tract (X6) | Innate Immune Responses to Influenza Viruses Adolfo Garcia-Sastre
17:30:00 Mechanisms for Protection from Intestinal Inflammation | Butyrophilins: Complexity in Costimulation at the Mucosal Surface Joanne L. Viney
17:30:00 Immunity in Respiratory Tract (X6) | Innate Immunity to Bacterial Pneumonia Shawn J. Skerrett
18:00:00 Immunity in Respiratory Tract (X6) | Short Talk: Streptococcus pneumoniae Activates a Type I Interferon Response Depending on Pneumolysin as Well as the Host Cell Molecules STING and IRF3 Uwe Moritz Eberhard Koppe
18:00:00 Mechanisms for Protection from Intestinal Inflammation | Short Talk: Human Mesenchymal Stromal Cells (Msc) Modulate Gut Inflammation and Th17 Responses In Experimental Inflammatory Bowel Disease Vanessa Beatriz Freitas Alves
18:30:00 Mechanisms for Protection from Intestinal Inflammation | Recent Advances in IBD Therapy Maria T. Abreu
18:30:00 Immunity in Respiratory Tract (X6) | Innate Immune Responses in Asthma Patricia W. Finn
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 1
Monday, February 28, 2011
07:00:00 Breakfast
08:00:00 Immunity in Respiratory Tract (X6) | Navigating the Lung - The Ins and Outs of Adaptive Immune Responses
08:00:00 Viruses in Health and Disease
08:15:00 Viruses in Health and Disease | Chronic Viral Infection, Autophagy and IBD Thaddeus Stappenbeck
08:15:00 Immunity in Respiratory Tract (X6) | Respiratory Infections: Do We Ever Recover? Tracy Hussell
08:30:00 Immunity in Respiratory Tract (X6) | Regulating Inflammation during the Host Response to Respiratory Virus Infection: It's about Self Control Thomas J. Braciale
08:30:00 Viruses in Health and Disease | Is the Direct Targeting of the Mucosa Necessary for an HIV Vaccine? Genoveffa Franchini
08:45:00 Immunity in Respiratory Tract (X6) | Chemokine Control of Effector and Regulatory T Cell Trafficking into the Lung Andrew D. Luster
08:45:00 Viruses in Health and Disease | Short Talk: TLR Agonists and/or IL-15 Adjuvanted Mucosal SIV-Vaccine Prevented Gut CD4+ Memory T Cell Loss After SIVmac251-Challenge in Macaques Yong Jun Sui
09:00:00 Viruses in Health and Disease | An African Perspective on Inflammation and Activation in the Female Genital Tract during HIV Infection Jo-Ann Passmore
09:00:00 Immunity in Respiratory Tract (X6) | Regulation of T Cell Immunity to Respiratory Virus Infections David L. Woodland
09:20:00 Coffee Break
10:00:00 Viruses in Health and Disease | Short Talk: Mucosal Innate Immunity and Natural Control of HIV-1 Transmission during Human Pregnancy Elisabeth Menu
10:00:00 Immunity in Respiratory Tract (X6) | Short Talk: Lung Surveillance Revealed by Two-Photon Live Imaging Emily E. Thornton
10:30:00 Immunity in Respiratory Tract (X6) | Short Talk: Lymphocytes in the Frontline; Human Lung CD8+ T Cells Recognizing Influenza Virus Reside in Airway Epithelium Berber Piet
10:30:00 Viruses in Health and Disease | Prime and Pull: Protection against Genital HSV Infection Haina Shin
11:15:00 On Own for Lunch and Recreation
11:15:00 Poster Setup
13:00:00 Poster Viewing
14:30:00 Workshop 2: Dendritic Cells, Macrophages and Mucosal Immunoregulation Cherié L. Butts, Joanne L. Viney
14:45:00 Evolution of Immune-Suppressive and Immune-Responsive Capacities in the Lung during Development in Mice
15:00:00 Essential Role of Lung Resident Macrophages in Regulating Airway Tolerance in Response to Innocuous Inhaled Antigen
15:15:00 Characterization of Dendritic Cell Subsets in Human Vaginal Mucosa
15:30:00 Gut-Specific Lymphocyte Homing as a Key Player in Oral Immunological Tolerance Barbara Cassani
15:45:00 Cooperation of Lymph Nodes and Intestinal Lamina Propria in Foxp3+ Regulatory T Cell Mediated Intestinal Tolerance Usriansyah Hadis
16:00:00 CX3CR1 Regulates Intestinal Macrophage Homeostasis, Bacterial Translocation and Colitis
16:15:00 Oral Delivery of TLR Ligands Programs Splenic Dendritic Cells to Induce T Regulatory Responses
16:30:00 Coffee Available
17:00:00 Control of Immune Responses in the Skin, Eye and Genital Tract
17:00:00 Immunity in Respiratory Tract (X6) | Inflammatory Aspects of Adaptive Immunity
17:15:00 Immunity in Respiratory Tract (X6) | Anti-Helminth Immunity in the Airways Graham S. Le Gros
17:15:00 Control of Immune Responses in the Skin, Eye and Genital Tract | Regulation of Dendritic Cell and T Cell Function by Lymphoid Stroma Shannon J. Turley
17:30:00 Immunity in Respiratory Tract (X6) | Short Talk: A Novel Subset of TH2 Memory/Effector Cells that Produce Inflammatory IL-17 Cytokine and Promote the Exacerbation of Allergic Asthma Yui-Hsi Wang
17:30:00 Control of Immune Responses in the Skin, Eye and Genital Tract | Ocular Immune Privilege, T Regulatory Cells and Autoimmunity Rachel Caspi
18:00:00 Control of Immune Responses in the Skin, Eye and Genital Tract | Short Talk: Innate and Adaptive Mucosal Immune Checkpoints in Chronic and Recurrent Bacterial Cystitis Thomas J. Hannan
18:00:00 Immunity in Respiratory Tract (X6) | Chemokines and Respiratory Immune Responses Nicholas W. Lukacs
18:30:00 Control of Immune Responses in the Skin, Eye and Genital Tract | Immunoregulation in the Female Reproductive Tract Sarah Howie
18:30:00 Immunity in Respiratory Tract (X6) | Toll-Like Receptor Regulation of Antigen-Presenting Cells and Responses to Mycobacterium tuberculosis Clifford V Harding
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 2
Tuesday, March 1, 2011
07:00:00 Breakfast
08:00:00 Immunoregulatory Mechanisms (Joint)
08:15:00 Tolerogenic Plasmacytoid Dendritic Cells Dominique Kaiserlian
08:30:00 Short Talk: MyD88-Dependent Signals Synergize with Retinoic Acid to Educate Gut-Associated Dendritic Cells Eduardo Javier Villablanca
08:45:00 Short Talk: Multiple CD4+ T Cell Subsets Produce Immunomodulatory IL-10 during Acute Respiratory Syncytial Virus Infection Kayla A. Weiss
09:00:00 Regulatory T Cell Flexibility and Stability Yasmine Belkaid
09:20:00 Coffee Break
10:00:00 Short Talk: Immunomodulatory Role of Progesterone on Immune Cell Function in Uterine and Other Tissues Cherié L. Butts
10:15:00 Short Talk: Epithelial Cell-Derived Cytokines Protect against GI Nematode Infection De'Broski R. Herbert
10:30:00 The Functions of IL-22 in Mucosal Immunity Wenjun Ouyang
11:00:00 On Own for Lunch and Recreation
11:00:00 Poster Setup
13:00:00 Poster Viewing
14:30:00 Workshop 3: NODS/TLRs and Innate Immunity Gerard Eberl, Dana Philpott
14:45:00 BAI1 (Brain Angiogenesis Inhibitor 1) is a Novel Pattern Recognition Receptor that Mediates Binding and Engulfment of Gram-Negative Bacteria Soumita Das
15:00:00 Regulation of Anti-Microbial Peptides and IL-17 by TLR1 during Oral Yersinia Enterocolitica Infection R William DePaolo
15:15:00 TLR5 Ligand Stimulates Colonic IL-22 Production by LTi-like Cells in an IL-23R Independent Fashion Matthew J. Giefer
15:30:00 Bacterial Flagellin Stimulates TLR5-Dependent Defense Against Vancomycin-Resistant Enterococcus Infection Melissa Kinnebrew
15:45:00 Toll-Like Receptor 5 Stimulation Protects Mice from Clostridium Difficile Colitis Irene Jarchum
16:00:00 Nod1 Prevents Systemic Inflammation by Recruiting Neutrophils to Clear Translocated Commensals after Clostridium Difficile Infection Naohiro Inohara
16:10:00 Nod Proteins Regulate Intestinal Inflammation
16:20:00 The Role of Mammalian PGLYRP2 in Enteric Mucosal Immune System Jooeun Lee
16:30:00 Coffee Available
17:00:00 Immunity in Respiratory Tract (X6) | Damage Control
17:00:00 Mucosal B Cells and Lymphoid Organogenesis
17:15:00 Immunity in Respiratory Tract (X6) | Antibody-Mediated Damage Control Liise-anne Pirofski
17:15:00 Mucosal B Cells and Lymphoid Organogenesis | Generation and Diversification of Human IgA Responses in Gut-Associated Lymphoid Tissue Jonathan Spencer
17:30:00 Mucosal B Cells and Lymphoid Organogenesis | Short Talk: Extramedullary V(D)J Recombination in Gut Lamina Propria B Lineage Cells Duane R. Wesemann
17:30:00 Immunity in Respiratory Tract (X6) | Short Talk: Defective BCR Internalization and Calcium Mobilization in Common Variable Immunodeficiency (CVID) Marianne L. Boes
18:00:00 Mucosal B Cells and Lymphoid Organogenesis | Regulation of Splenic Marginal Zone B Cell Responses by Mucosal Signals Andrea Cerutti
18:00:00 Immunity in Respiratory Tract (X6) | Signaling Hubs Balancing Host Defense and Lung Injury during Pneumonia Joseph P. Mizgerd
18:20:00 Immunity in Respiratory Tract (X6) | Short Talk: RAGE Promotes Inflammatory Responses to DNA in the Lung Cherilyn M. Sirois
18:30:00 Mucosal B Cells and Lymphoid Organogenesis | Lymphoid Tissue Inducer Cells: Members of the Bigger Family of RORgammat+ Innate Lymphoid Cells Gerard Eberl
18:35:00 Immunity in Respiratory Tract (X6) | Short Talk: IL-1 Signaling in Lung Recovery from Influenza-Induced Damage Catherine Sanders
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 3
Wednesday, March 2, 2011
07:00:00 Breakfast
08:00:00 Immunity in Respiratory Tract (X6) | Immunotherapy: Helping the Host
08:00:00 Innovative Approaches in Modern Medicine and Vaccine Development
08:15:00 Innovative Approaches in Modern Medicine and Vaccine Development | Visualizing Tolerance vs. Priming in vivo Using Novel Imaging, Labeling and Tracking Technologies Paul Garside
08:15:00 Immunity in Respiratory Tract (X6) | Nonspecific Enhancement of Resistance to Lung Viruses by Nanoparticle-Induction of BALT Allen G. Harmsen
08:30:00 Innovative Approaches in Modern Medicine and Vaccine Development | Short Talk: Computational Approaches for design of Cyclooxygenase-2 Selective Inhibitors as Anti-inflammatory agents Ruby Gupta
08:30:00 Immunity in Respiratory Tract (X6) | Lung Lymphoid Tissue and Regulation of Local Immune Responses Troy D. Randall
08:45:00 Immunity in Respiratory Tract (X6) | Antibody-Based Therapies: Promise and Complexity Arturo Casadevall
08:45:00 Innovative Approaches in Modern Medicine and Vaccine Development | Protein Domains, Signaling Networks, and Immunity Ramnik J. Xavier
09:00:00 Innovative Approaches in Modern Medicine and Vaccine Development | Short Talk: Detecting Disease-Related Biologic Neighborhoods by Metaproteomic Analysis at Mucosal-Luminal Interface
09:00:00 Coffee Break
09:00:00 Immunity in Respiratory Tract (X6) | Short Talk: Epithelial Resistance to Pneumonia Induced by TLR Synergy Scott E. Evans
10:00:00 Immunity in Respiratory Tract (X6) | TLR4 Agonists Facilitate “Rapid Acting Vaccine” Against the Respiratory Tract Pathogen, Influenza A Jory R. Baldridge
10:00:00 Innovative Approaches in Modern Medicine and Vaccine Development | Cytotoxic T Lymphocytes, Virus Strategies and Sterilizing Immunity Andrew Yates
10:30:00 Innovative Approaches in Modern Medicine and Vaccine Development | Novel TLR Therapies for Treating Allergic Rhinitis and Asthma Robert M. Hershberg
10:30:00 Immunity in Respiratory Tract (X6) | Short Talk: Muramyl Dipeptide Induces NOD2-Dependent Modulation of Protective Host Response Against Influenza Virus Francois Coulombe
11:15:00 Poster Setup
11:15:00 On Own for Lunch and Recreation
13:00:00 Poster Viewing
14:30:00 Workshop 4: Epithelial Barrier Function and Bugs Bana Jabri, De'Broski R. Herbert
14:45:00 Activation of Mucosal Innate Immune Responses by Short Chain Fatty Acids and Toll-Like Receptor Ligands Paria Mirmonsef
15:00:00 Dual Role of Epithelial Fucosylation in the Small Intestine: Co-Habitation and Defense Niches for Commensal and Pathogenic Bacteria Y Akiyama
15:15:00 IRT5 Generates Tolerogenic DCs and Foxp3+ Regulatory T Cells to Suppress Inflammatory Immune Disorders Chang-Suk Chae
15:30:00 Epithelial Multidrug Resistance-1 (MDR1) Gene Modulates Specific NFKB-Response to Bacterial Flagellin and Promotes a Pro-Inflammatory Response in the Intestinal Epithelium
15:45:00 Synergistic Interactions between Intestinal Intraepithelial Lymphocytes and Epithelial Cells Determines Responses to Pathogen-Associated Molecules Mahima Swamy
16:00:00 Mucosal Associated Invariant T Cells Function in the Intestine Lionel Le Bourhis
16:15:00 Reduction of Disulphide Bonds Unmasks Potent Antimicrobial Activity of Human Beta-Defensin 1
16:30:00 Coffee Available
17:00:00 Immunity in Respiratory Tract (X6) | Vaccines Inducing Pathogen-Specific Lung Immunity
17:00:00 Genetic and Molecular Basis of Intestinal Inflammation and Allergy
17:15:00 Genetic and Molecular Basis of Intestinal Inflammation and Allergy | What Genetic Studies Are Teaching Us about Mucosal Biology and Intestinal Inflammation John D. Rioux
17:15:00 Immunity in Respiratory Tract (X6) | Local Immunity Induced by Live Attenuated Pandemic Influenza Vaccines Kanta Subbarao
17:30:00 Genetic and Molecular Basis of Intestinal Inflammation and Allergy | Autoimmune Dysregulation in Celiac Disease Ludvig Magne Sollid
17:30:00 Immunity in Respiratory Tract (X6) | Short Talk: Pulmonary DNA Immunization Generates Antigen-Specific CD8+T Cells in the Lung Airways that Protect Against Respiratory Lethal Viral Challenge Maytal Bivas-Benita
18:00:00 Immunity in Respiratory Tract (X6) | Requirements for Immunity Against Pneumonic Tularemia Catharine . M. Bosio
18:00:00 Genetic and Molecular Basis of Intestinal Inflammation and Allergy | Short Talk: Co-Adjuvant Effects of Retinoic Acid and IL-15 Induce Inflammatory Immunity to Dietary Antigens Valerie Abadie
18:30:00 Genetic and Molecular Basis of Intestinal Inflammation and Allergy | Treating Food Allergy Hugh A. Sampson
18:30:00 Immunity in Respiratory Tract (X6) | Balancing Mucosal Immunity in a Vaccine Context Jay K. Kolls
19:00:00 Social Hour w/ Lite Bites
20:00:00 Entertainment
Thursday, March 3, 2011
09:00:00 Departure
4th Annual Pharma R&D Asia Congress
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