Biotech China 2014
New Insights into Normal versus Dysregulated B Cell Function (D6)
Fairmont Chateau Whistler
4599 Chateau Boulevard Whistler, British Columbia V0N 1B4 Canada
Whistler, British Columbia
http://keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=1105
   Deadlines
   ---------

     *  Abstract Deadline:
       13th December 2010

     *  Registration Deadline:
       11th February 2011


   Speakers
   --------

     *  Christopher C. Goodnow, Australian National University, Australia

     *  Barbara Lynne Kee, University Of Chicago, USA

     *  David G. Schatz, Yale University School of Medicine, USA

     *  John G. Monroe, Genentech, Inc., USA

     *  Ann J. Feeney, The Scripps Research Institute, USA

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Short Talks to be Chosen from Abstracts, ,

     *  Tomohiro Kurosaki, RIKEN Research Center for Allergy and
       Immunology, Japan

     *  Juergen Wienands, Georg August University of Goettingen, Germany

     *  Facundo D. Batista, London Research Institute, Cancer Research
       UK, United Kingdom

     *  Short Talk to be Chosen from Abstracts,

     *  Kenneth A. Dorshkind, University of California, Los Angeles, USA

     *  Nicole Baumgarth, University of California, Davis, USA

     *  Sidonia Fagarasan?, RIKEN Research Center for Allergy and
       Immunology, Japan

     *  Ralf Küppers, University of Duisburg-Essen, Medical School,
       Germany

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Short Talks to be Chosen from Abstracts, ,

     *  Frances E. Lund, University of Rochester Medical Center, USA

     *  David Gray, University of Edinburgh, United Kingdom

     *  Claudia Mauri, University College London, United Kingdom

     *  Short Talk to be Chosen from Abstracts,

     *  David M. Tarlinton, Walter and Eliza Hall Institute of Medical
       Research, Australia

     *  Speaker to be Announced,

     *  Andrea Cerutti, Mount Sinai School of Medicine, USA

     *  Randolph J. Noelle?, King’s College London, United Kingdom

     *  Short Talk(s) to be Chosen from Abstracts,

     *  Robert Brink, Garvan Institute of Medical Research, Australia

     *  Ari M. Melnick, Weill Cornell Medical College, USA

     *  Louis M. Staudt, National Cancer Institute, National Institutes
       of Health, USA

     *  Short Talk to be Chosen from Abstracts,

     *  Edward K. Wakeland, University of Texas Southwestern Medical
       Center, USA

     *  Jane H. Buckner, Benaroya Research Institute at Virginia Mason,
       USA

     *  David J. Rawlings, University of Washington / Seattle Children’s
       Hospital Research Institute, USA

     *  Stuart G. Tangye, Garvan Institute of Medical Research, Australia

     *  Short Talks to be Chosen from Abstracts, ,

     *  Marilyn R. Kehry, Biogen Idec, USA

     *  Anne Davidson, Feinstein Institute for Medical Research, USA

     *  Patrick C. Wilson, University of Chicago, USA

     *  Susan Moir, NIAID , National Institutes of Health, USA

   B lymphocytes play crucial roles in host defense against infection via
   a series of highly coordinated processes that include cell homing,
   antigen recognition, antibody secretion, antigen presentation, and/or
   cytokine release. To accomplish these myriad functions, B cells must
   maneuver through a complex series of primary and secondary
   developmental, homoeostatic, and activation-triggered checkpoints.
   These checkpoints dictate stochastic and molecularly directed events
   dependent upon local micro-environments, cell-cell interactions, and
   interactions with pathogenic or non-pathogenic organisms. Early events
   in this developmental cascade promote the generation of a diverse B
   cell antigen receptor repertoire that is essential for both survival
   and entry into downstream effector populations. In parallel, this
   repertoire is tested for self-reactivity at multiple steps leading to
   either loss or expansion of specific clones. Dysregulation of these
   complex processes can lead, alternatively, to immunodeficiency,
   autoimmune, or malignant disease. The overall goal of this meeting is
   to highlight recent studies of normal versus abnormal B cell
   development and function with an emphasis whenever possible to data
   using human models.

Schedule of Presentations:

Tuesday, April 12, 2011
15:00:00 Registration
18:15:00 Refreshments
19:15:00 Welcome and Keynote Address
19:45:00 Mechanism of Actively Acquired Tolerance or Immunity | Progress and Problems 50 Years After the Burnet-Medawar Nobel Prize Christopher Goodnow
Wednesday, April 13, 2011
07:00:00 Breakfast
08:00:00 Conventional (or Adaptive) B Cell Development
08:05:00 E Protein Transcription Factors and Lymphoid Specification Barbara Lynne Kee
08:30:00 Biochemical and Genome-Wide Analyses of RAG1 and RAG2 Interactions with DNA David Schatz
08:45:00 The Regulatory and Molecular Logic of IL-7R and pre-BCR Signaling in B Cell Development Harinder Singh
09:00:00 Epigenetic and 3-Dimensional Regulation of Antibody Repertoire Formation Ann J. Feeney
09:20:00 Coffee Break
09:45:00 Short Talk | Genetic and Epigenetic Repression of the Igkappa Intronic Enhancer by STAT5
10:00:00 Short Talk | Elimination of Self-Reactive B Cells by Follicular Dendritic Cell-Bound Antigen
11:15:00 On Own for Lunch and Recreation
11:15:00 Poster Setup
13:00:00 Poster Viewing
14:30:00 Workshop 1 | Short Talks to be Chosen from Abstracts
16:30:00 Coffee Available
17:00:00 B Cell Activation and Co-Receptor Signaling
17:05:00 Function of Store-Operated Calcium Entry in B Lymphocytes Tomohiro Kurosaki
17:15:00 Activation Signals for Naïve and Class-switched Memory B Cells Juergen Wienands
17:30:00 Early Events in B Cell Activation | From Single Molecules to Living Tissue Facundo D. Batista
18:15:00 Short Talk: The Tale of a Tail | The Role of Disk Large Protein 1 (Dlg1) in Isotype-Switched IgG-BCR Signaling
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 1
Thursday, April 14, 2011
07:00:00 Breakfast
08:00:00 Innate B Cells
08:05:00 B Cell Developmental Programs from Embryogenesis through Senescence Kenneth A. Dorshkind
08:20:00 Innate Regulation of B-1 Cell Responses to Influenza Infection Nicole Baumgarth
09:00:00 Innate Signaling Networks in Memory B Cell Responses Andrea Cerutti
09:20:00 Coffee Break
09:45:00 Human B Cell Subsets and the Cellular Origin of Chronic Lymphocytic Leukemia Ralf Küppers
10:00:00 Short Talk | Human B1 Cells Express the Novel Phenotype | CD20+CD27+CD43+CD70
10:20:00 Short Talk | An Innate-Like B Cell Subset Expands with Age
11:15:00 On Own for Lunch and Recreation
11:15:00 Poster Setup
13:00:00 Poster Viewing
14:30:00 Workshop 2 | Short Talks to be Chosen from Abstracts
16:30:00 Coffee Available
17:00:00 Effector and Regulatory B Cell Function
17:05:00 Impairment of Dendritic Cell, CD4 T Cell and CD8 T Cell Mediated Immune Responses following B Cell Depletion Frances E. Lund
17:30:00 Regulatory B Cell in Health and Disease Claudia Mauri
17:30:00 Programming and Regulation of T Cells by B Cells David Gray
18:30:00 Short Talk | Macrophages Induce Terminal Differentiation of Plasma Cells through CXCL10/IP-10
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 2
Friday, April 15, 2011
07:00:00 Breakfast
08:00:00 GC Reaction and B Cell Memory
08:05:00 Memory B Cell and Plasma Cell Differentiation David Tarlinton
08:30:00 Seq-ing AID in B Cell Tumor Development R Casellas
09:00:00 Tfh Cells and Memory B Cell Selection Carola G. Vinuesa
09:20:00 Coffee Break
09:45:00 Short Talk | Different B Cell Populations Mediate Early and Late Memory during an Endogenous Immune Response
10:30:00 Short Talk | Eosinophils are Required for the Long-Term Survival of Plasma Cells in the Bone Marrow
11:15:00 Poster Setup
11:15:00 On Own for Lunch and Recreation
13:00:00 Poster Viewing
16:30:00 Coffee Available
17:00:00 GC Transcriptional Programs and Alterations in B Lymphoma
17:05:00 Controlling Self-Reactive B Cells in the Germinal Center Reaction Robert Brink
17:30:00 Transcriptional Programming in Normal and Malignant Germinal Center B Cells Ari Melnick
18:00:00 Converging on the Achilles Heel of Lymphoma through Functional and Structural Genomics Louis M. Staudt
18:30:00 Short Talk: Nonstereotypic Follicular Lymphoma B-Cell Receptors Recognize Vimentin as a Shared Autoantigen
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 3
Saturday, April 16, 2011
07:00:00 Breakfast
08:00:00 B Cell Genetic Alterations Linked to Cell Intrinsic Autoimmunity and/or Immunodeficiency
08:05:00 B Cell Function in Murine Models of SLE Edward K. Wakeland
08:30:00 PTPN22 Modulates B Cell Tolerance in Human Autoimmunity Jane H. Buckner
09:00:00 Coffee Break
09:00:00 WASp-/- B Cells Promote Humoral Autoimmunity David J. Rawlings
09:45:00 Consequences of Loss-of Function Mutations in Primary Immunodeficiencies on Human B Cell Differentiation and Long-Lived Humoral Immunity Stuart G. a Tangye
10:15:00 Short Talk: Selective Utilization of TLR/MyD88 Signaling in B Cells for Enhancement of the Anti-Viral Germinal Center Response
10:45:00 Short Talk | Self-Ligand Dependent Selection of Rheumatoid Factor B Cells into the Marginal Zone Compartment
11:15:00 On Own for Lunch and Recreation
14:30:00 Workshop 3 | Short Talks to be Chosen from Abstracts
16:30:00 Coffee Available
17:00:00 Manipulation of B Cells in Human Disease
17:05:00 BAFF Inhibition in SLE Anne Davidson
17:30:00 The Human B Cell Response to Annual and H1N1 Influenza Virus Patrick C. Wilson
18:00:00 Immunopathogenesis of B Cells in HIV Infection Susan Moir
18:30:00 Short Talk | Increased Polyreactivity and Reduced Somatic Hypermutation Characterize Tissue-Like Memory B Cell-Derived Antibodies of Chronically HIV-Infected Individuals
19:00:00 Social Hour w/ Lite Bites
20:00:00 Entertainment
Sunday, April 17, 2011
09:00:00 Departure
4th Annual Pharma R&D Asia Congress
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