Biotech China 2014
GRC - Plasminogen Activation & Extracellular Proteolysis
Four Points Sheraton / Holiday Inn Express

Ventura, CA
http://www.grc.org/programs.aspx?year=2008&program=plasmino

Schedule of Presentations:

Sunday, February 10, 2008
16:00:00 Arrival and Check-in
18:00:00 Dinner
19:30:00 Welcome / Introductory Comments by GRC Site Staff
19:35:00 Discussion Edward Plow
19:35:00 Receptors in Thrombosis and Fibrinolysis
19:40:00 Protease activated receptors (PARs) in vascular biology and beyond Shaun Coughlin
20:20:00 Discussion
20:30:00 Probing cellular proteomes for transmembrane plasminogen receptors Lindsey Miles
20:50:00 Discussion
21:00:00 How the urokinase receptor engages different ligands Michael Ploug
21:20:00 Discussion
21:30:00 Informal Social
Monday, February 11, 2008
07:30:00 Breakfast
08:30:00 Group Photo
09:00:00 Inflammation, Pathogenesis and Host Defense
09:00:00 Discussion William Goldman
09:05:00 Extracellular proteolysis during primary pneumonic plague
09:25:00 Discussion
09:40:00 Immune regulation of fibrinolysis during infection Stephen Smiley
10:00:00 Discussion
10:15:00 Coffee Break
10:45:00 Genetic modification of thrombin-mediated proteolysis and innate immunity Jay Degen
11:05:00 Discussion
11:20:00 Cellular assembly and functions of the protein C system Charles T Esmon
11:40:00 Discussion
11:55:00 DIC and enhanced inflammation in LPS-treated Protein C-deficient mice Francis Castellino
12:15:00 Discussion
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
18:00:00 Dinner
19:30:00 Discussion Francis Castellino
19:30:00 Mechanisms of Dysregulated Proteolysis
19:35:00 The Annexin A2 system and vascular function in vivo Katherine Hajjar
20:00:00 Discussion
20:15:00 Urokinase Receptor deficient mice are deficient in skin wound healing and are protected from skin carcinogenesis: connection to skin stem cells Francesco Blasi
20:35:00 Discussion
20:50:00 The role of fibrin in Alzheimer's Disease Sidney Strickland
21:15:00 Discussion
21:30:00 Informal Social
Tuesday, February 12, 2008
07:30:00 Breakfast
09:00:00 Discussion Vincent Ellis
09:00:00 Proteolytic Pathways
09:05:00 Matriptase and its inhibitors - balancing cell surface proteolysis during tissue morphogenesis and cancer Roman Szabo
09:25:00 Discussion
09:40:00 The transmembrane serine protease hepsin activates pro-hepatocyte growth factor (HGF) and pro-urokinase plasminogen activator (uPA) and promotes tumor progression Daniel Kirchhofer
10:00:00 Discussion
10:15:00 Coffee Break
10:45:00 Cellular regulation of transmembrane serine protease activity Vincent Ellis
11:05:00 Discussion
11:20:00 von Willebrand Factor Binding Protein is a member of the Zymogen Activator and Adhesion Protein (ZAAP) family Paul Bock
11:40:00 Discussion
11:55:00 Unique strategies for predicting and measuring proteolysis: toward proteolytic networks Jeffrey Smith
12:15:00 Discussion
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
18:00:00 Dinner
19:30:00 Discussion Steven Gonias
19:30:00 Proteolysis in Tumor Biology
19:35:00 The urokinase receptor and integrin interactions in lung cancer cell signaling Harold Chapman
20:00:00 Discussion
20:15:00 Adhesion regulated proteolysis in ovarian carcinoma Sharon Stack
20:35:00 Discussion
20:50:00 Tissue degradation during individual and collective invasion Peter Friedl
21:15:00 Discussion
21:30:00 Informal Social
Wednesday, February 13, 2008
07:30:00 Breakfast
09:00:00 Discussion Sidney Strickland
09:00:00 Neurobiology and Sensory Perception
09:05:00 Fibrinogen functions in the nervous system Katerina Akassoglou
09:25:00 Discussion
09:40:00 Regulation of the blood brain barrier during ischemic stroke Dan Lawrence
10:00:00 Discussion
10:15:00 Coffee Break
10:45:00 Analysis of the role of type II transmembrane serine proteases in hearing loss Michel Guipponi
11:05:00 Discussion
11:20:00 LRP-1 is a multifunctional regulator during peripheral nerve injury and neuropathic pain Wendy Campana
11:40:00 Discussion
11:55:00 Tissue plasminogen activator (tPA) and the glial scar Stella Tsirka
12:15:00 Discussion
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
18:00:00 Dinner
19:00:00 Business Meeting
19:30:00 Late Breaking Hot Topics from Abstracts Thomas H Bugge
19:40:00 Discussion
19:55:00 Discussion
20:10:00 Discussion
20:25:00 Discussion
20:40:00 Discussion
20:55:00 Discussion
21:10:00 Discussion
21:25:00 Discussion
21:30:00 Informal Social
Thursday, February 14, 2008
07:30:00 Breakfast
09:00:00 Introduction Dudley Strickland
09:00:00 Atherosclerosis and Cardiovascular Disease Dudley Strickland
09:05:00 The cardiac serine protease corin in hypertension and heart disease Qingyu Wu
09:25:00 Discussion
09:40:00 Whole genome approaches to cardiovascular disease in model organisms David Ginsburg
10:00:00 Discussion
10:15:00 Coffee Break
10:45:00 Modulation of inflammatory pathways by LRP Dudley Strickland
11:05:00 Discussion
11:20:00 PCSK9, a secreted protease with a non-protease function Jay Horton
11:40:00 Discussion
11:55:00 PAI-1: a vascular rheostat for thrombosis and atherosclerosis Douglas Vaughan
12:15:00 Discussion
12:30:00 Lunch
13:30:00 Free Time
17:00:00 Farewell Reception
18:00:00 Dinner
19:30:00 Protease Engineering and Pharmacological Intervention Paul Bock
19:30:00 Introduction Paul Bock
19:35:00 Engineering the activity and specificity of proteases Edward Madison
20:00:00 Discussion
20:15:00 Reengineering bacterial cytotoxins for protease imaging and tumor targeting Thomas H Bugge
20:35:00 Discussion
20:50:00 New principles for pharmacological intervention with the plasminogen activation system Peter Andreasen
21:15:00 Discussion
21:30:00 Informal Social
Friday, February 15, 2008
07:30:00 Breakfast
12:00:00 Depart
4th Annual Pharma R&D Asia Congress
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