3D Tissue Models
Fragment-based Lead Discovery Conference
Paradise Point Resort & Spa
1404 Vacation Road
San Diego, CA

Event Sponsors

Schedule of Presentations:

Monday, February 18, 2008
08:00:00 Morning Session: Success Stories Martin Drysdale, Dan Erlanson
08:00:00 Opening Plenary Presentation Stephen Fesik
09:00:00 Session Intro Dan Erlanson
09:10:00 Integrating Fragments into Structure Based Medicinal Chemistry -Discovery and Development of Hsp90 Inhibitors for the Treatment of Cancer Martin Drysdale
09:50:00 Fragment-to-Clinic: Astex Experience David Rees
10:30:00 Break, Exhibits
11:00:00 Successes and Surprises with Fragments Wolfgang Jahnke
11:40:00 From a Scaffold to the Clinic Rick Artis
12:30:00 Lunch
13:30:00 Posters, Exhibits, FBLD Scavenger Hunt
15:00:00 Free Time
16:00:00 Afternoon/Evening Session: Chemical Biology and Drug Discovery Maurizio Pellecchia
16:00:00 Session Intro Maurizio Pellecchia
16:10:00 Fragment-based Approaches to Targeting Enzymes from Parasitic Organisms Gabriele Varani
16:40:00 NMR Spectroscopy in Hit Identification and Optimization Process and Reverse Chemical Genetics Maurizio Pellecchia
17:10:00 Break
17:20:00 BMSC Fragment Cocktails: Development and Experience in MSGPP Christophe Verlinde
17:50:00 Dynamics in Drug Design: Application of Freeze-Frame Click Chemistry in the Design of Acetylcholinesterase and Nicotinic Receptor Selective Ligands Palmer Taylor
18:20:00 Targeting drug-resistant variants of HIV reverse transcriptase: high resolution crystal engineering and fragment screening Eddy Arnold
19:00:00 Buffet Dinner, Posters, Exhibits
Tuesday, February 19, 2008
08:00:00 Morning Session: Methods & Emerging Technologies, Part I Wolfgang Jahnke
08:00:00 Session Introduction Vicki Nienaber
08:10:00 Fragment-based Screening in Real-time David Myszka
08:50:00 Fragment screening of drug targets by SPR and subsequent X-ray structural analysis Michael Hennig
09:30:00 Application of Enthalpy Arrays to Fragment-based Screening Michael Recht
10:10:00 Break, Exhibits
10:40:00 HT Fragment Screening using Fluorescence Correlation Spectroscopy Thomas Hesterkamp
11:20:00 In vivo Incorporation of NMR-active Unnatural Amino Acids Bernhard Geierstanger
12:00:00 Lunch
13:00:00 Posters, Exhibits, FBLD Scavenger Hunt
15:00:00 From Fragments to Leads: Seed, Assemble and Grow Gerhard Klebe
15:00:00 Afternoon Session: Methods & Emerging Technologies, Part II
15:40:00 Integrating Biophysical Methods into Fragment-Based Screening Glyn Williams
16:20:00 Pulling it all together: Faster Better Lead Discovery through Integration of Technologies Vicki Nienaber
17:00:00 Break, exhibits
17:30:00 Scientific Advisory Board Round Table
19:00:00 Dinner Reception, Poster & FBLD Scavenger Hunt Winners Announced
Wednesday, February 20, 2008
08:00:00 A Decade of Thinking Small: Highlights and Lessons Learned from Building a Fragment Discovery Company Harren Jhoti
08:00:00 Morning Session: Lessons Learned Roderick Hubbard, Harren Jhoti
08:20:00 Fragmentology Roderick Hubbard
09:20:00 How then Shall we Screen? Phil Hajduk
09:50:00 Break, Exhibits
10:05:00 Integrating Fragment-Based Methods into Drug Discovery: Some Examples Siegfried Reich
10:50:00 Fragment-based discovery for challenging targets Jim Wells
11:35:00 Closing Plenary Presentation Christopher Lipinski
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