Biotech China 2014
B Cells and Protection: Back to Basics - ESF-EMBO Symposium
Hotel Eden Roc
C/Port Salvi 57
, Sant Feliu de Guixols 17220
http://www.esf.org/conferences/11366
   Deadlines
   ---------

     *  Abstract Deadline:
       10th March 2011

     *  Registration Deadline:
       10th March 2011


   Speakers
   --------

   Martin BACHMANN , Cytos Biotechnology AG, CH – Nanoparticles targeting
   dendritic cells; Yehudit BERGMAN , The Hebrew University Hadassah
   Medical School, IL – Epigenetics of B-cell development; Nicolaas A.
   BOS , University Medical Center Groningen, NL – The site specificity
   of the IgA repertoire; Michael CANCRO , University of Pennsylvania
   School of Medicine, US – Roles for BLyS family members in establishing
   and maintaining humoral immunity; Francesca CHIODI , Karolinska
   Institutet, SE – Dysfunctional B cells in HIV -1 infection; Deborah
   DUNN - WALTERS , Kings College London School of Medicine, UK –
   Affinity maturation changes with age; Michael EHRENSTEIN , University
   College London, UK – Secreted IgM as regulator of autoimmune
   responses; Hiepe FALK , University of Berlin, DE – Long lived plasma
   cells and autoimmunity; Hana KOZAKOVA , Laboratory of Physiology,
   Immunity and Ontogenesis of Gnotobionts, ASCR , CZ – Amelioration of
   experimentally induced allergy by colonization with probiotic
   bacteria; Paul KUBES , University of Calgary, CA – Host- bacteria
   encounter in the blood vessels; François LEULIER , Institut de
   Biologie du Developpement de Marseille-Luminy, FR – The control of
   host-microbes mutualism in absence of B-cells: the Fly case;Franco
   LOCATELLI , Research Center, Bambino Gesù Children Hospital, IT; Nils
   LYCKE , Göteborg University, SE – Regulation of innate and adaptive
   immunity at mucosal membranes; Lill MARTENSSON - BOPP , The Babraham
   Institute, UK – The pre-B cell receptor checkpoint; Maria Angeles
   MUNOZ - FERNANDEZ , Hospital General Universitario Gregorio Maranon,
   ES – Carbosilane Dendrimers in HIV infection; Almudena R. RAMIRO ,
   Spanish National Cancer Research Center, ES – MicroRNA and the
   regulation of AID ; Yves-Jacques SCHNEIDER , Institut des Sciences de
   la Vie & Université Catholique de Louvain, BE – Transport of
   nanoparticles to and by M cells; Idit SHACHAR , The Weizmann Institute
   of Science, IL – Molecular Mechanisms Regulating B cell Survival in
   Health and Disease; Mikael SIGVARDSSON , Linköping University, SE –
   Shaping-up a lineage: Molecular regulation of B-lymphocyte Commitment;
   Jo SPENCER , Kings College London School of Medicine,UK – Generation
   of diversity in mucosal immunoglobulin; Mark THROSBY , Merus, NL –
   Development and applications of human therapeutic antibodies in
   infectious disease; Hedda WARDEMANN , Max Planck Institute for
   Infection Biology, DE – The antibody repertoire of antigen experienced
   B cells in health and disease.

   Microbes populated the earth long before any eukariotic cell.
   Therefore, in order to survive, mono and multi-cellular organisms had
   to develop mechanisms of adaptation, cohabitation and defense against
   bacteria, fungi and viruses. One of these mechanisms is mediated by
   immunoglobulins in the serum and at mucosal surfaces. B cells and
   their antibodies, both natural and adaptive, play a fundamental role
   in the immediate and late defence against microbes and in the control
   of the commensal microflora. They also protect the organism from
   viruses neutralizing them before infection. Therefore, although over
   the last years B cells have been considered the mere executors of the
   orders derived by the complex interaction between antigen presenting
   cells and T cells, new attention is concentrating on the humoral
   response. For example, B cells are now the cellular target of a new
   generation of vaccines against HIV , the best known T cell virus. It
   has been found that B cells sense the environment not only through
   their unique B cell receptor, but also using the more promiscuous and
   evolutionary ancient TLRs.
   This mode of recognition does not need T cells, but efficiently
   induces B cell activation and differentiation. Signal transduction
   from the TLR is now studied also in B cells. Additional complexity to
   the B cell field has been brought about by the discovery of microRNA
   and their function in normal and neoplastic development. Finally, new
   techniques borrowed from the development of physics allow the in vivo
   study of lymphocytes movement and function. Using confocal and
   two-photon microscopy is also possible to visualize contacts and
   interactions at the molecular level and verify our biochemical
   knowledge of the B cell “inside world”. New materials, such as
   nanoparticles and dendrimers, can be now used for vaccine development
   and a tight collaboration of biology and physics has started in order
   to define size, form, administration of new products and their
   cellular targets. The new findings in this field would be important
   also for companies interested in the prevention and therapy of
   infection and B-cell diseases.
   The conference aims at bringing together senior and young European
   scientists to discuss the newest findings with the hope of developing
   interests and collaborations. We also propose to invite to the
   conference the editors of 3 or 4 scientific journals with the highest
   impact factor. Most European scientists face difficulties in
   publishing in these journals. Apart from the quality of the
   manuscripts, we have the disadvantage that American science
   establishes trends and “fashion” indicating what is important to be
   published. This is partly due to the fact that the important
   immunological journals have the headquarters in the States and the
   editors, that decide whether an article is sent for review or not, are
   all young ex-scientists of American experience and background.
   Inviting the editors and organizing a mini symposium we hope to make
   them see and understand the type and quality of European science.

Schedule of Presentations:

Sunday, June 12, 2011
17:00:00 Registration at the ESF desk
19:00:00 Welcome Drink
20:00:00 Dinner
Monday, June 13, 2011
08:45:00 OPENING WORDS Rita Carsetti
08:50:00 ESF Presentation Martin Röllinghoff
08:55:00 Session 1 | The host microbe relationship | a long-standing armed peace Rita Carsetti
09:00:00 The antibody repertoire of antigen experienced B cells in health and disease Hedda WARDEMANN
09:00:00 The control of host-microbes mutualism in absence of B-cells | the Fly case François LEULIER
09:45:00 Host bacteria encounter in the blood vessels Craig JENNE
10:30:00 Coffee break
11:00:00 Amelioration of experimentally induced allergy by colonization with probiotic bacteria Hana KOZAKOVA
11:45:00 Role of microbes shaping the innate and adaptive immune response Andrew MacPherson
12:30:00 Lunch
16:00:00 Coffee break
16:25:00 SESSION 2 | Human leukocyte antigens (HLA) as markers of human population and their history Andrew MacPherson
16:30:00 TBC Steffen Jung
17:15:00 Regulation of innate and adaptive immunity at mucosal membranes Nils LYCKE
18:00:00 Dinner
20:30:00 Poster session
Tuesday, June 14, 2011
08:55:00 Session 3 | B cell diversity | “B” different Deborah K. Dunn-Walters
09:45:00 The site specificity of the IgA repertoire Nicolaas A. BOS
10:30:00 Coffee break
11:00:00 Generation of diversity in mucosal immunoglobulin Jonathan Spencer
11:45:00 Affinity maturation changes with age Deborah K. Dunn-Walters
12:30:00 Lunch
15:45:00 Coffee break
16:15:00 Poster Session
16:55:00 Session 4 | B cell development and function | the regulatory universe Yehudit Bergman
17:00:00 Shaping-up a lineage | Molecular regulation of B-lymphocyte Commitment Mikael SIGVARDSSON
17:45:00 Epigenetics of B-cell development Yehudit Bergman
19:00:00 Dinner
20:00:00 Poster Session
Wednesday, June 15, 2011
08:55:00 Session 5 | B cell development and function | the art of integrating signals Almudena R RAMIRO
09:00:00 The pre-B cell receptor Checkpoint Lill MÅRTENSSON-BOPP
09:45:00 Regulating B cell development and activation via RNA binding proteins Martin TURNER
10:30:00 Coffee break
11:00:00 MicroRNA and the regulation of AID Almudena R RAMIRO
11:30:00 Dysfunctional B cells in HIV-1 infection Francesca CHIODI
12:15:00 Molecular Mechanisms Regulating B cell Survival in Health and Disease Idit SHACHAR
13:15:00 Lunch
13:30:00 Afternoon | Half-day excursion
19:00:00 Dinner
20:30:00 Short Oral Presentations Maria Manuela ROSADO
20:35:00 Short-talk
20:45:00 Short-talk
21:00:00 Short-talk
21:15:00 Short-talk
21:30:00 Short-talk
21:45:00 Short-talk
Thursday, June 16, 2011
06:00:00 New Presentation
08:55:00 Session 6 | New technologies for old problems Mark THROSBY
09:00:00 Development and applications of human therapeutic antibodies in infectious disease Mark THROSBY
09:45:00 Transport of nanoparticles to and by M cells Yves-Jacques SCHNEIDER
10:30:00 Coffee break
11:00:00 Nanoparticles targeting dendritic cells Martin BACHMANN
11:45:00 Carbosilane Dendrimers in HIV infection Maria Angeles MUNOZ-FERNANDEZ
13:00:00 Lunch
15:25:00 Session 7 | When things go wrong: tumours and diseases Michael Cancro
15:30:00 TBC Franco LOCATELLI
16:15:00 Roles for BLyS family members in establishing and maintaining humoral immunity Michael Cancro
17:00:00 Coffee break
17:30:00 Secreted IgM as regulator of autoimmune responses Michael EHRENSTEIN
18:15:00 Long lived plasma cells and autoimmunity Hiepe FALK
19:30:00 Drinks Reception
20:00:00 Conference Dinner
Friday, June 17, 2011
08:00:00 Breakfast and departure
4th Annual Pharma R&D Asia Congress
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