9th Annual Biomarkers Congress
Antimicrobial Peptides
Il Ciocco Hotel and Resort
Il Ciocco - fraz. Castelvecchio Pascoli 55051 Barga, Italy 0583 7191
Lucca Barga, Italy
http://www.grc.org/programs.aspx?year=2011&program=antimicro
Applications for this meeting must be submitted by April 17, 2011. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Antimicrobial peptides (AMPs) are host-defense molecules produced by all living organisms, including bacteria, fungi, plants, invertebrates, vertebrates as well as humans. These molecules represent effectors of the metazoan innate immune system as well as defense molecules of microbes. In multicellular organisms they act at the front line of the defense system against pathogens where they are synthesized constitutively or inducibly at epithelial surfaces, the location where the initial contact with all microbes, from symbionts to pathogens, takes place. There is now evidence that these peptides represent key components at epithelial surfaces, the barrier between the external environment and the interior milieu, where they play an important role in defining the composition of microbiota and its interaction with the host.

Although many AMPs are cationic and have affinity to the negatively charged bacterial membrane that they disrupt, resulting in bacterial killing by lysis, there is upcoming evidence that AMPs can also kill microbes in a more sophisticated fashion. In addition to its microbicidal activity, several AMPs function also as chemoattractants for cells of both the adaptive and innate immunity and are able to modulate immune responses. Thus, AMPs constitute a link between the innate and adaptive immunity.

The 2011 Gordon Conference on Antimicrobial Peptides will present the latest research on the biology and activities of AMPs with emphasis on its role in health and disease. The Conference will feature a wide range of topics, such as structure/function analysis, regulation of expression, mechanisms of action, microbial avoidance strategies, human disease associations, model systems and its possible use as therapeutics. The connection of microbial and host-derived AMPs to the natural microflora and probiotics is a recent finding that will be emphasized as well as novel AMPs of different origin.

Invited speakers represent a diverse variety of scientific disciplines, including biochemistry, microbiology, molecular genetics, animal and plant biology, structural biology, biophysics, medicine, and innate immunity in general. The Conference will bring together a collection of investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some abstracts and poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented.

Schedule of Presentations:

Sunday, May 15, 2011
16:00:00 Arrival and Check-in
18:00:00 Dinner
19:30:00 Welcome | Introductory Comments by GRC Site Staff
19:40:00 Young Investigator Award Lecture
19:45:00 TBA
19:50:00 Discussion
20:00:00 Keynote Session | Antimicrobial Peptides - Novel Knowledge of an Ancient Defense System Birgitta Agerberth, Jens Schröder
20:05:00 AMPs as key factors for host-bacteria co-evolution Thomas Bosch
20:30:00 Discussion
20:45:00 Mechanisms of innate defence regulator peptides a new anti-infective strategy Robert Hancock
21:15:00 Discussion
21:30:00 Welcome Get-Together
Monday, May 16, 2011
07:30:00 Breakfast
08:55:00 Antimicrobial Peptides | Diversity and Phylogenetics Katrin Pütsep, Chuck Bevins
09:00:00 How bugs make lassos | Lessons from the bacterial AMP capistruin Mohamed A Marahiel
09:20:00 Discussion
09:35:00 Caenopores | C. elegans AMPs instrumental in nutrition and immunity Matthias Leippe
09:55:00 Discussion
10:10:00 Defensins in HIV transmission | friends or foes? Theresa L Chang
10:30:00 Discussion
10:45:00 Coffee Break | Group Photo
11:25:00 RNase A superfamily members involved in innate host defense Ester Boix
11:45:00 Discussion
12:00:00 TBA | Selected Poster Presentations
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
17:30:00 Other Functions of AMPs and Non-AMPs with Antimicrobial Activity Julia Dorin, Andy Ouellette
17:35:00 Pollen tube attractanting defensin-like polypeptides Tetsuya Higashiyama
17:50:00 Discussion
18:05:00 LL-37 monocyte interaction in vascular disease Oliver Soehnlein
18:25:00 Discussion
18:40:00 The multiple faces of proteins of the coagulation system Artur Schmidtchen
19:00:00 Discussion
19:10:00 TBA | Selected Poster Presentations
20:00:00 Dinner
Tuesday, May 17, 2011
07:30:00 Breakfast
09:00:00 Regulation of AMP Synthesis Gudmundur H. Gudmundsson, Ylva Engström
09:05:00 FOXO-dependent regulation of innate immune homeostasis Michael Hoch
09:20:00 Discussion
09:35:00 Metal withholding responses in the inflamed gut Manuela Raffatellu
09:55:00 Discussion
10:10:00 Coffee Break
10:30:00 Induction of cathelicidin in fighting enteric infections Rubhana Raqib
10:50:00 Discussion
11:05:00 Regulation of antimicrobial peptide expression in C. elegans epidermis Jonathan Ewbank
11:25:00 Discussion
11:40:00 TBA | Selected Poster Presentations
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
17:30:00 Microbial Responses and Resistance to AMPs Hans-Georg Sahl, William M. Shafer
17:35:00 Molecular basis of MprF-mediated bacterial AMP resistance Christoph Ernst
17:50:00 Discussion
18:05:00 Bacterial resistance to microcin C Konstantin Severinov
18:25:00 Discussion
18:35:00 Eukaryotic AMPs as Specific Bacterial Cell Wall Inhibitors Tanja Schneider
18:55:00 Discussion
19:10:00 TBA | Selected Poster Presentations
20:00:00 Dinner
Wednesday, May 18, 2011
07:30:00 Breakfast
09:00:00 Structural and Functional Parameters of AMP Action Gill Diamond, Margitta Dathe
09:05:00 Structure of Human Cathelicidin LL-37 and Functional Role of Its Cationic Side Chains Guangshun Wang
09:20:00 Discussion
09:35:00 Effect of the hydrophobicity to net positive charge ratio on antibacterial and anti-endotoxin activities of structurally similar antimicrobial peptides Yechiel Shai
09:55:00 Discussion
10:10:00 Two-Peptide (Class-IIb) Bacteriocins Jon Nissen-Meyer
10:30:00 Discussion
10:45:00 Coffee Break
11:20:00 Dynamic transitions of membrane-active peptides Anne Ulrich
11:40:00 Discussion
11:55:00 Structural basis of the α-defensin functional versatility Wuyuan Lu
12:15:00 Discussion
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
17:30:00 AMPs in Host-Microbe and Microbe-Microbe Interactions Pieter Hiemstra
17:35:00 Antimicrobial peptides control nitrogen-fixing endosymbiotic bacteria in legume plants Peter Mergaert
17:50:00 Discussion
18:05:00 Defensins as essential regulators of intestinal microbial ecology Nita Salzman
18:25:00 Discussion
18:40:00 Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization Tadayuki Iwase
19:00:00 Discussion
19:10:00 TBA | Selected Poster Presentations
19:30:00 Business Meeting
20:00:00 Dinner
Thursday, May 19, 2011
07:30:00 Breakfast
09:00:00 AMPs in Health Disease and Beyond Paul B. McCray, Robert Bals
09:05:00 Neutrophil Extracellular Traps | a new strategy for using old weapons Arturo Zychlinski
09:20:00 Discussion
09:35:00 Extracellular histones as mediators of death in sepsis Charles T Esmon
09:55:00 Discussion
10:10:00 Coffee Break
10:40:00 Generation of Neoantimicrobial Peptides in Autophagic Organelles Vojo Deretic
11:00:00 Discussion
11:15:00 Role of AMPs in Crohn's disease Jan Wehkamp
11:35:00 Discussion
11:50:00 A mouse model of vitamin D deficiency increases susceptibility to invasive skin infections Beda Muehleisen
12:10:00 Discussion
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
17:30:00 AMPs | From Bench to Application Mona Ståhle
17:35:00 Design of Improved Pharmabiotics Paul Cotter
17:50:00 Discussion
18:00:00 Cystine-stabilized AMPs | from Discovery to Preclinic Hans-Henrik Kristensen
18:20:00 Discussion
18:30:00 Transgenic Potatoes as Bioreactors for AMPs Michael Kleine
18:50:00 Discussion
19:00:00 Hot Corner (News from the Lab - Controversial issues - New Methods) Michael Zasloff
20:00:00 Dinner
Friday, May 20, 2011
07:30:00 Breakfast
09:00:00 Departure
4th Annual Pharma R&D Asia Congress
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