Biotech China 2014
Nature Chemical Biology Symposium 2011: Cancer Chemical Biology
Royal Sonesta Hotel Boston
40 Edwin Land Blvd Cambridge, MA 02142 USA
Cambridge, Massachusetts
2011 celebrates the tenth anniversary of the approval of Imatinib. The drug is one of the first major success stories for rational drug design, and serves to highlight the contributions of chemical biology to cancer therapeutics and in understanding biological processes. The 2011 symposium will explore the chemical biology of cancer in terms of therapeutic opportunities and a comprehensive view of cancer biology. The three-day meeting will comprise a series of six scientific sessions that highlight

# The pathways that contribute to cancer and its treatment including cell death, epigenetic regulation, and metabolism.
# The chemical biology approaches of imaging and chemical genetics

Schedule of Presentations:

Thursday, October 20, 2011
12:30:00 Registration
14:00:00 Welcome and Opening Remarks Kimberly Stegmaier, Gregory L Verdine
14:10:00 Session 1 | Alternative Strategies and Therapeutics
14:15:00 Introduction
14:20:00 Micro and nano based drug delivery systems Robert Langer
15:00:00 Engineered protein therapeutics and diagnostic agents inspired by natureCochran Jennifer Cochran
15:40:00 Coffee Break
16:10:00 TBA Neal Rosen
16:50:00 Relating genetic features of human cancers to smallmolecule drug efficacies Stuart Schreiber
17:30:00 Poster Session and Welcome Reception
Friday, October 21, 2011
08:30:00 Continental Breakfast
08:55:00 Session 2 | Metabolism
09:00:00 Introduction Matt Vander Heiden
09:10:00 Mapping metabolic pathways in cancer by activity-based proteomics Benjamin F Cravatt
09:50:00 Coffee Break
10:20:00 Targeting IDH mutations in cancer
11:00:00 Targeting metabolic enzymes for cancer therapy Lewis Cantley
11:40:00 Lunch
12:55:00 Session 3 | Cancer Chemical Genetics
13:00:00 Introduction Angela Koehler
13:10:00 Probing cell death with small molecules Brent R Stockwell
13:50:00 Hunting the targets of natural product-inspired compound Herbert Waldmann
14:30:00 A chemical genomic approach to modulating mutant notchi Kimberly Stegmaier
15:10:00 Coffee Break
15:35:00 Session 4 | Cancer Imaging
15:40:00 Introduction Andrew Kung
15:50:00 Bioorthogonal reactions to image cancer targets in vivo Ralph Weissleder
16:30:00 A method for mapping the proteomic composition of spatially-defined compartments of living cells Alice Ting
17:10:00 In vivo imaging of tumor-associated proteases for early MRI detection and fluorescence-guided resection Roger Tsien
17:50:00 Poster Session and Reception
Saturday, October 22, 2011
08:30:00 Continental Breakfast
08:55:00 Session 5 | Epigentics
09:00:00 Introduction Ralph Mazitschek
09:10:00 Targeting histone methyltransferases in cancer therapy Victoria Richon
09:50:00 Coffee Break
10:20:00 Bromodomain inhibition in cancer James E. Bradner
11:00:00 Protein ligation: an enabling technology for studying protein post-translational modifications Tom Muir
11:40:00 Lunch
12:35:00 Session 6 | Cell Death
12:40:00 Introduction
12:50:00 A genome-wide loss-of-function screen reveals an important role for vitamin b6 metabolism in cisplatininduced apoptosis Guido Kroemer
13:30:00 Dissecting and drugging the BCL-2 family interaction network in refractory cancer Loren Walensky
14:10:00 Toward drugging the undruggable James Wells
14:50:00 Closing Remarks Mirella Bucci, Kimberly Stegmaier, Gregory L Verdine
4th Annual Pharma R&D Asia Congress
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