3D Tissue Models
Inflammation and Atherosclerosis
Ludwig Maximilians University (LMU)
Geschwister-Scholl-Platz 1 80539 Munich Germany
Munich, Germany
As a chronic inflammatory disease of the arterial wall, atherosclerosis is a leading cause of death and morbidity worldwide. This conference will highlight molecular mechanisms giving rise to the disturbed equilibrium of vascular homeostasis, lipid accumulation, immune responses and their clearance during atherogenesis. Leading specialists in the field will present recent observations linking genetic variants, lipids and inflammation, as well as providing insights into the role of inflammatory cell subsets, their mediators and signaling mechanisms in atheroprogression. Novel treatment options to interfere with these mechanisms, including peptide- and microRNA-based therapeutics, will be discussed.

Meeting chair: Prof Christian Weber (Ludwig Maximilians University, Munich, Germany)

Schedule of Presentations:

Thursday, September 20, 2012
08:55:00 Registration
09:25:00 Welcome and Introductions
09:30:00 Session 1 | Genes, lipids, and systemic inflammation
09:30:00 New pathways in atherosclerosis identified through human genetics Daniel Rader
10:05:00 Non-coding RNA ANRIL and mechanisms of atherosclerosis at human chromosome 9p21 Lesca Miriam Holdt
10:25:00 Role of ABC transporters in cholesterol efflux and immune responses Alan Tall
11:00:00 Morning Break
11:30:00 The tryptophan metabolite 3-hydroxyanthranilic aid (3-HAA) lowers plasma lipids and decreases atherosclerosis in hypercholesterolemic mice
11:50:00 Oxidation-specific epitopes are major targets of innate immunity in atherosclerosis Christoph Binder
12:25:00 Abcam
12:45:00 Lunch
13:40:00 Session 2 | Early Inflammatory and immune-driven atherogenesis Francois Mach, Alan Tall
13:45:00 Novel molecules in vascular rearrangement Beat Imhof
14:20:00 Ambivalent roles of neutrophil-derived cathelicidin in arterial healing and atherosclerosis Oliver Soehnlein
14:40:00 Arterial intimal dendritic cells and the initiation of atherosclerosis Myron Cybulsky
15:15:00 Afternoon Break
15:45:00 Interference of the CD30-CD30L pathway reduces atherosclerosis development
16:05:00 Defective signal regulatory protein alpha (SIRPa) signaling reduces atherosclerosis in mice
16:25:00 tbc Frederic Geissmann
17:00:00 Drinks Reception & Poster Session
Friday, September 21, 2012
08:55:00 Session 3 | Mechanisms of progression: microRNAs, lipid and immune stress Ebru Erbay
09:00:00 Micro-managing atherosclerosis: miRNAs In lipoprotein and plaque biology
09:35:00 miR-92a is differentially expressed in oxLDL-activated endothelial cells in response to shear stress and modulates atherosclerosis development in mice Xavier Loyer
09:55:00 Immune regulatory pathways in atherosclerosis Ziad Mallat
10:30:00 Morning Break
11:00:00 Targeting lipotoxic endoplasmic reticulum stress in cardiometabolic syndrome Ebru Erbay
11:20:00 Macrophage c-Mac expression level predicts the risk of atherosclerosis and regulates disease progression Oscar Pello
11:40:00 Monocyte subset trafficking controls plaque regression in mice Stephane Potteaux
12:00:00 Foam cell macrophage polarization and MMP expression in the absence of T and B lymphocytes Andrew Newby
12:20:00 Lunch
13:15:00 Session 4 | Novel treatment options Stefanie Dimmeler
13:20:00 Anti-chemokine treatments in atherosclerosis and acute ischemic complications Fabrizio Montecucco
13:50:00 Drug-induced macrophage autophagy in atherosclerosis: for better or worse? Wim Martinet
14:10:00 Inflammasome activation in atherosclerosis Eicke Latz
14:45:00 Afternoon Break
15:15:00 Reversal of murine plaque hypoxia prevents apoptosis and necrotic core expansion Judith Sluimer
15:35:00 Bone marrow endothelial progenitors agument atherosclerotic plaque regression in a mouse model of plasma lipid lowering Jana Barlic-Dicen
15:55:00 miRNAs: biomarkers and mediators of cardiovascular disease Stefanie Dimmeler
16:30:00 Close
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