9th Annual Biomarkers Congress
New Frontiers in Neurodegenerative Disease Research (J8)


Santa Fe, New Mexico
http://www.keystonesymposia.org/index.cfm?e=web.meeting.program&meetingid=1242
Sponsored by Janssen R&D, Pharmaceutical Companies of Johnson & Johnson, Takeda Pharmaceutical Company Limited and Vertex Pharmaceuticals Incorporated. Supported by an educational donation provided by Amgen. 

Schedule of Presentations:

Sunday, February 3, 2013
16:00:00 Arrival and Registration
Monday, February 4, 2013
07:00:00 Breakfast
08:00:00 Welcome and Keynote Address
08:05:00 Modeling Pathology in Simpler Cells Susan L Lindquist
09:00:00 Protein Aggregation and Propagation of Misfolded Proteins in the Brain
09:10:00 Transmission of alpha-Synculein in Parkinson's Disease Virginia Man-Yee Lee
09:20:00 Prion Propagation and its Wider Implications in Neurodegeneration John Collinge
09:25:00 Prion-Like Aspects of Alzheimer Pathology Mathias Jucker
09:30:00 Strategies to Ameliorate Neurodegenerative Diseases by Adapting the Proteostasis Network Jeffery Kelly
09:40:00 Coffee Break
11:45:00 Poster Setup
13:00:00 Poster Viewing
14:00:00 On Own for Lunch and Recreation
16:30:00 Coffee Available
17:00:00 Mechanisms of Early Disease Intervention and Biomarkers Michael L. Hutton
17:10:00 Tau Biomarkers, Transmission and Therapies John Q. Trojanowski
17:20:00 Non-Coding Repeat Expansions in C9ORF72 as a Novel Cause of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis Rosa Rademakers
17:30:00 Short Talk: Ataxin-1 Amyloid Oligomers Form in a Mouse Model of Spinocerebellar Ataxia Type 1 and Correlate with Disease Pathogenesis
17:40:00 Short Talk: pERK-PPARgamma Protein Complexes In AD Cognitive Enhancement Kelly T. Dineley
17:50:00 Short Talk: A Meta-Analysis of Inflammation Gene Sets in Neurodegenerative Disease
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 1
Tuesday, February 5, 2013
07:00:00 Breakfast
07:30:00 Poster Setup
08:00:00 Poster Viewing
08:05:00 Molecular Mechanisms of Neuronal Vulnerability Rosa Rademakers
08:10:00 Mechanisms of Cell Death in Neurodegeneration Valina Dawson
08:20:00 Huntington's Disease Amber Southwell
08:30:00 Short Talk: Restricted Expression of Mutant Huntingtin to Parvalbumin-Positive Cell Populations causes Hyperactivity and Altered Synaptic Function in the Motor Cortex Sarah E. Dougherty
08:40:00 ApoE, Amyloid Deposition and Abeta Clearance
08:50:00 Role of RNA/DNA Binding Protein FUS in Neurodegeneration Eric Huang
09:00:00 Short Talk: Immunophenotyping of Transgenic Mouse Models of CNS Proteinopathies Keith W. Crosby
09:20:00 Coffee Break
11:00:00 Lunch
12:00:00 Poster Session 2
14:30:00 Workshop (Joint): iPSC Technologies and their Application
14:40:00 Introduction Fred H. Gage
14:50:00 Introduction Su-Chun Zhang
15:00:00 Deficits in Human Trisomy 21 iPSCs and Neurons: A Model for Down Syndrome Intellectual Disability Anita Bhattacharyya
15:10:00 Contribution of Human Astrocytes to Rett Syndrome Beatriz Freitas
15:20:00 Reprogramming of Pericyte-Derived Cells of the Adult Human Brain into Induced Neuronal Cells Marisa Karow
15:30:00 High Throughput iPS Characterization
16:30:00 Coffee Available
17:00:00 Novel Approaches for the Therapeutic Intervention of Neurodegenerative Disease R. Steven Paulson
17:10:00 Tau-based Therapeutics for Alzheimer’s Disease and Related Tauopathies Michael L. Hutton
17:20:00 Nurr1 as Target for Neuroprotection and Therapeutic Intervention in Parkinson´s Disease Anders Bjorklund
17:30:00 The Development of Abeta Target Specific Immunotherapies for AD Ronald B DeMattos
17:40:00 Short Talk: Chemical Genetic Screens of TARDBP and FUS Modifiers in C. elegans and Zebrafish Models of ALS Pierre Drapeau
17:50:00 Short Talk: Increased Cholinergic Activity Restores Memory Function in a Mouse Model of AD Rebecca Canter
19:00:00 On Own for Dinner
Wednesday, February 6, 2013
07:00:00 Breakfast
08:00:00 Epigenetics and Genomics (Joint) Bruce A. Yankner
08:10:00 DNA Methylome during Developmental Neurogenesis Yi Eve Sun
08:20:00 Epigenetic Mechanisms in Dementia André Fischer
08:30:00 Functional Genomic Analyses of Pathways Dysregulated in Frontal Temporal Dementia Daniel H. Geschwind
08:40:00 Neuronal Activity-Induced Changes of DNA Methylation Landscape in the Adult Brain Hongjun Song
08:50:00 Short Talk: A Key Role for the Chromatin Remodeler CHD5 for Neuronal Differentiation and Tumor Suppression in the Nervous System Johan Holmberg
09:00:00 Short Talk: Genome-Wide Analysis of DNA Methylation and Genotype in 750 Individuals Reveals Global Regulatory Changes in Brain Enhancers Associated with Alzheimer’s Disease Matthew L. Eaton
09:20:00 Coffee Break
11:00:00 Poster Setup
13:00:00 Poster Viewing
14:30:00 On Own for Lunch and Recreation
16:30:00 Coffee Available
17:00:00 Aging and Genome Integrity Lu Gan
17:10:00 Modeling the Role of Genomic Instability in Aging and Alzheimer’s Disease Bruce A. Yankner
17:20:00 DNA Damage Signaling and Neurogenesis Peter J. McKinnon
17:30:00 Genome Integrity, Chromatin Remodeling and Neurodegenerative Disorders Li Huei Tsai
17:40:00 Short Talk: Expanding the Transcriptomes at Unstable Tandem Repeat Loci Paula D. Ladd
17:50:00 Short Talk: Progranulin and Granulin: Reciprocal Modulators of Organismal Stress Response Aimee W. Kao
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 3
Thursday, February 7, 2013
07:00:00 Breakfast
08:00:00 Neurobiology of Disease Valina Dawson
08:10:00 Sleep and Alzheimer’s Disease: Potential Cellular, Molecular, and Network Connections David M Holtzman
08:20:00 Understanding Molecular Mechanisms of Neurodegeneration in Parkinson’s Disease Ted Dawson
08:30:00 Axon Degeneration in Development and Disease Marc Tessier-Lavigne
08:40:00 Pathogenic Events Triggered by Tau Acetylation in Neurodegeneration
08:50:00 Targeting Neurodegeneration by Boosting Antibody Uptake in Brain Ryan J. Watts
09:00:00 Coffee break
14:30:00 On Own for Lunch and Recreation
16:30:00 Coffee Available
17:00:00 iPSC Modeling of Developmental and Degenerative Neurological Diseases (Joint) Hongjun Song, Li Huei Tsai
17:10:00 Understanding Functions of Schizophrenia Susceptibility Genes using Pluripotent Human Stem Cells Guo-li Ming
17:20:00 Discovery of Potential Therapeutic Compounds with Patient-Specific and Symptom-Relevant Neural Crest Derived from Familial Dysautonomia-iPSC Gabsang Lee
17:30:00 Probing Neuroplasticity Pathways in Neuropsychiatric Disorders with Patient Specific Stem Cell Models & Small Molecules
17:40:00 Short Talk: Modeling Tauopathies Using Isogenic Human Induced Pluripotent Stem Cells Helen Fong
17:50:00 Short Talk: Induced Pluripotent Stem Cell Models of Frontotemporal Dementia Sandra Almeida
19:00:00 Social Hour w/ Lite Bites
20:00:00 Entertainment
Friday, February 8, 2013
09:00:00 Departure
4th Annual Pharma R&D Asia Congress
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