9th Annual Biomarkers Congress
14th Annual G Protein-Coupled Receptor (GPCR) Retreat
Wyndham Cleveland at PlayhouseSquare
1260 Euclid Avenue
Cleveland, Ohio
http://case.edu/med/ophthalmology/Seminars/2013GPCR.html
Presented by Case Western Reserve University School of Medicine
Departments of Ophthalmology, Pharmacology, and Proteomics

Schedule of Presentations:

Thursday, October 17, 2013
14:30:00 Registration
16:30:00 Structural insights into G protein coupled receptor signaling Brian Kobilka
18:00:00 Welcome Reception and Poster Session 1 (odd numbered posters)
19:30:00 Dinner
Friday, October 18, 2013
07:30:00 Breakfast
08:00:00 Symposium 1: Hubert Van Tol Symposium on animal models
08:15:00 Genetic approaches to understand oligomerizations of GPCRs Krzysztof Palczewski
08:30:00 Proteinase-stimulated signaling in vitro & in vivo: a GPCR-enzyme Partnership Morely Hollenberg
08:45:00 Protective effect of the RGS2-eIF2B binding domain (RGS2eb) against pathological cardiac hypertrophy K Lee
09:15:00 GRK2 Inhibition in the Failing Heart - Nearing Translation Walter Koch
10:00:00 Coffee Break
10:30:00 Symposium 2: GPCR Signaling in Vision
11:00:00 Targeted design of signaling-biased arrestins Vsevolod V. Gurevich
11:15:00 Molecular chaperones in the biogenesis and quality control of rhodopsin Michael Cheetham
11:30:00 Supramolecular architecture of the rhodopsin-transducin complex
12:00:00 Lunch
13:00:00 Symposium 3: Biophysical Studies of GPCRs
13:30:00 Structure of the agonist-bound neurotensin receptor NTS1 Reinhard Grisshammer
14:00:00 Understanding the role of Ligands on GPCR Activation by NMR Scott Prosser
14:15:00 Cell-autonomous tuning of opioid sensitization by substance P
14:30:00 Probing the receptor-G protein interaction in live cells using dual-color fluorescence correlation spectroscopy (DCFCS) and Forster resonance energy transfer (FRET)
14:45:00 Structure, dynamics, and function of unmodified GPCRs in phosopholipid bilayers under physiological conditions Stanley Opella
15:00:00 Coffee Break
15:15:00 Symposium 4: Translational GPCR Research
15:30:00 Attacking challenging drug targets: gene transcription downstream of GPCRs Rick Neubig
16:00:00 Early safety assessment: when and how much Derek Leishman
16:30:00 From hit to the Clinic
17:00:00 Panel Discussion-Translating Biology to Therapeutics
18:00:00 Poster Session 2 with Reception Dinner (even numbered posters present)
19:30:00 Dinner
21:00:00 Board Meeting (to discuss next retreat) all PIs welcome
Saturday, October 19, 2013
07:30:00 Breakfast
08:00:00 Symposium 5: Non-Canonical GPCR Signaling
08:30:00 Crosstalk between GPCR and integrins Xiaoping Du
09:00:00 Noncanonical GPCR signaling mechanisms Jean-Pierre Vilardaga
09:15:00 Biased signaling and allosteric moculation of the Angiotensin II type 1 receptor Bruno Clément
09:30:00 Signaling through GPCRs by S-nitrosylation Jonathan Stamler
10:00:00 Coffee Break
10:30:00 Symposium 6: GPCR Action Inside the Cell
11:00:00 Ubiquitin and Intracellular Signaling by GPCRs JoAnn Trejo
11:15:00 Intracrine GPCR signalling in the adult cardiomyocyte
11:30:00 Functional cooperativity from an interaction between a GPCR and the intracellular synthase of its agonist Jean Luc Parent
11:45:00 Movement of Gs between plasma membrane receptors and intracellular compartments Nevin Lambert
12:00:00 Poster Awards and Closing Remarks - Marvin Nieman (Organizing Committee)
12:15:00 Lunch and Depart
4th Annual Pharma R&D Asia Congress
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