Biotech China 2014
14th Annual G Protein-Coupled Receptor (GPCR) Retreat
Wyndham Cleveland at PlayhouseSquare
1260 Euclid Avenue
Cleveland, Ohio
Presented by Case Western Reserve University School of Medicine
Departments of Ophthalmology, Pharmacology, and Proteomics

Schedule of Presentations:

Thursday, October 17, 2013
14:30:00 Registration
16:30:00 Structural insights into G protein coupled receptor signaling Brian Kobilka
18:00:00 Welcome Reception and Poster Session 1 (odd numbered posters)
19:30:00 Dinner
Friday, October 18, 2013
07:30:00 Breakfast
08:00:00 Symposium 1: Hubert Van Tol Symposium on animal models
08:15:00 Genetic approaches to understand oligomerizations of GPCRs Krzysztof Palczewski
08:30:00 Proteinase-stimulated signaling in vitro & in vivo: a GPCR-enzyme Partnership Morely Hollenberg
08:45:00 Protective effect of the RGS2-eIF2B binding domain (RGS2eb) against pathological cardiac hypertrophy K Lee
09:15:00 GRK2 Inhibition in the Failing Heart - Nearing Translation Walter Koch
10:00:00 Coffee Break
10:30:00 Symposium 2: GPCR Signaling in Vision
11:00:00 Targeted design of signaling-biased arrestins Vsevolod V. Gurevich
11:15:00 Molecular chaperones in the biogenesis and quality control of rhodopsin Michael Cheetham
11:30:00 Supramolecular architecture of the rhodopsin-transducin complex
12:00:00 Lunch
13:00:00 Symposium 3: Biophysical Studies of GPCRs
13:30:00 Structure of the agonist-bound neurotensin receptor NTS1 Reinhard Grisshammer
14:00:00 Understanding the role of Ligands on GPCR Activation by NMR Scott Prosser
14:15:00 Cell-autonomous tuning of opioid sensitization by substance P
14:30:00 Probing the receptor-G protein interaction in live cells using dual-color fluorescence correlation spectroscopy (DCFCS) and Forster resonance energy transfer (FRET)
14:45:00 Structure, dynamics, and function of unmodified GPCRs in phosopholipid bilayers under physiological conditions Stanley Opella
15:00:00 Coffee Break
15:15:00 Symposium 4: Translational GPCR Research
15:30:00 Attacking challenging drug targets: gene transcription downstream of GPCRs Rick Neubig
16:00:00 Early safety assessment: when and how much Derek Leishman
16:30:00 From hit to the Clinic
17:00:00 Panel Discussion-Translating Biology to Therapeutics
18:00:00 Poster Session 2 with Reception Dinner (even numbered posters present)
19:30:00 Dinner
21:00:00 Board Meeting (to discuss next retreat) all PIs welcome
Saturday, October 19, 2013
07:30:00 Breakfast
08:00:00 Symposium 5: Non-Canonical GPCR Signaling
08:30:00 Crosstalk between GPCR and integrins Xiaoping Du
09:00:00 Noncanonical GPCR signaling mechanisms Jean-Pierre Vilardaga
09:15:00 Biased signaling and allosteric moculation of the Angiotensin II type 1 receptor Bruno Clément
09:30:00 Signaling through GPCRs by S-nitrosylation Jonathan Stamler
10:00:00 Coffee Break
10:30:00 Symposium 6: GPCR Action Inside the Cell
11:00:00 Ubiquitin and Intracellular Signaling by GPCRs JoAnn Trejo
11:15:00 Intracrine GPCR signalling in the adult cardiomyocyte
11:30:00 Functional cooperativity from an interaction between a GPCR and the intracellular synthase of its agonist Jean Luc Parent
11:45:00 Movement of Gs between plasma membrane receptors and intracellular compartments Nevin Lambert
12:00:00 Poster Awards and Closing Remarks - Marvin Nieman (Organizing Committee)
12:15:00 Lunch and Depart
Biotech China 2014
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