Biotech China 2014
Nature - CNIO Cancer Symposium: Frontiers in Tumour Heterogeneity and Plasticity
Auditorium Mutua Madrileña Foundation
Paseo de la Castellana 33 28046
Madrid, Spain
The Nature - CNIO Cancer Symposium on Frontiers in Tumour Heterogeneity and Plasticity will coincide with the 10th anniversary of the inauguration of the CNIO. Tumour heterogeneity and plasticity have substantial implications for basic and clinical cancer research. To cover some of the most relevant and recent advances in this area, we have invited world leading experts to speak about: the cancer cell of origin, the clonal evolution of cancer, microenvironment and heterogeneity, tumour cell plasticity and tumour heterogeneity in the clinic. The program is aimed at setting the scene for the exchange of novel ideas and discussions on emerging molecular mechanisms of tumour heterogeneity and its clinical implications.

Schedule of Presentations:

Sunday, October 27, 2013
20:00:00 Welcome cocktail for speakers & participants
Monday, October 28, 2013
08:00:00 Registration
09:00:00 Opening remarks Maria Blasco
09:05:00 Keynote Lecture Erwin Wagner
09:30:00 Clinical and functional relevance of intratumor heterogeneity in breast cancer Kornelia Polyak
10:30:00 Coffee break
11:10:00 Session 1: The Cancer Cell of Origin Erwin Wagner
11:15:00 Intrinsic and extrinsic mechanisms regulating cutaneous cancer stem cells Cedric Blanpain
11:45:00 Modeling Pathogenesis of Primary Liver Cancer in Lineage Specific Cell Types Snorri S Thorgeirsson
12:15:00 Forward genetic approaches in the mouse to uncover molecular networks of tumourigenesis
12:30:00 Exploring the Hierarchical Organization of Colorectal Cancer Eduard Batlle
13:00:00 Using Neurofibromatosis to model Cancer: therapeutic insights Luis F Parada
13:30:00 Lunch
15:00:00 Session 2: Clonal Evolution of Cancer Barbara Marte
15:05:00 Genomic Examination of Tumour Heterogeneity Elaine Mardis
15:30:00 Short Talk: “Cancer heterogeneity landscapes via high-throughput single cell sequencing”
15:45:00 Targeting essential growth drivers in human cancer Hiroyuki Mano
16:15:00 Coffee break
17:00:00 Selection and adaptation during metastatic cancer progression Christoph A Klein
17:30:00 Short Talk: “Heterogeneity among early-stage K-Ras driven NSCLC lesions predicts tumor aggressiveness and allows the identification of valuable therapeutic targets”
17:45:00 Beug Foundation: Metastasis Research Prize Award
18:00:00 Poster session with wine and cheese
Tuesday, October 29, 2013
09:00:00 Session 3: Microenvironment and Heterogeneity
09:05:00 Origins of triple-negative breast cancer in African American women Victoria Seewaldt
09:30:00 Short Talk: “Intra-tumour Microenvironmental Diversity predicts highgrade breast cancer prognosis”
09:45:00 Intravital microscopy reveals cancer cell heterogeneity in brain tumor progression Frank Winkler
10:15:00 Coffee break
11:00:00 Macrophages in tumor promoting inflammation Alberto Mantovani
11:30:00 Short Talk: “Perivascular macrophages in mammary tumors induce localized and transient blood vessel permeability and tumor cell intravasation”
11:45:00 Improving existing cancer therapy by targeting the tumor microenvironment
12:15:00 Lunch
14:00:00 Session 4: Tumour Cell Plasticity Scott Lowe
14:05:00 EMT reversion for metastatic colonization Angela Nieto
14:30:00 Short Talk: “Serpins shield brain metastatic cells from death signals and vascular detachment” Manuel Valiente-Cortes
14:45:00 Melanoma heterogeneity and metastasis Sean J. Morrison
15:15:00 Coffee break
16:00:00 Exploring tumor heterogeneity using 40 dimensions in single cells Dan Peer
16:30:00 Short Talk: “Elucidating The Role Of Circadian Rhythm Disruption In Transformation and Lung Tumorigenesis”
16:45:00 Intratumour heterogeneity: evolution through space and time Charles Swanton
17:15:00 Short Talk: “Lineage-specific control of melanoma progression and cell plasticity by the RAB7 GTPase” Maria Soengas
17:30:00 Dissecting cancer heterogeneity using mouse models and RNAi Scott Lowe
18:00:00 Poster session with wine and cheese
Wednesday, October 30, 2013
08:50:00 Fundación Banc Sabadell Keynote Session
08:55:00 Keynote Lecture Scott Lowe
09:00:00 Targeting tumor heterogeneity and plasticity:a view from the clinical side José Baselga
10:00:00 Session 5: Tumour Heterogeneity in the Clinic
10:05:00 Do Patient-derived Xenograft Models Recapitulate Tumor Heterogeneity?” S. Gail Eckhardt
10:30:00 Short Talk: “EGFR is required in liver macrophages for IL-1-induced IL-6 production and hepatocellular carcinoma formation”
10:45:00 Heterogeneity of Resistance to Kinase Inhibitors Jeffrey A. Engelman
11:15:00 Coffee break
12:00:00 The Development of Predictive Biomarkers in Clinical Trials in the Context of Potential Tumor Heterogeneity Lillian L. Siu
12:30:00 Short Talk: “Mechanistic insights into adaptive chemoresistance driven by dynamic heterogeneity”
12:45:00 Targeting Clonal Heterogeneity and Signaling Networks in Myeloid Malignancies Ross Levine
13:15:00 Closing remarks
Biotech China 2014
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