| Sunday, May 18, 2008 | ||
| 16:00:00 | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) | |
| 18:00:00 | Dinner | |
| 19:30:00 | Welcome / Introductory Comments by GRC Site Staff | |
| 19:50:00 | Perspectives on NMR in Structural and Systems Biology | |
| 19:50:00 | Seeing the Invisible with NMR Spectroscopy | Lewis Kay |
| 20:30:00 | Discussion | |
| 20:40:00 | Structure and Pathway Information Recovery from Biological NMR Spectroscopic Data | Jeremy Nicholson |
| 21:20:00 | Discussion | |
| Monday, May 19, 2008 | ||
| 07:30:00 | Breakfast | |
| 09:00:00 | New Approaches in Rapid Multi-Dimensional NMR: Acquisition, Processing, Automation | Christina Redfield |
| 09:00:00 | Advances in GFT Projection NMR Spectroscopy | Thomas Szyperski |
| 09:25:00 | Discussion | |
| 09:35:00 | Optimal Strategies for Sparse Sampling | Jeffrey Hoch |
| 10:00:00 | Discussion | |
| 10:10:00 | Multi-Way Decomposition for Complete Assignment and Structure of Proteins | Martin Billeter |
| 10:35:00 | Discussion | |
| 10:45:00 | Coffee Break / Group Photo | |
| 11:15:00 | Tools for Fast Data Acquisition and Analysis in Protein NMR Spectroscopy | Bernhard Brutscher |
| 11:40:00 | Discussion | |
| 11:50:00 | Hyper-Dimensional Real-Time NMR spectroscopy in Structural Genomics | Victor Jaravine |
| 12:05:00 | Discussion | |
| 12:10:00 | TBA | |
| 12:25:00 | Discussion | |
| 12:30:00 | Lunch | |
| 13:30:00 | Free Time / Excursion | |
| 16:00:00 | Poster Session | |
| 17:30:00 | Characterization of the intrinsically disordered protein ensembles and their interactions in biological regulation | Julie Forman-Kay |
| 17:30:00 | NMR of Partially Folded, Unfolded and Misfolded proteins | Stephan Grzesiek |
| 17:55:00 | Discussion | |
| 18:05:00 | NMR Characterization of Conformational Disorder in Unfolded and Partially Folded Proteins | Martin Blackledge |
| 18:30:00 | Discussion | |
| 18:40:00 | Mapping protein folding landscapes by NMR: New insights into folding intermediates | Peter Wright |
| 19:05:00 | Discussion | |
| 19:15:00 | TBA | |
| 20:00:00 | Dinner | |
| Tuesday, May 20, 2008 | ||
| 07:30:00 | Breakfast | |
| 09:00:00 | Automated metabolite identification and quantification by NMR | David Wishart |
| 09:00:00 | NMR Opportunities in Metabolomics/Metabonomics | Jeremy Nicholson |
| 09:25:00 | Discussion | |
| 09:35:00 | The life of a Worm: Sex, Food, and Starvation - The Role of Small Molecules in the Ecology of C. elegans | Art Edison |
| 10:00:00 | Discussion | |
| 10:10:00 | Application of NMR Spectroscopy Based Metabolomics to Understanding the Regulation of Systemic Metabolism | Jules Griffin |
| 10:35:00 | Discussion | |
| 10:45:00 | Coffee Break | |
| 11:15:00 | Metabolic Changes Due to Expression of Oncogenes | Gerhard Wagner |
| 11:40:00 | Discussion | |
| 11:50:00 | TBA | |
| 12:10:00 | TBA | |
| 12:30:00 | Lunch | |
| 13:30:00 | Free Time / Excursion | |
| 16:00:00 | Poster Session | |
| 17:30:00 | Exploring the Potential of Ultra-Fast/Ultra-High Sensitivity NMR | Thomas Szyperski |
| 17:30:00 | Some Unusual Experiments At the Interface of NMR, EPR and MRI | Lucio Frydman |
| 17:55:00 | Discussion | |
| 18:05:00 | New Methods for DNP-NMR in Biological Applications | Ulrich Guenther |
| 18:30:00 | Discussion | |
| 18:40:00 | Towards a Shuttle DNP Spectrometer | Christian Griesinger |
| 18:55:00 | Discussion | |
| 19:00:00 | TBA | |
| 19:15:00 | Discussion | |
| 20:00:00 | Dinner | |
| Wednesday, May 21, 2008 | ||
| 07:30:00 | Breakfast | |
| 09:00:00 | Challenges and Successes in the Comparison of Atomic-level Simulations to Experimental Data | Carlos Simmerling |
| 09:00:00 | Quantitative Computational Approaches to the Prediction of Protein Structure and Dynamics | Martin Billeter |
| 09:25:00 | Discussion | |
| 09:35:00 | Protein dynamics: Experiment and theory on fast and slow timescales | Art Palmer |
| 10:00:00 | Discussion | |
| 10:10:00 | Dynameomics | Valerie Daggett |
| 10:35:00 | Discussion | |
| 10:45:00 | Coffee Break | |
| 11:15:00 | Dynamic Control of Ligand Binding Modes of the p53-Binding Cleft in MDM2 | Scott Showalter |
| 11:30:00 | Discussion | |
| 11:35:00 | Using an ensemble approach in the refinement of an NMR derived structure. Comparison with the x-ray structure and molecular dynamics calculations | Matthias Buck |
| 11:50:00 | Discussion | |
| 11:55:00 | TBA | |
| 12:10:00 | Discussion | |
| 12:30:00 | Lunch | |
| 13:30:00 | Free Time / Excursion | |
| 16:00:00 | Poster Session | |
| 17:30:00 | Can Magic-Angle Spinning NMR Protein Structures Exceed the Quality of Crystallography and Solution NMR? | Chad Rienstra |
| 17:30:00 | Protein Structure and Dynamics by Solid State NMR | Josh Wand |
| 17:55:00 | Discussion | |
| 18:05:00 | Characterization of Dynamics in Rotating Solids Using Perdeuterated Proteins | Bernd Reif |
| 18:30:00 | Discussion | |
| 18:40:00 | TBA | |
| 18:55:00 | Discussion | |
| 19:00:00 | Hybrid Solution and Solid-State NMR Approach to Determine the High-Resolution Structure and Topology of Membrane Proteins | Gianluigi Veglia |
| 19:15:00 | Discussion | |
| 19:30:00 | Business Meeting | |
| 20:00:00 | Dinner | |
| Thursday, May 22, 2008 | ||
| 07:30:00 | Breakfast | |
| 09:00:00 | Unique NMR Insights on Biomolecular Dynamics in Solution | James Prestegard |
| 09:00:00 | Chemical Shifts, Dipolar Couplings, and What to Do With It All | Ad Bax |
| 09:25:00 | Discussion | |
| 09:35:00 | Nanosecond to Microsecond Protein Dynamics Probed by Magnetic Relaxation Dispersion of Buried Water Molecules | Bertil Halle |
| 10:00:00 | Discussion | |
| 10:10:00 | Towards a Quantitative Dynamical Proxy for Protein Conformational Entropy | Josh Wand |
| 10:35:00 | Discussion | |
| 10:45:00 | Coffee Break | |
| 11:15:00 | Pathways of conformational transitions elucidated by pressure NMR and MD | Dorothee Kern |
| 11:40:00 | Discussion | |
| 11:50:00 | Visualizing Motions in RNA by NMR | Hashim M Al-Hashimi |
| 12:15:00 | Discussion | |
| 12:30:00 | Lunch | |
| 13:30:00 | Free Time | |
| 16:00:00 | Poster Session | |
| 17:30:00 | NMR Studies of the Bacterial Disulfide Oxidoreductase, DsbD | Christina Redfield |
| 17:30:00 | Biomolecular Complexes and Interactions | Peter Wright |
| 17:55:00 | Discussion | |
| 18:05:00 | Inter-domain and inter-molecular structural relationships probed by paramagnetic metal ions in solution and in the solid state | Claudio Luchinat |
| 18:30:00 | Discussion | |
| 18:40:00 | Structural basis for the function of yeast Oligosaccharyltransferase subunits: Ost4p and Stt3p | Smita Mohanty |
| 18:55:00 | Discussion | |
| 19:00:00 | Structures of Proteins and Protein-Carbohydrate Complexes from Sparse Labeling and Paramagnetic Constrains | James Prestegard |
| 19:25:00 | Discussion | |
| 20:00:00 | Dinner | |
| Friday, May 23, 2008 | ||
| 07:30:00 | Breakfast | |
| 09:00:00 | Depart | |
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