Biotech China 2014
Gordon Research Conference: Isotopes in Biological & Chemical Sciences
Hotel Galvez

Galveston, TX
http://www.grc.org/programs.aspx?year=2014&program=isotopes
At the 2014 meeting, the "Isotopes" GRC will celebrate its 60th anniversary. Over the past 60 years this conference has emphasized the use of isotopes in the study of inorganic, organic, environmental, biogeochemistry, and biochemical reaction mechanisms and other processes. In more recent years the conference has come to recognize the importance of isotopes in the biomedical sciences. This includes applications of isotopes in medicine, in the determination of protein structure and dynamics, and the use of isotopic probes in studies on enzymatic reaction mechanisms.

Schedule of Presentations:

Sunday, February 2, 2014
16:00:00 Arrival and Check-in
18:00:00 Dinner
19:30:00 Welcome / Introductory Comments by GRC Site Staff
19:40:00 Physical Aspects of Isotope Effects (session in honor of Richard (Dick) Schowen)
19:45:00 Presentation of Prof. Schowen and his contributions Daniel Quinn
20:10:00 The utility of NMR spectroscopy for the measurement of multiple kinetic isotope effects on enzymatic reactions Andy Bennett
20:40:00 Discussion
20:50:00 Isotope-effect calculations in the supramolecular age Ian Williams
21:20:00 Discussion
Monday, February 3, 2014
07:30:00 Breakfast
08:30:00 Group Photo
09:00:00 From Methods Development to Medicine (session in memory of W.W. (Mo) Cleland)
09:05:00 Mo' Cleland - Theory and Application of Isotope Effects to Enzyme Reactions Paul Cook
09:30:00 Solvent Isotope-induced Equilibrium Perturbation by Isocitrate Lyase John Blanchard
10:00:00 Discussion
10:10:00 Coffee Break
10:40:00 There, and Back Again: Closing the Loop in Protein-Tyrosine Phosphatases Alvan Hengge
11:10:00 Discussion
11:20:00 Unmasking the Last Mysteries of Pyruvate Carboxylase Catalysis Tonya Zeczycki
11:50:00 Discussion
12:00:00 TBA (Contributed Talk)
12:20:00 Discussion
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
18:00:00 Dinner
19:30:00 Analytical and Mechanistic Studies of Isotope Effects
19:35:00 Progress and promise toward automated intramolecular high precision IRMS Tom Brenna
20:00:00 Discussion
20:10:00 New approaches for measurement of kinetic isotope effects and their application to enzyme mechanisms Andrew Murkin
20:40:00 Discussion
20:50:00 TBA (Contributed Talk)
21:05:00 Discussion
21:10:00 TBA (Contributed Talk)
21:25:00 Discussion
Tuesday, February 4, 2014
07:30:00 Breakfast
09:00:00 Isotope Effects in Organic Reactions Matt Meyer
09:05:00 Exploiting the mechanism of C-H bond amination of aryl azides to trigger [1,2] migrations Tom Driver
09:25:00 Discussion
09:35:00 TBA (Contributed Talk)
09:50:00 Discussion
09:55:00 TBA (Contributed Talk)
10:10:00 Discussion
10:15:00 Coffee Break
10:50:00 Grasping Hydroacylation via Isotope Handles Vy Dong
11:15:00 Discussion
11:25:00 On the Role of Entropy and Enthalpy in Conformational Isotope Effects Dan O'Leary
11:50:00 Discussion
12:00:00 Reactivity, Selectivity, and Kinetic Isotope Effects in Quenching of a Naked Aryl Anion Charles Perrin
12:25:00 Discussion
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
18:00:00 Dinner
19:30:00 Enigmatic Observations with Isotope Effects
19:30:00 Non-enzymatic oxidation of deuterated polyunsaturated fatty acids Mikhail Shchepinov
20:00:00 Discussion
20:10:00 Smelling Vibrations Efthimios Skoulakis
20:40:00 Discussion
20:50:00 TBA (Contributed Talk)
21:05:00 Discussion
21:10:00 TBA (Contributed Talk)
21:25:00 Discussion
Wednesday, February 5, 2014
07:30:00 Breakfast
09:00:00 Isotopes in Environmental Studies
09:05:00 Insights into Enzymatic Transformation of Organic Contaminants using CSIA Barbara Sherwood Lollar
09:30:00 Discussion
09:40:00 TBA (Contributed Talk)
09:55:00 Discussion
10:00:00 Coffee Break
10:30:00 Kinetic isotope effects of nitroarene oxidation and reduction: New proxies for assessing the biodegradation of nitroaromatic explosives Thomas Hofstetter
11:00:00 Discussion
11:10:00 The odds and evens of mercury isotopes: mechanisms of mass independent fractionation and implications for understanding Hg biogeochemistry Bridget Bergquist
11:40:00 Discussion
11:50:00 Model-based Interpretation of Isotope Data for Quantification of Pollutant Transformation in the Environment Boris van Breukelen
12:20:00 Discussion
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
18:00:00 Dinner
19:00:00 Business Meeting
19:30:00 Theory and Calculations of Isotope Effects Steve Schwartz
19:35:00 Good and bad transition states and misbehaving kinetic isotope effects Dan Major
20:00:00 Discussion
20:10:00 Calculations of kinetic isotope effects as a tool to probe phosphoryl transfer reactions catalyzed by enzymes and ribozymes Darrin York
20:40:00 Discussion
20:50:00 TBA (Contributed Talk)
21:05:00 Discussion
21:10:00 TBA (Contributed Talk)
21:25:00 Discussion
Thursday, February 6, 2014
07:30:00 Breakfast
08:30:00 Business Meeting
09:00:00 Heavy Enzymes
09:05:00 Enzymatic transition states, lifetimes, protein motion and heavy enzymes Vern Schramm
09:30:00 Discussion
09:40:00 TBA (Contributed Talk)
09:55:00 Discussion
10:00:00 Coffee Break
10:30:00 Isotope probes of tunneling and dynamics at ensemble, single molecule and ultrafast levels Nigel Scrutton
11:00:00 Discussion
11:10:00 Heavy Enzyme Kinetic Isotope Effects on Proton Transfer in Alanine Racemase Michael Toney
11:40:00 Discussion
11:50:00 TBA (Contributed Talk)
12:05:00 Discussion
12:10:00 TBA (Contributed Talk)
12:25:00 Discussion
12:30:00 Lunch
13:30:00 Free Time
16:00:00 Poster Session
18:00:00 Dinner
19:30:00 Frontiers in Enzyme Mechanisms
19:35:00 Shifting Sands in Our Understanding Of Enzymatic Methyl Transfer Judith Klinman
20:00:00 Discussion
20:10:00 Mechanistic investigation of a potential Diels-Alderase: alpha-Secondary deuterium isotope effects on an enzyme catalyzed [4+2]-cycloaddition Mark Ruszczycky, Hung-wen Ben Liu
20:50:00 Discussion
21:00:00 Concluding Remarks
Friday, February 7, 2014
07:30:00 Breakfast
09:00:00 Departure
4th Annual Pharma R&D Asia Congress
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