Health China
The Endoplasmic Reticulum (ER) as a hub for Organelle Communication

Girona, Spain
The Endoplasmic Reticulum (ER) as a hub for Organelle Communication

Schedule of Presentations:

Sunday, October 26, 2014
06:00:00 New Presentation
15:00:00 Registration
18:30:00 Welcome Notes Keynote Lecture: Tom Rapoport
19:30:00 Welcome Dinner
21:30:00 Scientific mixer for non-speakers with refreshments
Monday, October 27, 2014
09:00:00 Activation of Atg1 kinase by receptor-bound targets initiates selective autophagy
09:25:00 Targeting of proteins from the ER to the INM ulrike Kutay
09:30:00 Session 1: Autophagy and Membrane Targeting Tom Rapoport
09:50:00 Parallels between ER-Golgi traffic and autophagy Ferro Novick
10:15:00 An ER-resident SNARE protein is relocated to autophagosomal structures for membrane fusion events during autophagosome biogenesis
10:30:00 Coffee break
11:15:00 Session 2: Translocation and Membrane Targeting II Blanche Schwappach
11:15:00 Principles of organellar targeting revealed by proximity-specific ribosome profiling
11:40:00 SRP-independent targeting to the endoplasmic reticulum revisited
13:00:00 Lunch
14:30:00 How mRNAs are localized to the Endoplasmic Reticulum.
15:00:00 Poster Session (Posters A-L) Randy Schekman
17:30:00 Session 3: Quality Control/ER Associated Degradation I
17:30:00 Keeping the ER membrane clean: Lipid acetylation and export
17:55:00 At the intersection of ER protein quality control and lipid droplets
18:10:00 Defining the N-glycan signal for ERAD of misfolded glycoproteins in plants
18:35:00 Novel quality control vesicles compartmentalize timing for ERAD of unfolded glycoproteins
19:00:00 Dinner
20:30:00 Poster Session (Posters A-L)
Tuesday, October 28, 2014
08:30:00 Poster Session (Posters M-Z)
09:00:00 Session 4: Folding and post-translational modifications Blanche Schwappach
09:00:00 Post-translational formylglycine generation - a unique and essential redox catalysis in the ER
09:25:00 Cooperation between the STT3A and STT3B complexes to maximize asparagine-linked glycosylation efficiency
09:50:00 Oxidative folding of cone snail toxins by specialized venom gland protein disulfide isomerases
10:15:00 Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u
10:30:00 Coffee break
11:15:00 A novel ERAD branch mediates quality control of inner nuclear membrane proteins Pedro Carvalho
11:15:00 Session 5:ER Associated Degradation II Tom Rapoport
11:40:00 Proteasome 19S RP binding to the Sec61 channel plays a key role in ERAD
12:05:00 Malostery and Mislocation: lessons from regulated ERAD Randy Hampton
12:30:00 A haploid genetic screen identifies TMEM129 as a novel Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I
12:45:00 Lunch
13:00:00 Tour to Dali museum, with packed lunch
14:00:00 Girona City Tour/ Golf activity
17:00:00 Dinner
18:00:00 COPII and the capture of cargo for secretion and membrane for autophagy Randy Schekman
Wednesday, October 29, 2014
06:00:00 New Presentation
09:00:00 Mechanism of sorting and export of bulky procollagen VII from the endosplasmic reticulum
09:00:00 Session 6: Trafficking Randy Schekman
09:25:00 Membrane anchorage of the COPII coat
09:50:00 Physiological insights into ER retrieval Blanche Schwappach
10:15:00 Cargo segregation, membrane rigidity and coat selectivity influence COPII vesicle formation
10:30:00 Coffee break
11:15:00 Session 7: Ion Homeostasis Blanche Schwappach
11:15:00 Intracellular membrane signaling hubs coordinating calcium release hotspots in atria
11:40:00 On protein transport into and calcium leakage from the human ER
12:05:00 pH-dependent protein quality control by ERp44 Roberto Sitia
12:30:00 Membrane homeostasis and quality control in the ER
13:00:00 Lunch
15:00:00 Poster Session (Posters M-Z)
17:30:00 Session 8: Lipid Biosynthesis
17:55:00 Keeping membrane lipids in balance: deciphering the metabolic flux of fatty acids Sepp DKohlwein Kohlwein
18:20:00 Puddle jumping - sterol transport at ER-PM contact sites?
18:45:00 Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer
19:00:00 Dinner
20:00:00 Free Time – buses to Girona City Centre will depart from the hotel lobby
Thursday, October 30, 2014
09:00:00 Is protein misfolding in the ER oncogenic Randal J. Kaufman
09:00:00 Session 9: ER structure and contact sites Other Stress Pathways
09:25:00 Protein folding homeostasis in the Endoplasmic Reticulum David Maron
09:50:00 Chemically induced oligomerisation prevents activation of ATF6 and sensitizes cells to ER stress
10:15:00 Ire1 and Perk coordinately regulate mRNA decay during the Unfolded Protein Response
10:30:00 Coffee break
11:15:00 Session 10: ER Structure and Contact Sites I Tom Rapoport
11:15:00 Molecular basis of mitochondrial behavior Jodi Nunnari
11:40:00 ER membrane fusion by the GTPase atlastin James McNew
12:20:00 Spatial organisation of early secretory pathway in mammalian cells David Stephens
12:45:00 Polarization of the endoplasmic reticulum in yeast is mediated by ER-septin tethering
13:00:00 Lunch
15:00:00 Session 11: ER Structure and Contact Sites II Randy Schekman
15:00:00 Role of the Erv41-Erv46 complex as a retrograde receptor to retrieve escaped endoplasmic reticulum proteins Charles Barlowe
15:25:00 Roles for actin and myosin in ER-mediated mitochondrial fission Henry N .Higgs
15:50:00 Lipid droplet biogenesis in the ER
16:15:00 ER contact sites define the position and timing of endosome fission
16:30:00 Elections for organizers of a new EMBO ER conference series (if funded)
17:00:00 Panel discussion for students – How to pick a good post-doc lab? Maya Schuldiner, Blanche Schwappach, Lars Ellgaard, Tom Rapoport & Ciara Gallagher
20:00:00 Farewell banquet dinner Siloc Restaurant
Friday, October 31, 2014
06:00:00 Breakfast and departure
Biotech China 2014
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