3D Tissue Models
3rd DNA Replication/Repair Structures and Cancer Conference
Fiesta Americana Condesa
Blvd.Kukulkán km 16.5 Zona Hotelera
Cancun, Mexico
https://www.fusion-conferences.com/conference71.php
3rd DNA Replication/Repair Structures and Cancer Conference
Fusion Conferences Ltd
https://www.fusion-conferences.com/conference71.php
Fiesta Americana Condesa
Blvd.Kukulkán km 16.5 Zona Hotelera
Cancun
Mexico

Schedule of Presentations:

Sunday, February 11, 2018
09:00:00 Group Trip: Tulum (signups required in advance)
15:00:00 Registration & Welcome Reception
16:00:00 Welcome and Opening Remarks by John Tainer & Tom Blundell
16:10:00 STRUCTURAL FEATURES OF HIGH FIDELITY DNA REPLICATION
16:35:00 REPLICATION FORK REVERSAL DURING DNA INTERSTRAND CROSSLINK REPAIR REQUIRES CMG HELICASE UNLOADING
16:50:00 REPLICATION STRESS SHAPES A PROTECTIVE CHROMATIN ENVIRONMENT ACROSS FRAGILE GENOMIC REGIONS
17:05:00 SINGLE MOLECULE VIEW OF THE STRUCTURE SPECIFIC 5' NUCLEASES Samir Hamdan
17:30:00 ENFORCEMENT OF DNA LIGATION FIDELITY Scott Williams
17:55:00 Meet the Poster Presenters I Moderators: Susan Tsutakawa and Chris Brosey
18:20:00 Refreshments
18:50:00 Meet the Poster Presenters II Susan Tsutakawa
19:10:00 ELABORATED ACTION OF THE HUMAN PRIMOSOME Tahir Tahirov
19:25:00 UNDERSTANDING HOW DNA PRIMASE WORKS REQUIRES KNOWLEDGE OF ITS ARCHITECTURAL DYNAMICS Walter Chazin
19:50:00 THE ORIGIN RECOGNITION COMPLEX AND CHROMOSOME DUPLICATION: STRUCTURE, FUNCTION AND HUMAN GENETICS Bruce Stillman
20:20:00 Dinner at Leisure
Monday, February 12, 2018
07:00:00 Breakfast
08:00:00 COMPREHENSIVE ANALYSIS OF DNA REPAIR CAPACITY IN NORMAL AND CANCEROUS CELLS Zachary Nagel
08:15:00 Session Introduction by Marco Foiani
08:20:00 MECHANISMS FOR MAINTAINING GENOME STABILITY AT THE REPLICATION FORK Karlene A Cimprich
08:45:00 MECHANISMS OF REMODELING STALLED REPLICATION FORKS Brandt Eichman
09:10:00 FUNCTIONS OF SINGLE-STRAND DNA BINDING PROTEINS IN MAINTAINING GENOME STABILITY David Cortez
09:25:00 IDENTIFICATION OF UHRF2 (RNF107) AS A NOVEL ICL SENSOR PROTEIN REQUIRED FOR THE FANCONI ANEMIA PATHWAY Martin Cohn
09:50:00 RAD51C IN DNA FORK PROTECTION AND STABILITY Katharina Schlacher
10:15:00 Refreshments & Poster Viewing
10:45:00 Session Introduction by Katharina Schlacher Katharina Schlacher
10:50:00 AN INTEGRATED ATR, ATM AND mTOR-MECHANICAL NETWORK CONTROLLING NUCLEAR PLASTICITY AND CELL MIGRATION Marco Foiani
11:15:00 ATR AND mTOR REGULATE NUCLEUR ACTIN POLYMERIZATION IN RESPONSE TO REPLICATION STRESS TO ALTER NUCLEUR ARCHITECTURE AND MAINTAIN GENOME STABILITY
11:30:00 STRUCTURAL BIOLOGY OF POLY(ADP-ribose) POLYMERASE ENZYMES John Pascal
11:55:00 BRIDGING DNA REPAIR AND NAD(H) ENERGETICS: TRACKING ARCHITECTURAL REGULATION OF APOPTOSIS-INDUCING FACTOR DURING PARTHANATOS
12:20:00 CELLULAR RESPONSES TO DNA DOUBLE-STRAND BREAKS Steve Jackson
13:05:00 Lunch at Leisure & Free Time
16:25:00 Session Introduction by Susan Lees-Miller Susan Lees-Miller
16:30:00 TARGETING THE REPLICATION STRESS RESPONSE IN CANCER
16:55:00 MECHANISM THROUGH WHICH ATR KINASE INHIBITION INDUCES UNSCHEDULED ORIGIN FIRING Christopher Bakkenist
17:10:00 COUPLING RECOGNITION AND REACTIVITY IN A STRUCTURE-SPECIFIC NUCLEASE Jane Grasby
17:35:00 CTIP-BRCA1 COMPLEX AND MRE11 NUCLEASE PLAY A CRITICAL ROLE IN MAINTAINING REPLICATION FORKS IN THE PRESENCE OF CHAIN TERMINATING NUCLEOTIDE ANALOGS
17:50:00 Meet the Poster Presenters III Susan Tsutakawa
18:15:00 Poster Session & Refreshments (even poster numbers only)
18:55:00 WNT/b-catenin signaling in BRCA-deficient cells Madalena Tarsounas
19:20:00 INHIBITORS OF THE RAD52-ssDNA INTERACTION ​Maria Spies
19:45:00 TARGETING RAD52 PROTEIN-PROTEIN INTERACTIONS IN CANCER THERAPY
20:25:00 Publication Opportunity: Progress in Biophysics and Molecular Biology (Published by Elsevier) Announcement by Tom Blundell Tom L Blundell
20:40:00 Dinner at Leisure
Tuesday, February 13, 2018
07:00:00 Breakfast
08:15:00 Session Introduction by Bennett Van Houten Bennett Van Houten
08:20:00 APOBEC MUTAGENESIS IN CANCER Reuben S Harris
08:45:00 POLYMERASE THETA PROMOTES ERROR-PRONE REPAIR BY alt-NHEJ AT THE EXPENSE OF ERROR-FREE HR Agnel Sfeir
09:00:00 THE CONCERTED ROLES OF FANCM AND Rad52 IN THE PROTECTION OF COMMON FRAGILE SITES Xiaohua Wu
09:15:00 INSIGHTS INTO CARCINOGENESIS FROM STRUCTURAL AND BIOLOGIC ANALYSES OF THE BRCA2 TUMOUR SUPPRESSOR Ashok Venkitaraman
09:40:00 Refreshments & Poster Viewing
10:10:00 CHARACTERIZATION OF GENOMIC REARRANGEMENTS IN RESPONSE TO CRISPR/Cas9-INDUCED DOUBLE-STRAND BREAKS
10:25:00 PHOSPHATE STEERING IS CRITICAL FOR CATALYSIS AND PREVENTION OF OFF-TARGET INCISIONS IN HUMAN FLAP ENDONUCLEASE Susan Tsutakawa
10:50:00 POLY (ADP-RIBOSE) POLYMERASE 1 IN DNA DAMAGE RECOGNITION Karolin Luger
11:15:00 COMMON FRAGILE SITE INSTABILITY: A RACE AGAINST TIME Michelle Debatisse
11:40:00 ADVANCES IN THE FIELD OF MUTATIONAL SIGNATURES: MECHANISTIC INSIGHTS AND CLINICAL APPLICATIONS
12:25:00 Lunch at Leisure & Free Time
12:40:00 Group Trip: Snorkeling (signups required in advance)
16:30:00 Session Introduction by Simon Boulton Simon Boulton
16:35:00 DNA-PKcs STRUCTURE FORMS A STAGE FOR THE ACTORS AND SUGGESTS AN ALLOSTERIC MECHANISM FOR MODULATING DNA DOUBLE-STRAND-BREAK REPAIR Tom L Blundell
17:00:00 PROTEOMICS-GRADE STRATEGIES FOR INTEGRATIVE STRUCTURAL BIOLOGY David Schriemer
17:25:00 NON-HOMOLOGOUS END JOINING OPERATES BY A “LIGASE-FIRST” MECHANISM Benjamin Stinson
17:40:00 SINGLE-MOLECULE ANALYSIS OF MULTICOMPONENT DNA REPAIR SYSTEMS Terence Strick
18:05:00 INTEGRATIVE STRUCTURE MODELING OF DNA-PKcs Andrej Sali
18:30:00 Poster Session & Refreshments (odd poster numbers only)
19:10:00 ROLES OF Ku70/Ku80 IN NHEJ, FROM DSB RECOGNITION TO LIGATION Jean-Baptiste Charbonnier
19:35:00 INTERSECTIONS BETWEEN MRN AND THE NON-HOMOLOGOUS END JOINING MACHINERY Tanya Paull
20:00:00 PNKP - A MEANS TO FIX THE ENDS Mark Glover
20:25:00 Dinner at Leisure
Wednesday, February 14, 2018
06:00:00 New Presentation
07:00:00 Breakfast
08:15:00 Session Introduction by Lorena Beese Lorena Beese
08:20:00 DYNAMICS AND MECHANICS OF DNA TETHERING BY CORE c-NHEJ FACTORS AND BY THE MRE11/RAD50/NBS1 COMPLEX
08:45:00 ASSEMBLING THE HUMAN RESECTOSOME ONE MOLECULE AT A TIME Ilya Finkelstein
09:10:00 FUNCTION AND REGULATION OF MCM8-9 IN DNA RECOMBINATION Michael Trakselis
09:25:00 STRUCTURAL INSIGHTS INTO THE ACTIVATION OF ATM AND ATR KINASES Domi Baretic
09:40:00 ATRX PROMOTES DNA REPAIR SYNTHESIS AND CROSS-OVER FORMATION DURING HOMOLOGOUS RECOMBINATION Markus Löbrich
09:55:00 Poster Session & Refreshments (all posters)
10:40:00 Session Introduction by Richard Wood Richard Wood
10:45:00 STRUCTURE AND MECHANISM OF THE RED RECOMBINATION SYSTEM FROM BACTERIOPHAGE LAMBDA Charles Bell
11:00:00 THE RELEASE OF MEIOTIC dsDNA FRAGMENTS PROMPTS A NOVEL VIEW ON DSB FORMATION Franz Klein
11:15:00 SAMHD1 PROMOTES DNA END RESECTION TO FACILITATE DNA REPAIR BY HOMOLOGOUS RECOMBINATION
11:30:00 REPLICATIVE AND TRANSLESION SYNTHESIS DNA POLYMERASES IN ICL REPAIR Orlando D. Schärer
11:55:00 STRUCTURAL ANALYSES OF DNA POLYMERASE THETA VARIANTS Sylvie Doublié
12:20:00 STRUCTURAL BASIS FOR THE ESSENTIAL ROLE OF LOOP1 IN POLYMERASE μ WHILE PROCESSING DOUBLESTRAND BREAKS DNA SUBSTRATES DURING NHEJ Marc Delarue
12:35:00 UNRESOLVED DNA INTERMEDIATES AS A SOURCE OF DNA BREAKS AND CHROMOSOME ABERRATIONS Stephen West
13:15:00 Lunch at Leisure & Free Time
16:25:00 Session Introduction by Jane Grasby Jane Grasby
16:30:00 FUNCTION AND EXECUTION OF RTEL1 ACTIVITIES AT VERTEBRATE TELOMERES Simon Boulton
16:55:00 REPLICATION ASSOCIATED DNA REPAIR Lorena Beese
17:20:00 COMBINING SINGLE-MOLECULE METHODS TO STUDY DNA MISMATCH REPAIR Dorothy Erie
17:45:00 PUBLISHING WITH THE NATURE RESEARCH JOURNALS: A LOOK BEHIND THE SCENES
17:55:00 Refreshments & Poster Viewing
18:25:00 STRUCTURAL BIOLOGY OF DNA MISMATCH REPAIR Titia K. Sixma
18:50:00 DIFFERENTIAL INTERACTIONS BETWEEN THE SLIDING CLAMP AND MUTL Alba Guarne
19:05:00 NON-REPAIR FUNCTIONS OF DNA-PKcs Susan A Miller
20:00:00 Gala Dinner & Poster Awards
Thursday, February 15, 2018
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
07:00:00 Breakfast
08:15:00 Session Introduction Tom L Blundell
08:20:00 DAMAGE SENSOR ROLE OF UV-DDB DURING BASE EXCISION REPAIR:STIMULATION OF APE1 AND OGG1 Bennett Van Houten
08:45:00 DNA DAMAGE REGULATES GENE EXPRESSION VIA BASE EXCISION REPAIR Cynthia Burrows
09:10:00 DNA TRANSLOCATION BY A TRANSCRIPTION-REPAIR COUPLING FACTOR Alexandra Deaconescu
09:25:00 STRUCTURAL ANALYSIS OF PROTEIN DNA REMODELLER Karl-Peter Hopfner
09:50:00 New PresentationSTRUCTURE AND REGULATION OF HUMAN INO80 COMPLEX Dale Wigley
10:15:00 Refreshments & Poster Viewing
10:50:00 MOLECULAR MECHANISM OF TRANSCRIPTION TRANSCRIPTION-COUPLED REPAIR Dong Wang
11:05:00 AN MCM-RELATED HELICASE AND OTHER REPLICATION-RELATED MACHINERY FOUND ON THE MOBILE ELEMENT BEHIND THE MRSA EPIDEMIC Phoebe Rice
11:30:00 BASE EXCISION REPAIR GLYCOSYLASES MUTYH AND NEIL1: THE GOOD, THE BAD AND THE DAMAGED Sheila David
11:55:00 LESION SEARCH AND BASE EXTRUSION STRATEGY OF THYMINE DNA GLYCOSYLASE Ivaylo Ivanov
12:10:00 THE RISE OF THE MOLECULAR MACHINES WITH CANCER IMPLICATIONS John Tainer
12:35:00 Closing Comments by John Tainer & Tom Blundell
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