9th Annual Biomarkers Congress
15th North American Regional Meeting - International Society for the Study of Xenobiotics
Town and Country Resort and Convention Center
500 Hotel Circle North
San Diego, California 92108
http://
15th North American Regional Meeting 
International Society for the Study of Xenobiotics
Town and Country Resort and Convention Center
San Diego
California 


Schedule of Presentations:

Sunday, October 12, 2008
02:00:00 Advances and Applications in Prediction of Biotransformation Pathways | Golden West Deepak Dalvie
02:00:00 Overview on the Role of Biotransformation in Drug Discovery Deepak Dalvie
02:40:00 New(er) Tools for Rapid Metabolite Identification Kevin Bateman
09:00:00 Golden West
09:00:00 In Vivo Safety Assessment Using Chronically Instrumented Animal Models R. Dustan Sarazan
09:00:00 California | Cardiovascular Safety of Human Pharmaceuticals: Current Issues in Science and Drug Development R. Dustan Sarazan
09:00:00 An Overview of the Bioanalysis of Protein Therapeutics Binodh DeSilva
09:40:00 Clinical Assessment of Neutralizing Antibodies to Protein Therapeutics Michele S. Swanson
09:40:00 QT Interval Prolongation: Electrophysiology to Bedside CRAIG T JANUARY
10:20:00 Refreshment Break | Altas Ballroom Foyer
10:20:00 Refreshment Break
10:40:00 PK/PD Considerations of Antibodies Joseph P. Balthasar
10:40:00 Drug Induced Vascular Injury G. H. Thomas
11:20:00 Protein Metabolism/catabolism in the Disposition of Protein Therapeutics Paul J. Fielder
11:20:00 Drug Induced Vascular Injury Brian R. Berridge
12:00:00 New Presentation
12:00:00 New Presentation
12:00:00 MetaSite Applications in Predicting Phase I Metabolic Bio-transformations Gabriele Cruciani
12:00:00 New Presentation
14:00:00 Overview on Renal Structure, Function, Metabolism and Toxicity Hitoshi Endou
14:00:00 Current Concepts in Renal Drug Disposition and Toxicity | California Hitoshi Endou
14:40:00 Drug-drug Interaction and Renal Drug Transporters Richard Kim
15:20:00 Refreshment Break | Atlas Ballroom Foyer
15:20:00 Refreshment Break | Altas Ballroom Foyer
15:40:00 Mechanisms of Renal SLC22 Drug Transporters and Potential Effects of Mutations Hermann Koepsell
16:20:00 Genetic Determinants of Renal Drug Clearance and Toxicity Kathleen M. Giacomini
16:20:00 Fingerprint Based Methods for Predicting Sites of Metabolism C Scott Boyer
Monday, October 13, 2008
08:00:00 Altas Ballroom (Town & Country/San Diego)
08:30:00 Minimizing Drug Toxicities During Drug Discovery and Development | Altas Ballroom (Town & Country/San Diego) Tom Baillie, Sid Nelson
08:30:00 Overview: Methods for Predicting Drug Toxicity During Development Jim Stevens
09:00:00 Drug Interaction with Inflammatory Stress: Animal Models of Idiosyncratic Reactions Bob Roth
09:40:00 Refreshment Break | Grand Exhibit Hall
10:00:00 Integrating ‘omics’ technologies into Safety Evaluation and Risk Assessment Lois-Lehman McKeeman
10:35:00 Drug Metabolites and Toxicity: Experimental Approaches to Help Focus on What is Important Scott Obach
11:10:00 Regulatory Approaches for Safety Assessment of Drug Metabolites Aisar Atrakchi
12:00:00 BREAK
13:30:00 Altas Ballroom (Town & Country/San Diego)
14:30:00 P450 and Xenobiotic Receptor Humanized Mice Frank Gonzalez
14:30:00 Determining Cross-Species Exposure-Receptor Occupancy Relationships for a Dual-Pharmacology CNS Compound: An Exercise in Translational Pharmacology. Christopher L. Shaffer
14:30:00 Transgenic Models for DMEs and Transporter Function Xinxin Ding
14:30:00 Role of Drug Disposition in Idiosyncratic Drug Toxicity Kevin Park
14:30:00 Atlas Ballroom (Town & Country/San Diego)
15:00:00 Relevance of In Vitro and In Vivo Models to Drug-induced Liver Injury Jim Stevens
15:00:00 P450-reductase Knockout Mouse Models for Drug Metabolism Research Xinxin Ding
15:00:00 Refreshment Break | Grand Exhibit Hall
15:30:00 Refreshment Break | Grand Exhibit Hall
15:30:00 Refreshment Break | Grand Exhibit Hall
16:00:00 Insights from the Human UGT1 Transgenic Mice Robert H. Tukey
16:00:00 Relevance of In Vitro and In Vivo Models to Idiosyncratic Reactions in the Skin Jack Uetrecht
16:30:00 Relevance of In Vitro and In Vivo Models to Cardiovascular Toxicity Tim Hammond
16:30:00 Drug Transporter-knockout Mouse Models and Drug Bioavailability John Schuetz
Tuesday, October 14, 2008
08:30:00 Successful Development of Biotherapeutics: Scientific and Regulatory Strategies and Hurdles for Toxicology and ADME/PK Stanley Roberts, Paul Pearson
08:30:00 ADME/PK Strategies for Small Molecules and Biotherapeutics Lisa A. Shipley
09:00:00 Structural Basis of Uptake Transporter Function Richard Kim
09:00:00 Structural Basis for the Intestinal Bile Acid Transporter ASBT Activity Peter Swaan
09:00:00 Optimizing ADME/PK Properties of Biotherapeutics Lisa Damico
09:30:00 Toxicology Study Strategies for Biopharmaceuticals in Comparison to Small Molecules Mary Ellen Cosenza
09:30:00 Species Related Differences in NTCP Structure/activity and Relevance to Drug Induced Cholestasis Elaine Leslie
10:00:00 Refreshment Break | Grand Exhibit Hall
10:00:00 Refreshment Break | Grand Exhibit Hall
10:30:00 OATP Transporters and Substrate Specificity Bruno Hagenbuch
10:30:00 Preclinical Development Strategies for Biotherapeutics Based Upon Product Attributes Joy A. Cavagnaro
11:00:00 Establishing the First in Human Dose for Biotherapeutics Jennifer E. Visich
11:00:00 Molecular Determinants of Specificity in the SLC22A Family Kathy Giacomini
11:30:00 The TeGenero Story: What Happened at Northwick Park and Lessons Learned Jenny Sims
14:00:00 Unusual Interspecies Differences in the Metabolism of a Cathepsin K Inhibitor Deborah Nicoll-Griffith
14:00:00 Novel Methods for Assessing Drug Transporter Activity Margareta Hammarlund-Udenaes, Jashvant D Unadkat
14:00:00 Measuring Site-specific Intestinal Absorption and Biliary Excretion in Humans Hans Lennarnes
14:00:00 Keeping the Lid on Pandora’s Box: Dealing with Issues in Drug Discovery and Development Donald Tweedie
14:00:00 Altas Ballroom (Town & Country/San Diego)
14:00:00 Keeping the Lid on Pandora’s Box: Dealing with Issues in Drug Discovery and Development Donald Tweedie
14:00:00 Unusual Interspecies Differences in the Metabolism of a Cathepsin K Inhibitor Deborah Nicoll-Griffith
14:00:00 Altas Ballroom (Golden West/California)
14:30:00 Determining Cross-Species Exposure-Receptor Occupancy Relationships for a Dual-Pharmacology CNS Compound: An Exercise in Translational Pharmacology. Christopher L. Shaffer
14:30:00 Imaging Hepatobiliary Drug Disposition in Humans with Gamma Scintigraphy Kim L. R. Brouwer
15:00:00 Refreshment Break | Grand Exhibit Hall
15:00:00 Refreshment Break
15:30:00 Can Plasma Protein Binding Represent a Safety Issue for Drug Development? The Radafaxine Case Paolo Rossato
15:30:00 Imaging P-glycoprotein Activity at the Blood-brain and Blood-placental Barrier: Studies in Human and Nonhuman Primates Jash Unadkat
16:00:00 The Effect of Losing Multiple Clearance Pathways on Drug Safety and Viability Shelby Anderson
16:00:00 Estimating Intracellular and Interstitial Tissue Concentrations of Drugs: Going Beyond Microdialysis Margareta Hammarlund-Udenaes
16:30:00 Identifying Reactive Intermediates in Drug Development: Making Difficult Decisions Donald Tweedie
17:00:00 Reception and Poster Awards Presentation / Student Presentations | Altas Ballroom (Golden West/California)
Wednesday, October 15, 2008
09:00:00 Genetic Variation in ABC Transporters and Drug Resistance in Leukemia Deanna L. Kroetz
09:00:00 Atlas Ballroom (Town & Country/San Diego)
09:00:00 Atlas Ballroom (Golden West/California)
09:00:00 Pharmacogenomics in Anticancer Therapy Federico Innocenti
09:00:00 Crystal Structure of the Mitochondrial Cytochrome P450 CYP24A1 C. David Stout
09:05:00 P-450: Structure and Function Eric F. Johnson
09:30:00 Crystallographic Studies of CYP46A1 Irina A. Pikuleva
09:30:00 Pharmacogenomics of Angiogenesis Inhibitors Federico Innocenti
10:00:00 Refreshment Break | Grand Exhibit Hall
10:00:00 Refreshment Break | Grand Exhibit Hall
10:30:00 Pharmacogenetics of EGFR Tyrosine Kinase Inhibitors Sharyn D. Baker
10:30:00 Structures of CYP3A4 Ligand Complexes: How Does Pharma Integrate this Information? Michael R. Wester
10:30:00 Structures of CYP3A4 Ligand Complexes: How Does Pharma Integrate this Information? Michael R. Wester
11:00:00 Whole Genome Association Studies to Identify Pharmacogenetic Signatures M. Eileen Dolan
11:00:00 Structural Analysis of Membrane-Bound P450s by Magic-Angle Spinning NMR Chad M Rienstra
13:30:00 The Implications of UDP-glucuronosyltransferase Oligomerization on Function and Structure Bob Tukey
13:30:00 UGT: Structure and Function John Miners
13:30:00 Epigenetics and Whole Genome Approaches to Drug Metabolism Ronald Hines
13:30:00 Atlas Ballroom (Town & Coutnry/San Diego)
13:30:00 The Role of Epigenetics in Regulating Cytochrome P450 Gene Expression Magnus Ingelman-Sundberg
13:30:00 Atlas Ballroom (Golden West/California)
14:00:00 Genetic Loci Responsible for Interindividual Differences in Response to Warfarin Michael D. Caldwell
14:00:00 Identification and Characterization of the UDP-glucuronic Acid and Substrate Binding Sites of Human UDP-glucuronosyltransferases: Crystallization and Photoaffinity Labeling Anna Radominska
14:30:00 Refreshment Break | Grand Exhibit Hall
14:30:00 Refreshment Break | Grand Exhibit Hall
15:00:00 Genetic and Genomic Variability in Human UDP-glucuronosyltransferase Chantal Guillemette
15:00:00 Genome Wide Approach to the Pharmacogenetics of Statins Michael Krauss
15:30:00 Pathway Approach to the Pharmacogenetics of Antihypertensives Julie A. Johnson
16:00:00 The Characterization of the Substrate Selectivity and Kinetics of Human UDP-glucuronosyltransferases John Miners
Thursday, October 16, 2008
09:00:00 Atlas Ballroom (Town & Country/San Diego)
09:00:00 Vulnerable Populations: DMPK Issues Tim Tracy
09:00:00 Ontogeny of Drug Metabolizing Enzymes: From In Utero to Puberty Steve Leeder
09:00:00 Stable Isotope Dilution Chiral LC-MS Analysis of Oxidized Bioactive Lipids Clementina Mesaros
09:00:00 Metabolism of Lipids/Fatty Acids as Markers/Modulators of Disease Dennis R. Koop
09:00:00 Atlas Ballroom (Golden West/California)
09:40:00 Isoprostane and Isofuran Pathways of Lipid Peroxidation Jack Roberts
09:40:00 Pharmacokinetics and Disposition of Drugs Commonly Administered During Pregnancy Mary F. Hebert
10:20:00 Refreshment Break | Grand Exhibit Hall
10:20:00 Refreshment Break | Atlas Ballroom Foyer
10:40:00 Temporal Changes in Drug Metabolizing Enzymes During Pregnancy: The Materno-placental Unit Tim Tracy
10:40:00 Resolvins and Protectins : Anti-inflammatory and Pro-resolving Actions of Omega-3 Fatty Acid-derived Mediators Matthew Spite
11:20:00 Drug Metabolism and Pharmacokinetics in the Elderly Ulrich Klotz
11:20:00 The Arachidonate Monooxygenase. An Enzymatic Pathway for the Generation of Physiologically Relevant Oxidized Lipid Mediators Jorge Cadevilla
4th Annual Pharma R&D Asia Congress
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