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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors
1. 2010 Hypoxia-induced autophagy: cell death or cell survival? Curr. Op. Cell Biol.,
2. 2009 Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. J. Cancer Res. (2009) 69, 358-368
3. 2008 Tumor cell metabolism; cancer’s Achilles heel. Cancer Cell 13, 472-82
4. 2008 PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis. Proc Natl Acad Sci USA. (2008) 105, 4745-50.
5. 2007 Hypoxia Signalling Controls Metabolic Demand. J. Curr. Op. Cell Biol. (2007) 19, 223-9.
6. 2006 Hypoxia signaling in Cancer and approaches to enforce Tumour Regression. Nature 441, 437-443
7. 2006 The Hypoxia-Inducible-Factor hydroxylases bring fresh air into Hypoxia Signaling. EMBO Rep 7: 41-5
8. 2004 A short synthetic peptide inhibits signal transduction migration and angiogenesus mediated by Tie2 receptor EMBO Rep. 5: 26. 2-7
9. 2003 HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1a in normoxia EMBO J. 22, 4082-4090
10. 2001 Hypoxia-inducible factor-1a (HIF-1a) escapes O2-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm EMBO Rep. 2, 615-20
11. 2000 An Arresting Start for MAPK. Science 290, 1515-1518
12. 1999 Regulation of MKP-1 degradation by p42/p44MAPK-dependent phosphorylation Science 286, 2514-2517
13. 1999 Defective thymocyte maturation in p44 MAP kinase (Erk1) knock out mice. Science 286, 1374-1377
14. 1999 Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry EMBO J. 18, 664-674.
15. 1996 Identification of MAP kinase domains by re-directing stress signals into growth factor responses Science 272, 1652-1655
16. 1994 Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1) EMBO J. 13, 3003-3010.
17. 1993 The Mitogen-Activated Protein kinases p42 and p44 MAPK are required for fibroblast Cell Proliferation. Proc. Natl. Acad. Sci. USA 90, 8319-8323
18. 1993 A Point Mutation of the Na+/H+ Exchanger Gene (NHE1) and Amplification of the Mutated Allele Confer Amiloride-Resistance upon Chronic Acidosis. Proc. Natl. Acad. Sci. USA 90, 4508-4512.
19. 1992 The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls 'H+ -sensing'. Proc. Natl. Acad. Sci. USA 89, 2424-2428
20. 1990 Growth factors induce phosphorylation of the Na+/H+ antiporter, a glycoprotein of 110 kDa Science 247, 723-726.
21. 1989 Molecular cloning, primary structure and expression of the human growth factor-activatable Na+/H+ antiporter Cell 56, 271-280
22. 1988 Serotonin stimulates DNA synthesis in fibroblasts via 5-HT-1B receptors coupled to Gi-protein Nature 335, 254-257.
23. 1988 Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of Phospholipase C EMBO J. 7, 161-168.
24. 1987 Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin Nature, 326, 800-803.
25. 1986 Functional expression of a transfected Na+/H+ antiporter human gene into antiporter-deficient mouse L cells. Proc.Natl.Acad.Sci USA. 83, 9388-9392
26. 1986 Pertussis toxin inhibits thrombin-induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts. EMBO J. 5, 55-60
27. 1985 a-thrombin-induced early mitogenic signalling events and G0 to S-phase transition of fibroblasts require continual external stimulation EMBO J. 4, 2927-2932
28. 1985 The growth factor activatable Na+/H+ exchange system. A genetic approach Trends in Biochem.Sci. 10, 453-455
29. 1984 A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH. Proc.Natl.Acad.Sci. USA 81, 4833-37
30. 1982 Growth factor activation of an amiloride sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation Proc.Natl.Acad.Sci. USA 79, 3935-3939
31. 1980 Relationship between increased aerobic glycolysis and DNA synthesis initiation studied using glycolytic mutant fibroblasts Nature 287, 445-447
32. 1980 Isolation of a Chinese hamster fibroblasts mutant defective in hexose transport and aerobic glycolysis: its use to dissect the malignant phenotype Proc.Natl.Acad.Sci. USA 77, 2698-2701
33. 1980 Identification of tetrodotoxin-sensitive Na+ channel in a variety of fibroblasts lines Nature 28, 162-164
34. 1978 Adenylate cyclase in fibroblast mutant defective in glycolipid and glycoprotein synthesis Nature 275, 223-224
35. 1978 Isolation and immunological characterization of a glucose-regulated fibroblasts cell surface glycosylation precursor Cell 13, 139-150
36. 1977 Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein systhesis or glucose deprivation. Cell 11, 941-947
37. 1977 Role of cell surface carbohydrate and proteins in cell behavior: studies on the biochemical reversion of an N-acetyl-glucosamine deficient fibroblasts mutant Proc.Natl.Acad.Sci. USA 74, 243-247
38. 1976 Mutants of Balb/c 3T3 fibroblasts defective in adhesiveness to substratum: evidence for alteration in cell surface proteins Proc.Natl.Acad.Sci. USA 73, 544-548

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