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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors
1. 2012 Attenuation of Age-Related Changes in Neuromuscular Synapses by Caloric Restriction and Exercise Proceedings of the National Academy of Sciences. In Press.
2. 2012 Multicolor Brainbow imaging in larval zebrafish In: Imaging in Developmental Biology: A Laboratory Manual, eds. Wong, R., Sharpe, J., and Yuste, R. Cold Spring Harbor Laboratory Press (in press).
3. 2012 Dynamic aspects of synaptic connections at the vertebrate neuromuscular junction In: Parnavalas J, Stern C, Stirling V, editors. The making of the nervous system. London: Pittman. p 340-55.
4. 2010 Ssecrett and NeuroTrace: Interactive visualization and analysis tools for large-scale neuroscience data sets IEEE Comput Graph Appl 30(3): 58-70. NIHMSID: NIHMS201133
5. 2010 Neurocartograpy. Neuropsychopharmacol Rev 35(1):342-3. PMCID: PMC2849285
6. 2010 Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors Proc Natl Acad Sci 107(8):3287-92. PMCID: PMC2840452.
7. 2010 Imaging the developing neuromuscular junction in vivo.   In: Wong RO, Sharpe J, editors. Imaging in Developmental Biology: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. In Press.
8. 2009 Semi-automated reconstruction of neural processes from large numbers of fluorescence images PLoS One 4(5):e5655. PMCID: PMC2682575
9. 2009 Discovering the wiring diagram of the brain In: Hey T, Tansley S, Tolle K, editors. The fourth paradigm: Data-intensive scientific discovery. Redmond, WA: Microsoft Corporation. p 75-82.
10. 2009 Ballistic delivery of dyes for structural and functional studies of the nervous system. CSH Protoc 2009(4):pdb.prot5202. NIHMSID: NIHMS196664
11. 2009 Controlling the orientation and synaptic differentiation of myotubes with micropatterned substrates Biophys J 97(10):2771-9. PMCID: PMC2776297
12. 2009 Super-resolution laser scanning microscopy through spatiotemporal modulation Nano Lett 9(11):3883-9. PMCID: PMC2783786
13. 2009 It's lonely at the top: winning climbing fibers ascend dendrites solo. Neuron 63(1):6-8. PMCID: PMC2790139
14. 2009 The interscutularis muscle connectome PLoS Biol 7(2): 265-77. PMCID: PMC2637925
15. 2008 Seeing circuits assemble Neuron 60(3):441-8. PMCID: PMC2661113
16. 2008 Imaging fluorescent mice in vivo using confocal microscopy. In: Correia JJ, Detrich HW, editors. Biophysical tools for biologists. Volume 2, In vivo techniques (Methods in cell biology, volume 89). San Diego: Academic Press. p 309-27
17. 2008 Ome sweet ome: what can the genome tell us about the connectome? Curr Opin Neurobiol 18(3):346-53. PMCID: PMC2735215
18. 2008 Ex vivo imaging of motor axon dynamics in murine triangularis sterni explants Nat Protoc 3(10): 1645-53. PMCID: PMC2583328
19. 2008 Lysosomal activity associated with developmental axon pruning J Neurosci 28(36):8993-9001. PMCID: PMC2693713
20. 2008 D axon structure extraction and analysis in confocal fluorescence microscopy images   Neural Comput 20(8):1899-927. PMCID: PMC2587013.
21. 2008 Rapid and modifiable neurotransmitter receptor dynamics at a neuronal synapse in vivo. Nat Neurosci 11(7):807-15. PMCID: PMC2700019
22. 2008 Development of presynaptic inhibition onto retinal bipolar cell axon terminals is subclass-specific. J Neurophysiol 100(1):304-16. PMCID: PMC2493474
23. 2008 A technicolour approach to the connectome A technicolour approach to the connectome
24. 2008 In vivo imaging of presynaptic terminals and postsynaptic sites in the mouse submandibular ganglion. Dev Neurobiol 68(6):760-70. PMCID: PMC2583331.
25. 2008 Synapse elimination In: Squire LR, Bloom FE, Spitzer NC, du Lac S, Ghosh A, Berg D, editors. Fundamental neuroscience. 3rd ed. San Diego: Academic Press. p 469-90
26. 2007 Imaging the neuromuscular junction over the past centuries Acta Physiologica Sinica. 59(6):683-96.
27. 2007 Automated axon tracking of 3D confocal laser scanning microscopy images using guided probabilistic region merging Neuroinformatics. 5(3):189-203
28. 2007 Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system   Nature 450:56-62.
29. 2007 Imaging axonal transport of mitochondria in vivo. Nat Methods 4(7):559-61.
30. 2007 Rapid synapse elimination after postsynaptic protein synthesis inhibition in vivo.    J Neurosci 27(22):6064-7.
31. 2007 The rise of the ‘projectome Nat Methods 4(4):307-8.
32. 2006 Repulsive force based snake model to segment and track neuronal axons in 3D microscopy image stacks Neuroimage 32(4):1608-20
33. 2006 Automating the collection of ultrathin serial sections for large volume TEM reconstructions Microsc Microanal 12:86-7
34. 2006 Translational neuroscience during the Second World War J Exp Biol 209:3485-7
35. 2005 Imaging the development of the neuromuscular junction In: Yuste R, Konnerth A, editors. Imaging in neuroscience and development: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. p 215-24.
36. 2005 Optical sectioning microscopy Nat Methods 2(12):920-31.
37. 2005 Fluorescence microscopy   Nat Methods 2(12):910-9.
38. 2005 A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis. J Comp Neurol 490(3):209-19.
39. 2005 Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitter.   Proc Natl Acad Sci 102:11088(31)-93. PMCID: PMC1182450.
40. 2005 Peptide tags for labeling membrane proteins in live cells with multiple fluorophores. Biotechniques 38(6):945-52
41. 2005 In vivo imaging of axonal degeneration and regeneration in the injured spinal cord.   Nat Med 11(5):572-7.
42. 2005 Method of labeling individual cells.   United States patent 6,869,772.
43. 2005 A practical guide: ballistic delivery of dyes for structural and functional studies of the nervous system   In: Yuste R, Konnerth A, editors. Imaging in neuroscience and development: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. p 111-8.
44. 2004 Axon branch removal at developing synapses by axosome shedding Neuron 44(4):651-61.
45. 2004 Age-associated synapse elimination in mouse parasympathetic ganglia J Neurobiol 60(2):214-26.
46. 2004 Comment on “Reelin promotes peripheral synapse elimination and maturation.” Science 303:1977.
47. 2004 Structural dynamics of synapses in living animals Curr Opin Neurobiol 14(1):105-11.
48. 2004 Nerve-independent formation of a topologically complex postsynaptic apparatus J Cell Biol 164(7):1077-87. PMCID: PMC2172060
49. 2003 Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition   Nature 424:430-4.
50. 2003 Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions. J Cell Biol 160(5):741-52. PMCID: PMC2173352.
51. 2003 In vivo time-lapse imaging of synaptic takeover associated with naturally occurring synapse elimination Neuron 37(1):67-73.
52. 2003 Synapse elimination In: Squire LR, editor. Fundamental neuroscience. 2nd ed. San Diego: Academic Press. p 533-54.
53. 2003 The role of neuronal identity in synaptic competition    Nature 424:426-30.
54. 2003 Watching the neuromuscular junction. J Neurocytol 32:767-75
55. 2003 LTP: perils and progress   Nat Rev Neurosci 4(11):926-9.
56. 2003 Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo. J Neurosci 23(36):11479-88
57. 2003 Synaptic dynamism measured over minutes to months: age-dependent decline in an autonomic ganglion.    Nat Neurosci 6(9):956-60.
58. 2002 Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase. Neuron 36(4):635-48.
59. 2002 Pre-existing pathways promote precise projection pattern      Nat Neurosci 5(9):861-7.
60. 2002 Confocal microscopy. In: Lichtman JW, editor. Modern light microscopy: principles and practice Washington: Soc Neurosci. p 93-108.
61. 2002 Light, lenses, and image formation in the light microscope   In: Lichtman JW, editor. Modern light microscopy: principles and practice. Washington: Soc Neurosci. p 1-28.
62. 2002 Modern light microscopy: principles and practice.    Washington: Soc Neurosci. 163 p.
63. 2002 Neurotransmitter receptor dynamics studied in vivo by reversible photo-unbinding of fluorescent ligands Neuron 34(6):865-76.
64. 2001 Critical thinking about critical periods.    Baltimore: Paul H Brookes Publishing Co.
65. 2001 Induction, assembly, maturation and maintenance of a postsynaptic apparatus. Nat Rev Neurosci 2(11):791-805.
66. 2001 The neuronal naturalist: watching neurons in their native habitat Nat Neurosci 4 Suppl:1215-20.
67. 2001 Asynchronous synapse elimination in neonatal motor units: studies using GFP transgenic mice Neuron 31(3):381-94.
68. 2001 Glial cell line-derived neurotrophic factor administration in postnatal life results in motor unit enlargement and continuous synaptic remodeling at the neuromuscular junction. J Neurosci 21(16):6136-46.
69. 2001 Synapse formation and maturation In: Cowan MW, Sudhof T, Stevens C, editors. Synapses. Johns Hopkins Press, p 571-612.
70. 2001 Developmental neurobiology overview: synapses, circuits, and plasticity   In: Bailey DB, Symons F, Bruer JT, Lichtman, JW, editors. Critical thinking about critical periods. Baltimore: Paul H Brookes Publishing Co, p 27-42.
71. 2001 Getting a bead on receptor movements Nat Neurosci 4(3):219-20.
72. 2000 Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP.    Neuron 28(1):41-51
73. 2000 The principles and practice of modern light microscopy Soc Neurosci short course syllabus. 202 p.
74. 2000 Multicolor "DiOlistic" labeling of the nervous system using lipophilic dye combinations Neuron 27(2):219-25.
75. 2000 Nerve terminals form but fail to mature when postsynaptic differentiation is blocked: in vivo analysis using mammalian nerve-muscle chimeras    J Neurosci 20(16):6077-86.
76. 2000 From plaque to pretzel: fold formation and acetylcholine receptor loss at the developing neuromuscular junction.   J Neurosci 20(10):3663-75
77. 2000 Synapse elimination and indelible memory   Neuron 25(2):269-78.
78. 1999 Development of the vertebrate neuromuscular junction. Annu Rev Neurosci 22:389-442.
79. 1999 Vital imagining and ultrastructural analysis of individual axon terminals labeled by iontophoretic application of lipophilic dye J Neurosci Methods 93(1):13-20.
80. 1999 Activity-driven synapse elimination leads paradoxically to domination by inactive neurons J Neurosci 19(22):9975-85.
81. 1999 Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo. Science 286:503-7.
82. 1999 Can molecules explain long-term potentiation? Nat Neurosci 2(7):597-604.
83. 1999 Axonal atrophy: the retraction reaction. Curr Opin Neurobiol 9(3):364-70.
84. 1999 Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction Neuron 23(1):33-44.
85. 1998 Synapse formation and elimination   In: Zigmond MJ, Bloom FE, Landis SC, Roberts JL, Squire LR, editors. Fundamental neuroscience. 1st ed (textbook). San Diego: Academic Press. p 547-80.
86. 1998 Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscle Science 279:1725-9.
87. 1998 Axon withdrawal during synapse elimination at the neuromuscular junction is accompanied by disassembly of the postsynaptic specialization and withdrawal of Schwann cell processes. J Neurosci 18(13):4953-65.
88. 1998 Development of the neuromuscular junction: genetic analysis in mice. J Physiol (Paris) 92:167-172.
89. 1998 . Method and apparatus for generating a three-dimensional topographical image of a microscopic specimen. United States patent 5,831,736.
90. 1998 Synaptic competition during the reformation of a neuromuscular map. J Neurosci 18(18):7328-35.
91. 1998 Synaptic segregation at the developing neuromuscular junction Science 282:1508-11.
92. 1997 Novel high resolution confocal scanning profilometer. In: Three-dimensional microscopy image acquisition and processing. Proc Intl Soc Optical Eng (SPIE) 2984:101-12.
93. 1997 Optical imaging in neuroscience. Grass calendar and 20 page supplement. Grass Instrument division of Astro-Med Inc.
94. 1997 Alterations in synaptic strength preceding axon withdrawal. Science 275:356-61.
95. 1996 Are neurotrophins synaptotrophins? Mol Cell Neurosci 7(6): 433‑42.
96. 1996 Mechanism of synapse disassembly at the developing neuromuscular junction. Curr Opin Neurobiol 6(1):104-12.
97. 1996 A quantitative fluorescence-imaging technique for studying acetylcholine receptor turnover at neuromuscular junctions in living animals J Neurosci Methods 64(2):199-208.
98. 1995 Brief communication: some observations on enamel thickeness and enamel prism packing in the Miocene hominoid Otavipithecus namibienis Am J Phys Anthropol 98(4):595-600.
99. 1995 Synapse disassembly at the neuromuscular junction. Burden S, editor. Sem Dev Biol 6:195-206.
100. 1994 Three-dimensional image reconstructions from a partially confocal scanning microscope. Proc Intl Soc Optical Eng (SPIE) 2302:379-88.
101. 1994 Synaptic plasticity studied in vivo using vital dyes, lasers, and computer-assisted fluorescence microscopy. Neuroprotocols 5:91-101.
102. 1994 Long-term synapse loss induced by focal blockade of postsynaptic receptors. Nature 372:519-24.
103. 1994 Rotating slit aperture for scanning microscopy—continuation in part United States patent 5,531,150.
104. 1994 Vital fluorescence and high resolution reflected light imaging of the neuromuscular junction in light microscope techniques for neurobiologists In: Fraser S, editor. Light microscopic imaging techniques, Soc Neurosci short course syllabus 3: 1-16.
105. 1994 In vivo imaging shows loss of synaptic sites from neuromuscular junctions in a model of myasthenia gravis Neurology 44(11):2138-45.
106. 1994 Regenerating muscle fibers induce directional sprouting from nearby nerve terminals: studies in living mice. J Neurosci 14(9):5672-86.
107. 1994 Confocal microscopy Sci Am 271:30-5.
108. 1994 Theoretical analysis of a rotating-disk partially confocal scanning microscope Appl Opt 33:585-96.
109. 1993 Gradual loss of synaptic cartels precedes axon withdrawal at developing neuromuscular junctions. Neuron 11(5):801-15.
110. 1993 Interactions between nerve and muscle: synapse elimination at the developing neuromuscular junction. Dev Biol 156(1):1-10.
111. 1993 Kit for converting a standard microscope into a single aperture confocal scanning epi-illumination microscope United States patent 5,235,457.
112. 1993 In vivo observations of pre- and postsynaptic changes during the transition from multiple to single innervation at developing neuromuscular junctions J Neurosci 13(2):834-55.
113. 1992 'Cartellian' competition at the neuromuscular junction Trends Neurosci 15(6):197-9.
114. 1992 From cell line to brain Nature 356:562-3.
115. 1992 Rotating slit aperture for scanning microscopy United States patent 5,101,295.
116. 1992 Method and apparatus of slow aperture scanning in a single aperture confocal epi-illuminator microscope. United States patent 5,099,363.
117. 1992 Kit for converting a slit lamp biomicroscope into a single aperture confocal scanning biomicroscope. United States patent 5,099,354.
118. 1991 Single aperture confocal scanning biomicroscope and kit for converting single lamp biomicroscope thereto United States patent 5,020,891.
119. 1991 The plasticity and stability of neuromuscular synapses in living mice. Restorative Neurology 5:71-83.
120. 1990 Neuromuscular junctions shrink and expand as muscle fiber size is manipulated: in vivo observations in the androgen-sensitive bulbocavernosus muscle of mice J Neurosci 10(8):2660-71.
121. 1990 Synaptic competition studied at developing and regenerated neuromuscular junctions in living mice. In: Advances in neural regeneration research. New York: Wiley-Liss. p 33-41.
122. 1990 In vivo visualization of the growth of pre- and postsynaptic elements of neuromuscular junctions in the mouse J Neurosci 10(3):894-908
123. 1990 Understanding synaptic competition in theory and in practice J Neurobiol 21(1):99-106.
124. 1990 Mechanisms of synaptic competition. J Neurobiol 21:1. New York: John Wiley and Sons
125. 1989 Single aperture confocal scanning epi-illumination microscope. United States patent 4,884,881.
126. 1989 Kit for converting a standard microscope into a single aperture confocal scanning epi-illumination microscope. United States patent 4,884,880.
127. 1989 Motor nerve terminal loss from degenerating muscle fibers Neuron 3(6):677-88.
128. 1989 High-resolution imaging of synaptic structure with a simple confocal microscope. New Biol 1(1):75-82.
129. 1989 In vivo visualization of pre- and postsynaptic changes during synapse elimination in reinnervated mouse muscle. J Neurosci 9(5):1781-805.
130. 1988 Postsynaptic receptor elimination during synaptic competition. In: Flohr H, editor. Post lesion neural plasticity Berlin: Springer-Verlag. p 123-8.
131. 1988 The maintenance and elimination of synapses at the adult neuromuscular junction. In: Petit TL, Ivy GO, editors. Neural plasticity: a lifespan approach. New York: Alan R. Liss, Inc. p 159-70.
132. 1988 The development and maintenance of synaptic connections at the neuromuscular junction. In: Easter S, Barald KF, Carlson BM, editors. From message to mind. Sunderland, MA: Sinauer. p 168-79.
133. 1987 Properties of motor units in the transversus abdominis muscle of the garter snake. J Physiol (Lond) 393:355-74.
134. 1987 Rearrangement of synapses during development In: Friedman DP, Clovet DH, editors. The role of neuralplasticity in the response to drugs. NIDA Research Monograph 78:15-29.
135. 1987 Visualizing synaptic connections undergoing change In: Reichardt LF, Easter SS, editors. The roles of cell lineage and epigenetic effects on neuronal development. Soc Neurosci short course syllabus. p 75-81.
136. 1987 Trophic factor theory matures Nature 326:336.
137. 1987 Synaptic sites on reinnervated nerve cells visualized at two different times in living mice. J Neurosci 7(5):1492-7.
138. 1987 Visualization of neuromuscular junctions over periods of several months in living mice. J Neurosci 7(4):1215-22.
139. 1987 Fluorescent probes that stain living nerve terminals J Neurosci 7(4):1207-14.
140. 1986 Relation of animal size to convergence, divergence and neuronal number in peripheral sympathetic pathways J Neurosci 6(1):158-63.
141. 1986 Axon outgrowth in vertebrates Nature 320:210-11.
142. 1985 Regular alternation of fiber types in the transversus abdominis muscle of the garter snake. J Neurosci 5(11):2979-88.
143. 1985 Geometrical differences among homologous neurons in mammals Science 228:298-302.
144. 1985 Multiple innervation of tonic endplates revealed by activity-dependent uptake of fluorescent probes Nature 314:357-9.
145. 1985 Principles of neural development (textbook). Sunderland, MA: Sinauer Press. 433 p.
146. 1984 Anatomical basis of specific connections between sensory axons and motor neurons in the brachial spinal cord of the bullfrog. J Neurosci 4(7):1754-63.
147. 1984 Physiological evidence for specificity of synaptic connections between individual sensory and motor neurons in the brachial spinal cord of the bullfrog J Neurosci 4(7):1745-53.
148. 1984 Neurobiology by GM Shepherd book review NEJ Med 310:1197.
149. 1984 On the specificity of sensory-motor and peripheral synaptic connections. In: Kuno M, editor. Neuronal growth and plasticity. Japan Scientific Societies Press. p 149-63.
150. 1983 Activity-mediated neural change Nature 30l:563-4.
151. 1983 Specific connections between nerve cells. Annu Rev Physiol 45:553-65.
152. 1982 The reorganization of synaptic connexions in the rat submandibular ganglion during post-natal development (J Physiol 1977; 273:155-77). Reprinted in: Patterson PH, Purves D, editors. Readings in developmental neurobiology. New York: Cold Spring Harbor Laboratory Press. p 563-90.
153. 1982 Factors involved in the restoration of specific neural connections-group report. Dahlem Konferenzen. In: Nicholls JG, editor. Repair and regeneration of the nervous system. Berlin: Springer-Verlag. p 343-79.
154. 1981 Regulation of the number of axons that innervate target cells. In: Garrod DR, Feldman JD, editors. Development in the nervous system. Cambridge University Press, British Soc Dev Biol. 5:233-43.
155. 1980 Elimination of synapses in the developing nervous system. Science 2l0:l53-7.
156. 1980 The elimination of some synaptic connections in autonomic ganglia during early postnatal life. In: Taxi J, editor. Ontogenesis and functional mechanisms of peripheral synapses. Amsterdam: Elsevier. 13:15-26.
157. 1980 On the predominantly single innervation of submandibular ganglion cells in the rat J Physiol (Lond) 302:l2l-30.
158. 1980 The elimination of redundant preganglionic innervation to hamster sympathetic ganglion cells in early post-natal life. J Physiol (Lond) 30l:2l3-28.
159. 1980 Innervation of sympathetic neurones in the guinea-pig thoracic chain. J Physiol (Lond) 298:285-99.
160. 1979 On the purpose of selective innervation of guinea-pig superior cervical ganglion cells. J Physiol (Lond) 292:69-84.
161. 1978 Selective innervation of mammalian sympathetic ganglion cells In: Scripta varia of the pontificiae academiae scientarum study week on nerve cells, transmitters and behavior. 45:517-32.
162. 1978 Formation and maintenance of synaptic connections in autonomic ganglia Physiol Rev 58(4):82l-62.
163. 1977 The reorganization of synaptic connexions in the rat submandibular ganglion during post-natal development J Physiol (Lond) 273(1):l55-77.
164. 1977 Inhibition of polymorphonuclear leukocyte capping by a chemotactic factor J Immunol 118(4):1375-8.
165. 1973 Inhibition of the mitochondrial respiratory chain by alkylhydroxynaphtoquines: reversal on discharge of the energized state. Biochim Biophys Acta 314(2):154-163.

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