Biotech China 2014

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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors
1. 2010 Metronomic irinotecan therapy combined with bevacizumab for effective treatment of preclinical advanced ovarian cancer: role of SDF-1 inhibition. Int J Cancer, submitted.
2. 2010 Binding properties of epidermal growth factor receptor targeted monoclonal antibodies: factors contributing to differences in toxicity profiles Clin. Cancer Res., submitted.
3. 2010 Human tumor xenografts that acquire resistance to metronomic cyclophosphamide chemotherapy retain sensitivity to maximum tolerated cyclophosphamide doses Mol Cancer Ther, submitted
4. 2010 Development of a resistance-like phenotype to sorafenib by human hepatocellular carcinoma cells is reversible and can be delayed by metronomic UFT chemotherapy Neoplasia, in press
5. 2010 Phase I/II trial of metronomic chemotherapy with daily dalteparin and cyclophosphamide, twice-weekly methotrexate and daily prednisone as therapy for metastatic breast cancer using vascular endothelial growth factor and soluble vascular endothelial growth factor receptor levels as markers of response. J Clin Oncol., 28: 723-730.
6. 2010 Cancer Stem Cells Promote Tumor Vascular Development - Response Cancer Res. Mar. 30, epub ahead of print.
7. 2010 Liver surgery induces an immediate mobilization of progenitor cells in liver cancer patients: A potential role for G-CSF Cancer Biol Ther. May 18; 9(9). Epub ahead of print.
8. 2010 Impact of UFT/cyclophosphamide metronomic chemotherapy and antiangiogenic drug therapy assessed in a new preclinical model of locally advanced orthotopic hepatocellular carcinoma Neoplasia 12: 264-274
9. 2010 Potent preclinical impact of metronomic low-dose oral topotecan combined with the antiangiogenic drug pazopanib for the treatment of ovarian cancer Mol Cancer Ther 9: 996-1006
10. 2010 Anti-Tumor Effect of CT-322 as an Adnectin Inhibitor of Vascular Endothelial Growth Factor Receptor-2. mAbs 2: 199-208
11. 2009 Comparative impact of trastuzumab and cyclophosphamide on HER-2 positive human breast cancer xenografts Clin Cancer Res 15: 6358-6366
12. 2009 Low-dose metronomic cyclophosphamide combined with vascular disrupting therapy induces potent anti-tumor activity in preclinical human tumor xenograft models Mol Cancer Ther 8: 2872-2881.
13. 2009 Contribution of G-CSF to the acute mobilization of endothelial precursor cells by vascular disrupting agents Cancer Res., 69: 7524-7528.
14. 2009 Tumor and Host-Mediated pathways of resistance and disease progression in response to antiangiogenic therapy Clinical Cancer Res (Pathways), 15: 5020-5025.
15. 2009 Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via VEGF and SDF1. Cancer Res., 69: 7243-7251
16. 2009 Signalling to the polarity complex controls breast cancer invasion and metastasis. Proc. Nat’l Acad. Sci., USA, 106: 14028-14033.
17. 2009 Effective treatment of advanced human melanoma metastasis in immunodeficient mice using combination metronomic chemotherapy regimens. Clin. Cancer Res., 15: 4867-4874.
18. 2009 Cetuximab causes a dose-dependent increase in circulating transforming growth factor-a that acts as pharmacodynamic marker for optimal biologic dosing Clin. Cancer Res. 15: 2397-2405.
19. 2009 Acceleration of metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis Cancer Cell, 15: 232-239
20. 2009 Autocrine expression of VEGF upon uptake of tumor-derived microvesicles containing oncogenic EGFR. Proc. Nat’l Acad. Sci., USA, 106: 3794-3799.
21. 2008 Long term progression and therapeutic response of visceral metastatic disease non-invasively monitored in mouse urine using b-human choriogonadotropin secreting tumor cell lines. Mol. Cancer Ther. 7: 3452-3459
22. 2008 Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents Cancer Cell, 14: 263-273.
23. 2008 Tumor angiogenesis New Engl. J. Med. 358: 2039-2049
24. 2008 An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice J. Leukoc. Biol. 84: 59-67
25. 2008 Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas Proc. Nat’l. Acad. Sci., USA 105: E54.
26. 2008 Development of a preclinical model of spontaneous human melanoma CNS metastasis. Cancer Res., 68: 4500-4505
27. 2008 Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors Neoplasia, 10: 489-500.
28. 2008 Antiangiogenic and anti-colorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib Br. J. Cancer, 98: 1619-1629.
29. 2008 A pharmacokinetic and pharmacodynamic study on metronomic irinotecan in metastatic colorectal cancer patients Br. J. Cancer 98: 1312-1319.
30. 2008 Pharmacology of the novel anti-angiogenic peptide, ATN-161 (Ac-PHSCN-NH2): observation of a U-shaped dose response in several preclinical models of angiogenesis and tumor growth. Clin. Cancer Res., 14: 2137-2144
31. 2008 Phase I trial and pharmacokinetic study of bevacizumab in pediatric patients with refractory solid tumors: A Children’s Oncology Group Study J. Clin. Oncol., 26: 399-405
32. 2008 VEGF-mediated decrease in plasma sVEGFR-2 levels as a surrogate biomarker for tumor growth. Cancer Res., 68: 521-529
33. 2007 Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after lim ischemia. Cirulation Res., 101: 1310-1318
34. 2007 Id1 restrains p21 expression to control endothelial progenitor cell formation. PLoS One 2 (12): e1338.
35. 2007 Molecular and cellular biomarkers for angiogenesis in clinical oncology. Drug Discovery Today 12: 806-812
36. 2007 Multiple circulating pro-angiogenic factors systemically induced by sunitinib malate (SU11248) are tumor-independent and correlate with anti-tumor efficacy. Proc. Nat’l Acad. Sci. (USA), 104: 17069-17074
37. 2007 Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis Mol. Imaging 6: 289-296
38. 2007 Detecting vascular changes in tumor xenografts using micro-ultrasound and micro-CT following treatment with VEGFR-2 blocking antibodies Ultrasound Med. Biol. 33: 1259-1268.
39. 2007 Pharmacodynamic and pharmacokinetic study of chronic low-dose metronomic cyclophosphamide therapy in mice Molecular Cancer Therapeutics. 6: 2280-2289.
40. 2007 Antiangiogenic strategies on defense: blocking rebound by the tumor vasculature after chemotherapy Cancer Res. 67: 7055-7058.
41. 2007 Vascular endothelial growth factor levels in immunodepleted plasma of cancer patients as a possible pharmacodynamic marker for bevacizumab activity J. Clin. Oncol. 25: 1816-1818
42. 2007 Therapies combining a targeted antiangiogenic drug and cytotoxic or metronomic chemotherapy reduce the tumor stem-like cell fraction in glioma xenograft tumors. Cancer Res. 67: 3560-3564
43. 2007 Enhanced natural killer cell and erythropoietic activities in VEGF-A-overexpressing mice delay F-MuLV-induced erythroleukemia Blood, 109: 2139-2146.
44. 2006 The multifaceted circulating endothelial cell in cancer: from promiscuity to surrogate marker and target identification Nature Reviews Cancer, 6: 835-845.
45. 2006 Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science, 313: 1785-1787.
46. 2006 On the origin and nature of elevated levels of circulating endothelial cells (CECs) after treatment with a vascular disrupting agent J. Clin. Oncol., 24: 4040.
47. 2006 High-dose celecoxib and metronomic low-dose cyclophosphamide is an effective and safe therapy in patients with relapsed and refractory aggressive histology non–Hodgkin's lymphoma Clinical Cancer Res., 12: 5190-5198.
48. 2006 Influence of formulation vehicle on metronomic taxane chemotherapy: nanoparticle albumin-bound versus cremophor EL-based paclitaxel Clinical Cancer Res., 12: 4331-4338.
49. 2006 Antiangiogenic therapy: a universal chemosensitization strategy for cancer? Science, 312: 1171-1175
50. 2006 Highly efficacious non-toxic preclinical treatment for advanced metastatic breast cancer using combination oral UFT – cyclophosphamide metronomic chemotherapy. Cancer Res., 66: 3386-3391
51. 2006 Circulating endothelial cell kinetics and viability predict survival in breast cancer patients receiving metronomic chemotherapy Blood, 108: 452-459.
52. 2006 Targeted anti-VEGFR-2 therapy leads to short and long term impairment of vascular function and increase in tumorn hypoxia Cancer Res., 66: 3639-3648.
53. 2006 Strategies for delaying or treating in vivo acquired resistance to trastuzumab (Herceptin®) in human breast cancer xenografts Clin. Cancer Res., 12: 904-916
54. 2006 Low-dose metronomic cyclophosphamide and weekly tirapazamine: a well tolerated combination regimen with enhanced efficacy that exploits tumor hypoxia Cancer Res. 66: 1664-1674.
55. 2005 Circulating endothelial progenitor cells N Engl J Med. 353: 2613-2616.
56. 2005 Therapeutic implications of intrinsic or induced angiogenic growth factor redundancy in tumors revealed Cancer Cell 8: 269-271.
57. 2005 Angiogenesis as a therapeutic target: advances and prospects Nature, 438: 967-974
58. 2005 Downregulation of DNA mismatch repair proteins in human and murine tumor spheroids: implications for multicellular resistance to alkylating agents Molecular Cancer Therapeutics, 4: 1484-1494.
59. 2005 ras oncogene triggers upregulation of cIAP2 and XIAP in intestinal epithelial cells: EGF receptor-dependent and –independent mechanisms of ras-induced transformation. J. Biol. Chem., 280: 37383-37392.
60. 2005 Metronomic low-dose chemotherapy boosts CD95-dependent antiangiogenic effect of the thrombospondin peptide ABT-510: a complementation antiangiogenic strategy Clinical Cancer Res. 11: 6678-6685.
61. 2005 Low-dose metronomic combined with intermittent bolus-dose cyclophosphamide is an effective long-term chemotherapy treatment strategy. Cancer Res., 65: 7045-7051.
62. 2005 The optimal biological dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity Blood 106: 3058-3061
63. 2005 In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: modulation by lower dose chemotherapy. Cancer Res., 65: 5365-5373.
64. 2005 Cyclophosphamide-methotrexate metronomic chemotherapy for the palliative treatment of metastatic breast cancer. A comparative pharmacoeconomic evaluation Ann. Oncol. 16: 1243-1252.
65. 2005 The splenic microenvironment is a source of pro-angiogenesis/inflammatory mediators accelerating the expansion of murine erythroleukemic cells. Blood, 105: 4500-4507.
66. 2005 Careful decoy receptor titering is required to inhibit tumor angiogenesis while avoiding adversely altering VEGF bioavailability Molecular Therapy 11: 300-310.
67. 2005 A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice Am. J. Pathol. 166: 843-855
68. 2005 Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis: implications for cellular surrogate marker analysis of antiangiogenesis. Cancer Cell 7: 101-111
69. 2005 Anti-vascular endothelial growth factor receptor-2 (Flk-1/KDR) antibody suppresses contact hypersensitivity Exp Dermatol. 13: 671-681.
70. 2004 Increased plasma VEGF as a surrogate marker for optimal biologic dosing of VEGFR-2 monoclonal antibodies. Cancer Res. 64: 6616-6625.
71. 2004 Gene expression analysis of tumor spheroids reveals a role for suppressed DNA mismatch repair in multicellular resistance to alkylating agents. Mol. Cell. Biol. 24: 6837-6849.
72. 2004 Biomarkers, surrogate end points, and the acceleration of drug development for cancer prevention and treatment: an update prologue Clin Cancer Res. 10: 3881-3884.
73. 2004 Reanalysis of cancer drugs: old drugs, new tricks Clin. Cancer Res., 10: 3897-3907.
74. 2004 Rationale for biomarkers and surrogate endpoints in mechanism-driven oncology drug development Clin. Cancer Res., 10: 3885-3896
75. 2004 Antiangiogenic basis of low-dose metronomic chemotherapy Nature Reviews Cancer, 4: 423-436.
76. 2004 A naturally occurring soluble form of vascular endothelial growth factor receptor 2 detected in mouse and human plasma. Mol. Cancer Res., 2: 315-326
77. 2004 A comparative analysis of low dose metronomic cyclophosphamide reveals absent or low grade toxicity on tissues highly sensitive to the toxic effects of maximum tolerated dose regimens. Cancer Res., 64: 3994-4000.
78. 2004 Anti-adhesive antibodies targeting e-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro Molecular Cancer Therapeutics, 3: 149-159.
79. 2004 Versican/PG-M G3 domain promotes tumor growth and angiogenesis. The FASEB Journal, 18: 754-756.
80. 2004 Radiation resistance of human melanoma analysed by retroviral insertional mutagenesis reveals a possible role for dopachrome tautomerase Oncogene, 23: 30-38
81. 2003 Selective anti-endothelial effects of protracted low-dose BAL-9504, a novel geranylgeranyl-transferase inhibitor. Eur. J. Pharmacology 477: 17-21.
82. 2003 Marked differences between vascularity and angiogenesis in childhood pilocytic and anaplastic astrocytomas Medical Pediatric Oncology, 41: 516-526
83. 2003 Thrombospondin-1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc. Nat’l Acad. Sci. (USA), 100: 12917-12922.
84. 2003 Metronomic Therapy with Cyclophosphamide and Dexamethasone for Prostate Carcinoma. Cancer, 98: 1643-1648.
85. 2003 Contrasting effects of VEGF gene disruption in embryonic stem cell-derived versus oncogene-induced tumors EMBO J., 22: 4091-4102
86. 2003 Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells Cancer Res., 63: 4342-4346
87. 2003 Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization Journal of Biological Chemistry, 278: 30170-30179.
88. 2003 A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function Molecular & Cellular Biology, 23: 2658-2668
89. 2002 Imatinib mesylate (STI 571) reduces Bcr-Abl mediated VEGF secretion in chronic myelogenous leukemia. Molecular Cancer Res., 1: 89-95
90. 2002 Clinical translation of angiogenesis inhibitors. Nature Reviews Cancer, 2: 727-739.
91. 2002 Disruption of cell-cell adhsion enhances antibody-dependent cellular cytotoxicity: Implications for antibody-based therapeutics of cancer. Cancer Res., 62: 6891-6900
92. 2002 High frequency doppler ultrasound monitors the effects of antivascular therapy on tumor blood flow. Cancer Res., 62: 6371-6375.
93. 2002 Protracted low-dose effects on human endothelial cell proliferation, adhesion and migration in vitro reveals a potential "antiangiogenic window" for chemotherapeutic drugs Cancer Res., 62: 6938-6943.
94. 2002 Anti-tumor and anti-angiogenic effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water Cancer Res., 62: 2731-2735.
95. 2002 VEGF isoform expression as a determinant of blood vessel patterning in human melanoma xenografts. Cancer Res., 62: 1838-1846
96. 2002 A role of survivin in chemoresistance of endothelial cells mediated by VEGF. Proc. Nat’l. Acad. Sci., USA, 99: 4349-4354
97. 2002 Effect of p53 status on tumor response to antiangiogenic therapy. Science, 295: 1526-1528.
98. 2002 Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug resistant human breast cancer xenograft Clin. Cancer Res., 8: 221-232.
99. 2001 Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak EMBO Journal, 20: 5919-5928.
100. 2001 Differentiated tumor architecture is lost in gastric cancer xenografts but maintained in spheroid culture. Gastroenterology, 121: 839-852.
101. 2001 Acquired resistance to the anti-tumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis Cancer Res. 61: 5090-5101
102. 2001 Induction of Anoikis and Suppression of Human Ovarian Tumor Growth In Vivo by Downregulation of Bcl-XL Cancer Res. 61: 4837-4841
103. 2001 RB2/p130 gene-enhanced expression down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in vivo Cancer Res., 61(2):462‑468
104. 2001 Heterogeneous vascular dependency of tumor cell populations. Am. J. Path., 158: 1325-1334
105. 2000 TYRP-2 mediated resistance to cis-diamminedichloroplatinum(II) in human melanoma cells is independent of tyrosinase, TYRP1 expression, and melanin content. Melanoma Res. 10: 499-505.
106. 2000 Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341. Clin. Cancer Res., 6: 3719-3728
107. 2000 Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner. Oncogene, 19: 4611-4620.
108. 2000 Activated ras prevents downregulation of Bcl-XL triggered by detachment from the extracellular matrix: a mechanism of ras-induced resistance to anoikis in intestinal epithelial cells J. Cell Biol., 149: 447-455.
109. 2000 Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J. Clin. Invest., 105: R15-R24.
110. 2000 Tumor angiogenesis: past, present and the near future. In Carcinogenesis, 21: 505-515.
111. 2000 Oncogenes and tumor angiogenesis: differential modes of VEGF upregulation in ras-transformed epithelial cells and fibroblasts Cancer Res., 60: 490-498.
112. 2000 Tyrosinase-related protein-2 as a mediator of melanoma specific resistance to cis-diamminedichloroplatinum(II): therapeutic implications Oncogene, 19: 395-402.
113. 2000 High-frequency color flow imaging of the microcirculation Ultrasound Med. Biol. 26: 63-71
114. 1999 Marked induction of the IAP family anti-apoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells Biochemical and Biophysical Research Communication, 264: 781-788
115. 1999 Proteolytic switching’: opposite patterns of regulation of gelatinase B and its inhibitor Timp-1 during human melanoma progression and consequences of gelatinase B overexpression. Br. J. Cancer, 80: 504-512
116. 1999 Functional dissociation of anoikis-like cell death and activity of stress activated protein kinase. Biochemical and Biophysical Research Communications, 260: 48-53.
117. 1999 Collateral expression of pro-angiogenic and tumorigenic properties in intestinal epithelial cell variants selected for resistance to anoikis Neoplasia, 1: 23-30.
118. 1999 Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma Oncogene, 18: 1023-1032.
119. 1998 Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas Clin. Cancer Res., 4: 791-797.
120. 1998 Termination of the dormant phenotype of early stage primary human cutaneous melanoma by overexpression of vascular endothelial growth factor. Angiogenesis, 2: 203-217
121. 1998 Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors Cancer Lett. 131: 35-44
122. 1998 Downregulation of the pro-apoptotic protein Bak is required for the ras-induced transformation of intestinal epithelial cells. Current Biol., 8: 1331-1334
123. 1998 von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids. Cancer Res., 58: 4957-4962.
124. 1998 E-cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27KIP1 J. Cell. Biol., 142: 557-571
125. 1998 Protein expression of the cell-cycle inhibitor p27Kip1 in malignant melanoma: inverse correlation with disease-free survival Am. J. Path. 153: 305-312.
126. 1998 Impact of oncogenes in tumor angiogenesis: mutant K-ras upregulation of VEGF/VPF is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells Proc. Natl. Acad. Sci. (USA), 95: 3609-3614.
127. 1997 Neutralizing antibodies against EGF and ErbB-2/neu receptor tyrosine kinases down-regulate VEGF production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors Am. J. Path., 151: 1523-1530.
128. 1997 Differential expression patterns of S100A2, S100A4 and S100A6 during progression of human malignant melanoma Int. J. Cancer, 74: 464-469
129. 1997 Abrogation of taxol-induced G2-M arrest and apoptosis in human ovarian cancer cells grown as multicellular tumor spheroids Cancer Res., 57: 2388-2393.
130. 1996 TGF-β mediated G1 arrest in a human melanoma cell line lacking p15INK4B: Evidence for cooperation between p21CIP1/WAF1 and p27KIP1. Oncogene, 13: 2447-2457.
131. 1996 Cyclin kinase inhibitor p21WAF1/CIP1 in malignant melanoma. Am. J. Path., 149:1813-1822.
132. 1996 Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents Nature Medicine, 2:1204-1210
133. 1996 Reversal of hyaluronidase of adhesion-dependent multicellular drug resistance in mammary carcinoma cells J. Natl. Cancer Inst., 88:1285-1296
134. 1996 Endogenous interleukin 6 can function as an in vivo growth-stimulatory factor for advanced-stage human melanoma cells Clin. Cancer Res., 2:1417-1425
135. 1996 Multiple features of advanced melanoma recapitulated in tumorigenic variants of early stage (radial growth phase) human melanoma cell lines: evidence for a dominant phenotype. Cancer Res., 56:3075-3086
136. 1995 TGFβ1 is an autocrine positive regulator of colon carcinoma U9 cells in vivo as shown by transfection of a TGF-β1 antisense expression plasmid Cell Growth Diff., 6:1635-1642.
137. 1995 Massive programmed cell death in intestinal epithelial cells induced by three-dimensional growth conditions: suppression by mutant c-H-ras oncogene expression. J. Cell Biol., 131:1587-1598
138. 1995 Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res., 55:4575-4580
139. 1995 The 92 kDa gelatinase B is expressed by advanced stage melanoma cells: Suppression by somatic cell hybridization with early stage melanoma cells. Cancer Res., 55:4174-4181
140. 1995 Constitutive production of 92 kDa gelatinase B can be suppressed by alterations in cell shape Exp. Cell Res., 218:508-515
141. 1995 Expression of leukemia inhibitory factor (LIF) and interleukin-11 (IL-11) by human melanoma cell lines: LIF, IL-6, and IL-11 are not co-regulated. J. Interferon and Cytokine Res., 15:455-460
142. 1995 The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells Oncogene 10:1855-1864
143. 1995 Interleukin 12: Newest member of the antiangiogenesis club. J. Natl. Cancer Inst., 87:557-559.
144. 1995 Retroviral insertional mutagenesis as a stragegy for the indentificaiton of genes associated with cis-diamminedichloroplatinum (II) resistance Cancer Res., 55:1139-1145
145. 1994 Extent of vascularization as an independent prognostic indicator in thin (0.76 mm) malignant melanomas Am. J. Path., 148:510-514.
146. 1994 Rapid acquisition of `multicellular' drug resistance after transient exposure of mammary tumor cells to alkylating agents J. Natl. Cancer Inst. 86:975-982.
147. 1994 Progressive loss of sensitivity to endothelium-derived growth inhibitors expressed by human melanoma cells during disease progression. J. Cell. Physiol., 159:245-255
148. 1994 Variant sublines of early-stage human melanomas selected for tumorigenicity in nude mice express a multicytokine resistant phenotype Am. J. Pathol., 144:776-786.
149. 1993 Growth advantage (clonal dominance) of metastatically-competent tumor cell variants expressed under selective two or three dimensional tisue culture conditions. In Vitro Cell. & Dev. Biol., 29A: 742-748
150. 1993 Lack of influence of c-Ha-ras expression on the drug sensitivity of human bladder cancer histocultured in three-dimensions. cer Res., 13:941-946.
151. 1993 Increased resistance to oncostatin M-induced growth inhibition of human melanoma cell lines derived from advanced-stage lesions Cancer Res., 53:2708-2711.
152. 1993 Establishment and characterization of first trimester human trophoblast cells with extended lifespan Exp. Cell Res., 206:204-211
153. 1993 Acquired multicellular-mediated resistance to alkylating agents in cancer. Proc. Natl. Acad. Sci. (USA), 90: 3294-3298
154. 1993 Repression of autocrine TGF-β1 and β2 in quiescent CBS colon carcinoma cells leads to progression of tumorigenic properties Cell Growth and Differentiation, 4:115-123.
155. 1993 Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression J. Cell Biol., 120:1281-1288.
156. 1993 Responsiveness of normal/dysplastic melanocytes and melanoma cells from different lesional stages of progression to the growth inhibitory effects of TGF-β Mol. Cell. Diff., 1:21-40.
157. 1993 Tumor cells grown as monolayers or multicellular spheroids indicate autoregulation of TGF-β gene expression is dependent on tissue architecture In Vitro. Develop. Cell Biol., 29:105-108
158. 1992 Structure and function of murine TIMP gene Matrix 1:269-74
159. 1992 Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells Cancer Res., 52:6969-6975
160. 1992 Expression of multicytokine resistance and multigrowth factor independence in advanced stage metastatic cancer: malignant melanoma as a paradigm Am. J. Path., 141:519-524
161. 1992 A fibroblast-derived growth inhibitor of human melanoma cells from early but not advanced stages of tumor progression Proc. Nat. Acad. Sci., U.S.A., 89:9215-9219.
162. 1992 TGF-β1 as a negative growth regulator of human cancer growth in vivo revealed by transfection of an anti-sense expression vector. J. Cell Biol., 116:187-196
163. 1992 Extensive multi-organ metastases of histologically-intact human bladder carcinoma in nude mice. Int. J. Cancer, 49:938-939
164. 1991 Transglutaminase stabilizes melanoma adhesion under laminar flow Cell Biophysics, 18:123-143.
165. 1991 Cloning and overexpression of TGF-β1 cDNA in a mammary adenocarcinoma: in vitro and in vivo effects Growth Factors, 5:305-316
166. 1991 Ha-ras induction of the invasive phenotype results in up-regulation of epidermal growth factor receptors and altered responsiveness to epidermal growth factor in human papillary transitional cell carcinoma cells Cancer Res., 51: 4486-4491.
167. 1991 Cytogenetic heterogeneity of genetically marked and metastatically competent "dominant" tumor cell clones Cancer Genetics & Cytogenetics, 54:153-161.
168. 1991 Reduction of TGF-beta activity abrogates growth promoting tumor cell-cell interactions in vivo. J. Cell. Physiol., 148:380-390.
169. 1991 Autocrine and paracrine regulation of tissue inhibitor of metalloproteinases (TIMP), transin and urokinase gene expression in metastatic and nonmetastatic mammary carcinoma cells Cell Growth and Differentiation, 2:335-341.
170. 1991 Constitutive expression and secretion of proteases in nonmetastatic SP1 mammary carcinoma cells and its metastatic sublines Int. J. Cancer, 48:557-561
171. 1991 Fibroblast interactions with human melanoma cells affect tumor cell growth as a function of tumor progression Proc. Natl. Acad. Sci. (USA), 88:6028-6032
172. 1991 Dominance of metastatically competent cells in primary murine breast neoplasms is necessary for distant metastatic spread Int. J. Cancer, 47:118-123.
173. 1991 Drug-induced hypomethylation and reactivation of the asparagine synthetase gene: a new model for acquired drug resistance Cancer Res., 51: 985-989
174. 1990 Cure of human melanoma lung metastases in nude mice with chronic indomethicin therapy combined with multiple rounds of 1L-2: characteristics of killer cells generated in situ Int. Immunol., 2: 1149-1158
175. 1990 Overexpression of normal and mutated forms of c-Ha-ras induce orthotopic bladder invasion in a human superficial transitional cell carcinoma Proc. Natl. Acad. Sci. (USA), 87:9047-9051
176. 1990 Tumor cell surface β1-4-linked galactose binds to lectin(s) on microvascular endothelial cells and contributes to organ colonization J. Cell. Biol., 111:773-782.
177. 1990 Basement membrane invasion by first trimester human trophoblast: requirement for branched complex-type asn-linked oligosaccharides Clin. Exp. Metastasis, 8: 305-317
178. 1989 Modulation by interferons of HLA antigens, high molecular weight -- melanoma associated antigen and intracellular adhesion molecule-1 expression by cultured melanoma cells with different metastatic potential Cancer Research, 49: 2980-2987
179. 1989 Enhanced tumorigenicity, melanogenesis, and metastasis of a human malignant melanoma observed after subdermal implantation in nude mice J. Natl. Cancer Inst., 81: 938-944.
180. 1989 Mechanisms of cellular invasiveness: A comparison of amnion invasion in vitro and metastatic behaviour in vivo J. Natl. Cancer Inst., 81: 768-775.
181. 1989 Increased class I major histocompatibility antigen expression fails to alter tumor immunogenicity of a spontaneous murine carcinoma J. Natl. Cancer Institute, 81: 759-767.
182. 1989 Possible involvement of Ca2+ mobilization and protein kinase c activation in the induction of spontaneous metastasis by mouse mammary adenocarcinoma cells. Cancer Res., 49: 2597-2602
183. 1989 Characterization of a metastasis deficient lectin-resistant human melanoma mutant. Int. J. Cancer, 43: 134-139
184. 1988 Genetic evidence for progressive selection and overgrowth of primary tumors by metastatic cell subpopulations Cancer Res., 48: 6109-6114.
185. 1988 Highly pigmented human melanoma variant which metastasizes widely in nude mice including to skin and brain Cancer Res., 48: 4897-4903
186. 1988 Genetic tagging of tumor cells with retrovirus vectors: clonal analysis of tumor growth and metastasis in vivo. Mol. Cell. Biol., 8: 3143-3149.
187. 1988 Differential induction by immune interferon of the gene products of the HLA-D region on the melanoma cell line MeWo and its metastatic variant MeM 50-101 J. Immunol., 141: 913-920
188. 1988 Heritable high frequency modulation of antigen expression in neoplastic cells exposed to 5-aza-2' deoxycytidine or hydroxyurea: analysis and implications. Cancer Res., 48: 2440-2445
189. 1988 Isolation and characterization of spontaneous wheat germ agglutinin-resistant (WGAr) human melanoma mutants displaying remarkably different metastatic profiles in nude mice. Cancer Res. 48: 665-670
190. 1987 Metastatic potential of SP1 mouse mammary adenocarcinoma cells is differentially induced by activated and normal forms of c-H-ras Oncogene 1: 149-155.
191. 1987 Reduced levels of DNA 5-methylcytosine in metastatic variants of the human melanoma cell line MeWo Cancer Res. 47: 2264-2267
192. 1987 Selection of metastatic variants from a non-metastatic murine tumor after treatment with 2'deoxy-5-azacytidine or hydroxyurea: implications for the mechanisms of tumor progression. Cancer Res., 47: 2690-2695
193. 1987 β1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis. Science 236: 582-585
194. 1987 Alteration of the tumorigenic and metastatic properties of neoplastic cells is associated with the process of calcium phosphate mediated DNA transfection Proc. Natl. Acad. Sci. (USA) 84: 1263-1267
195. 1986 Periodate-oxidized adenosine induction of murine thymidine kinase: role of DNA methylation in the generation of tumor cell heterogeneity Cancer Res. 46: 577-582.
196. 1985 Induction of thymidine kinase activity in a spontaneously enzyme-deficient murine tumor cell line by exposure in vivo to the DNA hypomethylation agent 5-Aza-2'-deoxycytidine: implications for mechanisms of tumor progression Cancer Res. 45: 5294-5298.
197. 1985 Enhanced expression of class 1 MHC (Dk) gene products on immunogenic variants of a spontaneous murine carcinoma J. Natl. Cancer Inst. 75: 291-301.
198. 1984 Single-step selection of unique human melanoma variants displaying unusually aggressive metastatic behavior in nude athymic mice Invasion & Metastasis 4: 31-43.
199. 1984 Adoptive immune therapy of mice bearing poorly immunogenic metastases using T lymphocytes stimulated in vitro against highly immunogenic mutant sublines. Int. J. Cancer 34: 709-716
200. 1984 Metastatic properties of distinct phenotypic classes of lectin-resistant mutants isolated from the murine MDAY-D2 cell line Somatic Cell and Molecular Genetics 10: 503-519
201. 1984 Characterization of in vitro immunoselected variants from a highly metastatic murine tumor for alterations in malignant behavior in vivo. Int. J. Cancer 33: 669-675.
202. 1984 Alterations in sensitivity to nonspecific cell-mediated lysis associated with tumor progression: characterization of activated macrophage- and natural killer cell-resistant tumor variants. J. Natl. Cancer Inst. 73: 483-491
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