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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors
1. 2011 Potent mGluR5 antagonists: Pyridyl and thiazolylethynyl 1-3,5-disrupted-phenyl series . Bioorg Med Chem Lett (submitted).
2. 2011 Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators Bioorg. Med. Chem. Lett 20:5617-22 PMCID: PMC Journal – In Process
3. 2011 Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs, and partial antagonists Bioorg Med Chem Lett (in press) PMCID: PMC Journal – In Process
4. 2011 Molecular switches on mGluR allosteric ligands that modulate modes of Pharmacology Biochemistry (in press) PMCID: PMC Journal – In Process
5. 2011 Design and synthesis of substituted N-(1,3-Diphenyl-1H-pyrazol-5-yl) benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 Bioorg Med Chem Lett (in press) PMCID: PMC Journal – In Process
6. 2011 Highly Selective mAChR subtype I (M1) allosteric agonists based on a 1-(1’-substituted)-1,4’-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one scaffold with disease modifying potential for Alzheimer’s Disease J. Med. Chem. (submitted)
7. 2011 Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive alloseric modulator (PAM) that decreases cocaine self-administration in rats ACS MedChemLett (submitted)
8. 2011 Discovery of N-Aryl Piperzaines as selective mGlur5 potentiators with efficacy in a rodent model predictive of anti-psychotic activity ACS MedChemLett (submitted)
9. 2010 Metabotropic glutamate receptors: physiology, pharmacology, and disease Annual Reviews in Pharmacology and Toxicology. 50:295-322. PMCID: PMC2904507
10. 2010 Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders Mol Biosyst 6:1345-54. PMCID: PMC 20582156
11. 2010 3-cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats Bioorg Med Chem Letter 20:4390-4. PMCID: PMC 20598884
12. 2010 Synthesis and SAR of novel, 4-(phenylsulfamoyl) phenylacetamide mGluR4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS) Bioorg Med Chem Lett 20:5175-8. PMCID: PMC 20667732
13. 2010 3D Qsar coMFA study of benzoxazepine derivatives as mGluR5 positive allosteric modulators Bioorg Med Chem Lett 20:5922-24. PMCID: PMC 20732812
14. 2010 Chemincal lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM Bioorg Med Chem Lett 20:558-62. PMCID: PMC: 2004578
15. 2010 Discovery of novel allosteric modulators of metabotropic glutatmate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity Mol Pharmacol Oct. 13 [Epub ahead of print]. PMCID: PMC 20923853
16. 2010 Differntial effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation arrestin 3 recruitment and receptor downregulation ACS Chem Neurosci 1:542-551. PMCID: PMC 20835371
17. 2010 Structure-activity relationships in a Novel Series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5 Bioorg Med. Chem 18:3026-35. PMCID: PMC 20382541
18. 2010 Identification of mrtabotropic glutamate receptor subtype 5 potentiators using virtual high-throughput screening ACS Chem Neurosci 1:288-305. PMCID: PMC 20382541
19. 2010 The antipsychotic potential of muscarinic allosteric modulation Drug News and Perspectives 23:229-240. PMCID: PMC Journal – In Process
20. 2010 Selective potentiation of the metabotropic glutamate receptor subtype 2 blocks phencyclidine-induced hyperlocomotion and brain activation. Neuroscience 168:209-18. NIHMSID: 193246 PMCID: PMC Journal – In Process
21. 2010 The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats Neuropshychopharmacology 35:2021-36. PMCID: PMC 2055310
22. 2010 Attenuation of cocaine’s reinforcing and discriminative stimulus effects via muscarinic acetylcholine M1 receptor stimulation J. Pharmacol. Exp. Ther. 332:959-69. PMCID: PMC 2835434
23. 2010 Discovery and Development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype (mAChR 1 or M(1)) antagonist in vitro and in vivo probe Curr Top Med Chem (in press). PMCID: PMC Journal – In Process
24. 2010 Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous system ACS Chemical Neuroscience (in press). PMCID: PMC Journal – In Process
25. 2010 A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and can restore impairments to reversal learning J Neurosci (in press) PMCID: PMC 281132
26. 2010 Orthosteric-and allosteric-induced ligand-directed trafficking at GPCRs Curr Opinion in Drug Discovery and Development 13:587-594 PMCID: PMC Journal – In Process
27. 2010 Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential Neuropharmacology 60:66-81. PMCID: PMC 20637216
28. 2010 The antipsychotic potential of muscarinic allosteric modulation Drug News & Perspectives. (in press) PMCID: PMC Journal – In Process
29. 2010 Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7 Mol Pharmacol 77:459-68. PMCID: PMC 20026717
30. 2010 Re-exploration of the PHCCC Scaffold: discovery of improved positive allosteric modulators of mGluR4 ACS Chem Neurosci 16:411-419. PMCID: PMC 20582156
31. 2009 A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin Bioorg Med Chem Lett 19:3204-08. PMCID: PMC Journal – In Process
32. 2009 Structure activity relationships comparing N-(6-methylpyridin-yl)-substituted ArylAmides to 2-methyl-6-(substituted-arylethynyl) pyridines or 2-methyl-4-(substituted-aryl ethynyl) thiazoles as novel mGluR5 antagonists J. Med. Chem. 52:3563-75. PMCID: PMC2894482
33. 2009 Discovery of Molecular Switches that modulate modes, of mGluR5 Pharmacology In Vitro and In Vivo within a series of functionalized, regioisomeric 2- and 5- (Phenylethynyl) pyrimidines” J. Med. Chem 52:4103-06. NIHMSID: 132590 PMCID: PMC Journal – In Process
34. 2009 Synthesis and structure-activity-relationships of novel allsoteric potentiators of the M4 muscarinic acetylcholine receptor ChemMedChem 4:1600-1607. PMCID: PMC 2887613
35. 2009 Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4) Bioorg. Med. Chem. Lett 19:4967-4970. PMCID: PMC2752865
36. 2009 A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning Mol Pharmacol 76:356-68. PMCID: PMC2713127
37. 2009 [18F]fallypride dopamine D2 receptor studies using delayed microPET scans and a Logan plot Nucl Med Biol 36:931-40 PMCID: PMC2771119
38. 2009 Allosteric Modulators of GPCRs as a Novel Approach for Treatment of CNS Disorders Nature Review Drug Discov. 8:41-54. PMCID: PMC2907734
39. 2009 Discovery and SAR of Novel mGluR5 non-competitive antagonists not based on an MPEP chemotype Bioorg Med Chem Lett 19:3209-13. NIHMSID: 113891 PMCID: PMC Journal – In Process
40. 2009 mGluR5 PAMs facilitate LTP and LTD induction Neuropsychopharmacology 34:2057-71. PMCID: PMC 2884290.
41. 2009 Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-Benzyl Isatins J Med Chem 52:3445-48 PMCID: PMC Journal – In Process
42. 2009 Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) Part II: Challenges in hit-to-lead Bioorg Med Chem Lett 19:962-6. PMCID: PMC Journal – In Process
43. 2009 Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273 ChemMedChem 4:505-11. PMCID: PMC2865690
44. 2009 Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs) J. Med. Chem. 52:4115-18. PMCID: PMC2765192
45. 2009 Promise of mGluR2/3 activators in psychiatry Neuropsychopharmacology 34:248-9. PMCID: PMC2907744
46. 2008 Selective allosteric activation of the M1 muscarinic acetylcholine receptor produces antipsychotic-like activity and disease modifying potential for Alzheimer’s Disease J. Neurosci. 28:10422-33. PMCID: PMC18842902
47. 2008 Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders Trends Pharmacol Sci 30:148-55. PMCID: PMC2907736
48. 2008 Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia Trends Pharmacol Sci 30:25-31. PMCID: PMC2907735
49. 2008 Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Mol Pharmacol 75:577-88. PMCID: PMC2684909
50. 2008 Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties Bioorg Med Chem Lett. 18:5439-42. NIHMSID: 75284 PMCID: PMC Journal – In Process
51. 2008 Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas-The effect of capping the distal basic piperidine nitrogen Bioor Med Chem Lett 18:5443-47. NIHMSID: 75286 PMCID: PMC Journal – In Process
52. 2008 Centrally active allosteric potentiators of muscarinic acetylcholine receptor subtype 4 (mAChR4) reverse amphetamine-induced hyperlocomotor behavior in rats J. Pharmacol. Exp. Ther.327:941-53. PMCID: PMC2745822
53. 2008 Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo [3,4-d] pyrimidines as novel mGluR4 positive allosteric modulators Bioorg Med Chem 18:5626-30. PMCID: PMC18793851
54. 2008 Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4 Mol Pharmacol. 74:1345-58. PMCID: PMC18664603
55. 2008 Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate different signaling pathways in baby hamster kidney cells Neuropharmacology 55:419-427. PMCID: PMC18625258
56. 2008 Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract-piriform Cortex Synapse Neuropharmacology 55:440-446. PMCID: PMC18625254
57. 2008 Opportunities and challenges of psychiatric drug discovery: roles for scientists in academic, industry, and government settings Neuropsychopharmacology 33:2048-60. PMCID: PMC18216778
58. 2008 MGluR5 mediates the interaction between late-LTP, network activity, and learning PLoS ONE 3:e2155. PMCID: PMC2364645
59. 2008 Synthesis and SAR of a MGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold Bioorg Med Chem Lett. 18:4098-101. PMCID: PMC18550372
60. 2008 Schizophrenia: moving beyond monoamine antagonists Molecular Interventions. 8:99-107. PMCID: PMC Journal – In Process
61. 2008 Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated Neuropharmacol. 54:804-14. PMCID: PMC2431171
62. 2008 N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2yl)methyl]phenyl}-2 hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors Mol Pharmacol. 73:909-18. PMCID: PMC18056795
63. 2008 A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors Mol Pharmacol 73:1213-24. PMCID: PMC18171729
64. 2008 Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists Bioorg Med Chem Lett 18:885-90. PMCID: PMC2275053
65. 2008 mGluR5 positive allosteric modulators Drugs of the Future. 33:355-60. PMCID: PMC Journal – In Process
66. 2008 An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission Nat Chem. Biol. 4:42-50. PMCID: PMC Journal – In Process
67. 2007 Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses Mol Pharmacol. 71:1389-98
68. 2007 Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA Bioorg Med Chem Lett. 17:1386-91
69. 2007 Molecular Pharmacology in the Postgenomic Era Mol. Pharmacol. 71: 1-2
70. 2007 D1- and D2-like dopamine receptors regulate signaling properties of group I metabotropic glutamate receptors in the rat globus pallidus Eur. J. Neurosci. 26:852-62
71. 2007 A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors J. Pharmacol. Exp. Ther. 322:254-64
72. 2007 A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis Mol. Pharmacol. 72:477-84
73. 2007 Preclinical drug discovery research and training at Vanderbilt ACS Chem Biol. 2: 17-20
74. 2006 Glutamate-based therapeutic approaches: Allosteric modulators of metabotropic glutamate receptors Curr Opin Pharmacol. 6:98-102
75. 2006 Metabotropic Glutamate Receptor Ligands in Therapeutics, The Glutamate Receptors (Gereau R.W., and Swanson, G.T., eds). Humana Press. Inc.,  Totowa, NJ
76. 2006 mGluR7’s lucky number Proc. Natl. Acad. Sci. USA. 103:251-2
77. 2006 A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators Mol. Pharmacol. 70:616-26
78. 2006 Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice J. Pharmacol. Exp. Ther. 318:173-85
79. 2006 Design, synthesis, and in vivo efficacy of novel glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-Phenyl-1-(propylsulfonyl) piperidin-4-yl] menthyl benzamides ChemMedChem . 1:807-11
80. 2006 Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl) benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes J. Med. Chem. 49:3332-44
81. 2005 Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus Neuropharmacol 49: 57-69
82. 2005 Group III metabotropic glutamate-receptor mediated modulation of excitatory transmission in rodent substantia nigra pars compacta dopamine neurons
83. 2005 A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models J Pharmacol. Exp. Ther. 313:199-206
84. 2005 Clozapine potentiation of N-methyl-D-aspartate receptor currents in the nucleus accumbens: Role of NR2B and protein kinase A/Src kinases J. Pharmacol. Exp. Ther. 313: 594-603
85. 2005 Novel potential therapeutics for schizophrenia: focus on the modulation of metabotropic glutamate receptor function Curr Neuropharmacol. 3: 9-34
86. 2005 New and emerging approaches to treatment of schizophrenia Curr Neuropharmacol. 3: 1-2
87. 2005 Modulation of N-methyl D-aspartate receptor function as a novel approach for development of antipsychotic agents In: S. van de Witte (Ed) Thinking About Cognition: Concepts, Targets, and Therapeutics, Solvay Pharmaceuticals Conferences, IOS Press, Amsterdam
88. 2005 Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes J. Pharmacol. Exp. Ther. 315:1212-19
89. 2005 A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators Mol. Pharmacol. 68:1793-1802
90. 2005 A selective allosteric potentiator of metabotropic glutatmate (mGlu2) receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity J. Pharmacol. Exp. Ther. 315:1181-1187
91. 2005 Metabotropic glutamate receptors in the basal ganglia motor circuit Nature Rev. Neurosci. 6: 787-98
92. 2005 New therapeutic frontiers for metabotropic glutamate receptors Curr. Top. Med. Chem. 5:847-57
93. 2005 NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin Neuropharmacol. 49: 135-145
94. 2004 The mGluR5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP), potentiates PCP-induced cognitive deficits in rats Psychopharmacol. 175:310–318.
95. 2004 Metabotropic glutamate receptors. In: W. J. Lennarz and M.D. Lane (Eds) Encyclopedia of Biological Chemistry. Academic Press/Elsevier Science, San Diego, CA
96. 2004 Effects of typical and atypical antipsychotics on human glycine transporters Schizophrenia Res. 71:103-12
97. 2004 Metabotropic glutamate receptors modulate feedback inhibition in a developmentally regulated manner in rat dentate gyrus. J Physiol 561:395-401
98. 2004 Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 (mGluR5) from a series of n-(1,3-diphenyl-1h-pyrazol-5-yl) benzamides that potentiate receptor function . J. Med. Chem. 47: 5825 - 5828
99. 2004 A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 (mGluR5) in rat forebrain . J. Pharmacol. Exp. Ther. 309:568–577
100. 2003 G-protein coupled receptor kinases regulate metabotropic glutamate receptor 5 function and expression Neuropharmacol. 44:699-706
101. 2003 Distinct functional roles of metabotropic glutamate receptors 1 and 5 in the rat globus pallidus J. Neurosci. 23:122-130
102. 2003 Modulation of inhibitory transmission in the rat globus pallidus by activation of mGluR4 Annals New York Acad. Sci. 1003:435-437
103. 2003 Physiological roles and therapeutic potential of metabotropic glutamate receptors Annals New York Acad. Sci. 1003:12-21
104. 2003 The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia Proc. Natl. Acad. Sci. USA 100: 13019-1302
105. 2003 Allosteric modulation of the group iii metabotropic glutamate receptor mglur4: a novel approach to parkinson’s disease treatment Proc. Natl. Acad. Sci. USA 100: 13668-13673
106. 2003 N-Desmethyl clozapine, major metabolite of Clozapine is an ectopic site agonist at the M1 muscarinic receptor Proc. Natl. Acad. Sci. USA 100:13674-13679
107. 2003 Development of a scintillation proximity assay for analysis of Na+/Cl- dependent neurotransmitter transporter activity Analytical Biochem. 321:31-37
108. 2003 A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5) Mol. Pharmacol. 64:731-740
109. 2003 Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4’-fluorophenyl)-3-(4’-phenylphenoxy)propyl])sarcosine Neuropharmacol. 45:585-593
110. 2003 The GlyT1 inhibitor NFPS potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior. J. Neurosci. 23:7586-91
111. 2003 Group III metabotropic glutamate receptor-mediated modulation of the striato-pallidal synapse J. Neurosci. 23: 7218-7226
112. 2003 Metabotropic glutamate5 (mGluR5) receptors modulate locomotor activity and sensorimotor gating in rodents J. Pharmacol. Exp. Ther. 306:116-123
113. 2003 Glutamate receptors and Parkinson's disease: Opportunities for intervention Drugs Aging 20:377-97
114. 2003 Difference in mGluR5 interaction between positive allosteric modulators from two structural classes Annals New York Acad. Sci. 1003:481-484
115. 2003 Modulation of excitatory transmission onto midbrain dopaminergic neurons of the rat by activation of group III metabotropic glutamate receptors Annals New York Acad. Sci. 1003:479-480
116. 2002 Haloperidol-induced alteration in the physiological actions of group I mGluRs in the subthalamic nucleus and the substantia nigra pars reticulata Neuropharmacology 43: 147-159
117. 2002 Localization and physiological roles of metabotropic glutamate receptors in the direct and indirect pathways of the basal ganglia Amino Acids. 23:185-91
118. 2002 Differential regulation of mGluR5-mediated phosphoinositide hydrolysis and extracellular signal-regulated kinase responses by PKC in cultutred astrocytes J. Neurochem. 83: 110-118
119. 2002 Dopmaine modulates the function of Group II and Group III metabotropic glutamate receptors in the substantia nigra pars reticulata J. Pharmacol. Exp. Ther. 302:433-441
120. 2002 NMDA-Induced phosphorylation and regulation of mGluR5 Pharmacol., Biochem, Behav. (special issue devoted to metabotropic glutamate receptors) 73:299-306
121. 2002 Interaction between metabotropic glutamate receptor 7 and alpha tubulin. . J. Neurochem. 80: 980-988
122. 2002 Direct and indirect modulation of the N-methyl D-aspartate receptor: Potential for development of novel antipsychotic therapies Curr Drug Targets-CNS Neurol Disord. 1: 1-16
123. 2002 Metabotropic glutamate receptors Pharmacol. Biochem. Behav. (special issue devoted to metabotropic glutamate receptors) 74: 255-256
124. 2002 activation of group-III metabotropic glutamate receptors inhibits the production of Rantes in glial cell cultures J. Neurosci. 22: 5403-5411
125. 2002 Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function. Mol. Pharmacol. 61:1303-1312
126. 2002 Modulation of the basal ganglia by metabotropic glutamate receptors: Potential for novel therapeutics. Curr Drug Targets-CNS Neurol Disord. 1: 239–250
127. 2002 Distinct physiological roles of the Gq coupled metabotropic glutamate receptors co-expressed in the same neuronal populations J. Cellular Physiol. 191: 125 – 137
128. 2001 Activation of group I and III metabotropic glutamate receptors inhibits excitatory transmission in the rat subthalamic nucleus Neuropharmacol. 41: 32-41
129. 2001 Physiological roles of multiple metabotropic glutamate receptor subtypes in the rat basal ganglia. In: I. Ilinsky (Ed) Basal Ganglia and Thalamus in Health and Movement Disorders, Klumer/Plenum Academic Publishers, New York, NY
130. 2001 The roles of metabotropic glutamate receptors in modulating the activity of the subthalamic nucleus. In: L.F.B. Nicholson (Ed . Basal Ganglia VII. Klumer/Plenum Academic Publishers, New York, NY
131. 2001 Metabotropic glutamate receptors in the globus pallidus. In: L.F.B. Nicholson (Ed Basal Ganglia VI. Klumer/Plenum Academic Publishers, New York, NY
132. 2001 Molecular determinants in the of metabotropic glutamate receptor signaling Trends Pharmacol Sci. 22: 114-120
133. 2001 Coordinate regulation of metabotropic glutamate receptors Curr Opin Neurobiol 11:357-362
134. 2001 Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptor J. Neurosci. 21: 9619-9628
135. 2001 Activation of group I metabotropic glutamate receptors produces a direct excitation and disinhibition of GABAergic projection neurons in the substantia nigra pars reticulata J. Neurosci. 21:7001-7012
136. 2001 Allosteric interaction between the N-terminal domain and the ligand-binding domain of NR2A Nat Neurosci 4: 894-901
137. 2001 Activation of metabotropic glutamate receptor 1 inhibits glutamatergic transmission in the substantia nigra pars reticulata Neurosci. 105:881-889
138. 2001 Cyclic AMP-dependent protein kinase phosphorylates group III metabotropic glutamate receptors and inhibits their function as presynaptic receptors J. Neurochem. 78: 756-766
139. 2001 mGluR1 and mGluR5 receptors differentially regulate CA1 pyramidal cell function J. Neurosci. 21: 5925-593
140. 2001 Activation of Group III mGluRs Inhibits GABAergic and glutamatergic transmission in the substantia nigra pars reticulata . J Neurophysiol. 85:1960-1968
141. 2000 Upregulation of the metabotropic glutamate receptor mGluR4 in human hippocampal neurons with reduced seizure vulnerability Annal Neurol. 47:26‑35
142. 2000 Distribution and roles of metabotropic glutamate receptors in the basal ganglia motor circuit: implications for treatment of Parkinson's disease and related disorders Pharmacol Ther 88:427-435
143. 2000 Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus J. Neurosci. 20: 7871-7879
144. 2000 Functional down-regulation of GluR2 in piriform cortex of kindled animals Synapse. 38: 489-498
145. 2000 cAMP-dependent protein kinase inhibits mGluR 2 coupling to G-proteins by direct receptor phosphorylation J. Neurosci. 20: 5663 – 5670
146. 2000 Activation of group II metabotropic glutamate receptors inhibit synaptic excitation of the substantia nigra pars reticulata J. Neurosci. 20: 3085-3094
147. 2000 Peripheral glutamate receptors: molecular biology and role in taste sensation J. Nutrition. 130:1039S-1042S
148. 2000 Muscarinic-induced modulation of potassium conductances is unchanged in hippocampal pyramidal cells that lack functional M1 receptors Neurosci. Lett. 278:61‑64
149. 1999 Fragile X mouse: Strain effects of knockout phenotype and evidence suggesting deficient amygdala function Neurosci. 94: 185-192
150. 1999 Localization of metabotropic glutamate receptor 7 mRNA and mGluR7a protein in the rat basal ganglia J. Comp. Neurol. 415: 266‑284
151. 1999 Activation of N-methyl-D-aspartate receptors reverses desensitizaton of metabotropic glutamate receptor mGluR5 in native and recombinant systems Annals N.Y. Acad. Sci. 868: 526-530
152. 1999 Activiation of Protein kinase C disrupts presynaptic inhibition by group II and group III metabotropic glutamate receptors and uncouples the receptor from GTP binding proteins Annals N.Y. Acad. Sci. 868: 554-557
153. 1999 Distribution of group III mGluRs in rat basal ganglia with subtype-specific antibodies Annals N.Y. Acad. Sci. 868:531-534
154. 1999 Metabotropic Glutamate Receptors as Novel Drug Targets in Neuropharmacology Science and Medicine 6: 28-37
155. 1999 Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia J. Comp. Neurol. 407: 33‑46
156. 1999 Muscarinic receptor subtypes involved in hippocampal circuits Life Sci. 64: 501‑509
157. 1999 Activation of N-methyl-D-aspartate receptors reverses desensitization of metabotropic glutamate receptor mGluR5 in native and recombinant systems J. Neurochem. 72: 174‑184
158. 1999 Immunohistochemical distribution of RGS7 protein and cellular selectivity in colocalizing with Gq proteins in the adult rat brain J. Comp. Neurol. 403: 486‑501
159. 1999 Heterogeneity of metabotropic glutamate receptors in autonomic cell groups of the medulla oblongata of the rat Proc. Natl. Acad. Sci. (USA) 95:11465-11470
160. 1998 RGS4 inhibits signaling by group I metabotropic glutamate receptors. J. Neurosci. 18: 905‑913
161. 1998 Tyrosine kinase potentiates NMDA receptor current by reducing tonic Zn2+ inhibition Nature Neurosci. 1: 185 - 191
162. 1998 Phosphorylation of mitogen-activated protein kinase in cultured rat cortical glia by stimulation of metabotropic glutamate receptors J. Neurochem. 71: 603‑612
163. 1998 Distribution and developmental regulation of metabotropic glutamate receptor 7a in rat brain J. Neurochem.71: 636‑645
164. 1998 Activation of the genetically-defined m1 muscarinic receptor potentiates NMDA receptor currents in hippocampal pyramidal cells Proc. Natl. Acad. Sci. (USA) 95:11465-11470
165. 1998 Protein kinase C and A3 adenosine receptor activation inhibit presynaptic metabotropic glutamate receptor (mGluR) function and uncouple mGluR from GTP-binding proteins J. Neurosci. 18: 6136-6146
166. 1997 Physiological roles of multiple metabotropic glutamate receptor subtypes in the hippocampus. In: F. Moroni, F. Nicoletti, and D.E. Pellegrini-Giampietro (Eds) Metabotropic Glutamate Receptors and Brain Function. Portland Press Ltd. London
167. 1997 Alterations in glutamate transporter protein levels in kindling-induced epilepsy J. Neurochem. 68: 1564-1570
168. 1997 4-Methylhomoibotenic acid activates a novel metabotropic glutamate receptor coupled to phosphoinositide hydrolysis J. Pharmacol. Exp. Ther. 283: 742-749
169. 1997 Pharmacology and functions of metabotropic glutamate receptors Annual Reviews in Pharmacology and Toxicology 37: 205-237
170. 1996 Roles of metabotropic glutamate receptors in glial function and glial-neuronal communication J. Neurosci. Res. 46:131-137
171. 1996 A novel form of glial-neuronal signalling by coactivation of metabotropic glutamate and b-adrenergic receptors in rat hippocampu J. Physiol. 494: 743-755
172. 1996 Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype specific antibodies J. Neurosci. 16: 2044 - 2056
173. 1996 The metabotropic glutamate receptors. In: Cellular and Molecular Neurobiology, Constance Hammond (Ed.), Academic Press, London
174. 1996 Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses J. Neurophysiol. 76: 3798-3806
175. 1995 Metabotropic glutamate receptor (mGluR)-mediated potentiation of cAMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR. J. Neurochem. 64: 592-599
176. 1995 Down-Regulation of AMPA receptor subunit GluR2 subunit in amygdaloid kindling J. Neurochem. 64: 462-465
177. 1995 Pharmacological differentiation of the effects of coactivation of beta-adrenergic and metabotropic glutamate receptors in rat hippocampus Neurosci. Lett. 186: 119-122
178. 1995 Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability . J. Neurophysiol. 74: 122-129
179. 1995 Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1 J. Neurosci. 15:6879-6889
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