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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors
1. 2010 The Role of Biomedical Imaging in Future Healthcare Scenarios Medical Device Manufacturing and Technology 2006. Touch Briefings
2. 2010 The New Anatomist - The Anatomical Record biomedical imaging
3. 2010 Site-Specific Neurotoxicity Cellular and Molecular Mechanisms of Toxin Action, Vol. 4. Taylor and Francis
4. 2010 Innovation or Reinvention Future Pharmaceuticals Q4: 141-144
5. 2009 Will personalized medicine help in “transforming” the business of healthcare Personalized Medicine 6:555-565
6. 2009 DIA Journal special edition on Biomarkers None
7. 2008 The Purkinje cells as a site of action of neurotoxicity Cellular and Molecular Mechanisms of Toxin Action, Vol. 4
8. 2008 Technologic Innovations that will Improve the Quality of Care and the Quality of Life for the Cancer Patient Coping with Cancer (Jacobs, L.K, ed.) Nova Scientific Publishers, pp.13-21.
9. 2007 The Role of Biomarkers in Drug Development Future Pharmaceuticals US 5: 44-52.
10. 2007 Editorial for Biomarkers Edition Drug Information J. 41:551-553
11. 2006 The Role of Biomedical Imaging in Future Healthcare Scenarios. Medical Device Manufacturing and Technology TouchBriefings 4 :58-59
12. 2006 Innovation and Reinvention Future Pharmaceuticals US 2: 142-145
13. 2005 The business of biomarkers in pharmaceutical development American Pharmaceutical Review. 8(6): 34-37.
14. 2004 Developmental Neurotoxicity of Ketamine: Morphometric Confirmation, Exposure Paramaters, and Multiple Flourescent Labeling of Apoptotic Neurons Tox Sci. 81: 364-370
15. 2003 Quantitative Neurotoxicity Computational Neuroanatomy (G.Ascoli, ed) Humana Press. pp. 383-400.
16. 2003 New Tools for New Technologies American Pharmaceut.Outsourcing. (2003) 4:36-40
17. 2002 Ontogeny of N-methyl-d-aspartate (NMDA) receptor system and susceptibility to neurotoxicity Tox. Sci. 68; 9-17.
18. 2002 Subcellular interactions between parallel fibre and climbing fibre signals in Purkinje cells predict sensitivity of classical conditioning to interstimulus interval Integr Physiol Behav Sci. 37:265-292.
19. 2001 Biomedical Imaging: 2001 and Beyond New Anatomist 265:37-53
20. 2000 Research Equipment and Resource Requirements Of NIH-Supported Investigators: An Assessment of Current Conditions and Recommendations for Future Funding and Programs FASEB Publication
21. 2000 Magnetic Resonance Imaging: From Atomic Physics to Visualization, Understanding and Treatment of Brain Disorders FASEB Breakthroughs in Science.
22. 1999 Virtual Neuropathology: 3-Dimensional Visualization and Quantitation of Lesions Due to Toxic Insult. Toxicol. Patholog. 28:100-104
23. 1999 Virtual Neuropathology: A new approach to preclinical pathology using Magnetic Resonance Imaging Microscopy Spectroscopy 14(7) 17-22.
24. 1999 Infrared spectroscopic imaging of biochemical modifications induced in the cerebellum of the Niemann-Pick type C mouse J.Biomed.Optics 4(1 ):7-13.
25. 1999 3-Dimensional Visualization of Excitotoxic Lesions in Rat Brain using Magnetic Resonance Imaging Microscopy NeuroProtocols 10:737-741
26. 1999 Scientists accountable to public for funding support AAA Newsletter 8(2):5-6
27. 1999 More Money for Shared Instrumentation AAA Newsletter 8(1):4-5
28. 1999 AAA opposes expansion of USDA regs AAA Newsletter 8(1):3
29. 1999 Redefining rats, mice and birds Science 284: 49-50
30. 1998 Infrared microspectroscopic imaging of the cerebellum of normal and drug treated rats. Cell. Mol. BioI. 44, 29-38
31. 1998 Enhancing the development and use of emerging" science in regulatory decisions CDER intranet, FDA
32. 1998 Infrared spectroscopic imaging as a tool for pathology. Progress in Biomedical Optics, Vol. 3257 (Mantsch, H.H. and Jackson, M., eds.) SPIE, Billingham, WA pp. 178-186
33. 1997 Imaging Brain Structure and Function: Emerging Technologies in the Neurosciences Ann. NY Acad. Sc., Vo1. 820
34. 1997 Applications of fourier transform infrared imaging microscopy in neurotoxicity Ann.N.Y.Acad.Sci. 820, 234-247
35. 1997 Protein kinase C -activators and inhibitors Cellular and Molecular Mechanisms of Toxin Action, Vol. 1 (Lazarovici, P. and Gutman, Y., eds.) Harwood Academic Publishers, pp. 405-426
36. 1997 Time-resolved imaging of protein kinase C activation during sea urchin egg fertilization Exp.Cell Res. 234 (1), 115-124.
37. 1996 High resolution fluorescent labeling of living cerebellar slices Brain Res.730: 125-132.
38. 1996 Human olfactory neuroepithelial cells: tyrosine phosphorylation and process extension are increased by the combination of IL-1beta, IL-6, NGF, bFGF. Exp. Neurol. 142 (1),179-194
39. 1996 Synergistic activation of protein kinase C by arachidonic acid and diacylglycerols in vitro: Generation of membrane-bound, cofactor-independent protein kinase C activity Bioch.Biophys.Acta 1292: 167-176.
40. 1995 Membrane protein kinases and phosphatases. Handbook of Biomembranes. Vol. 3. (Meir Shinitzky, ed.). VCH/Balaban Publishers, pp. 253-281.
41. 1995 Effects of diacylglycerols on conformation of phosphatidylcholine headgroups in phosphatidylcholine/ phosphatidylserine bilayers Biophys.J. 69:965-973
42. 1995 Application of a membrane fusion assay for rapid drug screening Pharmaceut. Res. 12:1417-1422.
43. 1995 Translocation and activation of protein kinase C by a tumor promoting alkane, pristane. Cancer Res. 55:518-524
44. 1995 Incorporation of fluorescent lipids into rat hippocampal and cerebellar slices. Neurolmage 1, 264-275
45. 1995 Imaging protein kinase C activation in living sea urchin eggs after fertilization. Dev.Biol. 172, 675­682
46. 1994 Arachidonic acid and diacylglycerol act synergistically to induce long-term potentiation in the CA3 region of the rat hippocampus Neuroscience, 60, 737-743.
47. 1994 Monitoring of neural networks in brain slices using fluorescently labeled phospholipids Neuroprotocols: A Companion to Methods In Neurosciences, 5, 5-11.
48. 1994 Cellular Biochemistry in Intact Neuronal Systems NeuroProtocols: A Companion to Methods in Neurosciences. Academic Press.
49. 1994 Effects of Diacylglycerols and Ca2+ on structure of Phosphatidlycholine/Phosphatidlyserine Bilayers Biophys, J., 66, 382-393
50. 1994 Incorporation of fluorescent lipids into living brain slices. "Time-Resolved Laser Spectroscopy in Biochemistry" SPIE Proceedings, Vol. 2137, "Time-resolved laser spectro-scopy in Biochemistry IV", SPIE­-The International Society for Optical Engineering, Bellingham. pp. 39-48
51. 1994 Lateralization of membrane-associated protein kinase C in rat piriform cortex: specific to operant training cues in the olfactory modality Behav.Brain Res., 61, 37-46
52. 1994 NeuroProtocols: A Companion to Methods in Neurosciences Vol.5.Academic Press, San Diego. pp. 1, 4
53. 1993 Associative learning changes in protein kinase C in synaptosomes of the rabbit hippocampus. Proc.NatI.Acad.ScLU.SA, 90, 4286-4289
54. 1993 The mechanism of activation of Protein Kinase C in long-term neuronal processes. Invited Minireview, Cellular Signalling, 5, 695-708
55. 1992 Protein Kinase C: Current concepts and future perspectives Ellis Horwood, London
56. 1992 Chemical modification of arginine residues of protein kinase C. Biochem. Intern. 27, 439-447
57. 1992 Staurosporine neurotropic effects in PC12 cells are independent of protein kinase C. Mol. Pharmacol. 42, 35-43
58. 1992 Interaction of alamethicin, mellitin and protein kinase C with pure and phospholipid monolayer Bioelectrochem. & Bioeng. 28:85-103
59. 1992 Heterogenous distribution of fluorescent phorbol ester in living sea urchin embryos. Biol.Bull., 183, 365-366
60. 1992 Identification of two populations of protein kinase C activity in rat brain membranes. J. Neurochem., 58,461-470
61. 1992 Cell-specificity of molecular changes during memory storage. J.Neurochem., 60, 646-651
62. 1992 Lipid vesicles which can bind to protein kinase C and activated the enzyme in presence of EGTA. Eur.J.Biochem, 208, 327-332
63. 1992 Cellular memory in vertebrates and invertebrates. In: Development, transplantation and plasticity of the nervous system.eds J.R. Cronly-Dilion and M. Ferguson. Chapman and Hall, London, pp.215­235.
64. 1992 Membrane-associated protein kinase C activity. In, Protein Kinase C: Current concepts and future perspectives., Ellis Horwood, West Sussex, pp.80-101.
65. 1992 Invited review, Biochem.Biophys. Biophys.Acta, 1134, 261-272
66. 1991 Dephosphorylation in the parasite, Leishmania major Acta Cient.Venezol. 42, 142-152.
67. 1991 Action of organic solvents on protein kinase C. Eur. J. Pharmacol. Mol. Pharm.206: 301-308.
68. 1991 Association of Protein Kinase C Phosphorylation Pathways: An integral component of associative memory processes Prog.Brain Research 89: 235-247
69. 1991 Divalent cation-induced changes in conformation of protein kinase C. Biophys. Chem., 39, 215-224
70. 1991 Arachidonic acid and diacylglycerol synergistically activate protein kinase C in vitro and in vivo. Biochem.Biophys.Res.Comm. 179, 1522-1528
71. 1990 Ligand-induced conformational changes in protein kinase C Int. J. BioI. Macromol. 12: 251-6
72. 1990 The role of membrane biophysical properties in the regulation of protein kinase C activity. Trends in Pharmacol. Sci. 11: 317-20
73. 1990 Structural distinction between soluble and particulate protein kinase C species J. Prot. Chem. 9: 209-20
74. 1990 Lipid dependent surface conformations of protein kinase C Biochim. Biophys. Acta. 1039: 33-41
75. 1990 Penetration of protein kinase C into lipid bilayers Arch. Biochem. Biophys. 277: 318-23
76. 1990 Extracellular phosphorylation in the parasite, Leishmania major Biochim. Biophys. Acta. 1023 (2): 293-8.
77. 1990 Identification of protein kinase C in Entamoeba histolytica. Compo Biochem. Physiol., 97B,707-711
78. 1990 Application of high pressure to fractionate membrane protein-lipid complexes. A case study of protein kinase C Anal. Biochem.191: 80-85.
79. 1990 In vitro linoleic acid activation of protein kinase C Biochim. Biophys. Acta. 1054: 297-303
80. 1989 High pressure extraction of membrane-associated protein kinase C J. Neurochem. 52: 1950-3
81. 1988 Characterization of the cAMP­induced activation of sodium channels in toad bladder membrane vesicles Am. J. Physiol. 254: C802-8.
82. 1987 Possible involvement of phosphorylation/dephosphorylation in regulation of epithelial sodium channels. Membrane Receptors, Dynamics and Energetics (K.WA Wirtz et aI., eds.). Plenum Press, New York and London, pp. 261-8
83. 1987 Developmental changes in the concentration of a-bungarotoxin binding sites in the brain of tobacco hornworm, Manduca sexta Neurochem. Int. 10: 571-81
84. 1987 Characterization of acetylcholinesterase in the larval brain of the tobacco hornworm, Manduca sexta Insect Biochem. 17: 99-109
85. 1986 Developmental changes in choline uptake and acetylcholine metabolism in the larval brain of the tobacco hornworm, Manduca sexta Develop. Brain Res. 26: 201-209
86. 1985 Cholinergic titers in the brain of Manduca sexta during larval-pupal development Insect Neurochemistry and Neurophysiology (A.J. Borkovec and T.J. Kelly, eds.). Plenum Press, New York and London, pp. 417-9
87. 1985 Choline acetyltransferase activity in the larval brain of Manduca sexta Insect Biochem. 15: 685-95
88. 1982 The chemistry and axonal action of two insect toxins derived from the venom of the scorpion Buthotus judaicus. Toxicon. 20 (1): 323-9
89. 1982 Purification, characterization and action of two insect toxins from the venom of scorpion Buthotus judaicus. Biochim. Biophys. Acta 701 (3): 370-81
90. 1980 Toxins selective to insects derived from scorpion venoms Natural Toxins (D. Eaker and T. Wadstrom, eds.) Pergamon Press, New York and Oxford, pp. 637-646.
91. 1979 Cytological and genetic loalization of a Y-autosome translocation in an Australian strain of the housefly, Musca domestica Experientia 35: 172-3
92. 1979 C-banding of the housefly, Musca domestica, autosomes and sex chromosomes Experientia 35: 174-5.
93. 1979 Recombination in the male housefly, Musca domestica Experientia 35: 175

4th Annual Pharma R&D Asia Congress
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