9th Annual Biomarkers Congress

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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors
1. 2009 Identification of the mouse SIRT3 mitochondrial localization sequence and comparison of in-vivo mitochondrial deacetylation and respiratory function of the long and short SIRT3 isoforms Submitted), 2009.
2. 2009 SIRT3 is a Mitochondrial localized Tumor Suppressor Gene and Loss of Function Results in Impaired Mitochondrial Integrity and Metabolism (In revisions Cancer Cell), 2009
3. 2009 Sample Preparation and Proteomic Profiling of Cervical Swabs to Identify Biomarkers for Cervical Cancer Screening Proteomics (In press
4. 2009 Genomic and Phenotypic analysis reveals a key role for CCN1 (CYR61) in BAG3 modulated adhesion and invasion Journal of Pathology (In press
5. 2009 Molecular and Clinical Responses to Gefitinib Combined with Paclitaxel and Radiation in Patients with Locally Advanced Head and Neck Cancers from a Pilot Phase I Clinical Study (Submitted), 2009.
6. 2008 CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 DMR Cancer Research 68: 5546-5551
7. 2008 DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation. Cancer Research 68:2726-2735
8. 2008 Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA Nature 451:202-206
9. 2008 DNMT1 as a Molecular Target in a Multi-Modality Resistant Phenotype in Tumor Cells. Mol. Can. Res. 6:243-249
10. 2008 High Incidence of Oral Dysesthesias on a Trial of Gefitinib, Paclitaxel, and Concurrent External Beam Radiation for Locally Advanced Head and Neck Cancers. Amer. J. Clin. Oncol. 31:557-560
11. 2008 SET1/MLL forms a complex with BAT3 and CTCFL/BORIS modulate H3K4 histone dimethylation and gene expression Mol. Cell. Biol. 28:6720-6729
12. 2008 SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression. Int. J. Biol. Sci. 4:291-299
13. 2008 Patterns of Care for Women with Cervical Cancer in the US Cancer 113:743-749
14. 2007 Distinct Gene Expression Signatures of CIN HPV Infected Cervical Epithelial and Stoma tissue revealed by laser-dissection microscopy-assisted Microarray Profiling. 18.        Cancer Research 67:7113-7123, 2007. (Featured on the Journal Cover)
15. 2007 DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16(ink4A) down-regulation J. Biomed. Sci.
16. 2007 Thioredoxin and Thioredoxin Reductase as Redox-Sensitive Signaling Factors as Potential Molecular Targets for Cancer Therapy. Curr. Pham. Design. 33:3368-3377
17. 2007 BAG-4/SODD and Associated Anti-Apoptotic Proteins are Associated with Aggressiveness of Epithelial Ovarian Cancer. Clin. Can. Res. 13:6585-6592
18. 2007 Chromatin Compaction and the Radiation Response by Cancer Cells. The Cancer Journal 65-69
19. 2006 In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor triapine (3-aminopyridine-2carboxaldehyde-thiosemicarbazone). Clin. Can. Res. 12: 2912-2918
20. 2006 Redox Signaling in Cancer Biology Antioxidants and Redox Signaling 8:1249-1252
21. 2006 Distinct Effects of Ionizing Radiation on In Vivo Murine Kidney and Brain Normal Tissue Gene Expression Clin. Can. Res. 12:3823-3830
22. 2006 Identification of chromosomal alterations important in the development of cervical intraepithelial neoplasia and invasive carcinoma using alignment of DNA microarray data. Gynecologic Oncology, (Apr 26),
23. 2005 The new field of epigenomics: implications for cancer and other common disease research. Epigenetics and Cancer Cold Spring Harb. Symp. Quant Biol. 69:447-456
24. 2005 A new regulatory role of thioredoxin: S-denitrosation of proteins and low molecular weight S-nitrosothiols J. Am. Chem. Soc. 16:127:15815-23
25. 2005 The Epigenome as a Molecular Marker and Target: Implications for Cancer. Cancer 9:1789-1793
26. 2005 Redox-Sensitive Signaling Factors as a Novel Molecular Targets for Cancer Therapy. Resistance to epidermal growth factor receptor-targeted therapy. Drug Resist Updat 8:322-30
27. 2005 Clinical and Biologic Effects of Concomitant Therapy With Proteasome Inhibitor Bortezomib and Re-irradiation in Patients with Recurrent Head and Neck Squamous Cell Carcinoma Int. J. Rad. Oncol. Biol. Phys. 63:1400-1412
28. 2005 Thioredoxin reductase as a novel molecular target for cancer therapy Cancer Letters, 236:164-174
29. 2005 Co-activation of ERK, NF-kB and GADD45b in response to ionizing radiation J. Biol. Chem. 280:12593-126012
30. 2004 Metabolic Oxidation/Reduction Reactions and Cellular Reponses to Ionizing Radiation: A Unifying Concept in Stress Response Biology Cancer Metastasis Rev. 23:311-322
31. 2004 Redox-sensitive signaling factors and antioxidants: how tumor cells respond to ionizing radiation. J. Nutr. 134:3213-3214
32. 2004 Distinct Effects on Gene Expression of Chemical and Genetic Manipulation of the Cancer Epigenome Revealed by a Multimodality Approach. Cancer Cell 6:361-371,
33. 2004 Thioredoxin Reductase as a Molecular Target for Anti-Cancer Agents that induce Oxidative Stress Cancer Research 64:6716-6724
34. 2004 Heat Shock Upregulates AP-1 and Inhibits NF-kB Activity: Possible role in radiosensitization of tumor cells Int. J. Hyperthermia 20:224-233
35. 2004 Target the HSP90 Molecular Chaperone with Geldanamycin, While Inhibiting Proteasomal Proteolysis with Bortezomib, Promotes Protein Ubiquitination, Causes ER-Derived Cytosolic Vacuolization and Enhances Antitumor Activity. Mol. Cancer Ther. 3:551-566
36. 2004 Oxidative Stress, Redox, and the Tumor Microenvironment. Semin. Radiat. Oncol. 23:311-322
37. 2004 Thermal Stress both Activates and Inhibits Redox Sensitive Signaling and Transcription Factors: Possible role in radiosensitization Int. J. Hyperthermia 20:213-223
38. 2004 Indomethacin and Ibuprofen Induce HSC-70 Nuclear Localization and Activation of the Heat Shock Response in HeLa Cells. Biochem Biophys Res Commun. 313:863-870
39. 2003 Tumorigenic mutant p53 inhibits stress-inducible kinase pathway and restores growth suppression Mol. Cell. Biol. 23:322-334
40. 2003 Increased Radiosensitization in Cervical Tumor Cells Geldanamycin and 17-Allylamino-17-Demethoxygeldanamycin Potentiates the Radiation Response of Cervical Tumor Cells In Vitro and In Vivo. Cancer Research 63:8984-8995
41. 2003 Inhibition of Cyclooxygenase-2 With NS398 Inhibits Radiation-induced Transformation, Micronuclei Formation, and Clonogenic Cell Death. Int. J. Rad. Biol. 79:879-888
42. 2003 Cytotoxic and Radiosensitizing Effects of 2-Deoxy-d-Glucose on HeLa Cells. Cancer Research 63:3413-3417
43. 2003 The Holy Grail of Radiation Oncology: Lessons learned from Hyperthermia. Int. J. Radiation Oncology Biol. Phys. 55:3-4
44. 2002 Indomethacin Lowers the Threshold Thermal Exposure for Hyperthermic Radiosensitization and Heat Shock Inhibition of Ionizing Radiation-Induced NF-kB Int. J. Radiat. Biol. 78:493-502
45. 2002 Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of g-glutamylcysteine synthetase. Free Radic. Biol. Med. 32:650-662
46. 2002 Treatment of Nasopharyngeal Cancer: Raising the Barr. J. Natl. Can. Inst. 94:1594-1595
47. 2002 A novel p53-inducible apoptogenic gene PRG3, encodes for a homologue of the apoptosis-inducing factor (AIF) FEBS Letters 524:163-171
48. 2002 Thioredoxin Reductase Regulates AP-1 Activity as well as Thioredoxin Nuclear Localization via Active Cysteines in Response to Ionizing Radiation Oncogene 12:6317-6327
49. 2002 Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: Mechanism of cell death British Journal of Cancer 87:805-812
50. 2001 The Role of NF-kB as One Downstream Target of p38MAPK in the Process of Indomethacin-induced Radiosensitization Cancer Research 61: 7689-7696
51. 2001 The Roles of Radiosensitizing as Well as Anti-Proliferative Effects of Resveratrol in Two Human Cervical Tumor Cell lines Cancer Letters 175: 165-173
52. 2001 Increased AP-1 Activity As Well As Resistance to Heat-Induced Radiosensitization, H2O2, and Cisplatin are Inhibited by Indomethacin in Oxidative Stress Resistant Cells. Cancer Research 61: 3486-3492
53. 2000 HIV TAT protein as a protein transduction system to introduce proteins in cells. Methods in Enzymology, Reed J.C., (ed). Vol. 311, pp 508-50-21
54. 2000 Changes in sub-nuclear structures and functional perturbations: Implications for radiotherapy. J. Cell. Biochem. 35:142-150
55. 2000 Thioredoxin nuclear translocation and interaction with redox factor-1 activate the AP-1 transcription factor in response to ionizing radiation Cancer Research 60, 6688-6695
56. 1999 Intracellular oxidation/reduction status in the regulation of transcription factors AP-1 and NF-kB Toxicology Letters 106:93-106
57. 1999 Heat Shock inhibits radiation-induced nuclear localization and activation of NF-kB DNA-binding. Possible role in radiation sensitization of tumor cells. J. Biol. Chem. 274:23061-23067
58. 1999 Redox Factor-1 (Ref-1) mediates the activation of AP-1 in HeLa and NIH 3T3 cells in response to heat J. Biol. Chem. 274:16959-16964
59. 1999 Transduced p16INK4a peptides inhibit hypo-phosphorylation of the retinoblastoma protein and cell cycle progression prior to activation of cdk2 complexes in late G1. Cancer Research 59:2577-80
60. 1998 The p53 gene and intrinsic cellular radiosensitivity in Tumor cells Breast Disease 9:22-24
61. 1997 Hypo-phosphorylation of the retinoblastoma protein by cyclin D:cdk4/6 results in active pRb. Proc. Natl. Acad. Sci. USA 94:10699-10704
62. 1993 Radiation signaling mediated by Jun activation following dissociation a cell type-specific repressor J. Biol. Chem. 268:4903-4907
63. 1992 Differential activation of serum responsive elements in the Egr-1 promoter by v-Src and v-myc. Oncogene 7:2065-2080
64. 1991 Transcriptional activation and repression by Fos are independent functions: the C-terminus represses immediate early gene expression via CArG elements. Mol. Cell. Biol. 10:4243-4255
65. 1989 Activation of human papillomavirus type-18 genes by herpes simplex virus type 1 viral trans-activators and phorbol esters J. Virol.63: 555-563
66. 1988 Inducible and constitutive enhancer domains in the human papillomavirus type-18 noncoding region J. Virol. 62:665-672
67. 1985 Endogenous analogs of N-methyl-4-,2,3,6-tetrahydro-pyridine: Indoleamine derived tetra hydro-beta-carboline as causative factors in Parkinson s disease. Adv. Neurology 45:179-182


4th Annual Pharma R&D Asia Congress
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