9th Annual Biomarkers Congress

View Profile

Perry Frey

Peer Reviewed Papers, Books, Chapters
Year Title Citation Authors
1. 2009 Radical triplets and suicide inhibition in reactions of 4-thia-D- and 4-thia-L-lysine with lysine 5,6-aminomutase Biochemistry 48, 8151-60
2. 2009 Evidence for Conformational Movement and Radical Mechanism in the Reaction of 4-Thia-L-Lysine with Lysine 5,6-Aminomutase. J. Phys. Chem. In press
3. 2009 Cobalamin coenzymes in enzymology Comprehensive Natural Products Chemistry II, In press
4. 2008 The radical SAM superfamily. Critical Reviews in Biochemistry and Molecular Biology 43, 63-88, Informa Healthcare USA, Inc
5. 2008 Cloning, expression, purification, cofactor requirements, and steady state kinetics of phosphoketolase-2 from Lactobacillus plantarum Bioorganic Chemistry 36, 121-127
6. 2007 Binding energy in the one-electron reductive cleavage of S-adenysylmethionine in lysine 2,3-aminomutase, a radical SAM enzyme Biochemistry 46, 12889-12895.
7. 2007 S-adenosylmethionine as an oxidant: the radical SAM superfamily TIBS 32, 101-110
8. 2007 Dioldehydrase: An essential role for potassium ion in the hemolytic cleavage of the cobalt—carbon bond in adenosylcobalamin Biochemistry 46, 7293-7301
9. 2007 Probing interactions from a solvent-exchangeable proton and monovalent cations with the 1,2-propanediol-1-yl radical intermediate in the reaction of dioldehydrase Protein Sci. 16, 1157-1164
10. 2007 5’-Peroxyadenosine and 5’-Peroxyadenosylcobalamin as intermediates in the aerobic photolysis of adenosylcobalamin Biochemistry 46, 7284-7292
11. 2007 Glutamate 2,3-aminomutase: A new member of the radical SAM superfamily of enzymes Biochim. Biophys. Acta, 1774, 286-296.
12. 2007 Enzymatic Reaction Mechanisms Oxford University Press: New York, A textbook, 832 pp.
13. 2006 Structure and mechanism of an ADP-glucose phosphorylase from Arabidopsis thaliana Biochemistry 45, 3154-3162
14. 2006 Enantiomeric free radicals and enzymatic control of stereochemistry in a radical mechanism: The case of lysine 2,3-aminomutases Biochemistry 45, 12639-12646
15. 2006 Identification of structural and catalytic classes of highly conserved amino acid residues in lysine 2,3-aminomutase. Biochemistry 45, 12647-12653
16. 2006 Analysis of the cob(II)alamin-5’-deoxy-3’,4’-anhydroadenosyl radical triplet spin system in the active site of diol dehydrase Biochemistry 45, 4362-4370
17. 2006 Isotope effects in the characterization of low barrier hydrogen bonds. Isotope Effects in Chemistry and Biology (A. Kohen and H.-H. Limbach, eds.) CRC Press, Taylor and Francis Group, Boca Raton, FL, Ch. 40, pp. 975-993.
18. 2006 Free radical mechanisms in enzymology Chem. Rev. 106, 3302-3316
19. 2006 An adaptable spectroelectrochemical titrator: The midpoint reduction potential of the iron-sulfur center in lysine 2,3-aminomutase Analytical Biochem. 349, 103-111
20. 2006 Snapshots of three radical intermediates at the active site of pyruvate oxidase. Nat. Chem. Biol. 2, 294-295
21. 2006 Cofactor-dependence in reduction potentials for [4Fe-4S]2+/1+ in lysine 2,3-aminomutase Biochemistry 45, 3219-3225
22. 2006 How an enzyme tames reactive intermediates: positioning of the active-site components of lysine 2,3-aminomutase during enzymatic turnover as determined by ENDOR spectroscopy . Am. Chem. Soc. 128, 10145-10154
23. 2005 pH-Dependence in the hydrolytic action of the human fragile histidine triad Eur. J. Org. Chem., 5198-5206
24. 2005 The X-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale. Proc. Natl. Acad. Sci. U.S.A. 102, 13819-13824
25. 2004 Low barrier hydrogen bonds Encyclopedia of Biological Chemistry 2, 594-598
26. 2004 Chemical intermediate in catalysis by thiamine diphosphate. Thiamine. Catalytic Mechanisms in Normal and Disease States (F. Jordan and M. S. Patel, eds), Marcel Dekker, NY, pp. 1-13
27. 2004 Strong hydrogen bonding in chymotrypsin and other serine proteases J. Phys. Org. Chem. 17, 511-520
28. 2004 A locking mechanism preventing radical damage in the absence of substrate, as revealed by the X-ray structure of lysine 5,6-aminomutase Proc. Natl. Acad. Sci. 101, 15870-15875
29. 2004 Ornithine cyclodeaminase: structure, mechanism of action and implications for the µ-crystallin family Biochemistry 43, 13883-13891
30. 2004 The mechanism of action of the fragile histidine triad, Fhit: Isolation of a covalent adenylyl-enzyme and chemical rescue of H96G-Fhit Biochemistry, 43, 7637-7642
31. 2004 Engineering human fhit, a diadenosine triphosphate hydrolase, into an efficient dinucleoside polyphosphate synthase. J. Amer. Chem. Soc. 126, 9548-9549
32. 2004 Crystallization and X-ray diffraction analysis of ornithine cyclodeaminase from Pseudomonas putida. Acta Crystallogr. D Biol. Crystallogr. 60(Pt 5), 941-944.
33. 2003 Suicide inactivation of dioldehydrase by 2-Chloroacetaldehyde: Formation of the ‘cis-Ethanesemidione’ radical, and the role of a monovalent cation Helvetica Chimica Acta 86, 3764-3775
34. 2003 Coordination and mechanism of reversible cleavage of S-adenosylmethionine by the [4Fe-4S] center in lysine 2,3-aminomutase J. Am. Chem. Soc. 125, 11788-11789
35. 2003 Kinetic and biochemical analysis of the mechanism of action of lysine 5,6-aminomutase Arch. Biochem. Biophys. 418, 49-54
36. 2003 Galactose mutarotase: pH dependence of enzymatic mutarotation Biochemistry 42, 4414-4420
37. 2003 Epimerization at carbon-5’ of (5’R)-[5’-2H] adenosylcobalamin by ribonucleoside triphosphate reductase: Cysteine 408-independent cleavage of the Co-C5’ bond Biochemistry 42, 4578-4584
38. 2003 Adenosyl coenzyme and pH dependence of the [4Fe-4S]2+/1+ transition in lysine 2,3-aminomutase. Arch. Biochem. Biophys. 414, 34-39
39. 2003 S-Adenosylmethionine: A wolf in sheeps’ clothing, or a rich man’s adenosylcobalamin? Chem. Rev. 103, 2129-2148
40. 2002 Concerted and stepwise dehydration mechanisms observed in wild-type and mutated Escherichia coli dTDP-glucose 4,6-dehydratase Biochemistry 41, 2797-2804
41. 2002 Facile hydrogen-deuterium exchange at the 5’-position of an analogue of S-adenosyl-L-methionine Bioorganic Chem. 30, 53-61
42. 2002 Mini-Series: Significant contributions to biological chemistry over the past 125 years. Surprises and revelations in biochemistry Biochem. & Mol. Biol. Ed. 30, 152-162
43. 2002 Rapid mix-quench MALDI-TOF mass spectroscopy for analysis of enzymatic systems Enzyme Kinetics and Mechanism, 354, Purich, D.L. (ed.), Academic Press, pp. 27-49
44. 2002 Galactose-1-phosphate uridylyltransferase: Kinetics of formation and reaction of uridylyl-enzyme intermediate in wild-type and specifically mutated uridylyltransferases Enzyme Kinetics and Mechanism, 354, Purich, D.L. (ed.), Academic Press, pp. 135-149
45. 2002 Evidence for a strong hydrogen bond in the catalytic dyad of transition-state analogue inhibitor complexes of chymotrypsin from proton-triton NMR isotope shifts J. Am. Chem. Soc. 124, 4196-4197
46. 2002 Identification of a novel pyridoxal 5’-phosphate binding site in adenosylcobalamin-dependent lysine 5,6-aminomutase from Porphyromonas gingivalis Biochemistry 41, 8767-8776
47. 2002 Characterization of a low barrier hydrogen bond in the active site of chymotrypsin. J. Mol. Struct. 615, 153-161
48. 2002 Interactions of diol dehydrase and 3’, 4’-anhydroadenosylcobalamin: Suicide inactivation by electron transfer Biochemistry 41, 1695-1702
49. 2001 Electron transfer in the substrate-dependent suicide inactivation of lysine 5,6-aminomutase Biochemistry 40, 5190-5199
50. 2001 Coenzymes and radicals Science 294, 2489-2490
51. 2001 Strong hydrogen bonding in molecules and enzymatic complexes Magn. Reson. Chem. 39, S190-S198
52. 2001 13NMR analysis of electrostatic interactions between NAD+ and active site residues of UDP-galactose 4-epimerase: Implications for the activation induced by uridine nucleotides. Biochemistry 40, 11279-11287
53. 2001 Mechanistic roles of Thr134, Tyr160, and Lys164 in the reaction catalyzed by dTDP-glucose 4,6-dehydratase Biochemistry 40, 9187-9195
54. 2001 The role of radicals in enzymatic processes The Chemical Record 1, 277-289
55. 2001 Dehydration is catalyzed by glutamate-136 and aspartic acid-135 active site residues in Escherichia coli dTDP-glucose 4,6-dehydratase Biochemistry 40, 12497-12504
56. 2001 Characterization of an allylic analogue of the 5’-deoxyadenosyl radical: An intermediate in the reaction of lysine 2,3-aminomutase. Biochemistry 40, 7773-7782
57. 2001 Probing catalysis by Escherichia coli dTDP-glucose-4,6-dehydratase: Identification and preliminary characterization of functional amino acid residues at the active site Biochemistry 40, 6598-6610
58. 2001 Acid-base catalysis by UDP-galactose 4-epimerase: Correlations of kinetically measured acid dissociation constants with thermodynamic values for tyrosine 149 Biochemistry 40, 6699-6705
59. 2001 Mutation Arg336 to Lys in Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase originates an enzyme with increased oxaloacetate decarboxylase activity FEBS Lett. 493, 1-5.
60. 2001 Inhibition of lysine 2,3-aminomutase by the alternative substrate 4-thialysine and characterization of the 4-thialysyl radical intermediate Arch. Biochem. Biophys. 387, 281-288.
61. 2001 Characterization of the transition-state structure of the reaction of kanamycin nucleotidyltransferase by heavy-atom kinetic isotope effects Biochemistry 40, 2972-2977
62. 2001 Correlation of low-barrier hydrogen bonding and oxyanion binding in transition state analogue complexes of chymotrypsin Biochemistry 40, 2439-2447
63. 2001 Identification of lysine 346 as a functionally important residue for pyridoxal 5’-phosphate binding and catalysis in lysine 2,3-aminomutase from Bacillus subtilis Biochemistry 40, 596-602
64. 2001 Radical mechanisms of enzymatic catalysis Annu. Rev. Biochem. 70, 121-148.
65. 2001 Radical mechanisms of S-adenosylmethionine-dependent enzymes Advances in Protein Chemistry 58, 1-45
66. 2000 Rate enhancements brought about by uridine nucleotides in the reduction of NAD+ at the active site of UDP-galactose 4-epimerase Bioorganic Chem. 8, 29-37.
67. 2000 Direct FeS cluster involvement in generation of a radical in lysine 2,3-aminomutase Biochemistry 39, 15668-15673.
68. 2000 Lysine 2,3-aminomutase and trans-4,5-dehydrolysine: Characterization of an allylic analogue of a substrate-based radical in the catalytic mechanism Biochemistry 39, 9561-9570
69. 2000 The deuterium isotope effect on the NMR signal of the low-barrier hydrogen bond in a transition-state analog complex of chymotrypsin. Biochem Biophys Res Commun 273, 789-792
70. 2000 Identification of cis-ethanesemidione as the organic radical derived from glycolaldehyde in the suicide inactivation of dioldehydrase and of ethanolamine ammonia-lyase Biochemistry 39, 6250-6257
71. 2000 Characterization of enzymatic processes by rapid mix-quench mass spectrometry: The case of dTDP-glucose 4,6-dehydratase Biochemistry 39, 13633-13640
72. 2000 Radical mechanisms in adenosylmethionine- and adenosylcobalamin-dependent enzymatic reactions. Arch. Biochem. Biophys. 382, 6-14
73. 2000 Synthesis and characterization of 3’,4’anhydroadenosylcobalamin: A coenzyme B12 analogue with unusual properties. J. Am. Chem. Soc. 122, 8807-8813.
74. 2000 A novel lysine 2,3-aminomutase encoded by the yod0 gene of Bacillus subtilis: Characterization and the observation of organic radical intermediates Biochem. J. 348, 539-549
75. 2000 Cloning, sequencing, heterologous expression, purification, and characterization of adenosylcobalamin-dependent D-lysine 5,6-aminomutase from Clostridium sticklandii J. Biol. Chem. 275, 106-114.
76. 2000 Roles of two conserved amino acid residues in the active site of galactose-1-phosphate uridylyltransferase: An essential serine and a nonessential cysteine. Biochemistry 39, 5397-5404
77. 2000 Strong hydrogen bonds in aqueous and aqueous-acetone solutions of dicarboxylic acids: Activation energies for exchange and deuterium fractionation factors J. Am. Chem. Soc. 122, 11258-11259.
78. 1999 Stereochemical retention of the configuration in the action of Fhit on phosphorus-chiral substrates Biochemistry 38, 3668-3676
79. 1999 Hydrogen bonding in complexes of carboxylic acids with l-alkylimidazoles: Steric and isotope effects on low barrier hydrogen bonding J. Chem. Soc. Perkin Trans. 2, 635-641
80. 1999 Spectroscopic evidence for the participation of an allylic analogue of the 5'-deoxyadenosyl radical in the reaction of lysine 2,3-aminomutase J. Am. Chem. Soc. 121, 9764-9765
81. 1999 Lysine 2,3-aminomutase from Clostridium subterminale SB4: Mass spectral characterization of cyanogen bromide-treated peptides and cloning, sequencing, and expression of the gene kamA in Escherichia coli J. Bacteriology 182, 469-476
82. 1999 Synthesis of undecagold labeling compounds and their applications in electron microscopic analysis of multiprotein complexes J. Struct. Biol. 127, 94-100.
83. 1999 Radical intermediates in the reaction of lysine 2,3-aminomutase Advances in Free Radical Chemistry, JAI Press Inc., pp. 1-43
84. 1999 Aminomutases Chemistry and Biochemistry of B12: Part II: Biochemistry of B12 (R. Banerjee, Ed.), John Wiley & Sons, Inc., pp. 835-857.
85. 1999 Radical reactions featuring lysine 2,3-aminomutase Comprehensive Natural Products Chemistry, Vol. 5 (C.D. Poulter, volume editor), Elsevier Science, Oxford, Chap. 9, pp. 205-223
86. 1999 Significance of metal ions in galactose-1-phosphate uridylyltransferase: An essential structural zinc and a nonessential structural iron Biochemistry 38, 13398-13406.
87. 1999 Standard free energy for the hydrolysis of adenylylated T4 DNA ligase and the apparent pKa of lysine 159 J. Biol. Chem. 274, 8586-8588
88. 1998 Kinetic mechanism of UDP-hexose synthase, a point variant of hexose-1-phosphate uridylyltransferase from Escherichia coli Biochemistry 37, 11385-11392
89. 1998 Steric enhancement of imidazole basicity in cis-urocanic acid derivatives: Models for the action of chymotrypsin Bioorganic Chemistry 26, 323-333
90. 1998 Fractionation factors and activation energies for exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes of chymotrypsin Proc. Natl. Acad. Sci. USA 95, 14664-14668
91. 1998 Low-barrier hydrogen bonding in aqueous and aprotic solutions of dicarboxylic acids: Spectroscopic characterization Bioorganic Chemistry 26, 213-219
92. 1998 Are there strong hydrogen bonds in aqueous solutions? Bioorganic Chemistry 26, 175-192
93. 1998 Galactose mutarotase: Purification, characterization, and investigations of two important histidine residues. Biochemistry 37, 14989-14997
94. 1998 Transient kinetics of formation and reaction of the uridylyl-enzyme form of galactose-1-P uridylyltransferase and its Q168R-variant: Insight into the molecular basis of galactosemia Biochemistry 37, 14500-14507
95. 1998 S-Adenosylmethionine-dependent reduction of lysine 2,3-aminomutase and observation of the catalytically functional iron-sulfur centers by electron paramagnetic resonance Biochemistry 37, 2578-2585
96. 1998 The strongly conserved lysine 256 of Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase is essential for phosphoryl transfer. Biochemistry 37, 6295-6302
97. 1998 Correlations of the basicity of His 57 with transition state analogue binding, substrate reactivity, and the strength of the low-barrier hydrogen bond in chymotrypsin Biochemistry 37, 11940-11948
98. 1998 S-adenosylmethionine: A 'poor man's coenzyme B12' in the reaction of lysine 2,3-aminomutase. Biochem. Soc. Trans. 26, 304-310
99. 1998 Phenylalanine hydroxylase from Chromobacterium violaceum: Uncoupled oxidation of tetrahydropterin and the role of iron in hydroxylation J. Biol. Chem. 273, 25594-25601.
100. 1998 The low barrier hydrogen bond in enzymatic catalysis J. Biol. Chem. 273, 25529-25532
101. 1997 Understanding enzymic catalysis: The importance of short, strong hydrogen bonds. Chemistry & Biology 4, 259-267
102. 1997 Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli. Biochemistry 36, 6294-6304
103. 1997 The role of S-adenosylmethionine as a poor man's adenosylcobalamin in the reaction of lysine 2,3-aminomutase Proceedings of the 4th European Symposium on Vitamin B12 and B12 Proteins, Wiley-VCH, Weinheim, Chap. 28, pp. 397-408
104. 1997 Radicals in enzymatic reactions Current Opinion in Chemical Biology 1, 347-356
105. 1997 Mechanistic roles of tyrosine 149 and serine 124 in UDP-galactose 4-epimerase from Escherichia coli Biochemistry 36, 10675-10684
106. 1997 A new concept for the mechanism of action of chymotrypsin: The role of the low-barrier hydrogen bond Biochemistry 36, 4576-4584
107. 1996 Lysine 2,3-aminomutase: Rapid mix-freeze-quench electron paramagnetic resonance studies establishing the kinetic competence of a substrate-based radical intermediate Biochemistry 35, 11081-11084
108. 1996 UDP-galactose 4-epimerase: NAD+ content and a charge-transfer band associated with the substrate-induced conformational transition Biochemistry 35, 7615-7620
109. 1996 Molecular structure of the NADH/UDP-glucose abortive complex of UDP-galactose 4-epimerase from Escherichia coli: Implications for the catalytic mechanism Biochemistry 35, 5137-5144.
110. 1996 Standard free energies for uridylyl group transfer by hexose-1-P uridylyltransferase and UDP-hexose synthase and for the hydrolysis of uridine-5'-phosphoimidazolate Biochemistry 35, 3426-3428
111. 1996 Crystal structures of the oxidized and reduced forms of UDP-galactose 4-epimerase isolated from Escherichia coli Biochemistry 35, 2557-2566
112. 1996 Correlation of electronic effects in N-alkylnicotinamides with NMR chemical shifts and hydride transfer reactivity J. Org. Chem. 61, 530-533
113. 1996 The Leloir pathway: A mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose FASEB J. 10, 461-470
114. 1996 Electrostatic acceleration of enolization in cationic ketones J. Amer. Chem. Soc. 118, 12253-12260
115. 1996 High-resolution X-ray structure of UDP-galactose 4-epimerase complexed with UDP-phenol Protein Science 5, 2149-2161
116. 1996 Re-face stereospecificity at C4 of NAD(P) for alcohol dehydrogenase from Methanogenium organophilum and for (R)-2-hydroxyglutarate dehydrogenase from Acidaminococcus fermentans as determined by 1H-NMR spectroscopy FEBS Letters 399, 92-94
117. 1996 Structural analysis of the H166G site-directed mutant of galactose-1-phosphate uridylyltransferase complexed with either UDP-glucose or UDP-galactose: Detailed description of the nucleotide/sugar binding site. Biochemistry 36, 1212-1222
118. 1996 m-Monothiopyrophosphate as a substrate for inorganic pyrophosphatase and UDP-glucose pyrophosphorylase Arch. Biochem. Biophys. 335, 183-190
119. 1996 The structure of nucleotidylated histidine-166 of galactose-1-phosphate uridylyltransferase provides insight into phosphoryl group transfer Biochemistry 35, 11560-11569
120. 1995 Three-dimensional structure of galactose-1-phosphate uridylyltransferase from Escherichia coli at 1.8 Ã… resolution Biochemistry 34, 11049-11061.
121. 1995 Standard free energy change for the hydrolysis of the a,b-phosphoanhydride bridge in ATP. Biochemistry 34, 11307-11310
122. 1995 Pulsed electron paramagnetic resonance studies of the lysine 2,3-aminomutase substrate radical: Evidence for participation of pyridoxal 5'-phosphate in a radical rearrangement Biochemistry 34, 10086-10093
123. 1995 On low-barrier hydrogen bonds and enzyme catalysis Science 269, 102-106
124. 1995 Galactose-1-phosphate uridylyltransferase from Escherichia coli, a zinc and iron metalloenzyme Biochemistry 34, 5610-5617
125. 1995 Low-barrier hydrogen bonding in molecular complexes analogous to histidine and aspartate in the catalytic triad of serine proteases. Biochemistry 34, 6919-6924
126. 1995 Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase: Revised amino acid sequence, site-directed mutagenesis, and microenvironment characteristics of cysteines 365 and 458 Biochemistry 34, 6382-6388
127. 1995 Observation of a second substrate radical intermediate in the reaction of lysine 2,3-aminomutase: A radical centered on the b-carbon of the alternative substrate, 4-Thia-L-lysine. Biochemistry 34, 10532-10537
128. 1994 Synthesis of UDP-4-deoxy-4-fluoroglucose and UDP-4-deoxy-4-fluorogalactose and their interactions with enzymes of nucleotide sugar metabolism J. Org. Chem. 59, 6994-6998
129. 1994 Preparation and characterization of a bifunctional fusion enzyme composed of UDP-galactose 4-epimerase and galactose-1-P uridylyltransferase. Bioconjugate Chemistry 5, 660-665
130. 1994 A simplified procedure for synthesizing nucleoside 1-thiotriphosphates: dATPS, dGTPS, UTPS, and dTTPS Biochem. Biophys. Res. Commun. 204, 150-155
131. 1994 A low-barrier hydrogen bond in the catalytic triad of serine proteases. Science 264, 1927-1930
132. 1994 Mapping the lipoyl groups of the pyruvate dehydrogenase complex by use of gold cluster-labels and scanning transmission electron microscopy Biochemistry 33, 9428-9437
133. 1994 Crystallization and preliminary crystallographic analysis of galactose-1-phosphate uridylyltransferase from Escherichia coli Acta Cryst. D50, 329-331.
134. 1994 Characterization and activation of naturally occurring abortive complexes of UDP-galactose 4-epimerase from E. coli. J. Biol. Chem. 269, 31496-31504.
135. 1993 Rapid hydrogen exchange at the acetyl (C2) methyl group of acetylthiamin pyrophosphate. J. Am. Chem. Soc. 115, 3332-3333
136. 1993 Lysine 2,3-aminomutase: Is adenosylmethionine a poor man's adenosylcobalamin? FASEB J. 7, 662-670
137. 1993 The pH-dependence for the hydrolysis of uridine 5'-phosphoimidazolates. Bioorganic Chem. 21, 238-248
138. 1993 The importance of binding energy in catalysis of hydride transfer by UDP-galactose 4-epimerase: A 13C- and 15N-NMR and kinetic study. Biochemistry 32, 13220-13230
139. 1993 Identification of lysine 153 as a functionally important residue in UDP-galactose 4-epimerase from Escherichia coli Biochemistry 32, 13231-13236
140. 1993 Stereochemistry of metal ion coordination to the terminal thiophosphoryl group of adenosine- 5'-O-(3-thiotriphosphate) at the active site of pyruvate kinase. Biochemistry 32, 14111-14116
141. 1993 Lysine 2,3-aminomutase and the mechanism of the interconversion of lysine and b-lysine Advances in Enzymology and Related Areas of Molecular Biology 66, 1-39, John Wiley & Sons
142. 1992 Characterization of iron-sulfur clusters in lysine 2,3-aminomutase by electron paramagnetic resonance spectroscopy Biochemistry 31, 10774-10781
143. 1992 Biochemistry (a textbook). Jones and Bartlett, Boston
144. 1992 Chemical, spectroscopic, and crystallographic studies of UDP-galactose 4-epimerase from Escherichia coli Proceedings of the First International Congress on Vitamins and Biofactors in Life Science, Kobe, Japan. J. Nutr. Sci. Vitaminol. Special Issue, 1992, pp. 461-464
145. 1992 Nucleotidyltransferases and phosphotransferases. Stereochemistry and covalent intermediates The Enzymes, 3rd ed. (Boyer, P.D. and Sigman, D.S., eds), 20, pp. 141-186, Academic Press, Inc
146. 1992 Functional and morphological studies of mitochondria exposed to undecagold clusters: Biologic surfaces labeling with gold clusters. Scanning Microscopy 6, 799-816
147. 1992 Structure of a substrate radical intermediate in the reaction of lysine 2,3-aminomutase Biochemistry 31, 10782-10789
148. 1992 Discrete monomeric metaphosphate anion as an intermediate in the hydrolysis of u-monothiopyrophosphate J. Am. Chem. Soc. 114, 9750-9755
149. 1992 An organic radical in the lysine 2,3-aminomutase reaction Biochemistry 31, 949-953
150. 1992 The molecular structure of UDP-galactose 4-epimerase from Escherichia coli determined at 2.5 Ã… resolution Proteins: Structure, Function, and Genetics 12, 372-381.
151. 1991 Enzymatic and chemical reactivities of sym-monothiopyrophosphate Proceedings of the International Conference on Organic and Bioorganic Chemistry of Phosphorus, Heteroatom Chem. 2, 171-176
152. 1991 Interactions of metal ions with m-monothiophrophosphate Biochemistry 30, 10307-10313
153. 1991 A novel mechanistic role for pyridoxal-5¢-phosphate Enzymes Dependent on Pyridoxal Phosphate and Other Carbonyl Compounds as Cofactors, I.U.B. Symposium 1990 (Fukui, T., Kagamiyama, H., Soda, K., and Wada, H., eds.) pp. 357-363, Pergamon Press, Oxford
154. 1991 The substrate reactivity of m-monothiopyrophosphate with pyrophosphate-dependent phosphofructokinase: Evidence for a dissociative transition state in enzymatic phosphoryl group transfer Biochemistry 30, 10313-10322
155. 1991 The isolation, purification, and preliminary crystallographic characterization of UDP-galactose 4-epimerase from Escherichia coli Proteins 9, 135-142
156. 1991 Metal cofactors of lysine-2,3-aminomutase J. Biol. Chem. 266, 7656-7660
157. 1991 Molecular properties of lysine-2,3-aminomutase J. Biol. Chem. 266, 7651-7655.
158. 1991 Evidence for monomeric metaphosphate as an intermediate in the hydrolysis of u-monothiopyrophosphate J. Am. Chem. Soc. 113, 9415-9416
159. 1991 The structure of tetramethyl m-monothiopyrophosphate Heteroatom Chemistry 2, 655-659
160. 1991 The mechanism of the hydrolysis of m-monothiopyrophosphate J. Am. Chem. Soc., 113, 9843-9848
161. 1990 Proton, carbon-13, and phosphorus-31 nuclear magnetic resonance spectral assignments for tobramycin, 2-(adenosine-5-phosphoryl)-tobramycin and 2-(adenosine-5-thiophosphoryl)- tobramycin. Arch. Biochem. Biophys. 280, 284-291.
162. 1990 The roles of S-adenosylmethionine and pyridoxal phosphate in the lysine 2,3-aminomutase reaction Ann N.Y. Acad. Sci. 585, 368-378
163. 1990 The importance of organic radicals in enzymatic cleavage of unactivated C-H bonds Chem. Rev. 90, 1343-1357
164. 1990 Activation of lysine 2,3-aminomutase by S-adenosylmethionine J. Biol. Chem. 265, 18112-18115
165. 1990 A chemical model for the pyridoxal 5-phosphate dependent lysine aminomutases J. Amer. Chem. Soc. 112, 8982-8983
166. 1990 Remodeling hexose-1-phosphate uridylyltransferase: Mechanism-inspired mutation into a new enzyme, UDP-hexose synthase Biochemistry 29, 10590-10593
167. 1990 Solvent effects on the solvolysis of ADPbS Bioorg. Chem. 18, 373-380
168. 1990 Methane monooxygenase catalyzed-oxygenation of 1,1-dimethylcyclopropane. Evidence for radical and carbocationic intermediates. Biochemistry 29, 1696-1700
169. 1990 The reaction of uridine diphosphate galactose 4-epimerase with a suicide inactivator Biochemistry 29, 2430-2436
170. 1989 Galactose-1-phosphate uridylyltransferase: Identification of His-164 and His-166 as critical residues by site-directed mutagenesis Biochemistry 28, 2094-2099
171. 1989 Chiral phosphorothioates: Stereochemical analysis of enzymatic substitution at phosphorus Advances in Enzymology & Related Areas of Molecular Biology (Meister, A., ed.), 62, 119-201, John Wiley & Sons
172. 1989 Intermediates in reductive transacetylation catalyzed by pyruvate dehydrogenase complex Ann. N.Y. Acad.Sci. 573, 21-35
173. 1989 2-Acetylthiamin pyrophosphate: An enzyme-bound intermediate in thiamin pyrophosphate- dependent reactions Biofactors 2, 1-9
174. 1989 Inactivation of the pyruvate dehydrogenase complex of Escherichia coli by fluoropyruvate Biochemistry 28, 9594-9602
175. 1989 2-acetylthiamin pyrophosphate. The pH-rate profile for hydrolysis of acetyl-TPP and the isolation of acetyl-TPP as a transient species in pyruvate dehydrogenase-catalyzed reactions Biochemistry 28, 9071-9080
176. 1989 UDP-galactose 4-epimerase. Phosphorus-31 nuclear magnetic resonance analysis of NAD+ and NADH bound at the active site Biochemistry 28, 2645-2654
177. 1989 Lysine 2,3-aminomutase. Support for a mechanism of hydrogen transfer involving S-adenosylmethionine J. Biol. Chem. 264, 1357-1360.
178. 1989 a-ketoacid dehydrogenase complexes of Escherichia coli: Stereospecificities of the three components for (R)-lipoate . Biochem. Biophys. 268, 465-474
179. 1988 Epimerization in the synthesis of thiophosphoanhydrides Bioorg. Chem. 16, 52-61
180. 1988 Structure and function of coenzymes. Chapter 11 in Biochemistry (second edition of a textbook, Zubay, G., coordinating author), 347-388, Macmillan, N.Y.
181. 1988 Effect of ion pairing on bond order charge localization in alkylphosphorothioates J. Amer. Chem. Soc. 110, 4059-4060
182. 1988 Uridine diphosphate galactose 4-epimerase. pH-dependence of the reduction of NAD+ by a substrate analog J. Biol. Chem. 263, 2638-2643
183. 1987 Complex pyridine nucleotide-dependent transformations Pyridine Nucleotide Coenzymes: Chemical, Biochemical & Medical Aspects (Dolphin, D., Poulson, R., and Avramovic, O., eds.), 2B, 461-511, John Wiley & Sons, Inc., New York.
184. 1987 Pathways of enzymatic phosphotransfer reactions Phosphorus & Sulfur 30, 563-566
185. 1987 Applications of chiral nucleoside phosphorothioates to studies of enzymatic reaction mechanisms Proceedings of 2nd International Symposium on Phosphorus Chemistry Directed Towards Biology, 267-278, Elsevier Science Publishers B.V., Amsterdam
186. 1987 Synthesis and properties of 2-acetylthiamin pyrophosphate: An enzymatic reaction intermediate. Biochemistry 26, 7575-7585
187. 1987 S-adenosylmethionine and the mechanism of hydrogen transfer in the lysine 2,3-aminomutase reaction The Evolution of Catalytic Function, Cold Spring Harbor Symposium on Quantitative Biology, LII, 571-577, CSH Press
188. 1987 The role of S-adenosylmethionine in the lysine 2,3,-aminomutase reaction. J. Biol. Chem. 262, 14859-14862
189. 1987 Prospects for improvement in biocatalysts for large scale applications Catalysis 1987, (Ward, J.W., ed.), 935-943, Proceedings of the 10th North American Catalysis Society Meeting, Elsevier, Amsterdam
190. 1987 The nucleotide sequence of the gal T gene of Escherichia coli Nucleic Acids Research 15, 8116
191. 1986 Galactose-1-phosphate uridylyltransferase. Purification of the enzyme and stereochemical course of each step of the double-displacement mechanism Biochemistry 25, 5583-5589
192. 1986 Mechanisms of enzymatic reactions: Stereochemistry. Proceedings of the XVth Steenbock Symposium, Elsevier, New York.
193. 1986 Stereochemical aspects of the actions of nucleotidyltransferases and phosphotransferases. Stereochemical course of each step in a double displacement mechanism. Mechanisms of Enzymatic Reactions: Stereochemistry (Frey, P.A., ed.), Proceedings of the XVth Steenbock Symposium, Elsevier Science Publishing Co., Inc., New York
194. 1986 Stereochemical course of thiophosphoryl transfer catalyzed by cytosolic phosphoenolpyruvate carboxykinase Biochemistry 25, 5571-5575
195. 1986 Mevalonate-5-diphosphate decarboxylase: Stereochemical course of ATP-dependent phosphorylation of mevalonate 5-diphosphate. Biochemistry 25, 4693-4698
196. 1986 Phosphorus-sulfur bond order in phosphorothioate anions. J. Amer. Chem. Soc. 108, 1720-1722
197. 1986 Pyruvate dehydrogenase complex of Escherichia coli: Radial mass analysis of subcomplexes by scanning transmission electron microscopy Biophys. J. 49, 56-58.
198. 1986 Dihydrolipoyl transacetylase of Escherichia coli Biochemistry 25, 8173-8178.
199. 1986 Gentamicin nucleotidyltransferase. Stereochemical inversion at phosphorus in enzymatic 2-deoxyadenylyl transfer to tobramycin J. Biol. Chem. 261, 15995-15999
200. 1986 Pyruvate dehydrogenase and 3-fluoropyruvate: Chemical competence of acetylthiamin pyrophosphate as an acetyl group donor to dihydrolipoamide Biochemistry 25, 6036-6043
201. 1985 Ketoglutarate dehydrogenase complex of Escherichia coli J. Biol. Chem. 260, 13690-13693
202. 1985 Quaternary structure of pyruvate dehydrogenase complex from E. coli. J. Biol. Chem. 260, 16049-16051
203. 1985 Pyruvate dehydrogenase complex of Escherichia coli: Thiamin pyrophosphate and NADH-dependent hydrolysis of acetyl-CoA J. Biol. Chem. 260, 14610-14615
204. 1985 Escherichia coli pyruvate dehydrogenase complex: Particle masses of the complex and component enzymes measured by scanning transmission electron microscopy Biochemistry 24, 2425-2431
205. 1985 Bond order and charge localization in nucleoside phosphorothioates Science 228, 541-545
206. 1985 Synthesis and rearrangements of alkyl phosphorothioates J. Org.Chem. 50, 936-940
207. 1984 A new method for synthesizing phosphoanhydrides: Synthesis of Adenosine 5 (2-thiodiphosphate) and adenosine 5(2-thiotriphosphate Biochemistry 23, 1978-1983
208. 1984 Stereochemical course of thiophosphoryl group transfer catalyzed by mitochondrial phosphoenolpyruvate carboxykinase Biochemistry 23, 1779-1783
209. 1984 Escherichia coli a-ketoglutarate dehydrogenase complex. Thiamin pyrophosphate-dependent hydrolysis of succinyl coenzyme A. J. Biol. Chem. 259, 4023-4026.
210. 1984 Escherichia coli pyruvate dehydrogenase complex. Thiamin pyrophosphate-dependent inactivation by 3-bromopyruvate. J. Biol. Chem. 259, 2905-2909
211. 1984 Cyclo-diphosphates as intermediates in reactions of nucleoside phosphorothioates with cyanogen bromide J. Amer. Chem. Soc. 106, 6038-6049.
212. 1984 Synthesis of undecagold cluster molecules as biochemical labeling reagents. 3. A dimeric cluster with a single reactive amino group Biochemistry 23, 3863-3868
213. 1984 Synthesis of undecagold cluster molecules as biochemical labeling reagents. 2. Bromoacetyl and maleimido undecagold clusters Biochemistry 23, 3857-3862
214. 1984 Synthesis of undecagold cluster molecules as biochemical labeling reagents. 1. Monoacyl and mono [N-(succinimidooxy)succinyl] undecagold clusters Biochemistry 23, 3849-3856
215. 1984 Synthesis of nucleotides for stereochemical investigations of phosphotransferases and nucleotidyltransferases Natural Products Chemistry (Zalewski, R.I and Skolik, J.J., eds.), 465-480, Elsevier Science Publishers B.V., Amsterdam
216. 1984 Labeling of macromolecular assemblies with undecagold clusters Proceedings of the 42nd Annual Meeting of the Electron Microscopy Society of America (Bailey, G., ed.), 160-161, San Francisco Press
217. 1984 Phosphorus-oxygen bond order in adenosine 5¢-O-phosphorothioate dianion J. Amer. Chem. Soc. 106, 8309-8310.
218. 1983 Stereochemical course of phosphoanhydride synthesis J. Amer. Chem. Soc. 105, 6605-6609
219. 1983 Effects of 17O and 18O on 31P NMR: Further investigation and applications J. Amer. Chem. Soc. 105, 5455-5461.
220. 1983 Selective contrast in images of crystalline cytochrome oxidase dimers Proceedings of the 41st Annual Meeting of the Electron Microscopy Society of America (Bailey, G., ed.), 442-443, San Francisco Press
221. 1983 Structure and function of coenzymes Chapter 6 in Biochemistry (a textbook, Zubay, G., ed.), 196-241, Addison-Wesley
222. 1982 Synthesis of chiral [18O] phosphorothioate analogs of adenine nucleotides. J. Amer. Chem. Soc. 104, 3476-3481
223. 1982 Mechanism of coupled electron and group transfer in Escherichia coli pyruvate dehydrogenase Ann. N.Y. Acad. Sci. 378, 250-264
224. 1982 Stereochemistry of enzymatic reactions of phosphates Tetrahedron, 38, 1541-1567, Pergamon Press, Ltd.
225. 1982 Galactose-1-phosphate uridylyltransferase: Detection, isolation and characterization of the uridylyl-enzyme. Methods Enzymol. 87, 20-36
226. 1982 Stereochemistry of selected phosphotransferases and nucleotidyltransferases. Methods Enzymol. 87, 213-235
227. 1982 Stereochemistry of enzymatic substitution at phosphorus. New Comprehensive Biochemistry (Neuberger,A. and vanDeenen, L.L.M., eds.), Stereochemistry (Ch. Tamm, Vol. Ed.) 3, 201-248.
228. 1982 The stereochemical configuration of Mn(II) • ADP at the active site of creatine kinase elucidated by electron paramagnetic resonance with Rp [-17O] ADP and Sp [-17O] ADP. J. Biol. Chem. 257, 15047-15053
229. 1982 Evidence implicating cyclo-diphosphates as intermediates in reactions of nucleoside phosphorothioates with cyanogen bromide J. Amer. Chem. Soc. 104, 5841-5842
230. 1982 Nucleoside phosphotransferase from barley. Characterization and evidence for ping pong kinetics involving phosphoryl enzyme J. Biol. Chem. 257, 4931-4939
231. 1982 Synthesis of Rp and Sp [-18O] ADP from Sp and Rp -cyanoethyl-adenosine 5-[1- thiodiphosphate]. J. Biol. Chem. 257, 1138-1141
232. 1982 Stereochemical course of nucleotidyl transfer catalyzed by bacteriophage T7-induced DNA polymerase Biochemistry 21, 2570-2572
233. 1981 Unambiguous determination of the stereochemistry of nucleotidyl transfer catalyzed by DNA polymerase I from Escherichia coli Biochemistry 20, 1245-1252
234. 1981 The stereochemical course of thiophosphoryl group transfer catalyzed by T4 polynucleotide kinase J. Biol. Chem. 256, 5965-5966
235. 1980 The stereochemical course of thiophosphoryl group transfer catalyzed by adenosine kinase Biochem. Biophys. Res. Commun. 94, 1052-1056.
236. 1980 Stereochemical course of a phosphokinase using a chiral [18O] phosphorothioate: Comparison with the transfer of a chiral [16O, 17O, 18O] phosphoryl group Biochemistry 19, 325-329.
237. 1979 Chiral [18O] phosphorothioates: The stereochemical course of thiophosphoryl group transfer catalyzed by nucleoside phosphotransferase J. Biol. Chem. 254, 4339-4341
238. 1979 Stereochemical courses of nucleotidyltransferase and phosphotransferase action. Uridine diphosphate glucose pyrophosphorylase, galactose-1-phosphate uridylyltransferase, adenylate kinase and nucleoside diphosphate kinase Biochemistry 18, 5548-5556
239. 1979 Uridine diphosphate galactose 4-epimerase. Alkylation of enzyme-bound diphosphopyridine nucleotide by p-(bromoacetamido) phenyl uridyl pyrophosphate, an active-site-directed irreversible inhibitor Biochemistry 18, 5337-5341.
240. 1979 p-(Bromoacetamido)phenyl uridyl pyrophosphate: An active-site-directed irreversible inhibitor for uridine diphosphate galactose 4-epimerase Biochemistry 18, 5332-5336.
241. 1979 Nucleophile in the active site of Escherichia coli galactose-1-phosphate uridylyltransferase: Degradation of the uridylyl-enzyme intermediate to N 3-phosphohistidine. Biochemistry 18, 2980-2984
242. 1978 Fluoropyruvate: An unusual substrate for Escherichia coli pyruvate dehydrogenase Biochem. Biophys. Res. Commun. 81, 274-279
243. 1978 Stereochemical course of thiophosphoryl group transfer catalyzed by adenylate kinase J. Amer. Chem. Soc. 100, 7757-7758
244. 1978 Synthesis of nucleoside [18O] pyrophosphorothioates with chiral [18O] phosphorothioate groups of known configuration. Stereochemical orientations of enzymatic phosphorylations of chiral [18O] phosphorothioates. J. Amer. Chem. Soc. 100, 7756-7757.
245. 1978 Escherichia coli pyruvate dehydrogenase complex: Site coupling in electron and acetyl group transfer pathways J. Biol. Chem. 253, 7234-7241
246. 1978 UDP-glucose pyrophosphorylase: Stereochemical course of the reaction of glucose 1-phosphate with uridine-5¢[1-thiotriphosphate]. J. Biol. Chem. 253, 3378-3380.
247. 1978 Uridine diphosphate galactose 4-epimerase: Nucleotide and 8-anilino-1-naphthalenesulfonate binding properties of the substrate binding site Biochemistry 17, 3551-3556
248. 1978 Escherichia coli uridine diphosphate galactose 4-epimerase: Circular dichroism of the protein and protein bound dihydronicotinamide adenine dinucleotide. Biochemistry 17, 516-520
249. 1977 Fluorescence and nucleotide binding properties of Escherichia coli uridine diphosphate galactose-4-epimerase: Support for a model for nonstereospecific action Biochemistry 16, 298-305
250. 1977 Acetylation stoichiometry of Escherichia coli pyruvate dehydrogenase complex Biochem. Biophys. Res. Commun. 77, 708-713
251. 1977 Enzymatic and 31P-nuclear magnetic resonance study of adenylate kinase-catalyzed stereospecific phosphorylation of adenosine 5¢-phosphorothioate J. Biol. Chem. 252, 4445-4448
252. 1977 Galactose-1-phosphate uridylyltransferase: Isolation and properties of a uridylyl-enzyme intermediate. Biochemistry 16, 1010-1016.
253. 1976 UDP galactose 4-epimerase catalyzed oxygen dependent reduction of a free radical substrate analogue by two electron reducing agents J. Amer. Chem. Soc. 98, 7886-7887
254. 1975 Uridine diphosphate galactose-4-epimerase: Uridine monophosphate-dependent reduction by a- and b-D-glucose J. Biol. Chem. 250, 7099-7105.
255. 1975 Escherichia coli pyruvate dehydrogenase complex: Improved purification and the flavin content Biochem. Biophys. Res. Commun. 62, 614-620.
256. 1974 Induced reoxidation and reactivation of a reduced uridine diphosphate galactose-4-epimerase complex J. Biol. Chem. 249, 856-858
257. 1974 Galactose-1-phosphate uridylyltransferase: Rate studies confirming a uridylyl-enzyme intermediate on the catalytic pathway Biochemistry 13, 3889-3894
258. 1974 Galactose 1-phosphate uridylyltransferase: Isolation of a uridylyl-enzyme intermediate J. Biol. Chem. 249, 2322-2324
259. 1974 UMP-dependent reduction of UDP-galactose 4-epimerase-NAD+ complex by sodium cyanoborohydride Biochim. Biophys. Acta. 334, 442-447
260. 1973 Studies on the mechanism of action of uridine diphosphate galactose-4-epimerase. II. Substrate-dependent reduction by sodium borohydride J. Biol. Chem. 248, 33-40
261. 1972 Studies on Escherichia coli pyruvate dehydrogenase complex. I. Effect of bromopyruvate on the catalytic activities of the complex J. Biol. Chem. 247, 2711-2716
262. 1972 Studies on the mechanism of action of uridine diphosphate-galactose-4-epimerase. I. An ambiguity in the chemical trapping of a proposed keto-intermediate by NaB3H4 J. Biol. Chem. 247, 1339-1342
263. 1971 Studies on the mechanism of hydrogen transfer in the coenzyme B12 dependent dioldehydrase reaction II J. Amer. Chem. Soc. 93, 1242-1251.
264. 1971 A reporter group at the active site of acetoacetate decarboxylase. I. Ionization constant of the nitrophenol J. Amer. Chem. Soc. 93, 7266-7269.
265. 1970 Comments on a proposed mechanism of action of B12 coenzyme J. Amer. Chem. Soc. 92, 4488-4489
266. 1968 Studies on the mechanism of the dioldehydrase reaction and the role of vitamin B12 coenzyme dissertation, Brandeis University
267. 1967 Studies on the mechanism of hydrogen transfer in the cobamide coenzyme-dependent dioldehydrase reaction J. Biol. Chem. 242, 5369-5377
268. 1967 The participation of the two non-equivalent C-5¢ hydrogens of B12 coenzyme in the catalytic process Biochem. Biophys. Res. Commun. 29, 873-879
269. 1966 The stereochemistry of the conversion of D and L 1,2-propanediols to propionaldehyde. Zagalak, B., Frey, P.A., Karabatsos, G.L., and Abeles, R.H.
270. 1966 Role of B12 coenzymes in the dioldehydrase reaction Fed. Proc. 25, 1639-1641
271. 1966 Studies on the mechanism of action of cobamide coenzymes. Chemical properties of the enzyme-coenzyme complex J. Biol. Chem. 241, 1751-1762.
272. 1966 The role of the B12 coenzyme in the conversion of 1,2-propanediol to propionaldehyde J. Biol. Chem. 241, 2732-2733
273. 1965 The stereochemistry of the conversion of propanediol to propionaldehyde. Biochem. Biophys. Res. Commun. 18, 551-556
274. 1964 Haptenic properties of paralytic shellfish poison conjugated to proteins by formaldehyde treatment Proc. Soc. Exper. Biol. & Med., 117, 425-430


4th Annual Pharma R&D Asia Congress
About Us | Privacy Policy | Site Map | FAQs | Advertise With Us | Community
BiotechScienceNews.com promotes research and ranks life scientists working in the life science spectrum involving biotechnology,
drug discovery, genomics, microbiology, neuroscience, medicine, pharmacology, cell biology, and molecular biology.