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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors Review type Summary Keywords File filename File mime type
1. 2010 Src regulates hVPS34 to mediate activation of S6K1 and cellular transformation. Submitted
2. 2009 Rac1 contributes to trastuzumab-resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer. Mol Cancer Ther. 2009 Jun; 8(6): 1557-69.
3. 2009 Mechanism of E-cadherin lysosomal degradation Nat Rev Cancer 9:143.
4. 2008 Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathway J. Biol. Chem. 283:5127-37.
5. 2007 Cdc42: downstream effector and regulator of ErbB1 as strategic target for anti-cancer therapeutic development in breast cancer Future Drug (Expert Review of Anticancer Therapy) 7: 147-157
6. 2006 Growth and motility inhibition of breast cancer cells by EGFR degradation is correlated with inactivation of Cdc42 Cancer Research 66: 3520-30
7. 2005 Development and regulation of monoclonal antibody product: Challenges and opportunities. Cancer and Metastasis Reviews 24: 569-584
8. 2005 Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L J. Biol. Chem. 280: 22883-91
9. 2003 Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation. Cell 114: 715-725
10. 2003 Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase. J. Biol. Chem. 278: 49293-49300.
11. 2002 Antiapoptotic cdc42 mutants are potent activators of cellular transformation. Biochemistry 41: 12350-12358.
12. 2000 Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex J. Biol. Chem. 275: 37307-37310.
13. 2000 The g-subunit of the coatomer complex binds Cdc42 to mediate transformation. Nature 405: 800-804
14. 2000 Activation of phospholipase D1 by Cdc42 requires the Rho insert region J. Biol. Chem. 275:15665-15668
15. 1998 Transformation activity of Cdc42 requires a region unique to Rho-related proteins. J. Biol. Chem. 273: 16655-16658
16. 1997 Interactions between Cdc42Hs and Rho-GDI is mediated through the Rho insert region J. Biol. Chem. 272: 26153-26158
17. 1996 Identification of a putative effector for Cdc42Hs with high sequence similarity to IQGAP2. J. Biol. Chem. 271: 21732-21737.
18. 1996 Use of a fluorescence spectroscopic read-out to characterize the interactions of Cdc42Hs with its target/effector, mPAK-3 Biochemistry 36: 1173-1180
19. 1996 Phosphatidylinositol-4,5-bisphosphate provides an alternative to guanine nucleotide exchange factors by stimulating the dissociation of GDP from Cdc42Hs. J. Biol. Chem. 271: 23815-23819.

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