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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors
1. 2010 Src regulates hVPS34 to mediate activation of S6K1 and cellular transformation. Submitted
2. 2009 Rac1 contributes to trastuzumab-resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer. Mol Cancer Ther. 2009 Jun; 8(6): 1557-69.
3. 2009 Mechanism of E-cadherin lysosomal degradation Nat Rev Cancer 9:143.
4. 2008 Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathway J. Biol. Chem. 283:5127-37.
5. 2007 Cdc42: downstream effector and regulator of ErbB1 as strategic target for anti-cancer therapeutic development in breast cancer Future Drug (Expert Review of Anticancer Therapy) 7: 147-157
6. 2006 Growth and motility inhibition of breast cancer cells by EGFR degradation is correlated with inactivation of Cdc42 Cancer Research 66: 3520-30
7. 2005 Development and regulation of monoclonal antibody product: Challenges and opportunities. Cancer and Metastasis Reviews 24: 569-584
8. 2005 Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L J. Biol. Chem. 280: 22883-91
9. 2003 Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase. J. Biol. Chem. 278: 49293-49300.
10. 2003 Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation. Cell 114: 715-725
11. 2002 Antiapoptotic cdc42 mutants are potent activators of cellular transformation. Biochemistry 41: 12350-12358.
12. 2000 Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex J. Biol. Chem. 275: 37307-37310.
13. 2000 The g-subunit of the coatomer complex binds Cdc42 to mediate transformation. Nature 405: 800-804
14. 2000 Activation of phospholipase D1 by Cdc42 requires the Rho insert region J. Biol. Chem. 275:15665-15668
15. 1998 Transformation activity of Cdc42 requires a region unique to Rho-related proteins. J. Biol. Chem. 273: 16655-16658
16. 1997 Interactions between Cdc42Hs and Rho-GDI is mediated through the Rho insert region J. Biol. Chem. 272: 26153-26158
17. 1996 Use of a fluorescence spectroscopic read-out to characterize the interactions of Cdc42Hs with its target/effector, mPAK-3 Biochemistry 36: 1173-1180
18. 1996 Phosphatidylinositol-4,5-bisphosphate provides an alternative to guanine nucleotide exchange factors by stimulating the dissociation of GDP from Cdc42Hs. J. Biol. Chem. 271: 23815-23819.
19. 1996 Identification of a putative effector for Cdc42Hs with high sequence similarity to IQGAP2. J. Biol. Chem. 271: 21732-21737.


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