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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors
1. 2012 Identification of an inhibitory ganglioside responsible for immune suppression by ovarian cancer Cancer Res. Accepted
2. 2012 . A new method to determine antigen-specific CD8+ T cell activity in vivo by hydrodynamic injection. Biomolecules. 2, 23-33.
3. 2011 nvariant NKT cells recognize glycolipids from pathogenic gram-positive bacteria. Nat. Immunol. 12: 966-974.
4. 2011 Functional Invariant NKT Cells in Pig Lungs Regulate the Airway Hyperreactivity: A Potential Animal Model. J. Clin. Immunol. 31: 228-239.
5. 2011 A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design. Nat. Med. 17: 1602-1609.
6. 2010 Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by V{alpha}14i NKT Cells. J. Immunol. 184: 141-153.
7. 2010 Replacing adenoviral vector HVR1 with a malaria B cell epitope improves immunogenicity and circumvents pre-existing immunity to adenovirus in mice. J. Clin. Inv. 120: 3688-3701.
8. 2010 Design of a novel CD1d-binding NKT cell ligand as a vaccine adjuvant. Proc. Natl. Acad. Sci. USA. 107: 13010-13015.
9. 2010 Re-evaluating the role of T cells for the development of T cell-based, malaria vaccine . Exp. Parasitol. 126: 421-425. Review.
10. 2010 A CD1d-dependent antagonist inhibits the activation of iNKT cells and prevents development of allergen-induced airway hyperreactivity. J. Immunol. 184: 2107-15.
11. 2010 A multifactorial mechanism in the superior anti-malarial activity of a-C-GalCer. J. Biomed. Biotech. 2010: 283612: 1-11.
12. 2010 A double-edged sword: The Role of NKT cells in Malaria and HIV Infection and Immunity. Seminar Immunol. 22: 87-96. Review.
13. 2009 Quantifying cytokine production by epitope-specific, HLA-restricted CD8+ T cells after stimulation by immobilized HLA-A2:Ig dimeric proteins. Scan. J. Immunol. 70: 415-422.
14. 2009 Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine iNKT cells. J. Immunol. 183: 4415-4421.
15. 2009 Alpha-C-Galactosylceramide as an adjuvant for a live attenuated influenza virus vaccine. Vaccine 27: 3766-3774.
16. 2009 Identification of C-glycoside analogues that display a potent activity against human NKT cells. Immunology 127: 216-225.
17. 2009 Chapter 32: Malaria In: Satoskar A, Simon G, Hotez P and Tsuji, M. eds. Medical Parasitology. Landes Bioscience. Austin, TX. 237-247. ISBN: 978-1-57059-695-7
18. 2009 Chapter 26: Toxoplasmosis In: Satoskar A, Simon G, Hotez P and Tsuji, M. eds. Medical Parasitology. Landes Bioscience. Austin, TX. 190-194. ISBN: 978-1-57059-695-7
19. 2009 Human CD1 dimeric proteins as indispensable tools for research on CD1-binding lipids and CD1-restricted T cells J. Immunol. Methods 345: 49-59.
20. 2008 Development of a Microarray System to Measure the Glycolipids Binding Properties with CD1d Proteins. J. Am. Chem. Soc. 130: 12348-12354.
21. 2008 Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand α-galactosylceramide Vaccine 26: 1807-1816.
22. 2008 Activation of iNKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-γ production and dampening of the adaptive Th1 and Th17 responses. J. Immunol. 181: 4791-4797.
23. 2008 Cognitive dysfunction in mice infected with Plasmodium berghei ANKA J. Infect. Dis. 197:1621-1627.
24. 2007 Percentage and function of NKT cells, a potential anti-HIV effector cell, are preserved by beginning HAART during acute and early HIV-1 Infection Int. Immunol. 19: 943-951.
25. 2007 The natural killer T-cell ligand alpha-C-galactosylceramide promotes ovarian cancer survival by dual regulation of the adaptive host immunity Gyn Oncology 104: S21.
26. 2007 Combined NKT cell-based immunotherapy eradicates established tumors in mice Cancer Res. 67: 7495-7504
27. 2007 Long-term IFN-g Dependent Efficacy of Activated Va14i Natural Killer T cells in the Prevention of Collagen-Induced Arthritis J. Immunol. 179: 2300-2309.
28. 2006 The glycolipid α-C-GalCer is a distinct inducer of dendritic cell maturation and both innate and adaptive T cell immunity in mice. Proc.Natl.Acad.Sci. USA. 103:11252-11257.
29. 2006 Recombinant human adenovirus serotype 35-based malaria vaccine: Immunogenicity and protection against Plasmodium yoelii in mice. Infect. Immun. 74: 313-320.
30. 2006 Endothelin in a Murine Model of Cerebral Malaria Exp. Biol. Med. 231: 1176-1181.
31. 2006 Long-term IFN-gamma dependent efficacy of activated V alpha 14I natural killer T-cells in the prevention of collagen-induced arthritis. Clin. Immunol. 119: S62
32. 2006 E and Z αC-Galactosylceramides via Julia-Lythgoe-Kocienski Chemistry: A Test of the Receptor Binding Model for Glycolipid Immunostimulants. Chem. Bio. Chem. 7: 1017-1022.
33. 2006 Structure-Based Discovery of Glycolipids for CD1d-mediated NKT cell activation: Tuning the Adjuvant versus Immunosuppression Activity. J. Am. Chem. Soc. 128: 9022-9023.
34. 2006 Pre-clinical studies towards rAd35-based malaria vaccines Am. J. Trop. Med. Hyg. 75: 304.
35. 2006 α-C-Galactosylceramides: Synthesis and Immunology Acc. Chem. Res. 39: 692-701. Review.
36. 2006 Long-term IFN-gamma dependent efficacy of activated valpha141 natural killer T cells in the prevention of collagen-induced arthritis Annals Rheum. Dis. 2006; 65: 141
37. 2006 NKT cells recognize diacylglycerol antigens from pathogenic bacteria. Nat. Immunol. 7: 978-986.
38. 2006 Glycolipids and phospholipids as natural CD1d-binding NKT cell ligands. Cell. Mol. Life Sci. 63:1889-1898. Review.
39. 2005 Glycolipid-presentation to natural killer T cells differs in an organ-dependent fashion. Proc. Natl. Acad. Sci. USA. 102: 1127-1132.
40. 2005 Reduced cerebral blood flow and N-acetyl aspartate in a murine model of cerebral malaria. Parasitol. Res. 96: 302 - 307.
41. 2005 Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 434: 520 - 525.
42. 2005 Synthesis and human NKT cell stimulating properties of 3-O-sulfo-alpha/beta-galactosylceramides. Bioorg. Med. Chem. 13:2907-2916.
43. 2005 Novel bacterial glycolipids and analogues as antigens for CD1d-restricted NKT cells Proc. Natl. Acad. Sci. USA. 102: 1352 -1356.
44. 2004 The C-glycoside analogue of the immunostimulant alpha-galactosylceramide (KRN7000): synthesis and striking enhancement of activity. Angew. Chem. Int. Ed. Eng. 19: 3818-3822.
45. 2004 Enhanced protective immunity against malaria by vaccination with a recombinant adenovirus encoding the circumsporozoite protein of Plasmodium lacking the GPI-anchoring motif Vaccine 22: 3575-3584.
46. 2004 Efficient Synthesis of alpha-C-Galactosyl Ceramide Immunostimulants: Use of Ethylene-Promoted Olefin Cross-Metathesis Org. Lett. 6: 4077-4080.
47. 2003 Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand a-galactosylceramide. J. Exp. Med. 198: 1631-1641.
48. 2003 The dendritic cell-specific chemokine DC-CK1 enhances protective cell-mediated immunity to murine malaria J. Immunol. 170: 3195-3203.
49. 2003 T cells as mediators of protective immunity against malaria liver stages. Trends in Parasitol. 19: 88-93. Review.
50. 2003 The role of natural killer T cells and other T cell subsets against infection by liver stages of malaria parasites. Microbes and Inf. 5: 499-506. Review.
51. 2002 The involvement of CD1d-restricted NKT cells in infectious processes Revision 21: 145-155. Review.
52. 2002 Assessing antigen-specific CD4+ and CD8+ T cell responses in mice after immunization with recombinant viruses. In: Malaria Methods and Protocols. Methods in Molecular Medicine. New Jersey: Humana Press Inc. Vol. 72: 361-367.
53. 2002 A novel immune mechanism against malaria: The involvement of NKT cells. Inf. Infl. Immun. 32: 2-9. In Japanese. Review.
54. 2002 The natural killer T cell ligand α-galactosylceramide enhances protective immunity induced by malaria vaccines J. Exp. Med. 195: 617-624.
55. 2001 Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR Int. J. Parasitol. 31: 1499-1502.
56. 2001 Progress towards a malaria vaccine: Efficient induction of anti-malaria immunity. Biol. Chemistry 382: 553-570. Review.
57. 2001 Peptide-based subunit vaccines against pre-erythrocytic stages of malaria parasites. Mol. Immunol. 38; 433-442. Review.
58. 2001 Complete, long-lasting protection against malaria of mice primed and boosted with two distinct viral vectors expressing the same plasmodial antigen. Proc. Natl. Acad. Sci. USA. 98: 11491-11496.
59. 2000 Multifactorial protective mechanisms to limit viral replication in the lung of mice during primary murine cytomegalovirus infection. Viral. Immunol. 13: 287-295.
60. 2000 Malaria Vaccine Development: Various immunization regimens for efficient induction of protective anti-malaria immunity Science and Culture 52: 288-304. Review.
61. 2000 Host-virus interactions during malaria infection in hepatitis B virus transgenic mice J. Exp. Med. 192: 529-536.
62. 2000 Innate response of murine γδ T cells to the synthetic polypeptide, poly Glu50Tyr50 J. Immunol. 165: 1790-1798.
63. 2000 α-GalCer-activated Vα14 natural killer T cells mediate protection against murine malaria Proc. Natl. Acad. Sci. USA. 97: 8461-8466.
64. 2000 Immunization and infection change the number of RAG expressing B cells in the periphery by altering immature lymphocyte production. J. Exp. Med. 191: 2113-2120.
65. 2000 Cutting Edge: The IgG response to the circumsporozoite protein is MHC class II-dependent and CD1d-independent: Exploring the role of GPIs in NKT cell activation and antimalarial responses J. Immunol. 164: 5005-5009.
66. 2000 gamma/delta T cells are a component of early immunity against preerythrocytic malaria parasites Inf. Immun. 68: 2224-2230.
67. 2000 Interferon-gamma Independent CD8+ T cell-mediated protective anti-malaria immunity induced by recombinant adenovirus Parasite Immunol. 22: 157-160.
68. 1999 Phenotypic and functional characterization of CD8+ T cell clones specific for a mouse cytomegalovirus epitope   Virology 155: 40-49.
69. 1999 Protective role of NKT cells against liver stages of malaria infection in mice. Am. J. Trop. Med. Hyg. 61: 341
70. 1999 Immunogenic properties of the merozoite surface proteint 1 gene of Plasmodium vivax. Vaccine 17: 2959-2968.
71. 1999 Current status of malaria vaccine development. Prog. Med. 191: 88-92. In Japanese. Review.
72. 1999 IFN‑γ but not NO nor NK cells are critical for the protective immunity to infection with blood‑stage Plasmodium berghei XAT Inf. Immun. 67: 2349-56.
73. 1998 Immunity and parasitic diseases Today’s Therapy 21: 1-2. In Japanese. Review.
74. 1998 Recombinant viruses expressing a human malaria antigen elicited protective cellular and humoral responses in mice Proc. Natl. Acad. Sci. USA. 95: 3954-9.
75. 1998 Recombinant Sindbis viruses expressing a cytotoxic T lymphocyte epitope of a malaria parasite or of an influenza virus elicit protection against the corresponding pathogen in mice J. Virol. 72: 6907-10.
76. 1998 Efficient induction of protective anti-malaria immunity by recombinant adenovirus. Vaccine 16: 1812-17.
77. 1997 Single immunizing dose of recombinant adenovirus efficiently induces CD8+ T cell-mediated protective immunity against malaria J. Immunol. 158: 1268-74.
78. 1996 Phenotypic and functional properties of murine g/d T cell clones derived from malaria immunized, ab T cell-deficient mice. Int. Immunol. 8: 359-66.
79. 1996 Characterization of in vivo primary and secondary CD8+ T cell responses induced by recombinant influenza and vaccinia viruses. Cell Immunol. 173: 96-107.
80. 1996 Plasmodium yoelii: Peptide immunization induces protective CD4+ T cells against a previously unrecognized cryptic epitope of the circumsporozoite protein Exp. Parasitol. 84: 223-30.
81. 1996 Differential infectivity of Plasmodium berghei and P. yoelii in vivo is established primarily after sporozoite invasion of liver cells Mol. Bio. Parasitol. 77: 7-17.
82. 1996 Immunity to malaria: Protective immune mechanisms mediated by T cells. Inf. Infl. Immun. 26: 2-9. In Japanese. Review
83. 1995 Murine epidermal Vg5/Vd1-TCR+ T cells respond to B cell lines and lipopolysaccharides. J. Invest. Dermatology 105: 58-61.
84. 1995 Development of anti-malaria immunity in mice lacking interferon- receptor. J. Immunol. 154: 5338-44.
85. 1994 Demonstration of heat-shock protein 70 in the sporozoite stage of malaria parasites. Parasitol. Res. 80: 16-21.
86. 1994 Tcells contribute to immunity against the liver stages of malaria in a/b T cell-deficient mice. Proc. Natl. Acad. Sci. USA. 91: 345-9.
87. 1993 Pfs 2400 can mediate antibody-dependent malaria transmission inhibition and may be the Pasmodium falciparum 11.1 gene product J. Exp. Med. 177: 273-81.
88. 1992 Monoclonal antibodies recognize a processing dependent epitope present in the mature CS protein of various plasmodial species. Parasite Immunol. 14: 457-69.
89. 1991 Immunity to malaria: Sporozoite vaccine development. Inf. Infl. Immun. 21: 149-56. In Japanese. Review.
90. 1990 The development of malaria vaccine: Induction of T cells is the main stream of sporozoite vaccine develoment Prog. Med. 152: 160. In Japanese. Review.
91. 1990 CD4+ cytolytic T cell clone confers protection against murine malaria. J. Exp. Med. 172:1353-7.
92. 1988 Establishment of murine T cell lines and clones, hybridomas and transfectomas In: Kaufman S, Kabelitz, D. eds. Methods in Microbiology. New York, Academic Press, 25: 205-235
93. 1987 Autoimmunity and immune circuit In: Wigzell H, Kyogoku M. eds. New Horizons in Animal Models for Autoimmune Disease. New York: Academic Press, 341-347.
94. 1987 Introducing Immunology, Nankodo Co., Ltd., Tokyo 96.   Originally edited by Staines, N., Brostoff, J.and James, K. Gower Medical Publishing Ltd., London (1985).
95. 1987 Shared idiotopes between anti-class II monoclonal antibodies and major histocompatibility complex restriction site of T cells Eur. J. Immunol. 117: 675-81.
96. 1986 The immune circuit: Somatic generation of epitopes involved in the mutual recognition by different subsets of T cells In: Reichlin M, Capra JD, eds. Idiotypes. New York: Academic Press, 249-261.
97. 1986 Adaptive construction of the immune circuit Prog Immunol VI 427-437.


4th Annual Pharma R&D Asia Congress
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