Biotech China 2014

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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors
1. 2011 Quantitative proteomics and transcrptomics addressing the estrogen receptor subtypemediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein Mol Cell Proteomics, 10.1074/mcp.M110.002170-1
2. 2011 Estrogen receptors: Diseases and estrogen receptor-subtype targeted therapies Clin Pharmacol Ther, 89, 44-55
3. 2011 Lactobacillus Paracasei F19 decreases fat storage by regulating fasting induced adipose factor (FIAF). PLoS ONE, 2010 Sep 30;5(9). Pii: e13087
4. 2011 Both LXR isoforms control energy expenditure by regulating BAT activity Proc. Natl. Acad. Sci. USA, 108, 403-408
5. 2011 Estrogen receptor b signals left ventricular hypertrophy sex differences in normotensive deoxycorticosterone acetate-salt mice Hypertension, 3, 648-654
6. 2011 The role of the estrogen/estrogen-receptor-beta axis in the genomic response to pressure overload-induced hypertrophy Physiol. Genomics, in press 2011.
7. 2011 Critical role of astroglial ApoE and Liver X Receptor expression for microglial A phagocytosis” J. Neuroscience, in press 2011
8. 2010 SOX9 mediates the retinoic acid-induced HES-1 gene expression in human breast cancer cells Breast Cancer Res. Treat., 120, 317-326
9. 2010 Genome-wide mapping of estrogen receptor b binding regions reveals extensive cross talk with AP-1 Cancer Res. 70, 5174-5183
10. 2010 Nuclear receptor in analytics – a fruitful joint venture or a wasteful futility? Trends Analyt. Chem., 29, 297-305
11. 2010 Characterization of neuropathological and biochemical changes during the disease progression in liver X receptor b -/- mice, a model of adult neuron disease . J. Neuropathol. Exp. Neurol., 69, 593-605
12. 2010 Proteomic analysis of the estrogen receptor alpha receptosome Mol. Cell Proteomics 9.7, 1411-1422
13. 2010 Gonadotropin-positive pituitary tumors accompanied by ovarian tumors in aging female ERb-/- mice. Proc. Natl. Acad. Sci. USA, 107, 6453-6458
14. 2010 Levels of 17a-estradiol receptors expressed in embryonic and adult zebrafish following in vivo treatment of natural or synthetic ligands PLoS ONE 5(3): e9678.doi:10.1371/journal. Pone.0009678
15. 2010 ADD1/SREBP1c activates the PGC1-a promoter in brown adipocytes Biochim. Biophys. Acta, 1801, 421 429
16. 2010 GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRb in the hepatic acute phase response. Genes Dev., 24, 381-395
17. 2010 RBCK1 drives breast cancer cell proliferation by promoting transcription of estrogen receptor a and cyclin B1 Cancer Res., 70, 1265-1274
18. 2010 The human ADFP gene is a direct Liver-X-Receptor (LXR) target gene and differentially regulated by synthetic LXR ligands Mol. Pharmacol. 77, 79—86
19. 2010 Tumor-mediated liver X receptor-a activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses Nature Medicine, 16, 98-106
20. 2010 Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G2/M checkpoint signaling. Breast Cancer Res.Treat
21. 2010 Estrogen-dependent gallbladder carcinogenesis in LXRb-/- female mice Proc. Natl. Acad. Sci. USA, 14763-14768
22. 2010 Estrogen signaling via estrogen receptor b. J. Biol. Chem., 285, 39575-39579
23. 2010 Perspective: Estrogen receptors in colorectal cancer: Goalkeepers, strikers or bystanders Cancer Prev. Res. 8, 897-899
24. 2010 Liver X receptor b and thyroid hormone receptor a in brain cortical layering . Proc. Natl. Acad. Sci. USA, , 107, 12305-12310
25. 2010 ERb: recent understanding of estrogen signaling Trends Endocrinol Metab., 21, 545-552
26. 2009 E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis Mol. Cell Biol., 29, 2230-2242
27. 2009 Rapid regulation of KATP channel activity by 17b-estradiol in pancreatic b-cells involves the estrogen receptor b and the atrial natriuretic peptide receptor Mol. Endocrinol., 23, 1973-1982
28. 2009 Hes-6, an inhibitor of Hes-1, is regulated by 17b-estradiol and promotes breast cancer cell proliferation Breast Cancer Res., 11:R79, 1-9
29. 2009 Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARa-dependent stearoyl-coenzyme a desaturase PLosOne, 4, 1-14
30. 2009 bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver Arterioscler. Thromb. Vasc. Biol., 29, 1488-1495
31. 2009 Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells Cell Stem Cell, 5, 409-419
32. 2009 The human thioredoxin reductase-1 splice variant TXNRD1_v3 is an atypical inducer of cytoplasmic filaments and cell membrane filopodia. Biochim Biophys. Acta, 1793, 1588-1596
33. 2009 Disruption of estrogen receptor signaling enhances intestinal neoplasia in ApcMin/+ mice Carcinogenesis, 30, 1581-1590
34. 2009 Genetic mapping of Mom5, a novel modifier of ApcMin-induced intestinal tumorigenesis Carcinogenesis, 30, 1591-1596
35. 2009 : Tumor repressive functions of estrogen receptor b in SW480 colon cancer cells Cancer Res., 15, 6100-6106
36. 2009 Functional interaction of DYX1C1 with estrogen receptors suggest involvement of hormonal pathways in dyslexia Human Molecular Genetics, 18, 2802- 2812
37. 2009 Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice J. Clin. Invest., 119, 1626-1637
38. 2009 GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus Mol. Cell, 34, 510-518
39. 2009 Ablation of estrogen receptor a or b eliminates sex differences in mechanical pain threshold in normal and inflamed mice Pain, 143, 37-40
40. 2009 The oxysterol receptor LXR inhibits proliferation of human breast cancer cells Carcinogenesis, 30, 575-579,
41. 2009 A role for epithelial-mesenchymal transition in the etiology of benign prostatic hyperplasia Proc. Natl. Acad. Sci. USA, 106, 2859-2863
42. 2009 Hormonal regulation of prolactin cell development in the fetal pituitary gland of the mouse Endocrinology, 150, 1061-1068
43. 2009 Minireview: Liver X receptor b: Emerging roles in physiology and diseases Mol. Endocrinol., 23, 129-136
44. 2009 Spatiotemporal dynamics of the expression of estrogen receptors in the postnatal mouse brain Mol. Psychiatry, 14, 223-232
45. 2009 Stromal growth and epithelial cell proliferation in ventral prostates of liver X receptor knockout mice Proc. Natl. Acad. Sci. USA, 106, 558-563
46. 2008 Genome-wide identification of estrogen receptor a-binding sites in mouse liver Mol. Endocrinol., 22, 10-22
47. 2008 Different roles of estrogen receptors α and β in the regulation of E-cadherin protein levels in a mouse mammary epithelial cell line Cancer Res. 68, 8695-8704
48. 2008 Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes J. Biol. Chem, 283, 22723-22736
49. 2008 Estrogen receptor β selective ligand 5α-androstane-3β, 17β-diol stimulates spermatogonial deoxyribonucleic acid synthesis in rat seminiferous epithelium in vitro Endocrinol., 149, 2917-2922
50. 2008 RAP250 is a coactivator in the transforming growth factor β signaling pathway that interacts with Smad2 and Smad3 J. Biol. Chem., 283, 8995-9001
51. 2008 Pancreatic exocrine insufficiency in LXRβ-/- mice is associated with a reduction in aquaporin-1 expression Proc. Natl. Acad. Sci. USA, 105, 15052-15057
52. 2008 Expression of liver X receptor β is essential for formation of superficial cortical layers and migration of later-born neurons Proc. Natl. Acad. Sci. USA, 105, 13445-13450
53. 2008 PLoS Genetics, 4, 1-16 Metabolic actions of estrogen receptor beta (ERβ) are mediated by a negative cross-talk with PPARγ
54. 2008 Estrogen receptor β protects against acoustic trauma in mice J. Clin. Investigation, 118, 1563-1570
55. 2008 The genome landscape of ERα- and ERβ-binding DNA regions Proc. Natl. Acad. Sci. USA, 105, 2604-2609
56. 2008 A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells Oncogene, 27, 1019-1032
57. 2008 Liver X receptor b (LXR b): A link between b-sitosterol and amyotrophic lateral sclerosis-Parkinson’s dementia Proc. Natl. Acad. Sci. USA, 105, 2094-2099
58. 2007 Estrogen receptor b deficient female mice develop a bladder phenotype resembling human interstitial cystitis Proc. Natl. Acad. Sci. USA, 104, 9806-9809
59. 2007 Estrogen receptors: How do they signal and what are their targets Physiol. Rev., 87, 905-931
60. 2007 Wrestling rules in transrepression: As easy as SUMO-1, -2, -3 Mol. Cell, 25, 178-180
61. 2007 Ovarian wedge resection restores fertility in estrogen receptor b knockout (ERb-/-) mice Proc. Natl. Acad. Sci. USA, 104, 600-605
62. 2007 Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis Proc. Natl. Acad. Sci. USA, 104, 15665-15670
63. 2007 Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer Breast Cancer Res., 9:R25, 1-11
64. 2007 Estrogen receptor b is essential for sprouting of nociceptive primary afferents and for morphogenesis and maintenance of the dorsal horn interneurons Proc. Natl. Acad. Sci. USA, 104, 13696-13701
65. 2007 : Estrogen receptor b2 negatively regulates the transactivation of estrogen receptor a in human breast cancer cells Cancer Res., 67, 3955-3962
66. 2006 Estrogen receptors: new players in diabetes mellitus Trends Mol. Med., 12, 425-431
67. 2006 The hair follicle as an estrogen target and source Endocrine Rev., 6, 677-706
68. 2006 Estrogen receptor b expression in the embryonic brain regulates development of calretinin-immunoreactive GABAergic interneurons Proc. Natl. Acad. Sci. USA., 103, 19338-19343
69. 2006 Estrogen receptor b inhibits angiogenesis and growth of T47D breast cancer xenografts Cancer Res., 23, 11207-11213
70. 2006 Role of estrogen receptor b in uterine stroma and epithelium: Insights from estrogen receptor b mice Proc. Natl. Acad. Sci. USA., 103, 18350-18355
71. 2006 : Cholesterol-sensing receptors, liver X receptor and , have novel and distinct roles in osteoclast differentiation and activation. J. Bone Min Res., 21, 1276-1287
72. 2006 Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: A possible mechanism is through direct regulation of signal transducer and activator of transcription 3 Mol. Endocrinol., 6, 1287-1299
73. 2006 Lung dysfunction causes systemic hypoxia in estrogen receptor b knockout (ERb-/-) mice Proc. Natl. Acad. Sci. USA., 103, 7165-7169
74. 2006 Estrogen receptor b polymorphism is associated with prostate cancer risk. Clin. Cancer Res., 12, 1936-1941
75. 2006 Estrogen receptor (ER) b modulates ERa-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen responsive promoters Mol. Endo., 20, 534-543
76. 2006 Role of estrogen receptor b in colonic epithelium Proc. Natl. Acad. Sci. USA., 103, 2959-2964
77. 2006 Muscle GLUT4 regulation by estrogen receptors ER and ER Proc. Natl. Acad. Sci. USA., 103, 1605-1608
78. 2005 Reflections on the discovery and significance of estrogen receptor b. Endocrine Rev., 29, 465-478
79. 2005 EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation Nucleic Acids Res., 33, 3561-3569
80. 2005 Liver X receptors a and b regulate renin expression in vivo, J. Clin. Invest. 115, 1913-1922
81. 2005 The liver X receptor-b is essential for maintaining cholesterol homeostasis in the testis Endocrinology, 146, 2519-2530
82. 2005 Increased estrogen receptor bcx expression during mammary carcinogenesis Clin. Cancer Res., 11, 3170-3174
83. 2005 A previously uncharacterized role for estrogen receptor b: Defeminization of male brain and behavior Proc. Natl. Acad. Sci. USA., 102, 4608-4612
84. 2005 Inactivation of liver X receptor b leads to adult-onset motor neuron degeneration in male mice Proc. Natl. Acad. Sci. USA., 102, 3857-3862
85. 2005 Early onset of puberty and ovarian failure in CYP7B1 knockout mice Proc. Natl. Acad. Sci. USA., 102, 2814-2819
86. 2005 Estrogen receptor a and imprinting of the neonatal mouse ventral prostate by estrogen Proc. Natl. Acad. Sci. USA., 102, 1484-1489
87. 2005 Transcriptional corepression by SHP: molecular mechanisms and physiological consequences Trends Endocrin. Met, 16, 478-488
88. 2005 Steroids and the scientis . Mol. Endocrinol., 19, 1412-1417
89. 2004 Estrogen receptors ERa and ERb in proliferation in the rodent mammary gland Proc. Natl. Acad. Sci. USA, 101, 3739-3746
90. 2004 Autoimmune glomerulonephritis with spontaneous formation of splenic germinal centers in mice lacking the estrogen receptor alpha gene Proc. Natl. Acad. Sci. USA, 101, 1720-1724
91. 2004 Association of estrogen receptor b gene polymorphisms with bulimic disease in women Mol. Psychiatry, 9, 28-34
92. 2004 Estrogen receptor b inhibits 17b-estradiol-stimulated proliferation of the breast cancer cell line T47D Proc. Natl. Acad. Sci. USA, 101, 1566-1571
93. 2004 Principles for modulation of the nuclear receptor superfamily Nature Reviews Drug Discovery, 3, 950-964
94. 2004 Putative metabolic effects of the liver X receptor (LXR) Diabetes, 53, S36-S42
95. 2004 Estrogen receptor beta in prostate cancer N. Engl. J. Med., 351, 2773-2774
96. 2004 HES-1 inhibits 17b-estradiol and heregulin-b1-mediated upregulation of E2F-1 Oncogene, 23, 8826-8833,
97. 2004 Characterization of the ERb -/- mouse heart Proc. Natl. Acad. Sci. USA., 101, 14234-14239
98. 2004 Estrogen receptor b (ERb) level but not its ERbcx variant helps to predict tamoxifen resistance in breast cancer Clin. Cancer Res., 10, 5769-5776
99. 2004 Aromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjögren’s syndrome . Proc. Natl. Acad. Sci. USA., 101, 12628-12633
100. 2004 Estrogen receptor b regulates epithelial cellular differentiation in the mouse ventral prostate Proc. Natl. Acad. Sci. USA., 101, 9375-9380
101. 2004 The expression of ERbcx in human breast cancer and the relationship to endocrine therapy and survival Clin. Cancer Res., 10, 2421-2428
102. 2004 Identification of tamoxifen-induced coregulator interaction surfaces within the ligand-binding domain of estrogen receptors Mol. Cell Biol., 24, 3445-3459
103. 2003 Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor a J. Biol. Chem., 278, 48283-48291,
104. 2003 What pharmacologists can learn from recent advances in estrogen signaling Trends Pharmacol. Sci
105. 2003 An endocrine pathway in the prostate, ERb, AR, 5a-androstane-3b, 17b-diol, and CYP7B1, regulates prostate growth Proc.Natl.Acad.Sci. USA, 99, 13589-13594
106. 2003 : Regulation of postnatal lung development and homeostasis by estrogen receptor b Mol. Cell. Biol., 23, 8542-8552
107. 2003 The three-dimensional structure of the liver X receptor b reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands J. Biol. Chem., 278, 38821-38828
108. 2003 : Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis Proc. Natl. Acad. Sci. USA., 100, 6694-6699
109. 2003 Estrogen receptor (ER)- b reduces ERa-regulated gene transcription, supporting a “ying yang” relationship between ERa and ERb in mice . Endocrinol. 17, 203-208
110. 2003 Estrogen receptor (ER) b knockout mice reveal a role for ERb in migration of corticol neurons in the developing brain Proc. Natl. Acad. Sci. USA, 100, 703-708
111. 2002 Abnormal vascular function and hypertension in mice deficient in estrogen receptor b Science, 295, 505-508
112. 2002 : Biological role of estrogen and estrogen receptors. Critical Rev. Biochem Critical Rev. Biochem Mol. Biol., 37, 1-28
113. 2002 Elucidation of estrogen receptor function in bone with the use of mouse models Trends Endocrin. Met., 13, 195-200
114. 2002 Involvement of estrogen receptor b in terminal differentiation of mammary gland epithelium. Proc. Natl. Acad. Sci. USA, 99, 15578-15583
115. 2002 Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue Mol. Pharmacol., 62, 1299-1305
116. 2002 An endocrine pathway in the prostate, ERb, AR, 5a-androstane-3b, 17b-diol, and CYP7B1, regulates prostate growth Proc.Natl.Acad.Sci. USA, 99, 13589-13594
117. 2002 Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration Proc.Natl.Acad.Sci. USA, 99, 13878-13883
118. 2002 Accumulation of foam cells in liver X receptor-deficient mice Circulation, 106, 1147-1153
119. 2002 Liver X receptor downregulates 11b-hydroxysteroid dehydrogenase type 1 expression and activity Diabetes, 51, 2426-2433
120. 2002 Estrogen actions in the brain Science STKE, 138, 2002. http://stke.sciencemag.org/cgi/content/full/sigtrans;2002/138/pe29
121. 2002 A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP EMBO reports, 5, 478-484
122. 2002 Liver X receptors as insuling-mediating factors in fatty acid and cholesterol biosynthesis J. Biol. Chem., 277, 10691-10697
123. 2002 Disruption of estrogen receptor b gene impairs spatial learning in female mice Proc.Natl.Acad.Sci. USA, 99, 3996-4001
124. 2002 Estrogen receptor beta in breast cancer Endocrine-Related Cancer, 9, 1-13
125. 2001 Structural insights into the mode of action of a pure antiestrogen Structure, 9, 145-153
126. 2001 Comparing nuclear receptors in worms, flies and humans Trends Pharmacol. Sci., 22, 611-615
127. 2001 : Mechanism of estrogen action Physiol. Rev. 81, 1535-1565
128. 2001 Role of estrogen receptor beta in estrogen action Annu. Rev. Physiol., 63, 165-92
129. 2001 Female estrogen receptor b -/- mice are partially protected against age-related trabecular bone loss J. Bone and Mineral Res., 16
130. 2001 Morphological abnormalities in the brains of estrogen receptor b knockout mice Proc.Natl.Acad.Sci. USA, 98, 2792-2796
131. 2001 Frequent loss of estrogen receptor-b expression in prostate cance Cancer Res., 61, 5331-5335
132. 2001 Neurosteroid hydroxylase CYP7B vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation J. Biol. Chem., 276, 23937-23944
133. 2001 A role for estrogen receptor b in the regulation of growth of the ventral prostate Proc.Natl.Acad.Sci. USA, 98, 6330-6335
134. 2001 Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRb-deficient mice J. Clin. Invest., 107, 565-573
135. 2000 Nematode genome sequence dramatically extends the nuclear receptor superfamily Trends Pharmacol. Sci., 21, 85-87
136. 2000 Estrogen receptors a and b in the rodent mammary gland Proc.Natl.Acad.Sci. USA, 97, 337-342
137. 2000 Cloning and characterization of RAP250, a novel nuclear receptor coactivator J. Biol. Chem. 275, 5308-5317
138. 2000 : Estradiol induces differential neuronal phenotypes by activating estrogen receptor a or b Endocrinol., 141, 1839-1845
139. 2000 Estrogen receptor (ER) b,a modulator of ERa in the uterus Proc.Natl.Acad.Sci. USA, 97, 5936-5941
140. 2000 Estrogen receptor b acts as a dominant regulator of estrogen signaling Oncogene, 19, 4970-4978
141. 2000 Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development Mechanisms of Development 97, 13-26
142. 2000 The Hairy and Enhancer of Split homologue-1 (HES-1) mediates the proliferative effect of 17b-estradiol on breast cancer cell lines Oncogene, 19, 5951-5953
143. 2000 DAX-1 functions as an LXXLL-containing corepressor for activated estrogen receptors J. Biol. Chem., 275, 39855-39859
144. 2000 Abolition of male sexual behaviors in mice lacking estrogen receptors a and b (abERKO) Proc.Natl.Acad.Sci. USA, 97, 14737-14741
145. 2000 False negatives in oestrogen-receptor assay The Lancet, 356, 944
146. 1999 Steroid and nuclear receptors EMBO J., 18, 6201-6210
147. 1999 Seeking ligands for lonely orphan receptors Science, 284, 1285-1286,
148. 1999 Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERb -/- mice J. Clin. Invest., 104, 895-901
149. 1999 Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist EMBO J., 18, 4608-4618
150. 1999 Transcriptional targets shared by estrogen receptor-related receptors (ERRs) and estrogen receptor (ER) a, but not by ERb. EMBO J. 18, 4270-4279
151. 1999 : Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors a and b Proc. Natl. Acad. Sci. USA, 96, 7077-7082
152. 1999 Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for binding to nuclear receptors J. Biol. Chem., 274, 6667-6677
153. 1999 The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERa and ERb. J. Biol. Chem., 247, 345-353
154. 1998 A regulatory role for RIP140 in nuclear receptor activation Mol. Endocrinol., 12, 864-881
155. 1998 Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor b Endocrinology, 139, 4252-4263
156. 1998 Cross-talk between steroids and NF-kB: what language Trends Biochem. Sci., 233-235
157. 1998 Estrogen is a male and female hormone Science & Medicine, 5, 36-45
158. 1998 Therapeutic potential of selective estrogen receptor modulators Current Opinion in Chemical Biology, 2, 508-511
159. 1998 ERb: a novel estrogen receptor offers the potential for new drug development Trends Endocrin. Met., 9, 387-395
160. 1998 Magic bullet for heart and bone Nature Medicine, 4, 152
161. 1998 The estrogen receptor b subtype: A novel mediator of estrogen action in neuroendocrine systems . Frontiers in Neuroendocrinol, 19, 253-286
162. 1998 Generation and reproductive phenotypes of mice lacking estrogen receptor b Proc.Natl.Acad.Sci. USA, 95, 15677-15682
163. 1997 Role of hydrophobic amino acid clusters in the transactivation activity of the human glucocorticoid receptor Mol. Cell Biol., 17, 934-945
164. 1997 Estrogen receptor b - Getting in on the action Nature Medicine, 3, 493-494
165. 1997 : Human estrogen receptor b-gene structure, chromosomal localization and expression pattern . J. Clin. Endocrinol. Metab., 82, 4258-4265
166. 1997 : Pancreatic b-cells are important targets for the diabetogenic effects of glucocorticoids . J. Clin. Invest. 100, 2094-2098
167. 1997 Insights into the molecular basis of agonism and antagonism in the oestrogen receptor as revealed by complexes with 17b-oestradiol and raloxifene Nature, 389, 753-758
168. 1997 Differential transactivation properties of the estrogen receptor isotypes (a, b): Estrogen-like effects with antiestrogens and antiestrogen effects with estrogen . Science, 277, 1508-1510
169. 1997 Mouse estrogen receptor b forms estrogen response element binding heterodimers with estrogen receptor a a. Mol. Endocrinol. 11, 1486-1496
170. 1997 Role of the Ada Adaptor Complex in Gene Activation by the Glucocorticoid Receptor . Mol. Cell Biol. 3065-3073
171. 1997 Estrogen receptor-b mRNA expression in rat ovary: Down-regulation by gonadotropins Mol. Endocrinol. 11, 172-182
172. 1997 Cloning and expression of a novel mammalian thioredoxin J. Biol. Chem., 272, 2936-2941
173. 1996 Cloning of a novel estrogen receptor expressed in rat prostate and ovary Proc.Natl.Acad.Sci. USA 93, 5925-5930
174. 1996 Orphan nuclear receptor - The first eight years. Mol. Endocrinol. 10, 1293-1307
175. 1995 Mass spectrometric analysis of a native zinc-finger structure: The glucocorticoid receptor DNA binding domain J. Am. Chem. Society, 117, 3319-3324
176. 1995 : Cytochrome P450 in the brain: Neuroendocrine functions Frontiers in Neuroendocrinology, 16, 224-236
177. 1995 Solution structure of a mammalian PCB-binding protein in complex with a PCB Nature Struct. Biol.2, 983-989
178. 1995 Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor Proc.Natl.Acad.Sci. USA, 92, 1699-1703
179. 1995 Negative cross-talk between ReIA and the glucocorticoid receptor: A possible mechanism for the antiinflammatory action of glucocorticoids Mol. Endocrinol. 9, 401-412
180. 1995 OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor Proc. Natl. Acad. Sci. USA, 92, 2096-2100
181. 1994 Delineation of a small region within the major transactivation domain of the human glucocorticoid receptor that mediates transactivation of gene expression Proc. Natl. Acad. Sci. USA. 91, 1619-1623
182. 1994 : Evolution of distinct DNA-binding specificities within the nuclear receptor family of transcription factors . Proc.Natl. Acad. Sci. USA., 91, 4175-4179
183. 1994 Effect of ethanol on cytochrome P450 in the rat brain. Proc Natl. Acad. Sci. USA., 91, 1019-1023
184. 1993 Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor Proc. Natl. Acad. Sci. USA, 90, 1440-1444
185. 1993 Structure and function of the DNA-binding domain of the glucocorticoid receptor and other members of the nuclear receptor supergene family Accounts of Chem. Res., 26, 644-650
186. 1993 : A systematic analytical chemistry/cell assay approach to isolate activators of orphan nuclear receptor from biological extracts: characterization of peroxisome proliferator-activated receptor activators in plasma J. Lipid Res., 34, 1583-1591
187. 1993 : Interactions of indolo[3,2-b]carbazoles and related polycyclic aromatic hydrocarbons with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver . Mol. Pharmacol., 44, 336-345
188. 1993 Direct interaction of the t1 transactivation domain of the human glucocorticoid receptor with the basal transcriptional machinery Mol. Cell. Biol., 13, 399-407
189. 1992 Importance of growth hormone for the induction of hepatic low density lipoprotein receptors Proc.Natl.Acad.Sci. USA, 89, 6983-6987
190. 1992 The dioxin and peroxisome proliferator-activated receptors: nuclear receptors in search of endogenous ligands Trends Pharmacol. Sci., 13, 241-245
191. 1992 Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor Proc.Natl.Acad.Sci. USA, 89, 4653-4657
192. 1991 High level expression of the major transactivation domain of the human glucocorticoid receptor in yeast cells inhibits endogenous gene expression and cell growth Mol. Endocrinology.,5, 1366-1372,
193. 1991 : The Glucocorticoid Receptor Binds to a Sequence Overlapping the TATA Box of the Human Osteocalcin Promoter: a Potential Mechanism for Negative Regulation Mol. Cell. Biol, 11, 3379-3383
194. 1990 Cloning, structure, and expression of a rat binding protein for polychlorinated biphenyls J. Biol. Chem., 265, 12690-12693
195. 1990 Solution structure of the glucocorticoid receptor DNA-binding domain Science, 249, 157-160
196. 1990 Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene Mol.Cell. Biol., 10, 4712-4719
197. 1990 Structural and regulatory analysis of the male-specific rat liver cytochrome P-450g: Repression by continuous growth hormone administration Mol. Endocrinol. 4, 53-58
198. 1989 Regulation of sexual differentiation in drug and steroid metabolism Trends Pharmacol. Sci., 10, 149-153
199. 1989 Transcriptional and posttranscriptional regulation of sexually differentiated rat liver cytochrome P-450 by growth hormone Mol. Endocrinol. 3, 1142-1147
200. 1989 The mechanism of cAMP-induced glucocorticoid receptor expression. Correlation to cellular glucocorticoid response. J. Biol. Chem. 23, 13679-13686
201. 1989 Distribution and regulation of 5a-androstane-3b,17b-diol hydroxylase in the rat central nervous system . Endocrinology 124, 1246-2699
202. 1989 High level expression in Escherichia coli of the DNA-binding domain of the glucocorticoid receptor in a functional form utilizing domain-specific cleavage of a fusion protein J. Biol. Chem. 264, 804-809
203. 1988 Identification of hormone-interacting amino acid residues within the steroid-binding domain of the glucocorticoid receptor in relation to other steroid hormone receptors J. Biol. Chem. 263, 6843-6846
204. 1988 Localization of glucocorticoid receptor mRNA in the male rat brain by in situ hybridization Proc. Natl. Acad. Sci. USA 85, 9331-9335
205. 1988 Sex change in cytochrome P-450 phenotype by growth hormone treatment of adult rat hepatocytes maintained in a culture system on matrigel Proc. Natl. Acad. Sci. USA 85, 9783-9787
206. 1988 Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation Cell 55, 361-369
207. 1988 : Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state Nature 33, 686-688
208. 1988 Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene Genes & Development 2, 1144-1154
209. 1988 cDNA cloning, sequence, and regulation of a major female-specific and growth hormone-inducible rat liver cytochrome P-450 active in 15b-hydroxylation of steroid sulfates Proc. Natl. Acad. Sci. USA 85, 4214-4217
210. 1988 : A progesterone responsive element maps to the far upstream steroid dependent DNase hypersensitive site of chicken lysozyme chromatin EMBO J. 7, 2063-2073
211. 1987 Biochemistry, molecular biology, and physiology of the glucocorticoid receptor Endocrine Reviews 8, 185-234
212. 1987 The molybdate-stabilized non-activated glucocorticoid receptor contains a dimer of Mr 90,000 non-hormone-binding protein J. Biol. Chem. 262, 11803-11806
213. 1987 Domain structure of the glucocorticoid receptor protein. Proc. Natl. Acad. Sci. USA 84, 4437-4440
214. 1986 Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone Proc. Natl. Acad.Sci. USA 83, 5899-5903
215. 1986 Stoichiometric analysis of the specific interaction of the glucocorticoid receptor with DNA J. Biol. Chem. 261, 11770-11778
216. 1986 Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA . Cell 46, 389-399
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