Biotech China 2014

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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors
1. 2011 Prolonged Exposure of Cortical Neurons to Oligomeric Amyloid-beta Impairs NMDA Receptor Function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate ASN NEURO. (in press).
2. 2011 Advances in Understanding Copper Transporters Ann. Rev. Nutr. (in press).
3. 2010 P2Y2 Nucleotide Receptors Mediate Metalloprotease-dependent Phosphorylation of the Epidermal Growth Factor Receptor and ERB3 in Human Salivary Gland Cells J. Biol. Chem. 285, 7545-7555.
4. 2010 A Novel Insulin Secretagogue Based on a Dinucleoside Polyphosphate Scaffold. J. Med. Chem. (in press).
5. 2010 2-MeS-β,γ-CCl2-ATP is a Potent Agent for Reducing Intraocular Pressure J. Med. Chem. (in press).
6. 2010 Targeting NADPH Oxidase and Phospholipase A2 in Alzheimer’s Disease Mol. Neurobiol. (in press).
7. 2010 P2Y2 Nucleotide Receptor Regulation of Lymphotoxin-a Secretion: Implications for the Develoment of Arterial Lesions Circulation. (submitted).
8. 2010 P2Y2 Nucleotide Receptors Mediate Inflammatory Responses in the Brain Mol. Neurobiol. (in press).
9. 2010 The P2Y2 Nucleotide Receptor in Inflammation and Angiogenesis In: Extracellular ATP and Adenosine as Regulators of Endothelial Cell Function (E. Gerasimovskaya and Kaczmarek, E., eds.) Springer Publ., Amsterdam NL (in press).
10. 2010 Simvastatin Stimulates Production of the Antiapoptotic Protein Bcl-2 Via Endothelin-1 and NFATc3 in SH-SY5Y Cells Mol. Neurobiol. 41, 384-391.
11. 2010 P2Y2 Nucleotide Receptor Activation Regulates Microvascular Endothelial Cell Tight Junction Assembly Circ. Res. (submitted).
12. 2010 Altered Microglial Copper Homeostasis in a Mouse Model of Alzheimer’s Disease J. Neurochem. (submitted).
13. 2010 Rat Parotid Gland Cell Differentiation in 3D Culture Tissue Eng. (in press).
14. 2009 Development of a Novel Transgenic Rat Over-expressing the P2Y2 Nucleotide Receptor Using a Lentiviral Vector J. Vasc. Res. 46, 447–458.
15. 2009 P2Y2 Receptor Transcription is Increased by NF-kB and Stimulates COX-2 Expression and PGE2 Release by Intestinal Epithelial Cells J. Immunol. 183, 4521-4529.
16. 2009 Amyloid b-Protein Stimulates Trafficking of Cholesterol and Caveolin-1 from the Plasma Membrane to the Golgi Complex in Mouse Primary Astrocytes. Neurosci. 162, 328-338.
17. 2009 Interleukin-1β Enhances Nucleotide-Induced α-Secretase-Dependent Amyloid Precursor Protein Processing in Rat Primary Cortical Neurons Via Up-regulation of the P2Y2 Receptor. J. Neurochem. 109, 1300-1310.
18. 2009 Identification of Hydrolytically Stable and Selective P2Y1 Agonists J. Med. Chem. 44, 1525-1536.
19. 2008 Binding of the P2Y2 Nucleotide Receptor to Filamin A Regulates Migration of Vascular Smooth Muscle Cells Circulation Res. 102, 581-588.
20. 2008 The Pro-inflammatory Cytokines Tumor Necrosis Factor-a and Interferon-g Regulate Cell Polarity in Rat Par-C10 Parotid Epithelial Cell Monolayers. Am. J. Physiol. (Cell Physiol.) 295, C1191-1201.
21. 2007 P2Y2 Nucleotide Receptor Activation Up-regulates Vascular Cell Adhesion Molecule-1 Expression and Enhances Lymphocyte Adherence to Human Submandibular Gland Cell Line Mol. Immunol. 45, 65-75.
22. 2007 The P2Y2 Nucleotide Receptor Requires Interaction with aV Integrins to Access and Activate G12 . Cell. Sci. 120, 1654-1662.
23. 2006 Differential Coupling of the P2Y1 Receptor to Ga14 and Gaq/11 Proteins During the Development of the Rat Salivary Gland Arch. Oral Biol. 51, 359-370.
24. 2006 P2 Receptors: Intracellular Signalling Pfluger’s Archiv.-Eur. J. Physiol. 452, 555-562.
25. 2006 P2 Receptors in Atherosclerosis and Post-angioplastic Restenosis Purinergic Signalling 2, 471-481
26. 2006 International Union of Pharmacology XLVI. Update and Subclassification of the P2Y G Protein-coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy. Pharm. Rev. 58, 281-341.
27. 2005 Molecular Determinants of P2Y2 Nucleotide Receptor Function: Implications for Proliferative and Inflammatory Pathways in Astrocytes Mol. Neurobiol. 31, 169-184.
28. 2005 Modulation of Endothelial Cell Migration by Extracellular Nucleotides. Involvement of Focal Adhesion Kinase and Phosphatidylinositol 3-Kinase-mediated Pathways. Thromb. Haemost. 93, 735-742.
29. 2005 P2Y2 Nucleotide Receptors Enhance a-Secretase-dependent Amyloid Precursor Protein Processing. . Biol. Chem. 280, 18696-18702.
30. 2005 P2 Receptors in Health and Disease. Biotech. Genet. Eng. Rev. 22, Ch 9 171-195.
31. 2005 Phospholipase A2 in Astrocytes: Responses to Oxidative Stress, Inflammation, and G protein-Coupled Receptor Agonists Mol. Neurobiol. 31, 27-41.
32. 2005 Mechanisms for Inhibition of P2 Receptor Signaling in Neural Cells. Mol. Neurobiol. 31, 65-80.
33. 2005 P2Y2 Nucleotide Receptor Up-regulation in Submandibular Gland Cells from the NOD.B10 Mouse Model of Sjögren’s Syndrome Arch. Oral. Biol. 50, 533-540.
34. 2005 Endocytosis Mechanism of P2Y2 Nucleotide Receptor Tagged with Green Fluorescent Protein: Clathrin and Actin Cytoskeleton-dependence Cell. Mol. Life Sci. 62, 1388-1399.
35. 2005 P2X7 Receptors Mediate Caspase-8/9/3-dependent Apoptosis in Rat Primary Cortical Neurons Purinergic Signalling 1 (4), 337-347.
36. 2005 Agonist-induced Phosphorylation and Desensitization of the P2Y2 Nucleotide Receptor Mol. Cell Biochem. 280, 35-45.
37. 2005 The P2Y2 Nucleotide Receptor Requires Interaction with av Integrins to Communicate with Go and Induce Cell Migration J. Biol. Chem. 280, 39050-39057.
38. 2005 P2Y2 Nucleotide Receptor Interaction with av Integrin Mediates Astrocyte Migration J. Neurochem. 95, 630-640.
39. 2005 Neuroprotective Mechanisms of Curcumin against Cerebral Ischemia-Induced Neuronal Apoptosis and Behavioral Deficits J. Neurosci. Res. 82, 138-148.
40. 2004 The Recently Deorphanized GPR80 (GPR99) proposed to be the P2Y15 Receptor is not a Genuine P2Y Receptor TiPS 26, 8-9.
41. 2004 Src homology 3 Binding Sites in the P2Y2 Nucleotide Receptor Interact with Src and Regulate Activities of Src, Proline-rich Tyrosine Kinase 2, and Growth Factor Receptors J. Biol. Chem. 279, 8212-8218.
42. 2004 P2X7 Receptors Stimulate Akt Phosphorylation In Astrocytes Br. J. Pharm. 141, 1106-1117
43. 2004 P2Y2 Receptors Activate Neuroprotective Mechanisms in Astrocytic Cells J. Neurochem. 91, 119-132.
44. 2004 The P2Y2 Nucleotide Receptor Mediates Vascular Cell Adhesion Molecule-1 Expression through Interaction with VEGF Receptor-2 (KDR/Flk-1) J. Biol. Chem. 279, 35679-35686.
45. 2004 Cloning, Up-regulation, and Mitogenic Role of the Porcine P2Y2 Receptor in Coronary Artery Smooth Muscle Cells. Mol. Pharm. 66, 1265-1274.
46. 2003 Prostaglandin E2 Production in Astrocytes: Regulation by Cytokines, Extracellular ATP, and Oxidative Agents. Prostaglandins Leukot. Essent Fatty Acids 69, 437-448.
47. 2003 Mechanisms of P2X7 Receptor-mediated ERK1/2 Phosphorylation in Human Astrocytoma Cells Am. J. Physiol.: Cell Physiol. 284, C571-C581
48. 2003 Characterization of the UDP-glucose Receptor (Renamed Here the P2Y14 Receptor) Adds Diversity to the P2Y Receptor Family TiPS 24, 52-55.
49. 2003 Signal Transduction Pathways for P2Y2 and P2X7 Nucleotide Receptors that Mediate Neuroinflammatory Responses in Astrocytes and Microglial Cells Biomed. Res. 14, 47-61.
50. 2003 The P2Y2 Nucleotide Receptor Mediates UTP-induced Vascular Cell Adhesion Molecule-1 Expression in Coronary Artery Endothelial Cells J. Biol. Chem. 278, 24960-24965.
51. 2003 P2X7 Nucleotide Receptor Activation Enhances IFNg-induced Type II Nitric Oxide Synthase Activity in BV-2 Microglial Cells J. Neurochem. 87, 344-352.
52. 2002 Purine Signaling and Potential New Therapeutic Approach: Possible Outcomes of NTPDase Inhibition Current Drug Targets.  3(3), 229-245.
53. 2002 Functional P2Y2 Nucleotide Receptors Mediate Uridine 5’-Triphosphate-Induced Intimal Hyperplasia in Collared Rabbit Carotid Arteries Circulation 106, 2720-2726.
54. 2002 Role of PKC and MAPK in cytosolic PLA2 Phosphorylation and Arachidonic Acid Release in Primary Murine Astrocytes J. Neurochem. 83, 259-270
55. 2001 P2Y2 Nucleotide Receptor Signaling in Human Monocytic Cells: Activation, Desensitization and Coupling to Mitogen-activated Protein Kinases J. Cell. Physiol. 187(2), 196-208.
56. 2001 P2Y2 Receptors Regulate Multiple Signal Transduction Pathways in Monocytic Cells. Drug Dev. Res. 53, 186-192.
57. 2001 P2Y receptors. In: The IUPHAR Compendium of Receptor Characterization and Classification, Edition 2. IUPHAR Media Publications, pp 306-320.
58. 2001 An RGD Sequence in the P2Y2 Receptor Interacts with aVb3 Integrins and is Required for Go-mediated Signal Transduction J. Cell Biol. 153(3), 491-501.
59. 2000 Extracellular UTP Stimulates Electrogenic Bicarbonate Secretion Across CFTR Knockout Gallbladder Epithelium Am. J. Physiol.: Gastrointest. Liver Physiol. 279 (1), G132-G138
60. 2000 Differential Agonist-induced Desensitization of P2Y2 Nucleotide Receptors by ATP and UTP Mol. Cell. Biochem. 206, 75-89.
61. 2000 Mechanisms of Agonist-dependent and -independent Desensitization of a Recombinant P2Y2 Nucleotide Receptor Mol. Cell. Biochem. 205, 115-123.
62. 1999 Dyslipidemia and Vascular Dysfunction in Diabetic Pigs Fed an Atherogenic Diet Arterioscler. Thromb. Vasc. Biol. 19, 2981-2992. 
63. 1999 P2Y Receptors in the Nervous System: Molecular Studies of a P2Y2 Receptor Subtype from NG-108-15 Neuroblastoma Glioma Hybrid Cells. Progress in Brain Res. 120, 33-43.
64. 1999 Desensitization of P2Y2 Receptor-activated Transepithelial Anion Secretion Am. J. Physiol. (Cell Physiol.) 276, C777-C787.
65. 1998 The Cloning and Expression of G Protein-coupled P2Y Nucleotide Receptors In: P2 Nucleotide Receptors (J.T. Turner, G.A. Weisman, and J.S. Fedan, eds.). Humana Press, Totowa, NJ, USA, Ch. 3, pp. 63-79.
66. 1998 P2 Nucleotide Receptors (J.T. Turner, G.A. Weisman, and J.S. Fedan, eds.). Humana Press, Totowa, NJ, USA.
67. 1998 Salivary Gland Nucleotide Receptors: Evidence for Functional Expression of Both P2X and P2Y Subtypes Eur. J. Morph. 36, 170-175.
68. 1998 Structural Basis of Agonist-induced Desensitization and Sequestration of the P2Y2 Nucleotide Receptor: Consequences of Truncation of the C-terminus J. Biol. Chem. 273, 29437-29444.
69. 1998 Salivary Gland Nucleotide Receptors: Changes in Expression and Activity Related to Development and Tissue Damage Ann. NY Acad. Sci. 842, 70-75.
70. 1998 P2Y Nucleotide Receptors in the Immune System: Signaling by a P2Y2 Receptor in U937 Monocytes Drug Dev. Res. 45, 222-228.
71. 1998 Structure and Function of P2Y2 Nucleotide Receptors in Cystic Fibrosis (CF) Epithelium. Adv. Exp. Med. Biol. 431, 417-424.
72. 1998 Future Directions in P2 Receptor Research In: P2 Nucleotide Receptors (J.T. Turner, G.A. Weisman, and J.S. Fedan, eds.). Chapter 16. Humana Press, Totowa, NJ, USA
73. 1998 2 Receptor Modeling and Identification of Ligand Binding Sites. In: P2 Nucleotide Receptors (J.T. Turner, G.A. Weisman, and J.S. Fedan, eds.). Humana Press, Totowa, NJ, USA, Ch. 8, pp. 135-166.
74. 1997 Transient Up-Regulation of P2Y2 Nucleotide Receptor mRNA Expression is an Immediate Early Gene Response in Activated Thymocytes Proc. Natl. Acad. Sci. (USA) 94, 831-836.
75. 1997 Identification and Characterization of P2Y2 Nucleotide Receptors in Human Retinal Pigment Epithelial Cells J. Neurosci. Research 48, 1-10.
76. 1997 Changes in P2Y1 Nucleotide Receptor Activity During the Development of Rat Salivary Glands Am. J. Physiol. (Cell Physiol.) 41, C1388-C1393.
77. 1997 Upregulation of P2Y2 Nucleotide Receptor in Rat Salivary Gland Cells During Short Term Culture Am. J. Physiol. (Cell Physiol.) 42, C1100-C1107.
78. 1996 Structure and Function of P2 Purinoceptors J. Pharm. Exp. Therap. 277, 1-9.
79. 1996 Cloned and Transfected P2Y4 Receptors: Characterization of a Suramin and PPADS Insensitive Response to UTP Br. J. Pharmacol. 119, 1301-1303
80. 1996 PPADS and Suramin as Antagonists at Cloned P2Y- and P2U-purinoceptors. Br. J. Pharmacol. 118, 704-710.
81. 1996 P2U Purinoceptors: cDNA Cloning, Signal Transduction and Structure-function Analysis In: P2 Purinoceptors: Localization, Function and Transduction Mechanisms (D.J. Chadwick and J.A. Goode, eds.). John Wiley & Sons Ltd., Chichester, UK. Vol. 198, pp. 193-207.
82. 1996 P2 Nucleotide Receptor Structure and Function In: Ecto-ATPases (L. Plesner, T.L. Kirley, and A.F. Knowles, eds.). Plenum Publ. Corp., New York, NY, USA, Ch. 29, pp. 231-237
83. 1995 Site‑directed Mutagenesis of P2U Purinoceptors: Positively Charged Amino Acids in Transmembrane Helices 6 and 7 Affect Agonist Potency and Specificity J. Biol. Chem. 270, 4185-4188.
84. 1995 G Protein-coupled P2 Purinoceptors: From Molecular Biology to Cellular and Tissue Responses. Trends in Pharmacol. Sci. 16, 133-139.
85. 1995 Cloning, Expression and Chromosomal Localization of a Human Uridine Nucleotide Receptor Gene. J. Biol. Chem. 270, 30845-30848
86. 1994 Functional Expression and Photoaffinity Labeling of a Cloned P2U Purinergic Receptor Proc. Natl. Acad. Sci.(USA) 90, 10449‑10453.
87. 1994 Classification of P2 Receptors: Not All G Protein‑coupled Receptors Can Be Classed as P2Y Trends in Pharm. Sci. 15, 280.
88. 1994 Cloning and Expression of a Human P2U Nucleotide Receptor: A Target for Cystic Fibrosis Pharmacotherapy Proc. Natl. Acad. Sci. (USA) 91, 3275‑3279.
89. 1993 Signal Transduction Pathways Coupled to a P2U Receptor in Neuroblastoma x Glioma (NG108-15) Cells J. Neurochem. 60, 1115-1125.
90. 1993 Extracellular ATP Reversibly Increases the Plasma Membrane Permeability of Transformed Mouse Fibroblasts to Large Macromolecules. Anal. Biochem. 209, 45‑52.
91. 1992 A Nucleotide Receptor in Vascular Endothelial Cells is Specifically Activated by the Fully Ionized Forms of ATP and UTP Biochem. J. 284, 733-739.
92. 1992 Mechanisms by which Extracellular ATP and UTP Stimulate the Release of Prostacyclin from Bovine Pulmonary Artery Endothelial Cells Biochim. Biophys. Acta. 1134, 61-72.
93. 1991 Transfer RNA4lys and Cell Cycle Progression: Characterization of TS‑694 Cells Exp. Cell Research 195, 536-540.
94. 1990 Covalent Incorporation of 3'-0-(4-benzoyl) Benzoyl ATP into a P2 Purinoceptor in Transformed Mouse Fibroblasts. J. Biol. Chem. 265, 7424‑7431
95. 1989 Study of the ATP4- Receptor-mediated Permeabilization of Transformed Mouse Fibroblasts and Its Desensitization J. Cell. Physiol. 139, 109‑115.
96. 1989 Methods for Permeabilizing Mammalian Cells to Macromolecules. In: Methods in Enzymology. (S. Fleischer and B. Fleischer, eds.). Academic Press, Orlando, Florida. Vol. 171, Ch. 43, pp. 869‑875.
97. 1989 Ionic Dependence of the ATP‑Induced Permeabilization Process in Transformed Mouse Fibroblasts: Role of Plasma Membrane Activities that Regulate Cell Volume. . Cell. Physiol. 138, 375‑383.
98. 1988 Growth Inhibition of Transformed Mouse Fibroblasts by Adenine Nucleotides Occurs via Generation of Extracellular Adenosine. J. Biol. Chem. 263, 12367‑12372.
99. 1985 Permeabilization of Transformed Cells in Culture by External ATP J. Membr. Biol. 86, 189‑196.
100. 1985 A Permeability Change in Mouse Fibroblasts Caused by Ionophores, and Its Relationship to Membrane Permeabilization by Exogenous ATP . Membr. Biol. 83, 251‑259.
101. 1984 Cellular Responses to External ATP which Precede an Increase in Nucleotide Permeability in Transformed Cells J. Cell. Physiol. 119, 211‑219
102. 1984 The Role of Calcium Ions in the Permeability Change Produced by External ATP in Transformed 3T3 Cells Biochim. Biophys. Acta. 775, 381‑388.
103. 1984 On the Role of Protein Phosphorylation in the ATP‑dependent Permeabilization of Transformed Cells J. Cell. Physiol. 118, 124‑132.
104. 1979 Active Ca2+ Transport by Vesicles Reconstituted from Triton X-100-solubilized Pigeon Erythrocyte Membrane Biochim. Biophys.Acta 555, 249-258
105. 1977 A Sephadex Column Procedure for Measuring the Uptake and Loss of Low Molecular Weight Solutes from Small, Lipid-rich Vesicles Anal. Biochem. 82, 376-384.

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