9th Annual Biomarkers Congress

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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors
1. 2012 Systemic Lupus International Collaborating Clinics (SLICC) Classification Criteria for Systemic Lupus Erythematosus in submission
2. 2012 on behalf of the LBSL02/99 Study Group Long-term Safety Profile of Belimumab Plus Standard Therapy in Patients With Systemic Lupus Erythematosus in submission
3. 2012 Gender-specific differences in the relationship between genetic susceptibility, T cell DNA demethylation and lupus flare severity in submission
4. 2012 SLE: novel therapies and outcome measures International Journal of Rheumatology (accepted in press).
5. 2012 Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK Ann Rheum Dis. 71:136-42. PMID: 21978998
6. 2012 Lupus Anticoagulant, but not anticardiolipin antibody predicts adverse preganancy outcomes in patients with antiphoshplipid antibodies in submission
7. 2011 BLISS-76 Study Group. A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus. Arthritis Rheum. 63(12):3918-30. PMID: 22127708
8. 2011 B lymphocyte stimulator levels in systemic lupus erythematosus: Higher circulating levels in African American patients and increased production after influenza vaccination in patients with low baseline levels Arthritis Rheum. 63:3931-41. PMID: 22127709
9. 2011 Safety profile and clinical activity of sifalimumab, a fully human anti–interferon-α monoclonal antibody, in systemic lupus erythematosus: a phase 1 multicenter, double-blind randomized study Ann Rheum Dis. 70:1905-13. PMID: 21798883
10. 2011 Auto-antibodies as Biomarkers for the Prediction of Neuropsychiatric Events in Systemic Lupus Erythematosus Ann Rheum Dis. 70:1726-32. PMID: 21893582
11. 2011 International consensus for a definition of disease flare in lupus. Lupus Foundation of America, Inc International Flare Consensus Initiative. Lupus. ;20:453-62.
12. 2011 Assessment of flares in lupus patients enrolled in a phase II/III study of rituximab (EXPLORER) Lupus. ;20(7):709-16. PMID: 21478286
13. 2011 on behalf of the BIOLUPUS GENLES networks. Association of PPP2CA polymorphisms with SLE susceptibility in multiple ethnic groups Arthritis Rheum. [Epub ahead of print] PMID: 21590681
14. 2011 Influenza vaccination responses in human systemic lupus erythematosus: impact of clinical and demographic features Arthritis Rheum. [Epub ahead of print] PMID: 21598235
15. 2011 Association of genetic variants in complement factor h and factor h-related genes with systemic lupus erythematosus susceptibility PLoS Genet. ;7(5):e1002079. Epub 2011 May 26.PMID: 21637784
16. 2011 Identification of novel genetic susceptibility loci in African American lupus patients using a candidate gene association study Arthritis Rheumatism [Epub ahead of print] PMID: 21792837
17. 2011 on behalf of BIOLUPUS and GENLES, Sawalha AH. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus Ann Rheum Dis. [Epub ahead of print] PMID: 21719445
18. 2011 Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort Genes Immun. [Epub ahead of print] PMID: 21270825
19. 2011 for the Systemic Lupus International Collaborating Clinics (SLICC). SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus. Ann Rheum Dis. [Epub ahead of print] PMID: 21342917
20. 2011 on behalf of the BIOLUPUS network, Nath SK, Harley JB, Sawalha AH. Fine mapping and trans-ethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21. Arthritis Rheum. . [Epub ahead of print] PMID: 21425124
21. 2011 Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus Epigenetics. ;6(5). [Epub ahead of print] PMID: 21436623
22. 2011 Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study Am J Hum Genet. 88:83-91. PMID: 21194677
23. 2011 Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet;43(3):253-8. PMID: 21336280
24. 2011 The genetics of systemic lupus erythematosus and implications for targeted therapy. Ann Rheum Dis. 70 Suppl 1:i37-43. Review. PMID: 21339217
25. 2011 Autoantibodies in systemic lupus erythematosus: comparison of historical and current assessment of seropositivity Lupus. ;20:250-255. PMID: 21362750
26. 2011 Reply to Letter to Editor. Arthritis Rheum. 63:1158. PMID: 21452334
27. 2011 Evolution of disease burden over 5 years in a multicentre inception SLE cohort Arthritis Care Res (Hoboken). [Epub ahead of print] PMID: 21954226
28. 2011 Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus Arthritis Rheum. [Epub ahead of print]
29. 2011 Ending the 50-year drought of FDA drug approval for SLE Bull NYU Hosp Jt Dis. ;69:238-42. PMID: 22035436
30. 2011 IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus. Ann Rheum Dis. Nov 16. [Epub ahead of print] PMID: 22088620
31. 2011 BIOLUPUS Network, James JA, Tsao BP, Scofield RH, Harley JB, Richardson BC, Sawalha AH. Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus Ann Rheum Dis. Nov 21. [Epub ahead of print] PMID: 22110124
32. 2010 TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus Arthritis Res Ther. 12 (4):R146. PMID: 20637106
33. 2010 The role of genetic variation near interferon-kappa in systemic lupus erythematosus J Biomed Biotechnol. 706825. Epub 2010 Jul 15. 2010. 706825. PMID: 20706608
34. 2010 An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA Ann Rheum Dis. ;70(1):54-9.PMID: 20833737
35. 2010 The Lupus Family Registry and Repository Rheumatology (Oxford). ;50(1):47-59. PMID: 20864496
36. 2010 Rituximab: Wanted dead or alive... Arthritis Rheum;62(8):2188-91. PMID: 20506315
37. 2010 Clinical trials in lupus: what have we learned so far? Rheumatology (Oxford). 49 (6):1025-7. PMID: 20123955
38. 2010 The efficacy and safety of abatacept in patients with non-life-threatening manifestations of SLE: Results of A 12-month exploratory study Arthritis Rheum. ;62(10):3077-87. PMID: 20533545
39. 2010 Systemic Lupus International Collaborating Clinics. Atherosclerotic vascular events in a multinational inception cohort of systemic lupus erythematosus Arthritis Care Res 62 (6):881-7.PMID: 20535799
40. 2010 Efficacy and safety of rituximab in patients with moderately-to-severely active systemic lupus erythematosus (SLE): Results from the randomized, double-blind phase II/III study EXPLORER Arthritis Rheum. 62:222-33 PMID: 20039413
41. 2009 Bone Marrow Edema Is the Most Specific Finding for Rheumatoid Arthritis (RA) on Noncontrast Magnetic Resonance Imaging of the Hands and Wrists: A Comparison of Patients with RA and Healthy Controls J Rheumatol. [Epub ahead of print] PMID: 19955056
42. 2009 What was wrong and might now go right with clinical trials for lupus? Curr Rheumatol Rep. 11:235-237 PMID: 19691925
43. 2009 Clinical trials for lupus--are we there yet? Bull NYU Hosp Jt Dis. ;67:267-270. PMID: 19852748
44. 2009 ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash, and immunologic manifestations in lupus patients with European ancestry Ann Rheum Dis. [Epub ahead of print] PMID: 19939855
45. 2009 Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus Arthritis Rheum. 60:1076-1084. PMCID:PMC2734382
46. 2009 Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing Genes Immun. 10:457-469. PMCID:PMC2714407
47. 2009 Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE). Hum Mol Genet. 18:1171-1180
48. 2009 Enhanced CD36 scavenger receptor expression in THP-1 human monocytes in the presence of lupus plasma: linking autoimmunity and atherosclerosis Exp Biol Med (Maywood). 234:354-360.
49. 2009 Clancy Expression of endothelial protein C receptor in cortical peritubular capillaries associates with poor clinical response in lupus nephritis Rheumatology ; 48:513-519 PMCID:PMC2722802
50. 2009 Profile Study Group; Italian Collaborative Group; German Collaborative Group; Spanish Collaborative Group; Argentinian Collaborative Group; SLEGEN Consortium, Wakeland EK, Alarcn-Riquelme ME, Mohan C. Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans J Clin Invest. 119:911-923
51. 2009 Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus Proc Natl Acad Sci U S A. 106:6256-6261
52. 2009 High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups Arthritis Rheum. 60:1085-95
53. 2009 Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population Genes Immun. 10:531-538.
54. 2009 Prospective analysis of neuropsychiatric events in an international disease inception cohort of SLE patients Ann Rheum Dis.
55. 2009 Genetic associations of LYN with systemic lupus erythematosus. Genes Immun. 10:397-403
56. 2009 Identification of new SLE-associated genes with a two-step Bayesian study design Genes Immun. 10:446-456
57. 2009 Evaluation of C1q genomic region in minority racial groups of lupus Genes Immununity. 10:517-5124.
58. 2009 Connective tissue diseases: What does the death of Riquent hold for the future of SLE? Nature Revues Rheumatol. 5:306-7
59. 2009 Plasma from systemic lupus patients compromises cholesterol homeostasis: a potential mechanism linking autoimmunity to atherosclerotic cardiovascular disease. Rheumatol Int.
60. 2009 A polymorphism within IL21R confers risk for systemic lupus erythematosus Arthritis Rheum. 60:2402-2407
61. 2009 What was wrong and might now go right with clinical trials for lupus? Curr Rheumatol Rep. 11:235-237.
62. 2009 A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus Arthritis Rheum. 61:1168-1178.
63. 2009 Novel evidence-based systemic lupus erythematosus responder index Arthritis Rheum. 61:1143-1151
64. 2008 Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci Nat Genet. 40: 204-10
65. 2008 New therapies in systemic lupus erythematosus - trials, troubles and tribulations....working towards a solution. Lupus. 17:967-970
66. 2008 Accumulation of coronary artery disease risk factors over three years: Data from an international inception cohort Arthritis Rheum. 59:176-180.
67. 2008 Belimumab Study Group. Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus Arthritis Res Ther. ;10: R109 PMCID:PMC2592791
68. 2008 Systemic Lupus International Collaborating Clinics. Systemic lupus international collaborating clinics renal activity/response exercise: comparison of agreement in rating renal response Arthritis Rheum. 58:1789-95
69. 2008 Systemic Lupus International Collaborating Clinics. Systemic lupus international collaborating clinics renal activity/response exercise: development of a renal activity score and renal response index Arthritis Rheum. 58:1784-8
70. 2008 Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. Ann Rheum Dis. 67:458-461.
71. 2008 Is individualized medicine on the horizon for lupus? Curr Rheumatol Rep. 10:257-258.
72. 2008 Clinical Trials Report (Lupus). Curr Rheumatol Rep. 10:264
73. 2008 LJP 394-90-09 Investigator Consortium. Abetimus sodium for renal flare in systemic lupus erythematosus: results of a randomized, controlled phase III trial. Arthritis Rheum. 58:2470-2480
74. 2008 Antiphospholipid antibodies and the antiphospholipid syndrome: clinical significance and treatment Semin Thromb Hemost. 34:256-266.
75. 2008 A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus Nat Genet. 40:152-4
76. 2008 Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans Genes Immun. 9:187-94
77. 2008 Short-Term outcome of neuropsychiatric events in SLE upon enrollment into an international inception cohort Arthritis Rheum 59:721-729
78. 2008 Autoantibodies and Neuropsychiatric events at diagnosis of SLE. Arthritis Rheumatism 58:843-53
79. 2007 Genetic association of IL-21 polymorphisms with systemic lupus erythematosus Ann Rheum Dis. 67:458-61
80. 2007 Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort. Lupus. 16:731-5
81. 2007 Thrombotic Microangiopathic Antiphospholipid Syndromes: A Continuum of Conditions? Future Rheumatology 2007 accepted, in press
82. 2007 Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus Lupus.;16:401-409
83. 2007 Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms. Arthritis Rheum. 56:2344-2351
84. 2007 Neuropsychiatric events at the time of diagnosis of sle: an international inception cohort study Arthritis Rheum. 56:265-73
85. 2007 Hormones and Other Women’s Issues Dubois’ Systemic Lupus Erythematosus
86. 2006 Antiphospholipid syndrome: what's new in understanding antiphospholipid antibody-related stroke? Curr Rheumatol Rep. 8:159-61
87. 2006 Catastrophic antiphospholipid syndrome Nature Clinical Practice Rheumatology 2: 81-89
88. 2006 The prevalence and clinical significance of antiphospholipid antibodies in rheumatoid arthritis Current Rheumatology Reports ;8(2):100-8
89. 2006 Assessment of disease activity in SLE Systemic Lupus Erythematosus - A Companion to Rheumatology
90. 2006 Do antiphospholipid antibodies develop for a purpose? Editorial Current Rheumatology Reports 8:109-13.
91. 2005 Computer-Assisted Pattern Recognition of Autoantibody Results Clinical and Diagnostic Laboratory Immunology, 12:1353-1357
92. 2005 Combined Oral Contraceptives in Women with SLE New England Journal of Medicine, 353:2550-2558.
93. 2005 Comparison of Mycophenolate Mofetil to Intravenous Cyclophosphamide for Induction Therapy of Severe Active Lupus Nephritis New England Journal of Medicine. 353:2219-2228.
94. 2005 DHEA: The Claims in Perspective Cleveland Clinic Journal of Medicine. 72:965-6, 968, 970-1
95. 2005 The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial. Ann Intern Med. ;142:953-62
96. 2005 JP The Role of Biomarkers in the Clinical Assessment of Lupus Best Practice and Research Clinical Rheumatology 19:709-26
97. 2005 BLyS antagonists and peptide tolerance Induction Lupus. ;14:204-9.
98. 2005 Emergence of targeted immune therapies for SLE Expert Opinion on Emerging Drugs Expert Opin Emerg Drugs. 10:53-65.
99. 2004 Diagnosis of the antiphospholipid syndrome: how far to go? Curr Rheumatol Rep. 6:469-72
100. 2004 Genetics of the Antiphospholipid Syndrome Current Rheumatology Reports 2004 6:458-62.
101. 2004 Effects of prasterone on disease activity and symptoms in women with active systemic lupus erythematosus Arthritis Rheum. 2004 Sep;50(9):2858-68.
102. 2004 Antibodies and clinical features of the antiphospholipid syndrome as criteria for systemic lupus erythematosus Lupus. ;13:869-76
103. 2004 Challenges in bringing the bench to bedside in drug development for SLE Nature Reviews Drug Discovery. 3:1036-46
104. 2004 Systemic Lupus International Collaborating Clinics (SLICC). Defining response in systemic lupus erythematosus: a study by the Systemic Lupus International Collaborating Clinics group. J Rheumatol. 31:2390-2394.
105. 2004 A toleragen for the Antiphospholipid Syndrome Lupus LJP 1082;13:335-338
106. 2004 Anti-beta 2 glycoprotein I and anti-phosphatidylserine antibodies are predictors of arterial thrombosis in patients with the antiphospholipid syndrome Am J Clin Pathol. 121:142-149
107. 2003 IgG autoantibodies against beta-2 glycoprotein I complexed with a lipid ligand derived from oxidized LDL are associated with arterial thrombosis in the antiphospholipid syndrome. Clin Dev Immunol. 10:203-11
108. 2003 The Antiphospholipid Syndrome and Atherosclerosis Clues to Pathogenesis Current Rheumatology Reports, 5:401-406
109. 2003 Prevalence, clinical significance and immunological characteristics of antibodies directed to protein S in patients with systemic lupus erythematosus Thrombosis Haemostasis. 90:636-41
110. 2003 Identification and characterization of a peptide mimetic that may detect a species of disease-associated anti-cardiolipin antibodies in patients with theantiphospholipid syndrome. Arthritis & Rheumatism, 48:737-745
111. 2003 Trials Report: ITP as a model for the Antiphospholipid Syndrome Current Rheumatology Reports 5:381-382
112. 2003 DHEA: A sex steroid in development for SLE Expert Opinion on Investigational Drugs. 2003 12:1017-25
113. 2003 Treatment of the antiphospholipid syndrome Systemic Lupus Erythematosus, Lahita ed. Academic Press.
114. 2002 Recurrent pregnancy loss with the antiphospholipid antibody Curr Rheumatol Rep. 2002 4:377-8.
115. 2002 Measuring Disease Activity in Systemic Lupus: Progress and Problems. Journal of Rheumatology J Rheumatol. ;29(11):2256-7
116. 2002 Treatment of SLE with Anti-CD154. Arthritis Rheum 2002 46:3251-8.
117. 2002 Regulation of the Vasculature: Clues from Lupus Current Opinion in Rheumatology 14:504-509.
118. 2002 Effects of Prasterone on Corticosteroid Requirements of Women with SLE Arthritis Rheumatism: 46:1820-1829
119. 2002 Dual Reactivity to Beta2 glycoprotein-I and Protein S: Increased Association with Thrombotic Events in the Antiphospholipid Syndrome Lupus, 11:215-220.
120. 2001 Appropriate management of antiphospholipid-related pregnancy in women without lupus who have low titer autoantibodies Current Rheumatology Reports, 3: 269-270.
121. 2001 What Causes the Antiphospholipid Syndrome? Current Rheumatology Reports, 3: 293-300.
122. 2001 Which Antiphospholipid Antibody Tests are More Useful? Rheumatic Disease Clinics of North America 27:525-49.
123. 2001 The Antiphospholipid Syndrome in Modern Therapeutics in Rheumatoid Diseases Tsokos ed, invited
124. 2001 Hormones and Vascular Diseases in Vascular Manifestations of Autoimmunity Asherson ed, CRC Press, 2001.
125. 2001 High thrombosis rate after fetal loss in the antiphospholipid syndrome: effective prophylaxis with aspirin Arthritis Rheum, 44(6):1466-7.
126. 2000 Severe Guillain-Barre like peripheral neuropathy in a patient with systemic lupus erythematosus: Recovery after two accidental burn injuries Journal of Clinical Rheumatology 6:278-282
127. 2000 SR proteins are autoantigens in patients with systemic lupus erythematosus. Importance of phosphoepitopes. Arthritis Rheum Aug;43(8):1768-78
128. 2000 Clinical Trials for The Antiphospholipid Syndrome Current Rheumatology Reports 2:233-235
129. 2000 Sex Hormone Binding Globulins and atherosclerotic risk in systemic lupus. Lupus, 2000 9: 217-222
130. 1999 A role for polymorphism at position 247 in the beta2-glycoprotein I gene in the generation of anti-beta2-glycoprotein I antibodies in the antiphospholipid syndrome Arthritis & Rheumatism 1999 Aug;42(8):1655-61
131. 1999 beta2 glycoprotein-1, a major target antigen of antiphospholipid antibodies, interferes with the binding of protein S by C4b Binding Protein and enhances the anticoagulant function of protein S. Thrombosis Haemostasis 81:748-757.
132. 1999 Pathogenesis and treatment of the antiphospholipid syndrome, Systemic Lupus Erythematosus Lahita ed. Academic Press
133. 1998 Frequency of antibodies to the cholesterol transport protein apolipoprotein A1 in patients with SLE. Lupus 7: 355-360.
134. 1997 Inhibition of methotrexate-induced rheumatoid nodules by colchicine: evidence from an in vitro model and regression in 7 of 14 patients. J. Clin. Rheum. 3:328-333.
135. 1997 Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes Arth. Rheum. 40:1308-1315
136. 1997 High prevalence of antiphospholipid antibodies in patients taking procainamide. J. Rheum. 24:1083-1088
137. 1997 Differential phosphorylation of the beta2 integrin CD11b/CD18 in the plasma and specific granule membranes of neutrophils. J. Leukocyte Biology. 61:313-321
138. 1996 Impact of hormones on autoimmune diseases in women Medscape Women=s Health. http://www.medscape.com (reprints available).
139. 1996 Mechanisms of the effects of methotrexate Bulletin Rheum. Dis. 45:6-8.
140. 1996 Complement activation and the antiphospholipid Syndrome: A Link Between Complement and the Coagulation System Lupus. 5:6-10.
141. 1995 Can women with systemic lupus erythematosus safely use exogenous estrogens? J. Clin. Rheum. 1:205-212
142. 1995 Treatment of the antiphospholipid syndrome J. Musculoskel. Med. 12: 43-53.
143. 1995 Cloning of a gene for Apolipoprotein A1 using serum from a patient with systemic lupus. Arth. Rheum. 38:1655-1659
144. 1994 Henoch-Schonlein Purpura remitting in pregnancy and during sex-steroid therapy. Brit. J. of Rheumatology. 33: 71-80
145. 1994 Dynamic state of beta 2 integrin phosphorylation: regulation of neutrophil aggregation by a phosphatase dependent pathway Clin. Immunol. Immunopath: 71:216-222
146. 1991 Staurosporine inhibits neutrophil phagocytosis but not iC3b binding mediated by complement receptor CR3 (CD11b/CD18). J.Immunol. 146(10):3557-3562
147. 1990 Two pathways of CD11b/CD18-mediated neutrophil aggregation with different involvement of protein kinase C-dependent phosphorylation J.Immunol. 145(8):2608-2615


4th Annual Pharma R&D Asia Congress
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