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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors
1. 2011 Biochemical and morphological consequences of human a-synuclein expression in a mouse a-synuclein null background. Eur J Neurosci, 33:642-656, 2011
2. 2009 The parkinson’s disease kinase, LRRK2, autophosphorylates its ROC/GTPase domain at multiple sites BBRC, 389:449-454, 2009
3. 2008 Animal Models of Parkinson’s Disease to Aid Drug Discovery and Development In: Animal and Translational Models for CNS Drug Discovery, Vol. 2 Neurological Disorders, Robert McArthur and Franco Borsini (eds), Academic Press
4. 2008 Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 {[2-(4-Benzo[1,3]dioxol-5-yl-2-tert-butylphenoxy)ethyl]-methylamino)-acetic acid indicate a preferential action in the brain stem and cerebellar vs. prefrontal cortical brain areas Neuropharmacol, 55:743-754, 2008
5. 2007 Differential loss of presynaptic dopaminergic markers in the basal ganglia of MPTP-treated squirrel monkeys Cell Transplantation, 16:229-44, 2007
6. 2006 Evaluation of white matter integrity in ex-vivo brains of amyloid plaque-bearing APPsw transgenic mice using diffusion tensor MRI. Exp. Neurol., 199:408-415, 2006
7. 2006 Neuroreplacement, growth factor and small molecule neurotrophic approaches for treating Parkinson’s Disease International Rev Neurobiol, 77: 179-217, 2006
8. 2006 Pharmacological Characterization of cGMP Regulation by the Bisarylpropylsulfonamide Class of Positive, Allosteric Modulators of AMPA Receptors J. Pharmacol. Exp. Ther., 319:293-298, 2006
9. 2005 Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer’s disease using magnetic resonance diffusion tensor imaging. Experimental Neurology, 191:77-85, 2005
10. 2005 Expression of GAD65 and GAD67 immunoreactivity in MPTP lesioned monkeys treated with or without L-DOPA Neurobiology of Disease, 20:347-59, 2005
11. 2005 Developing therapeutics for schizophrenia and other psychotic disorders NeuroRx. 2:579-89
12. 2004 Lack of specific A(1-42) suppression by NSAIDs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures. J. Pharmacol. Exp. Ther. 312:399-406, 2004
13. 2004 Differential regulation of behavioral, genomic and neuroendocrine responses by CRF infusions in rats. Pharmacology, Biochemistry and Behavior, 77: 447-455, 2004
14. 2004 Effectiveness of the Selective D4 Antagonist Sonepiprazole in Schizophrenia: A Placebo-Controlled Trial. Biol. Psychiatry, 55: 445-51, 2004
15. 2004 Studies of A-beta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575) J. Pharmacol. Exp. Ther. 309: 49-55, 2004
16. 2003 The -secretase inhibitor, DAPT, reduces A levels in vivo in the CSF of young (non plaque-bearing) and old (plaque-bearing) Tg2576 mice. Pharmacol. Exp. Ther., 305:864-871, 2003
17. 2003 Early Onset of Hippocampal-specific Decreases in Dendritic Spine Density in Transgenic Mice Over-Expressing Mutant APP Neurobiology of Disease, 13:246-53, 2003
18. 2003 Rapid habituation of hippocampal serotonin and norepinephrine release and anxiety-related behaviors, but not plasma corticosterone levels, to repeated footshock stress in rats Pharmacology, Biochemistry and Behavior, 74: 609-616, 2003
19. 2003 Activations of the Serotonin 5-HT2C receptor within the basolateral amygdala induces innate fear-like responses in an open-field environment Brain Research, 993:1-9, 2003
20. 2003 Deficiency of Nicastrin abolishes gamma-cleavage of amyloid precursor protein and Notch J. Biol. Chem., 278: 33445-9, 2003
21. 2000 The selective dopamine D4 receptor antagonist, PNU-101387G, prevents stress-induced cognitive deficits in monkeys Neuropsychopharmacology 23: 405-410, 2000
22. 1999 Increased levels of proneurotensin/neuromedin N mRNA in rat striatum and nucleus accumbens induced by 7-OH-DPAT and nafadotride Neuropsychopharmacology, 21: 304-311, 1999
23. 1998 Clozapine and haloperidol block the induction of behavioral sensitization to amphetamine and associated genomic responses in rats Mol. Brain Research, 61: 39-50, 1998
24. 1998 The role of dopamine D4 receptor in the induction of behavioral sensitization to amphetamine and accompanying biochemical and molecular changes J. Pharmacol. Exp. Ther., 286:497-508, 1998.
25. 1997 EEDQ reduces the striatal neurotensin mRNA response to haloperidol Peptides, 18: 527-535, 1997.
26. 1997 Psychostimulants and neuropeptide response Adv. Pharmacology, 42: 1014-1016
27. 1996 Immediate Early gene Induction by Antipsychotic Drugs: Role of D2, D3 and D4 receptors In: Pharmacological Regulation of Gene Expression in the CNS, Ed. K.M. Merchant, CRC Press, pp 25-50
28. 1996 Differential distribution of GABA-1, 2, 3, 5 2+3 immunoreactivity in the infralimbic region of the rat prefrontal cortex; a site for the efficacy of atypical antipsychotic drugs Neuroscience Letters, 210: 213-217, 1996.
29. 1996 Evans, Induction of c-fos mRNA in rat medial prefrontal cortex by antipsychotic drugs: Role of dopamine D2 and D3 receptors Cerebral Cortex, 6: 561-570, 1996
30. 1996 Pharmacological characterization of U-101387, A dopamine D4 receptor selective antagonist. J. Pharmacol. Exp. Ther., 279:1392-1403, 1996.
31. 1995 The role of NMDA receptor systems in neuropeptide responses to stimulants of abuse Drug and Alcohol Dependence, 37: 107-110, 1995
32. 1995 Muscimol administration attenuates haloperidol-induced acute increases in neurotensin mRNA expression in the caudate-putamen but not nucleus accumbens Brain Research., 691: 9-17, 1995.
33. 1994 Effects of chronic haloperidol and clozapine treatment on neurotensin and c-fos gene expression in striatal subregions J. Pharmacol. Exp. Ther., 271: 460-471, 1994
34. 1994 Induction of neurotensin and c-fos mRNA in distinct subregions of rat neostriatum following acute methamphetamine: comparison with acute haloperidol effects J. Pharmacol. and Exp. Ther., 269: 806-812
35. 1994 Neurotensin and c-fos mRNA are coexpressed in rat neostriatal neurons following acute haloperidol Molecular Brain Research, 23: 271-277, 1994
36. 1994 c-fos antisense oligonucleotide attenuates haloperidol-induced neurotensin mRNA expression in the dorsal striatum of the rat Mol. Cell. Neurosci., 5: 336-344, 1994
37. 1993 Differential induction of neurotensin and c-fos gene expression induced by typical versus atypical antipsychotics Proceedings Natl. Acad. Sci., 90: 3447-3451, 1993.
38. 1993 Differential loss of dopamine D2 receptor mRNA isoforms during aging in Fischer-344 rats Neuroscience Letters, 154: 163-167, 1993
39. 1993 Blunting of the neurotensin mRNA response to haloperidol in the striatum of aging rats: Possible relationship to decline in dopamine D2 receptor expression Brain Research, 616: 105-113, 1993
40. 1992 Responses of limbic and extrapyramidal neurotensin systems to stimulants of abuse: involvement of dopaminergic mechanisms Ann. N.Y. Acad. Sci., 668: 165-172
41. 1992 Distinct 5-HT1B and 5-HT1D Serotonin receptors in rat: Structural and pharmacological comparison of the two cloned receptors J. Molecular and Cellular Neurosci., 3: 578-587
42. 1992 Differential effects of haloperidol and clozapine on neurotensin gene transcription in rat neostriatum J. Neurosci., 12: 652-653, 1992
43. 1992 Expression of the proneurotensin gene in the rat brain and its regulation by antipsychotic drugs Ann. N.Y. Acad. Sci., 668: 54-69
44. 1992 BMY 14802, a potential antipsychotic drug, increases expression of proneurotensin mRNA in rat striatum Mol. Brain Research, 12: 279-284, 1992.
45. 1991 Haloperidol rapidly increases the number of neurotensin mRNA-expressing neurons in neostriatum of the rat brain Brain Research, 540: 311-314, 1991
46. 1991 Distinct patterns for the distribution of mRNA for the calmodulin-sensitive adenylate cyclase in rat brain: expression in areas associated with learning and memory Neuron, 6, 431-443, 1991.
47. 1990 Neurotensin-dopamine interactions in the substantia nigra of the rat brain J. Pharmacol. Exp. Ther., 255: 775-780, 1990
48. 1989 Role of dopamine D-1 and D-2 receptors in the regulation of neurotensin systems in the neostriatum and the nucleus accumbens Eur. J. Pharmacol., 160: 409-412
49. 1989 Dopamine D2 receptors exert tonic regulation over discrete neurotensin systems in the rat brain Brain Research, 500: 21-29, 1989
50. 1988 Changes in the limbic neurotensin systems induced by dopaminergic drugs Eur. J. Pharmacol., 153: 1-9, 1988
51. 1988 Characterization of methamphetamine effects on striatal-nigral dynorphin system Eur. J. Pharmacol., 155: 11-18, 1988
52. 1988 Effects of amphetamine analogs on CNS neuropeptide systems NIDA Research Monograph, 1988
53. 1987 Effects of methamphetamine on neurotensin concentrations in rat brain J. Pharmacol. Exp. Ther., 241: 443-447
54. 1987 Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of the rat Neuropharmacol., 26: 1677-1683
55. 1987 Effects of amphetamine analogues on neurotensin concentrations in rat brain European J. Pharmacol., 138: 151-154
56. 1987 Characterization of dopaminergic influence on striatal-nigral neurotensin systems Brain Research, 422: 200-203, 1987
57. 1987 Methamphetamine-induced changes in striatal-nigral dynorphin system: role of D-1 and D-2 receptors Eur. J. Pharmacol., 144: 245-246
58. 1987 Effects of 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA) isomers on the central serotonergic, dopaminergic and nigral neurotensin systems of the rat J. Pharmacol. Exp. Ther. 244: 977-982, 1987.
59. 1986 Comparison of responses by striatonigral substance P and neurokinin A systems to methamphetamine treatment Peptides, 983-987, 1986

4th Annual Pharma R&D Asia Congress
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