Hematopoietic Malignancies
Vermont Academy
Saxtons River,
Vermont, mm

Schedule of Presentations:

Saturday, July 21, 2007
14:00:00 Conference Registrations
18:00:00 FASEB Opening Reception
19:00:00 Dinner
20:45:00 Keynote Lecture
Sunday, July 22, 2007
07:30:00 Breakfast
08:45:00 General information
09:00:00 Stem cell interactions with the microenvironment David T Scadden
09:30:00 “MLL leukemia stem cells Susan Cleary
10:00:00 Profiling self-renewal in leukemia stem cells Guy Sauvageau
10:30:00 FASEB Sponsored Coffee Break
10:45:00 Identification and characterization leukemic stem cells in the Li Chai
11:00:00 Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors Patricia Ernst
11:15:00 MTG16 Regulates Hematopoietic Stem Cell Quiescence Scott W Hiebert
11:45:00 Hematopoietic stem cell formation - where does it all Nancy A Speck
12:15:00 . Group picture
12:15:00 Lunch
16:00:00 Poster Session I
18:00:00 Dinner
19:00:00 A novel role for the bHLH transcription regulator Id2 in the pathogenesis of CML Richard Van Etten
19:30:00 Transcription factors and myeloid leukemia Daniel G Tenen
20:00:00 Unraveling the complex biology of AML applying an integrated molecular approach: A unique AML subtype defined by expression and methylation profiling Ruud Delwel
20:15:00 Coffee Break
20:30:00 A cell-cycle independent function of tumor suppressor Ink4b in regulation of lineage choice” Linda Wolff
21:00:00 A mouse model of alkylator-induced MDS
21:15:00 NUP98-HOX gene fusions lead to myelodysplastic syndrom Peter Aplan
21:45:00 Social hour in the bar
Monday, July 23, 2007
07:30:00 Breakfast
09:00:00 Characterization of genetic pathways leading to therapyrelated myeloid leukemia Marc Zabeau
09:30:00 High resolution genomic studies of acute myeloid leukemia Matthew Walter
10:00:00 Tyrosine phosphorylation state regulates the activity of the transcription factors ICSBP/IRF8 and HoxA10 during myelopoiesis Elizabeth Eklund
10:30:00 FASEB Sponsored Coffee Break
10:45:00 Characterization and targeting oncogenic transcriptional Eric So
11:00:00 GATA-1, Trisomy 21, and M7 Leukemia Stuart Orkin
11:30:00 Effects of Shp2 Gain- or Loss-of Function on Hematopoiesis Ben Neel
12:00:00 Lunch
16:00:00 Poster Session II
18:00:00 Dinner
19:00:00 FBW7 Mutations in Leukemic Cells Mediate NOTCH Pathway Activation and Resistance to gamma-Secretase Inhibitors Thomas A. Look
19:30:00 The Fbw7 E3 ligase as a novel tumor supressor in T cell leukemia Iannis aifantis
19:45:00 microRNAs in normal hematopoiesis and leukemogenesis” Chang Zheng Chen
20:15:00 “Genomic analysis of acute lymphoblastic leukemia James R Downing
20:45:00 Coffee Break
21:00:00 Recent insights into Notch and leukemia Warren Pear
21:30:00 Down-regulation of Death Associated Protein Kinase 1 in Chronic Lymphocytic Leukemia Christoph Plass
22:00:00 Social hour in the bar
Tuesday, July 24, 2007
07:30:00 Stepwise leukemogenesis and targeting therapy Chang Zheng Chen
07:30:00 Breakfast
09:00:00 MLL-AF9 transforms primary human CD34+ progenitor cells and induces mixed lineage leukemia in mice James Mulloy
09:00:00 Chromosomal aneuploidy and leukemia Shai Izraeli
09:30:00 Role of chromosome 21 in myeloid Leukemia John A Kessler
09:45:00 “Molecular pathogenesis of B cell lymphoma Riccardo Dalla Favera
10:15:00 Pathogenesis and Treatment of Mantle Cell Lymphoma
10:40:00 . FASEB Sponsored Coffee Break
10:55:00 A loss-of-function RNA interference screen for molecular targets in cancer
11:25:00 Activation induced cytidine deaminase (AID) is required for germinal-center derived lymphomagenesis Laura Pasqualucci
11:45:00 Insights into the role of c-MYC in lymphoid malignancies” Chi Van Dang
12:15:00 Lunch
16:00:00 Poster Session III
18:00:00 Dinner
19:00:00 Insights into AML1-ETO gains-of-function Stephen Nimer
20:00:00 The ability of CBFβ-SMMHC to repress RUNX1 does not correlate with its ability to induce leukemia Paul Liu
20:30:00 Coffee Break
20:45:00 Myb Protein Binding Partners and Their Function in Human Leukemia Cells Alan Gewirtz
21:15:00 Context depended role of LRF/Pokemon in Oncogenesis” Pier Paolo
21:45:00 Social hour in the bar
Wednesday, July 25, 2007
07:30:00 Breakfast
09:00:00 Oncogene activation in the germinal center is the primary determinant of MM disease phenotype” Leif Bergsagel
09:30:00 Frequent engagement of the classical and alternative NF-κB pathways by diverse genetic abnormalities in multiple myeloma Christina Annunziata
09:50:00 Conclusions of a Seven Year Translational Research Initiative: Defining and Validating a Molecular Signature of High-Risk Multiple Myeloma John Shaughnessy
10:20:00 FASEB Sponsored Coffee Break
10:40:00 The SCID-Hu model: insights about the stem cell and the role of stromal cells in multiple myeloma Josh Epstein
11:10:00 A transgenic mouse model that faithfully reproduces the pathogenesis, biology and clinical features of multiple myeloma Marta Chesi
11:30:00 The MMSET Protein is a Histone methyl Transferase with Properties of a Transcriptional Co-Repressor Jon Licht
12:00:00 Lunch
18:00:00 Dinner
19:00:00 Signal Transduction in Myeloproliferative Diseases and AML Martin Carroll
19:30:00 The Fanconi Anemia/BRCA pathway and the DNA damage response Alan D Andrea
20:00:00 The C-MYB oncogene is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new TALL subtype in very young children Jean Soulier
20:15:00 Coffee Break
20:30:00 DNA damage and oncogenic stress: barriers to chromosomal translocations Andre Nussenzweig
21:00:00 DNA Breaks, End-joining Pathways, Translocations, and Lymphoma Frederick Alt
21:30:00 Business meeting to select location and chairpersons for 2009 conference
Thursday, July 26, 2007
07:30:00 Breakfast
09:00:00 The Role of JAK2 Activation in the Pathogenesis and Treatment of Myeloproliferative Disorders Ross Levine
09:30:00 BCR-|ABL kinase inhibitors: will the story ever end?” Michael Deininger
10:00:00 Targeting BCR-ABL kinase activity-independent signaling pathway and leukemic stem cells Shaoguang Li
10:15:00 FASEB Sponsored Coffee Break
10:30:00 Targeting transcriptional repression in B-cell lymphomas Ari Melnick
11:00:00 Signatures for Cancer Discovery Todd R Golub
11:25:00 .
11:30:00 Box Lunches Available
12:30:00 talks selected from submitted abstracts will also be presented in poster sessions
3D Tissue Models
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