The Challenge of Antibacterial Drug Development
Hilton San Diego Resort

San Diego, California


   Resistant bacterial strains are an increasing challenge for the entire
   health industry. There is a dire need to develop novel defense
   mechanisms and novel strategies to treat bacterial infections. To
   successfully tackle antibacterial resistance, novel targets are only
   part of the equation - challenges which also need to be addressed
   include predicting toxicology, selectivity, resistance, permeability
   and pk of a new lead, and creating new models for optimization of
   leads and compounds. This conference is designed to bring together top
   level scientists from the academic, pharmaceutical and biotech areas
   to define and refine the path of developing novel antibacterials.

Schedule of Presentations:

Tuesday, April 27, 2010
06:00:00 check-in
06:45:00 welcome
07:00:00 Registration and Morning Coffee
08:00:00 Chairperson's Opening Remarks
08:10:00 Overcoming the Difficulties in Antibacterial Drug Development KEYNOTE John Domagala
08:50:00 Defining the Medical Need for New Anti-MRSA Antibiotics Thomas D. Gootz
09:20:00 A Novel Oxazolidinone with Enhanced Efficacy Due to Intracellular Accumulation Andrea Marra
09:50:00 Networking Coffee Break
10:15:00 Microbiological Properties of the Novel Oxazolidinone Torezolid Karen Shaw
10:45:00 Structurally Novel Tetracyclines with MRSA Activity Xiao-Yi Xiao
11:15:00 Sponsored Presentation (Opportunity Available)
11:30:00 Delafloxacin: A Broad Spectrum Quinolone with Coverage Against MRSA Eric Burak
12:00:00 Luncheon Presentation (Sponsorship Opportunity Available) or Lunch on Your Own
13:00:00 Break
13:25:00 Chairperson's Remarks
13:30:00 Directed Expression and Characterization of Drug Resistance Determinants Herbert Schweizer
14:00:00 Stable Isotope Enhanced Antibiotics Graham Timmins
14:05:00 Gram - Negative Infections
14:30:00 Ribosome Antibiotic Binding (TM): Defining New Frontiers for the Design of Novel Antibiotics for MDR Gram-Negative Infections Erin M. Duffy
15:00:00 Sponsored Presentation (Opportunity Available)
15:15:00 Networking Refreshment Break, Poster and Exhibit Viewing
16:00:00 Structure-Guided Discovery of (S)-3-(aminomethyl)benzo[c][1,2]oxaborol-1(3H)-ol hydrochloride (ABX): A First in Class Antibacterial for Gram-Negative Infections Vincent Hernandez
16:30:00 POL7080 and a Novel Class of Antibiotics for Treatment of Gram-Negative Infections Based on Protein Epitope Mimetics Technology Klaus Dembowsky
17:00:00 New Agents for Multidrug-Resistant Gram-Negative Bacteria Malcolm Page
17:30:00 Networking Cocktail Reception in the Exhibit Hall
19:00:00 End of Day 1
Wednesday, April 28, 2010
06:00:00 check-in
07:00:00 welcome
07:45:00 Continental Breakfast Break-Out Discussions
07:50:00 Novel Strategies To Nip Restancies In The Bud
08:55:00 Chairperson's Opening Remarks
09:00:00 Mutant Prevention Concentration (MPC) Testing for Predicting Resistance Prevention/Selection by Antimicrobial Agents Joseph Blondeau
09:30:00 NVC-422, a Novel N-Chlorotaurine Derivative as Topical Antimicrobial Dmitri Debabov
10:00:00 Sponsored Presentation I (Opportunity Available)
10:15:00 Coffee Break, Poster and Exhibit Viewing
11:00:00 Artilysins – Novel Tools to Combat Antibiotic Resistant Bacteria Stefan Miller
11:30:00 Dissecting Assembly of Multi-Component Drug Efflux Complexes Helen I. Zgurskaya
12:00:00 End of Conference
12:40:00 Announcements
13:00:00 Adjourn
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