Kinase Inhibitor Chemistry
Hilton San Diego Resort

San Diego, California


   Kinase inhibitors have matured into key targets in drug discovery.
   They play an important role in cancer therapeutic developments and
   have recently been established as novel targets for metabolic
   diseases, pain treatment and CNS therapeutics. While a lot of
   knowledge is available about the biology of kinases, what the industry
   needs now is to explore the chemical space. More information on the
   structure, binding sites and binding interaction of kinases is
   necessary in order to optimize leads and to develop novel inhibitors.
   This meeting is focusing on the chemical space and current

Schedule of Presentations:

Wednesday, April 28, 2010
12:30:00 Registration
13:30:00 Chairperson's Opening Remarks
13:40:00 Discovery of Novel JNK Inhibitors for the Treatment of Parkinson’s Disease Philip LoGrasso
14:10:00 Talk Title to be Announced Roderick E Hubbard
14:40:00 Targeting the Polo-Box Domain of Polo-Like Knase 1 (Plk1) Kyung S Lee
15:10:00 Sponsored Presentations (Opportunity Available)
15:40:00 Networking Refreshment Break, Poster and Exhibit Viewing
16:20:00 2-Phenylamino-Pyrimidines: Finding Novel Chemical Space and Charting the Water of Activity/Selectivity in a Mature Scaffold Xiaolin Li
16:50:00 Talk Title to be Announced Sean G. Buchanan
17:20:00 Break-Out Discussions
18:30:00 End of Day
Thursday, April 29, 2010
07:30:00 Breakfast Workshop Presentation (Sponsorship Opportunity Available) or Morning Coffee
08:15:00 Chairperson's Opening Remarks
08:20:00 Featured Presentation Discovery of Novel Kinase Inhibitors Using Structure-Based Design Jose Duca
09:00:00 Structures of Protein Kinase CK2 and their Consequences for Inhibitor Design Karsten Niefind
09:30:00 Utilization of a Chemocentric Approach for the Rational Structure Based Design of DFG-out Allosteric B-Raf Inhibitors Justin Dietrich
10:00:00 Networking Coffee Break, Poster and Exhibit Viewing
10:45:00 Structural Bioinformatics-Based Prediction of Selectivity of a p38 MAP Kinase Inhibitor Li Xing
11:15:00 Rational Mutagenesis to Support Structure-Based Drug Design: MAPKAP Kinase 2 as a Case Study Maria Argiriadi
11:45:00 Teflon Phosphates”– Accessible Chemical Biological Tools to Study Kinase-Mediated Phosphorylation Pathways David Berkowitz
12:15:00 Sponsored Presentation (Opportunity Available)
12:30:00 Walk and Talk Luncheon in the Exhibit Hall (Last Chance for Poster and Exhibit Viewing)
13:55:00 Chairperson's Remarks
14:00:00 Developing Small Molecule Inhibitors for JAK 1 and 2 Jordan Fridman
14:30:00 Kinetic Analysis of the Enzyme Mechanism and the Allosteric Inhibition of CHK1 Jacques Ermolieff
15:00:00 Networking Refreshment Break
15:20:00 Discovery of PF-04577806, a Potent and Selective PKCbeta Inhibitor Hui Li
15:50:00 A Novel Platform Based Approach to Silence Kinase Drug Targets Using Covalent Inhibitors Juswinder Singh
16:20:00 Panel Discussions: Kinase Inhibitors – What is Next?
16:50:00 End of Conference
3D Tissue Models
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