Protein-Protein Interactions as Drug Targets
Hilton San Diego Resort

San Diego, California


   Protein-protein interactions ( PPI ) have established their role as
   key targets in drug discovery. Now in its third year, CHI’s
   Protein-Protein Interactions as Drug Targets conference is covering
   the journey from identifying PPI interaction pairs all the way to
   successfully developing a PPI inhibitor. Along the way, many questions
   will be addressed and obstacles will be discussed, including
   challenges the binding sites are presenting, modulation of PPI ,
   predicting PPI modes, and what can be done to target PPI successfully.

Schedule of Presentations:

Wednesday, April 28, 2010
12:30:00 Registration
13:30:00 Chairperson's Opening Remarks
13:40:00 Small Molecule Inhibitors of Protein-Protein Interactions: The Importance of Three-Dimensionality David C. Fry
14:10:00 Design, Synthesis and Evaluation of New Monovalent BIR2-Selective Inhibitors of the Anti-Apoptotic Protein XIAP Nicholas Cosford
14:40:00 Discovery of Protein-Protein Interaction Inhibitors through HTS Haian Fu
15:10:00 Structure Based Design of PDE4 Allosteric Modulators with Improved Safety Alex Burgin
15:25:00 Sponsored Presentations (Opportunity Available)
15:40:00 Networking Refreshment Break, Poster and Exhibit Viewing
16:20:00 Discovery of Novel Tetrahydroisoquinoline Derivatives as Bcl-2 Inhibitors John Porter
16:50:00 FRET-Based Determination in Living Cells of the Stoichiometry and Geometry of Some GPCR Homo-Oligomers in the Presence and Absence of Ligands Valerica Raicu
17:20:00 Break-Out Discussions
18:30:00 End of Day
Thursday, April 29, 2010
07:30:00 Breakfast Workshop Presentation (Sponsorship Opportunity Available) or Morning Coffee
08:15:00 Chairperson's Opening Remarks
08:20:00 Keynote Presentation | Joys and Challenges of Early-Stage Drug Discovery for Protein-Protein Interactions Michelle Arkin
09:00:00 Protein-Protein Interfaces: Toward Focused Chemical Databases? Xavier Morelli
09:30:00 Rational Design, Synthesis and Characterization of Potent, Non-Peptidic Smac Mimics/XIAP Inhibitors as Proapoptotic Agents for Cancer Therapy Pierfausto Seneci
10:00:00 Networking Coffee Break, Poster and Exhibit Viewing
10:45:00 Investigation of Protein-Protein Interactions by Combinatorial Domain Hunting - Squared (CDHsq) Stefanie Reich
11:15:00 Identification of Small Molecule Inhibitors of Myc Oncoprotein Function Lars-Gunnar Larsson
11:45:00 Peptides, Peptidomimetics for Modulation of Protein-Protein Interactions: Implications in Autoimmune Diseases and Cancer Seetharama Satyanarayanajois
12:15:00 Sponsored Presentation (Opportunity Available)
12:30:00 Walk and Talk Luncheon in the Exhibit Hall (Last Chance for Poster and Exhibit Viewing)
13:55:00 Chairperson's Remarks
14:00:00 Development of Small Molecules Targeting Menin-MLL Interaction in Leukemia Jolanta Grembecka
14:30:00 Using Semi-Rational Design and Protein Folding to Engineer Highly Specific Protein-Protein Interactions for Therapeutic Intervention Jody Mason
15:00:00 Networking Refreshment Break
15:20:00 Control PPI Process Complexity with a Genealogical Database Model Bill Harten
15:50:00 Finding Druggable Sites and Fragment Hits for Protein-Protein Interaction Targets Sandor Vajda
16:20:00 Coordinate Regulation of Multiple Biochemical Pathways by the Intersectin Scaffold John O'Bryan
16:50:00 End of Conference
3D Tissue Models
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