Phage and Yeast Display of Antibodies and Proteins
Sheraton Boston Hotel

Boston, Massachusetts


   Functional diversity and drug-like properties can be found from
   compound libraries using display methodologies. The most favored
   methods are yeast and phage display, as they offer a way to
   efficiently generate, screen, and optimize new classes of drugs. Get
   up to speed on the newest trends in antibody and peptide engineering.

Schedule of Presentations:

Monday, May 17, 2010
07:00:00 Registration and Morning Coffee
08:25:00 Keynote Presentations
08:30:00 Chairperson’s Opening Remarks Sachdev Sidhu
08:40:00 Phage Display Traps for Protein Conformation and Specific Composition Jim Wells
09:10:00 Research and Development of Next-Generation of Antibody-Based Therapeutics: Challenges and Opportunities Zhenping Zhu
09:40:00 Next-Generation Biologics Herren Wu
10:10:00 Grand Opening Coffee Break in Exhibit Hall
11:10:00 Q&A with Keynote Presenters Lutz Jermutus
11:30:00 Enhancing Library Diversity
11:35:00 Chairperson’s Remarks Andrew M Bradbury
11:40:00 Antibody Generation and Engineering Using Adaptor-Directed Phage and Yeast Display of Structure-Based Libraries
12:10:00 Determination of the True Diversity of a Human Antibody Library and Insights into the Human Antibody Repertoire, Using Next Generation DNA Sequencing Jaume Pons
12:40:00 Luncheon Presentation I
13:10:00 Luncheon Presentation II (Sponsor Opportunity Available)
13:55:00 Membrane Proteins And Cell-Based Selections
14:00:00 Chairperson’s Remarks Lutz Jermutus
14:05:00 Selection and Engineering of Antibodies Targeting Membrane Proteins Eric V. Shusta
14:35:00 Selection of Single-Domain Antibodies Targeting Brain Vasculature and Their Optimization for Imaging and Therapeutic Applications Danica Stanimirovic
15:05:00 Refreshment Break, Poster and Exhibit Viewing
15:45:00 Harnessing Somatic Hypermutation for Antibody Discovery and Optimization David King
16:15:00 Dissecting and Engineering High-Affinity Antibody-Antigen Interactions: Application to Viral Epitopes Jonathan R. Lai
16:45:00 Problem Solving Break-Out Sessions
17:45:00 Networking Cocktail Reception in the Exhibit Hall
Tuesday, May 18, 2010
08:00:00 Registration and Morning Coffee
08:20:00 Alternative Scaffolds And Display Systems
08:25:00 Chairperson’s Opening Remarks Karl Dane Wittrup
08:30:00 de novo Selection of High Affinity Antibodies from Synthetic Antibody Libraries Displayed on Phage as pIX-Fusion Proteins John Wheeler
09:00:00 Next-Generation Sequencing Technologies Applied to Antibody Display: By-Passing Primary Screening Nicolas Fischer
09:30:00 Engineered Bispecific Proteins that Target Multiple Tumor Vasculature Receptors Jennifer Cochran
10:00:00 Coffee Break, Poster and Exhibit Viewing
10:45:00 A “Super-Library” of Alternate Scaffolds for Engineering Molecular Recognition Balaji Rao
11:15:00 Phage-Encoded Bicyclic Peptides Christian Heinis
11:45:00 The Use of Pichia Surface Display for the Isolation of Nanobodies® with Desired Characteristics Joost Kolkman
12:15:00 Luncheon Presentations (Sponsorship Opportunities Available) or Lunch on Your Own
14:00:00 Chairperson’s Remarks David Lowe
14:05:00 Thermodynamic and Information-Based Design of IgG-Like Bispecific Antibodies Stephen J. Demarest
14:35:00 Aggregation-Resistant Human Antibody Domains through Directed Evolution Daniel Christ
15:05:00 Antibody Selection from Immunoglobulin Gene Libraries Expressed in Mammalian Cells Ernest S. Smith
15:35:00 Refreshment Break, Poster and Exhibit Viewing
16:15:00 Designing Quality in Antibodies: In Silico Aggregation Screening and Protein Engineering Methodologies to Improve Developability and Safety Profiles Jesús Zurdo
16:45:00 Human Antibody Discovery and Optimization in Yeast Michael J. Feldhaus
17:15:00 End of Conference
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