Helicase and NTP-Driven Nucleic Acids Motors: Structure, Function, Mechanism and Roles in Human Disease
Hyatt Grand Champions Resort & Spa
Indian Wells
CA, mm
Helicase/Translocase Structure
DNA Unwinding Mechanisms
Translocation Mechanisms
Helicases in DNA Replication
Helicases in DNA Repair and Recombination

Schedule of Presentations:

Saturday, June 23, 2007
16:00:00 Conference Registration
18:00:00 FASEB Opening Reception
19:00:00 Dinner
Sunday, June 24, 2007
07:30:00 Breakfast
10:00:00 Poster Session Group 1
12:00:00 Lunch
13:30:00 “AAA+ ATPases in DNA Replication Initiation”
14:10:00 “UvrD Helicase Unwinds DNA One Base Pair At A Time By A Two-Part Power Stroke” Wei Yang
14:40:00 “Structure and Mechanism of RecBCD” Dale Wigley
15:10:00 Group photo/Coffee Break
15:40:00 “Structure of a DnaB helicase hexamer and its complex with the helicase binding domain of the DnaG primase” Thomas A. Steitz
16:10:00 “Mechanistic studies of SRS2, a motor protein regulating recombination”
18:00:00 Dinner
19:00:00 “Allosteric control of the E. coli PriA helicase” Wlodzimierz Bujalowski
19:40:00 “Single stranded DNA translocation and DNA unwinding by E. coli UvrD and Rep are separable activities” Timothy M. Lohman
20:10:00 “Mechanistic studies of the T7 DNA helicase and polymerase” Smita Patel
20:40:00 Break
20:55:00 “Kinetic analysis of the optimally active form of DNA and RNA helicases” Kevin Raney
21:25:00 “DNA unwinding by the AddAB helicase” Mark Dillingham
Monday, June 25, 2007
07:30:00 Breakfast
10:00:00 Poster Session Group 1
12:00:00 Lunch
13:30:00 “Study of molecular mechanisms of helicases using single molecule fluorescence techniques” Taekjip Ha
14:10:00 “Single molecule studies of T7 DNA helicase” Michelle Wang
14:40:00 “Single molecule studies of FtsK” Carlos Bustamante
15:10:00 Coffee Break
15:40:00 “Long-range communications on DNA – Two views of a helicase mechanism” Mark D Szczelkun
16:10:00 “Rad54 protein translocates and cross-bridges dsDNA to stimulate the synapsis stage of homologous recombination”
18:00:00 Dinner
19:00:00 “Helicases in replisomes” Peter von Hippel
19:40:00 “Loading Mcm2-7 complexes at eukaryotic origins of replication” Stephen P Bell
20:10:00 “Pif1 family helicases” Virginia Zakian
20:40:00 Break
21:00:00 “Primer synthesis on single-stranded DNA-RPA filaments: Lessons from SV40 T antigen” Ellen Fanning
21:35:00 “Modular architecture and pathogenic alleles of the human mitochondrial replicative DNA helicase” Laurie S. Kaguni
Tuesday, June 26, 2007
07:30:00 Breakfast
10:00:00 Poster Session Group 2
12:00:00 Lunch
13:30:00 “DNA motor proteins: Single-molecule visualization and behavior” Stephen C Kowalczykowski
14:10:00 “Stepping of Individual RecBCD Molecules” Thomas T Perkins
14:40:00 “RecBCD enzyme: A dual-helicase recombination machine regulated by Chi hotspots” Gerald R Smith
15:10:00 Coffee Break
15:40:00 “Characterizing the interaction between UvrD and MutL in methyl-directed mismatch repair” Steve Matson
16:10:00 “Mechanisms of replication restart” Kenneth J. Marians
18:00:00 Dinner
19:00:00 “Probing the molecular mechanics of eukaryotic translation initiation” Jon Lorsch
19:40:00 “Mechanism of E. coli DbpA ATPase” Enrique De La Cruz
20:10:00 “Ntr1 activates the Prp43 helicase to trigger lariat-intron release from the spliceosome” Beate Schwer
20:40:00 Break
21:05:00 “RNA duplex unwinding by DEAD-box proteins” Eckhard Jankowsky
Wednesday, June 27, 2007
07:30:00 Breakfast
10:00:00 Poster Session Group 2
12:00:00 Lunch
13:30:00 “A diversity of mechanical behaviors by the multicomponent NS3 helicase from hepatitis C virus”
14:10:00 “Mycobacterial UvrD1 is a Ku-dependent DNA helicase that plays a role in multiple DNA repair events, including doublestrand break repair” Stewart Shuman
14:40:00 “RNA virus polymerases in replication”
15:10:00 Coffee Break
15:40:00 “Mechanism of DNA translocation in a replicative hexameric helicase” Leemor Tor
18:00:00 Dinner
19:00:00 “Structural and cellular mechanisms of bacterial RecQ DNA helicases” James Keck
19:40:00 “The Werner syndrome protein interacts functionally with translesion DNA polymerases” Larry Loeb
20:10:00 “Werner protein interactions and regulation” Vilhelm Bohr
20:40:00 Break
20:55:00 “Role for the Bloom's syndrome helicase in the repair of damaged replication forks” Leonard Wu
21:25:00 “BLM meets SUMO: wrestling with genomic instability and nuclear trafficking” Nathan Ellis
Thursday, June 28, 2007
07:30:00 Breakfast
09:00:00 “DNA remodeling by RSC complexes” Bradley R Cairns
09:40:00 “The structural basis of protein acetylation by p300/CBP transcriptional coactivator” Ronen Marmorstein
10:10:00 “yFACT makes nucleosomal DNA accessible without disassembling or translocating histone octamers” Tim Formosa
10:40:00 Coffee Break
11:10:00 “Mechanisms of ATP-dependent chromatin remodeling enzymes”
12:15:00 Box Lunches Available
3D Tissue Models
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