Joint Metastasis Research Society-AACR Conference in Conjunction with the Tumor Microenvironment Working Group of the AACR

Philadelphia, Pennsylvania


   American Association for Cancer Research

   Upcoming Conferences at the Forefront of Cancer Research

   September 12-15, 2010

   Joint Metastasis Research Society- AACR Conference In conjunction with
   the Tumor Microenvironment Working Group of the AACR

   Chairpersons: Patricia S. Steeg and Bruce R. Zetter
   Philadelphia, PA

   Please visit often for additional
   conferences and program updates.

Schedule of Presentations:

Sunday, September 12, 2010
16:30:00 Welcome and Keynote Address
16:35:00 Welcome Bruce R. Zetter
17:00:00 Special Presentation | Title to be announced S. Ward Casscells
17:30:00 Keynote Address | Title to be announced Joan Brugge
18:00:00 Plenary Session 1: The Influence of the Niche David C Lyden
18:30:00 ALK: An exploitable new target in non-small cell lung cancer Mace L. Rothenberg
19:00:00 The pre-metastatic niche: Adapting the foreign soil David C Lyden
19:30:00 Seed and soil hypothesis revisited Rakesh K Jain
20:00:00 Hypoxia-induced genes that promote metastasis: New targets for therapy Amato J. Giaccia
20:15:00 Short talk from selected proffered abstracts
20:30:00 Networking Reception
Monday, September 13, 2010
07:00:00 Meet-the-Expert Sessions
07:05:00 Funding paradigms in the tumor microenvironment Dinah S. Singer
07:20:00 Hypoxic tumor microenvironment: Validation of novel metabolic targets Jacques Pouysségur
07:45:00 Plenary Session 2: Translational Targets I George W. Sledge
07:50:00 Is the micrometastatic cell a clinical target? George W. Sledge
08:30:00 Targeting TGF-beta to suppress metastasis Lalage M. Wakefield
09:00:00 The role of tumor endothelin-1 in metastatic colonization of the lung Dan Theodorescu
09:30:00 Title to be announced Saburo Sone
10:00:00 Short talk from selected proffered abstracts
10:45:00 Concurrent Sessions
10:50:00 Session 1: TME - Stroma Zena Werb
11:00:00 Targeting stromal proteases as therapy for cancer Samuel R. Denmeade
11:15:00 Adult stromal cells for the targeted therapy of gastrointestinal cancers Pierre Cordelier
11:30:00 Title to be announced Zena Werb
12:00:00 Session 2: MRS - Genomics of Primary Tumors and Metastases G. Steven Bova
12:05:00 Exploring clonality in lethal metastatic prostate cancer: Potential value in reducing complexity G. Steven Bova
12:10:00 Comparing genomics of primary tumors and metastases for targets identification and biomarkers development in lung cancer Ignacio I. Wistuba
12:15:00 Epigenetic regulation of metastatic dispersal in childhood malignancy Stefan Burdach
13:15:00 Controversy Session: Anti-angiogenesis: Hot or Not?
13:20:00 The biology behind the successes and failures of VEGF-targeted therapies Lee M Ellis
13:30:00 Preclinical modelling of adjuvant and metastatic antiangiogenic therapies Robert S. Kerbel
14:30:00 Plenary Session 3: Novel Molecular Pathways Joan Massagué
14:45:00 Correlative biomarkers for anti-angiogenic therapy Jeffrey W. Clark
15:00:00 Metastasis meets microenvironment Joan Massagué
15:30:00 Necdin regulation by Nm23-H1 and EBNA3C: Insights from a virus Erle S. Robertson
16:00:00 Short talk from selected proffered abstracts
17:00:00 Concurrent Sessions
17:05:00 Session 3: TME - Inflammation and Immunity Alberto Mantovani
17:15:00 Chemokines in tumor progression and metastasis Alberto Mantovani
17:30:00 Polarizing immune responses to regulate solid tumor development Lisa M. Coussens
17:45:00 Stem cells, inflammation, and tumor immunity: From bedside to the bench Madhav V Dhodapkar
17:55:00 Short talk from selected proffered abstracts
18:00:00 Session 4: MRS - Metastatic Colonization Carrie W. Rinker-Schaeffer
18:05:00 Using metastasis suppressors to dissect cancer cell-microenvironmental interactions during metastatic colonization Carrie W. Rinker-Schaeffer
18:10:00 Novel mediators of tumor-stroma crosstalk in breast cancer bone metastasis Yibin Kang
18:15:00 Mesenchymal-epithelial transition (MET) in tumor cell metastasis Jacqueline Banyard
18:20:00 Short talk from selected proffered abstracts
18:30:00 Poster Session A
Tuesday, September 14, 2010
07:00:00 Meet-the-Expert Sessions
07:10:00 Neuroendocrine regulation of metastasis: Targeting the tumor macroenvironment Steve Cole
07:30:00 Metastasis assays in vivo and ‘metastasis assays’ in vitro: What do they mean? Danny R. Welch
08:00:00 Plenary Session 4: Dormancy Ann Chambers
08:05:00 Dissemination of prostate cancer cells to bone: Insight into the metastatic process, tumor cell dormancy and progression Robert L Vessella
08:30:00 Imaging experimental models of tumor metastasis and dormancy Ann Chambers
09:00:00 Stress signaling mechanisms and dormancy of disseminated tumor cells Julio Aguirre-Ghiso
09:30:00 A LPA1 inhibitor that functions as a metastasis suppressor Jean-Claude A. Marshall
10:30:00 Generation X Session: The Future of Tumor Progression Yves A. DeClerck
11:00:00 Short talks from selected proffered abstracts
13:30:00 Concurrent Sessions
13:35:00 Session 5: Metastasis and the Matrix Valerie M. Weaver
13:45:00 The force journey of a tumor cell Valerie M. Weaver
14:00:00 An integrin avb3-c-Src oncogenic unit promotes anchorage-dependence and tumor progression David A. Cheresh
14:15:00 Title to be announced Linda Gay Griffith
14:30:00 Short talk from selected proffered abstracts
14:45:00 Session 6: MRS - Site Specific Metastasis Andrea M. Mastro
15:00:00 An in vitro model of the vicious cycle of cancer metastasis in the bone Andrea M. Mastro
15:10:00 Translational leads for the treatment of breast cancer brain metastasis Diane Palmieri
15:20:00 The tumor microenvironment at different stages of the hepatic metastasis process Fernando Vidal-Vanaclocha
15:30:00 Short talk from selected proffered abstracts
16:00:00 Paget-Ewing Award Lecture
17:30:00 Poster Session B
19:30:00 Conference Banquet
Wednesday, September 15, 2010
07:00:00 Meet-the-Expert Sessions
07:15:00 Cancer micrometastasis and circulating tumor cells Klaus Pantel
07:30:00 Defining and validating molecular targets for high throughput screening James B. McMahon
07:45:00 Plenary Session 5: Stem Cells Max S Wicha
08:00:00 Regulation of breast cancer stem cells by the tumor microenvironment Max S Wicha
08:30:00 The Six1/Eya transcriptional complex as a regulator of EMT, cancer stem cells, and metastasis Heide L. Ford
09:00:00 Solid tumors target the hematopoietic stem cell niche during metastasis Russell S. Taichman
09:30:00 Additional speaker from submitted abstracts
10:30:00 Plenary Session 6: Translational Targets II Patricia Steeg
10:45:00 Title to be announced David Lacey
11:00:00 Signalling pathways as targets for therapy Suzanne A. Eccles
11:30:00 The role of adipocytes in promoting metastasis Ernst R. Lengyel
12:00:00 Departure
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