Colorectal Cancer: Biology to Therapy
Loews Philadelphia Hotel
Philadelphia, Pennsylvania
Philadelphia, Pennsylvania


   American Association for Cancer Research

   Upcoming Conferences at the Forefront of Cancer Research

   October 27-30, 2010

   Colorectal Cancer: Biology to Therapy

   Chairpersons: Anil K. Rustgi, Joanna L. Groden, and Richard M.
   Philadelphia, PA

   Please visit often for additional
   conferences and program updates.

Schedule of Presentations:

Wednesday, October 27, 2010
19:00:00 Keynote Session
19:15:00 Welcome and Opening Remarks Anil K Rustgi
19:30:00 Colorectal cancer genomes and their implications for basic and applied research Bert Vogelstein
20:00:00 Welcome Reception
Thursday, October 28, 2010
07:00:00 Continental Breakfast
08:00:00 Session 1: Intestinal Stem Cells
08:05:00 Targeting dormant drug-resistant cancer stem cells Linheng Li
08:30:00 In vitro analysis of intestinal stem cells Calvin Kuo
09:00:00 Relationship of progenitors within the stem cell niche Melissa Hirose Wong
09:30:00 Short talks from proffered papers
10:00:00 Break
10:30:00 Session 2: Regulation of the Genome
10:35:00 Dampening of TGFbeta responses by Myc-regulated microRNAs: Implications for colon cancer angiogenesis Andrei Thomas-Tikhonenko
11:00:00 DNA mismatch repair and colorectal cancer: Understanding pathogenic variants using yeast as a model system Alison Gammie
11:30:00 Integrative systems biology of colorectal cancer genomics: Unraveling the dominant oncogenic mechanisms Bruce J. Aronow
12:30:00 Poster Session A / Lunch
14:30:00 Session 3: Genetics of Susceptibility
14:35:00 Intermediate-penetrance genes in the predisposition to colorectal cancer Albert de la Chapelle
15:30:00 DNA repair and susceptibility to colon cancer Joanna L. Groden
16:00:00 Title to be announced Charles S. Fuchs
Friday, October 29, 2010
07:00:00 Continental Breakfast
08:00:00 Session 4: Inflammation and Tumor Microenvironment
08:05:00 Title to be announced Michael Karin
08:30:00 Gastrointestinal cancer and the tumor microenvironment Timothy C. Wang
09:00:00 Inflammation and cancer: Impact of COX-2 and other inflammatory mediators Raymond N DuBois
09:30:00 Short talks from proffered papers
10:00:00 Break
10:30:00 Session 5: Mouse Models of Intestinal Cancer
10:35:00 Inactivation of CCR1 suppresses colon cancer metastasis by blocking accumulation of immature myeloid cells Makoto Mark Taketo
11:00:00 Mechanisms of crypt fission Thaddeus Stappenbeck
11:30:00 Host genetic factors controlling development of flat colonic adenomas David Threadgill
12:00:00 Short talks from proffered papers
12:30:00 Mentoring Groups / Lunch on Own
14:30:00 Session 6: Advances in Diagnostics
14:35:00 Genetic opportunities for preventing death from colon cancer Sanford Markowitz
15:00:00 Early detection of colorectal cancer using stool DNA: Is it ready for prime time? Nita Ahuja
15:30:00 DNA methylation markers: Implications for therapy? Stephen B Baylin
16:00:00 Short talks from proffered papers
17:00:00 Poster Session and Reception
Saturday, October 30, 2010
07:00:00 Continental Breakfast
08:00:00 Session 7: Imaging of the GI Tract
08:05:00 Molecular imaging approaches to colorectal cancer Umar Mahmood
08:30:00 Advances in point of care microscopy Christopher H. Contag
09:00:00 Imaging colon cancer targets for therapy W S El-Deiry
09:30:00 Short talks from proffered papers
10:00:00 Break
10:30:00 Session 8: Clinical Trials and Experimental Therapeutics
10:35:00 Novel agent development in CRC: Approach to individualized therapy S. Gail Eckhardt
11:00:00 Managing the interface between chemotherapy and targeted therapy in patients with colorectal cancer Richard M Goldberg
11:30:00 Efficacy and toxicity of VEGF inhibitors: Predictive markers and biological insights Herbert Hurwitz
12:00:00 Short talks from proffered papers
12:30:00 Departure
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