Retinal Ganglion Cells
Convention Center

Fort Lauderdale, Florida





   30 April - 1 May 2010

   Convention Center, Fort Lauderdale, Florida, USA

   Two day satellite meeting prior to 2010 ARVO

   This conference aims to bring together leading basic and clinical
   scientists to share the latest research on retinal ganglion cells and
   their roles in vision and disease. The goal is to take a comprehensive
   look at this critical and complex class of neurons, examining their
   development and establishment of axonal and dendritic connections,
   their diverse functions in processing signals from the outer retina
   and detecting light directly, how they are affected in glaucoma, optic
   nerve damage, and other disease conditions, and how our understanding
   of these processes can lead to novel therapeutic approaches.

   • Signal processing by retinal ganglion cells
   • Photosensitive ganglion cells
   • Ganglion cell development and axonal targeting
   • Optic nerve damage and regeneration
   • Mechanisms of ganglion cell death/animal models
   • Pathogenesis/neuro-protection for ganglion cells
   • Gene defects associated with ganglion cell disease
   • Novel therapeutic approaches in glaucoma

Schedule of Presentations:

Friday, April 30, 2010
07:30:00 Registration
08:25:00 Welcome from Conference Chair T. Wensel
08:30:00 Session 1: Pathogenesis/Neuro-protection for ganglion cells R. Weinreb
08:35:00 The potential for stem cell treatments in glaucoma K. Martin
08:55:00 The significance of early markers of retinal ganglion cell damage J. Lindsey
09:20:00 Mitochondrial dysfunction and neuroprotection during Glaucomatous Neurodegeneration W. K. Ju
09:45:00 Effects of retinal ganglion cell loss on the lateral geniculate nucleus and visual cortex in glaucoma Y. Yucel
10:10:00 Refreshment break
10:20:00 Session 2: Optic nerve damage and regeneration T. Reh
10:25:00 Overview T. Reh
10:35:00 Gene regulatory networks in retinal ganglion cell development and optic nerve degeneration W. H. Klein
11:00:00 Progressive axonopathy in glaucoma D. J. Calkins
11:25:00 Are we there yet? Novel ways to enhance optic nerve regeneration L. Benowitz
11:50:00 Intrinsic control of axon regeneration in RGCs J. Goldberg
12:15:00 Lunch break
13:20:00 Session 3: Novel therapeutic approaches in glaucoma P. Kaufman
13:25:00 Molecular delivery in the anterior and posterior segment P. Kaufman
13:50:00 Mechanobiology in the aqueous outflow pathways - a target-rich environment E. Tamm
14:15:00 Monitoring RGCs in the real world J. Crowston
14:40:00 Glaucoma in the age of nanotechnology / neural knitting in the optic nerve / visual pathway R. Ellis-Behnke
15:05:00 Refreshment break
15:15:00 Session 4: Ganglion cell development and axonal targeting Carol Mason
15:20:00 Genes that control retinal ganglion cell specification, chiasm decussation, and targeting in the dLGN Carol Mason
15:45:00 Target recognition and synaptic specificity in developing retinal ganglion cells A. D. Huberman
16:10:00 Exploring ganglion cell development at single cell resolution J. Trimarchi
16:35:00 An instructive role for retinal ganglion cell activity in visual map development Michael Crair
17:00:00 Poster session
17:30:00 End of day 1
Saturday, May 1, 2010
07:55:00 Session 5: Signal processing by retinal ganglion cells D. Copenhagen
08:00:00 Overview D. Copenhagen
08:10:00 Synaptic basis for 'red-green' and 'blue-yellow' color opponency in primate retinal ganglion cells D. Dacey
08:35:00 Mixing of excitatory ON and OFF signals at the ganglion cell level: a new role for retinal gap junctions S. A. Bloomfield
09:00:00 The influence of light adaptation on the spatial structure of retinal receptive fields in primate G. Field
09:25:00 From synaptic activity to dendritic remolding: The possible roles of immune molecules in the activity-dependent synaptic plasticity N. Tian
09:50:00 NMDA receptor contributions to visual contrast coding in retinal ganglion cells J. Demb
10:15:00 Refreshment break
10:25:00 Session 6: Mechanisms of ganglion cell death/animal models R. Masland
10:30:00 Overview R. Masland
10:40:00 Biomechanical implications of early optic nerve head connective tissue damage, deformation and remodelling C. F. Burgoyne
11:05:00 The murine optic nerve head and its implications for glaucoma T. C. Jakobs
11:30:00 Gene expression profiling to identify early stages of glaucoma in mice G. Howell
11:55:00 Modulators of retinal ganglion cell survival in glaucoma D. J. Calkins
12:20:00 Lunch break
13:25:00 Session 7: Gene defects associated with ganglion cell disease J. Wiggs
13:30:00 Apoptotic regulatory genes as risk factors for ganglion cell loss in glaucoma J. Wiggs
13:55:00 Genetic risk factors for ganglion cell loss in African populations J. Fielding Hejtmancik
14:15:00 Gene defects associated with ganglion cell loss in primary open angle glaucoma H. Tseng
14:40:00 Ganglion cell disease caused by mitochondrial dysfunction D. Mackey
15:05:00 Refreshment break
15:10:00 Session 8: Photosensitive ganglion cells. D. Berson
15:15:00 Rods provide the principal input to melanopsin cells for circadian photoentrainment Samer Hattar
15:40:00 Retinal circuits of ganglion-cell photoreceptors K. Y. Wong
16:05:00 Central response to mRGC-activation R. Lucas
16:30:00 Sustained signaling of light by melanopsin retinal ganglion cells
16:55:00 Crossover inhibition: Corrects for synaptic rectification in ganglion cells in six ways F. S. Werblin
17:05:00 The circadian clock in the mammalian retina controls rod and cone input to ganglion cells S. C. Mangel
17:20:00 Pannexins, P2X7 receptors and mechanosensitivity; a novel autocrine signaling pathway in retinal ganglion cells C. H. Mitchell
17:30:00 Close of Conference
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