25th Annual Critical Issues in Tumor Microenvironment, Angiogenesis and Metastasis: from Bench to Bedside to Biomarkers
Royal Sonesta Hotel - Cambridge, MA

, United States 02142

   Course Director
   Rakesh K. Jain, Ph.D., Andrew Werk Cook Professor of Tumor Biology,
   Harvard Medical School; Director, E.L. Steele Laboratory of Tumor
   Biology, Department of Radiation Oncology, Massachusetts General
   Hospital, Boston, MA, USA , Faculty, Peter Carmeliet, M.D., Ph.D.,
   Professor of Medicine; Director, Vesalius Research Center, KU Leuven,
   Campus Gasthuisberg, Leuven, Belgium, Lisa Coussens, Ph.D., Professor,
   Pathology; Co-Director, Mouse Pathology Core; University of
   California, San Francisco; Department of Pathology and Laboratory
   Medicine; Pathology and Cancer Research Institute; San Francisco, CA,
   USA ,
   Harold F. Dvorak, M.D., Mallinckrodt Distinguished Professor of
   Pathology, Harvard Medical School; Founding Director, Center for
   Vascular Biology Research, Beth Israel Deaconess Medical Center,
   Boston, MA, USA , Isaiah J. Fidler D.V.M., Ph.D., R.E.

   The objective of this course is to discuss our current understanding
   of the tumor microenvironment and their relationship with metastasis.
   Emphasis will be placed on their pathophysiological significance and
   clinical relevance and treatment. Most cancer research to date has
   focused on understanding the biology of tumor cells in vitro with
   limited attention paid to the in vivo microenvironment in which these
   cells reside. Since nothing can reach tumor cells from blood without
   passing through the vascular and interstitial compartments, it seems
   reasonable to find out more about the structure and function of these
   two compartments.

Event Sponsors

Schedule of Presentations:

Monday, September 27, 2010
07:30:00 Registration
08:00:00 Continental Breakfast
08:30:00 Opening Remarks Rakesh K Jain
09:00:00 Tumor Microenvironment I: Angiogenesis and Vascular Transport Rakesh K Jain
10:00:00 Coffee Break
10:30:00 Tumor Microenvironment II: Interstitial and Lymphatic Transport Rakesh K Jain
12:00:00 Lunch provided on site
13:30:00 Normalization of Tumor Vasculature and Microenvironment by Antiangiogenic Therapy: from Bench to Bedside to Biomarkers Rakesh K Jain
15:00:00 Coffee Break
15:30:00 Taking Low-Dose Metronomic Chemotherapy from a Preclinical Concept to a Promising Clinical Treatment for Metastatic Disease Robert S. Kerbel
17:00:00 Adjourn
Tuesday, September 28, 2010
08:00:00 Continental Breakfast
08:30:00 The Biology of Cancer Metastasis Isaiah J. Fidler
10:00:00 Coffee Break
10:30:00 Therapy of Cancer Metastasis: Attacking the Stroma Isaiah J. Fidler
12:00:00 Lunch
13:30:00 Extrinsic Control of Solid Tumor Development by Immune Cells Lisa M Coussens
15:00:00 Coffee Break
15:30:00 Molecular Mechanisms of Tumor Progression and Metastasis Robert A Weinberg
17:00:00 Adjourn
Wednesday, September 29, 2010
08:00:00 Continental Breakfast
08:30:00 From a Model of Vessel Branching to Developing Anti-Angiogenic Agents Peter Carmeliet
10:00:00 Coffee Break
10:30:00 Hypoxia, Oxygen Sensing and Vessel Morphogenesis: Implications for Metastasis Peter Carmeliet
12:00:00 Lunch
13:30:00 Tumor Stroma Generation: Role of VPF/VEGF Harold F. Dvorak
15:00:00 Coffee Break
15:30:00 Drug Delivery Systems for Angiogenesis Inhibitors and Other Biomolecules Robert S. Langer
17:00:00 Adjourn
Thursday, September 30, 2010
08:00:00 Continental Breakfast
08:30:00 Genetics in Cancer Therapy Raju Kucherlapati
10:00:00 Coffee Break
10:30:00 Lessons from Clinical Trials of Targeted Therapies for Cancer George W. Sledge
12:00:00 Lunch provided on site
13:30:00 Mining the Human Proteome: Biomarker Discovery for Human Cancer and Its Metastases Marsha Moses
15:00:00 Coffee Break
15:30:00 Imaging Angiogenesis and Vascular Function in Cancer Patients A. Gregory Sorensen
17:00:00 Summary and closing remarks
3D Tissue Models
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